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Page 1
The Potentials of Methylene Blue as an Anti-Aging Drug.
Xue H, Thaivalappil A, Cao K. Xue H, et al. Cells. 2021 Dec 1;10(12):3379. doi: 10.3390/cells10123379. Cells. 2021. PMID: 34943887 Free PMC article. Review.
Methylene blue (MB), as the first fully man-made medicine, has a wide range of clinical applications. ...MB can bypass Complex I/III activity in mitochondria and diminish oxidative stress to some degree. This review summarizes the recent studies on the applic …
Methylene blue (MB), as the first fully man-made medicine, has a wide range of clinical applications. ...MB can bypass Complex …
Targeting mitochondrial dysfunction using methylene blue or mitoquinone to improve skeletal aging.
Poudel SB, Frikha-Benayed D, Ruff RR, Yildirim G, Dixit M, Korstanje R, Robinson L, Miller RA, Harrison DE, Strong JR, Schaffler MB, Yakar S. Poudel SB, et al. Aging (Albany NY). 2024 Mar 25;16(6):4948-4964. doi: 10.18632/aging.205147. Epub 2024 Mar 25. Aging (Albany NY). 2024. PMID: 38535998 Free PMC article.
Methylene blue (MB) is a well-established antioxidant that has been shown to improve mitochondrial function in both in vitro and in vivo settings. ...Additionally, we used MitoQ as an alternative approach to target mitochondrial oxidative stress during …
Methylene blue (MB) is a well-established antioxidant that has been shown to improve mitochondrial function in both in …
Targeting mitochondrial dysfunction in CNS injury using Methylene Blue; still a magic bullet?
Vekaria HJ, Talley Watts L, Lin AL, Sullivan PG. Vekaria HJ, et al. Neurochem Int. 2017 Oct;109:117-125. doi: 10.1016/j.neuint.2017.04.004. Epub 2017 Apr 7. Neurochem Int. 2017. PMID: 28396091 Free PMC article. Review.
We will also give an overview of one relatively new TBI therapeutic approach, Methylene Blue, currently being studied to ameliorate mitochondrial dysfunction following brain injury. We will also present novel experimental findings, that for the first time, ch …
We will also give an overview of one relatively new TBI therapeutic approach, Methylene Blue, currently being studied to ameli …
Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria.
Xiong ZM, Choi JY, Wang K, Zhang H, Tariq Z, Wu D, Ko E, LaDana C, Sesaki H, Cao K. Xiong ZM, et al. Aging Cell. 2016 Apr;15(2):279-90. doi: 10.1111/acel.12434. Epub 2015 Dec 14. Aging Cell. 2016. PMID: 26663466 Free PMC article.
Hutchinson-Gilford progeria syndrome (HGPS), a fatal premature aging disease, is caused by a single-nucleotide mutation in the LMNA gene. Previous reports have focused on nuclear phenotypes in HGPS cells, yet the potential contribution of the mitochondria, a key pla …
Hutchinson-Gilford progeria syndrome (HGPS), a fatal premature aging disease, is caused by a single-nucleotide mutation in the LMNA g …
Anti-Aging Potentials of Methylene Blue for Human Skin Longevity.
Xiong ZM, O'Donovan M, Sun L, Choi JY, Ren M, Cao K. Xiong ZM, et al. Sci Rep. 2017 May 30;7(1):2475. doi: 10.1038/s41598-017-02419-3. Sci Rep. 2017. PMID: 28559565 Free PMC article.
Oxidative stress is the major cause of skin aging that includes wrinkles, pigmentation, and weakened wound healing ability. Application of antioxidants in skin care is well accepted as an effective approach to delay the skin aging process. Methylene blue …
Oxidative stress is the major cause of skin aging that includes wrinkles, pigmentation, and weakened wound healing ability. Applicati …
Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways.
Atamna H, Nguyen A, Schultz C, Boyle K, Newberry J, Kato H, Ames BN. Atamna H, et al. FASEB J. 2008 Mar;22(3):703-12. doi: 10.1096/fj.07-9610com. Epub 2007 Oct 10. FASEB J. 2008. PMID: 17928358
Methylene blue (MB) has been used clinically for about a century to treat numerous ailments. ...Cycling of MB between oxidized and reduced forms may block oxidant production by mitochondria. Mitochondrial dysfunction and oxidative stress are thought to …
Methylene blue (MB) has been used clinically for about a century to treat numerous ailments. ...Cycling of MB between oxidized …
Cancer and Alzheimer's disease: intracellular pH scales the metabolic disorders.
Schwartz L, Peres S, Jolicoeur M, da Veiga Moreira J. Schwartz L, et al. Biogerontology. 2020 Dec;21(6):683-694. doi: 10.1007/s10522-020-09888-6. Epub 2020 Jul 2. Biogerontology. 2020. PMID: 32617766 Review.
These pathologies share common risk factors (inflammation and aging), with similar epidemiological and biochemical features such as impaired mitochondria. ...Low carb diet, lipoic acid, and/or methylene blue could then appear promising in both sets of …
These pathologies share common risk factors (inflammation and aging), with similar epidemiological and biochemical features such as i …
Mitochondrial pharmacology: electron transport chain bypass as strategies to treat mitochondrial dysfunction.
Atamna H, Mackey J, Dhahbi JM. Atamna H, et al. Biofactors. 2012 Mar-Apr;38(2):158-66. doi: 10.1002/biof.197. Epub 2012 Mar 15. Biofactors. 2012. PMID: 22419586 Free PMC article. Review.
This view has been demonstrated by testing the effect of several redox active agents on cellular senescence. Methylene blue (MB, redox potential 10 mV) appears to readily cycle between the oxidized and reduced forms using specific mitochondrial and cytosolic …
This view has been demonstrated by testing the effect of several redox active agents on cellular senescence. Methylene blue (M …
Exogenous Iron Induces Mitochondrial Lipid Peroxidation, Lipofuscin Accumulation, and Ferroptosis in H9c2 Cardiomyocytes.
Lyamzaev KG, Huan H, Panteleeva AA, Simonyan RA, Avetisyan AV, Chernyak BV. Lyamzaev KG, et al. Biomolecules. 2024 Jun 19;14(6):730. doi: 10.3390/biom14060730. Biomolecules. 2024. PMID: 38927133 Free PMC article.
We show that supplementation of exogenous iron in the form of ferric ammonium citrate at submillimolar doses induces production of reactive oxygen species (ROS) and lipid peroxidation in mitochondria that precede ferroptosis in H9c2 cardiomyocytes. The mitochondria- …
We show that supplementation of exogenous iron in the form of ferric ammonium citrate at submillimolar doses induces production of reactive …
Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice.
Poudel SB, Ruff RR, Yildirim G, Miller RA, Harrison DE, Strong R, Kirsch T, Yakar S. Poudel SB, et al. Arthritis Res Ther. 2024 Jun 8;26(1):118. doi: 10.1186/s13075-024-03349-y. Arthritis Res Ther. 2024. PMID: 38851726 Free PMC article.
Articular cartilage (AC) integrity and SCB morphology were assessed in 182 knee joints of 22-25 months old mice using the Osteoarthritis Research Society International (OARSI) scoring system and micro-CT, respectively. Additionally, we explored the effects of methylene …
Articular cartilage (AC) integrity and SCB morphology were assessed in 182 knee joints of 22-25 months old mice using the Osteoarthritis …
20 results