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Evaluation of protective effects of methylene blue on cisplatin-induced nephrotoxicity.
Usefzay O, Yari S, Amiri P, Hasanein P. Usefzay O, et al. Biomed Pharmacother. 2022 Jun;150:113023. doi: 10.1016/j.biopha.2022.113023. Epub 2022 Apr 25. Biomed Pharmacother. 2022. PMID: 35483196 Free article.
However, its usage is limited due to nephrotoxicity. This study aims to examine the applicability of methylene blue (MB) against CP-induced kidney injuries. ...
However, its usage is limited due to nephrotoxicity. This study aims to examine the applicability of methylene blue (MB …
Methylene Blue Induces Antioxidant Defense and Reparation of Mitochondrial DNA in a Nrf2-Dependent Manner during Cisplatin-Induced Renal Toxicity.
Samoylova NA, Gureev AP, Popov VN. Samoylova NA, et al. Int J Mol Sci. 2023 Mar 24;24(7):6118. doi: 10.3390/ijms24076118. Int J Mol Sci. 2023. PMID: 37047089 Free PMC article.
Cisplatin injections induced oxidative stress by depleting renal antioxidants at the transcriptome level but did not increase the rate of H(2)O(2) production in isolated mitochondria. Methylene blue, on the contrary, induced mitochondrial H(2)O(2) production. We sup …
Cisplatin injections induced oxidative stress by depleting renal antioxidants at the transcriptome level but did not increase the rate of H( …
Nephrotoxicity biomarkers following propanil (3,4-dichloropropionanilide) self-poisoning.
Shihana F, Wijerathna TM, Gawarammana IB, Shahmy S, Chathuranga U, Palangasinghe C, Mostafa A, Mackenzie L, Roberts MS, Buckley NA, Mohamed F. Shihana F, et al. Clin Toxicol (Phila). 2025 Apr;63(4):236-245. doi: 10.1080/15563650.2025.2457515. Epub 2025 Mar 4. Clin Toxicol (Phila). 2025. PMID: 40034038 Free article.
Plasma and urine concentrations of propanil, its main metabolite 3,4-dichloroaniline, the antidote methylthioninium chloride (methylene blue), and methaemoglobin levels were measured. RESULTS: Kidney biomarkers were measured in 52 of the 67 patients, with 40% develo …
Plasma and urine concentrations of propanil, its main metabolite 3,4-dichloroaniline, the antidote methylthioninium chloride (methylene …
Clinical pharmacokinetics and pharmacodynamics of ifosfamide and its metabolites.
Kerbusch T, de Kraker J, Keizer HJ, van Putten JW, Groen HJ, Jansen RL, Schellens JH, Beijnen JH. Kerbusch T, et al. Clin Pharmacokinet. 2001 Jan;40(1):41-62. doi: 10.2165/00003088-200140010-00004. Clin Pharmacokinet. 2001. PMID: 11236809 Review.
Its use, however, can be accompanied by haematological toxicity, neurotoxicity and nephrotoxicity. Since its development in the middle of the 1960s, most of the extensive metabolism of ifosfamide has been elucidated. ...The mechanisms of action of cytotoxicity, neurotoxici …
Its use, however, can be accompanied by haematological toxicity, neurotoxicity and nephrotoxicity. Since its development in the middl …
A dual-signal mode electrochemical aptasensor based on tetrahedral DNA nanostructures for sensitive detection of citrinin in food using PtPdCo mesoporous nanozymes.
Tang S, He B, Liu Y, Wang L, Liang Y, Wang J, Jin H, Wei M, Ren W, Suo Z, Xu Y. Tang S, et al. Food Chem. 2024 Dec 1;460(Pt 3):140739. doi: 10.1016/j.foodchem.2024.140739. Epub 2024 Aug 3. Food Chem. 2024. PMID: 39116770
Citrinin (CIT) is a mycotoxin with nephrotoxicity and hepatotoxicity, presenting a significant threat to human health that is often overlooked. ...Furthermore, PtPdCo mesoporous nanozymes exhibit catalase-like catalytic functions, generating significant electrochemical sig …
Citrinin (CIT) is a mycotoxin with nephrotoxicity and hepatotoxicity, presenting a significant threat to human health that is often o …
Chlorate poisoning: mechanism of toxicity.
Steffen C, Wetzel E. Steffen C, et al. Toxicology. 1993 Nov 12;84(1-3):217-31. doi: 10.1016/0300-483x(93)90118-c. Toxicology. 1993. PMID: 8266339
The high sensitivity of glucose-6-phosphate dehydrogenase to denaturation by chlorate explains the inefficacy of methylene blue to reduce methaemoglobin formed, as the antidotal effect of methylene blue depends on NADPH formed mainly by the oxidation o …
The high sensitivity of glucose-6-phosphate dehydrogenase to denaturation by chlorate explains the inefficacy of methylene blue …
Methemoglobinemia associated with massive acetaminophen ingestion: a case series.
Rianprakaisang T, Blumenberg A, Hendrickson RG. Rianprakaisang T, et al. Clin Toxicol (Phila). 2020 Jun;58(6):495-497. doi: 10.1080/15563650.2019.1657883. Epub 2019 Aug 26. Clin Toxicol (Phila). 2020. PMID: 31446806
In overdose, toxic metabolites are known to cause hepato- and nephrotoxicity. While G6PD deficiency may be a risk factor for methemoglobin production in the setting of acetaminophen overdose, it is rarely reported in patients who do not have this condition.Methods: We pres …
In overdose, toxic metabolites are known to cause hepato- and nephrotoxicity. While G6PD deficiency may be a risk factor for methemog …
Dual and ultrasensitive electrochemical aptamer-based antibiotic biosensor via cascaded DNA assembly amplifications.
Su C, Zhang X, Ming Y, Li D, Jiang B, Xiang Y, Yuan R. Su C, et al. Talanta. 2026 May 1;301:129278. doi: 10.1016/j.talanta.2025.129278. Epub 2025 Dec 24. Talanta. 2026. PMID: 41448059
Kanamycin (KAN) and tobramycin (TOB), as aminoglycoside antibiotics, can induce irreversible ototoxicity and dose-dependent nephrotoxicity risks to human health through residual contaminations. Consequently, sensitive monitoring of TOB and KAN residues in animal-derived fo …
Kanamycin (KAN) and tobramycin (TOB), as aminoglycoside antibiotics, can induce irreversible ototoxicity and dose-dependent nephrotoxicit …
Ifosfamide-induced neurotoxicity reversal with continuous veno-venous hemodialysis. A case report.
Cherry MA, Bhardwaj H, Hopps S, Srour S, Pant S. Cherry MA, et al. J Oncol Pharm Pract. 2013 Sep;19(3):261-4. doi: 10.1177/1078155212459285. Epub 2012 Nov 7. J Oncol Pharm Pract. 2013. PMID: 23135805
Symptoms of ifosfamide neurotoxicity can range from mild confusion, dizziness and hallucination to overt encephalopathy. Various treatment options like methylene blue, albumin infusion and rarely hemodialysis have been used to treat ifosfamide neurotoxicity. We here …
Symptoms of ifosfamide neurotoxicity can range from mild confusion, dizziness and hallucination to overt encephalopathy. Various treatment o …
Biosynthesis and Characterization of ZnO Nanoparticles Using Citrus reticulata Peel Followed by Photocatalytic, Antibacterial, and Antioxidative Nanotherapeutic Attributes Assessment Supported by Computer Simulation.
Molla A, Hoque MM, Richi FT, Kabir MH, Alam S, Ahmed NU, Emon NU, Shao C, Zeng C, Wang S, Geng P, Mamun AA. Molla A, et al. Int J Nanomedicine. 2025 Apr 16;20:4803-4829. doi: 10.2147/IJN.S493905. eCollection 2025. Int J Nanomedicine. 2025. PMID: 40259916 Free PMC article.
In addition, the photocatalytic activity of biosynthesized ZnO NPs was tested using methylene blue (MB) dye. RESULTS: X-ray diffraction (XRD) results indicate that NPs possess a hexagonal wurtzite crystal structure. ...The ADMET analysis also demonstrated that ZnO N …
In addition, the photocatalytic activity of biosynthesized ZnO NPs was tested using methylene blue (MB) dye. RESULTS: X-ray di …
13 results