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Methylene Blue Induces Antioxidant Defense and Reparation of Mitochondrial DNA in a Nrf2-Dependent Manner during Cisplatin-Induced Renal Toxicity.
Samoylova NA, Gureev AP, Popov VN. Samoylova NA, et al. Int J Mol Sci. 2023 Mar 24;24(7):6118. doi: 10.3390/ijms24076118. Int J Mol Sci. 2023. PMID: 37047089 Free PMC article.
Cisplatin injections induced oxidative stress by depleting renal antioxidants at the transcriptome level but did not increase the rate of H(2)O(2) production in isolated mitochondria. Methylene blue, on the contrary, induced mitochondrial H(2)O(2) production. …
Cisplatin injections induced oxidative stress by depleting renal antioxidants at the transcriptome level but did not increase the rate of H( …
Homogenous repair of singlet oxygen-induced DNA damage in differentially transcribed regions and strands of human mitochondrial DNA.
Anson RM, Croteau DL, Stierum RH, Filburn C, Parsell R, Bohr VA. Anson RM, et al. Nucleic Acids Res. 1998 Jan 15;26(2):662-8. doi: 10.1093/nar/26.2.662. Nucleic Acids Res. 1998. PMID: 9421531 Free PMC article.
Photoactivated methylene blue was used to damage purified DNA and the mitochondrial DNA (mtDNA) of human fibroblasts in culture. ...Cultured fibroblasts were exposed to photoactivated methylene blue under conditions that would prod …
Photoactivated methylene blue was used to damage purified DNA and the mitochondrial DNA (mtDNA) of human …
Transient elevation of glycolysis confers radio-resistance by facilitating DNA repair in cells.
Bhatt AN, Chauhan A, Khanna S, Rai Y, Singh S, Soni R, Kalra N, Dwarakanath BS. Bhatt AN, et al. BMC Cancer. 2015 May 1;15:335. doi: 10.1186/s12885-015-1368-9. BMC Cancer. 2015. PMID: 25925410 Free PMC article.
METHODS: We stimulated glycolysis using mitochondrial respiratory modifiers (MRMs viz. di-nitro phenol, DNP; Photosan-3, PS3; Methylene blue, MB) in established human cell lines (HEK293, BMG-1 and OCT-1). ...CONCLUSIONS: These findings suggest that enhanced g …
METHODS: We stimulated glycolysis using mitochondrial respiratory modifiers (MRMs viz. di-nitro phenol, DNP; Photosan-3, PS3; Meth …
Spontaneous and photosensitiser-induced DNA single-strand breaks and formamidopyrimidine-DNA glycosylase sensitive sites at nucleotide resolutionin the nuclear and mitochondrial DNA of Saccharomyces cerevisiae.
Meniel V, Waters R. Meniel V, et al. Nucleic Acids Res. 1999 Feb 1;27(3):822-30. doi: 10.1093/nar/27.3.822. Nucleic Acids Res. 1999. PMID: 9889279 Free PMC article.
A system is described for mapping oxidative DNA damage (sites sensitive to formamidopyrimidine-DNA glycosylase and single-strand breaks) at nucleotide resolution in the nuclear and mitochondrial DNA of Saccharomyces cerevisiae. Our 3' end labelling met …
A system is described for mapping oxidative DNA damage (sites sensitive to formamidopyrimidine-DNA glycosylase and single-stra …
Cellular stress and AMPK activation as a common mechanism of action linking the effects of metformin and diverse compounds that alleviate accelerated aging defects in Hutchinson-Gilford progeria syndrome.
Finley J. Finley J. Med Hypotheses. 2018 Sep;118:151-162. doi: 10.1016/j.mehy.2018.06.029. Epub 2018 Jun 28. Med Hypotheses. 2018. PMID: 30037605
Progerin accumulation in the nuclear membrane and within the nucleus distorts the nuclear architecture and negatively effects nuclear processes including DNA replication and repair, leading to accelerated cellular aging and premature senescence. ...Interestingly, se …
Progerin accumulation in the nuclear membrane and within the nucleus distorts the nuclear architecture and negatively effects nuclear proces …
Gene-specific and mitochondrial repair of oxidative DNA damage.
Anson RM, Mason PA, Bohr VA. Anson RM, et al. Methods Mol Biol. 2006;314:155-81. doi: 10.1385/1-59259-973-7:155. Methods Mol Biol. 2006. PMID: 16673881
Here we show how the assay may be adapted to assess mitochondrial DNA (mtDNA) damage. In the mitochondrion, 8-oxoguanine is a significant oxidative lesion; in the laboratory, photoactivated methylene blue may be used to introduce this lesion into cells …
Here we show how the assay may be adapted to assess mitochondrial DNA (mtDNA) damage. In the mitochondrion, 8-oxoguanine is a …