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Comparative Analysis of PIPAC Nozzle Designs: Ex Vivo Evaluation of Aerosol Distribution, Penetration, and Tissue Concentration.
Karam E, Kockelmann F, Romdhane V, Barbey S, Viel R, Sébillot A, Roger S, Michot N, Giger-Pabst U, Ouaissi M. Karam E, et al. Ann Surg Oncol. 2025 Nov 10. doi: 10.1245/s10434-025-18675-x. Online ahead of print. Ann Surg Oncol. 2025. PMID: 41214259
Spatial aerosol deposition was measured using methylene blue for three-dimensional gravimetry in gram (g). PIPACs with doxorubicin and cisplatin were performed to assess penetration depth (m) and drug concentrations (g/g) in porcine peritoneal tissue samples from th …
Spatial aerosol deposition was measured using methylene blue for three-dimensional gravimetry in gram (g). PIPACs with doxorub …
The Role of Methylene Blue and Cyanocobalamin for Vasoplegic Syndrome in Liver Transplantation.
Longhitano Y, Albuelkasem E, Voza A, La Via L, Zanza C, Planinsic RM. Longhitano Y, et al. J Intensive Care Med. 2025 Aug;40(8):907-914. doi: 10.1177/08850666251347951. Epub 2025 Jun 5. J Intensive Care Med. 2025. PMID: 40473420
These patients were successfully treated with methylene blue and cyanocobalamin. All publications between January 1992 to september 2024 that assessed the use of methylene blue and/or cyanocobalamin in vasoplegia during liver transplantation in humans …
These patients were successfully treated with methylene blue and cyanocobalamin. All publications between January 1992 to sept …
Cardiotoxic and Cardioprotective Effects of Methylene Blue in the Animal Model of Cardiac Ischemia and Reperfusion.
Fernandes Junior HJ, de Araújo EA, Machado Junior JA, Lutz Motta FM, Guarize GF, Cheng LC, Tantray J, Medeiros JVR, Nicolau LAD, Barbosa AHP, Caixeta A, Rocco IS, Guizilini S, Pires-Oliveira M, Taha MO, Caricati-Neto A, Gomes WJ, Tallo FS, Menezes-Rodrigues FS. Fernandes Junior HJ, et al. Biomedicines. 2024 Nov 11;12(11):2575. doi: 10.3390/biomedicines12112575. Biomedicines. 2024. PMID: 39595141 Free PMC article.
Although methylene blue (MB) has long been used to treat VS due to cardiac ischemia and reperfusion (CIR) and/or surgery because of its vascular effects, MB's effects on the heart are unclear. ...Conclusions: These results indicate that MB produces a biphasic …
Although methylene blue (MB) has long been used to treat VS due to cardiac ischemia and reperfusion (CIR) and/or surger …
A multifunctional "three-in-one" fluorescent theranostic system for hepatic ischemia-reperfusion injury.
Liu J, Yin D, Zhang W, Wang X, James TD, Li P, Tang B. Liu J, et al. Chem Sci. 2024 Nov 13;15(47):19820-19833. doi: 10.1039/d4sc04962d. eCollection 2024 Dec 4. Chem Sci. 2024. PMID: 39568886 Free PMC article.
Hepatic ischemia-reperfusion injury (HIRI) is the main cause of postoperative liver dysfunction and liver failure. ...Given that hypochlorous acid (HOCl) plays a crucial oxidative role in HIRI, we developed a single-component multifunctional fluorescent theranostic platfor …
Hepatic ischemia-reperfusion injury (HIRI) is the main cause of postoperative liver dysfunction and liver failure. ...Given that hypo …
The protective effects of methylene blue on astrocytic swelling after cerebral ischemia-reperfusion injuries are mediated by Aquaporin-4 and metabotropic glutamate receptor 5 activation.
Lai Y, Han J, Qiu D, Liu X, Sun K, Fan Y, Wang C, Zhang S. Lai Y, et al. Heliyon. 2024 Apr 12;10(8):e29483. doi: 10.1016/j.heliyon.2024.e29483. eCollection 2024 Apr 30. Heliyon. 2024. PMID: 38644842 Free PMC article.
Methylene blue (MB) was found to exert neuroprotective effect on different brain diseases, such as ischemic stroke. ...Rats were exposed 1 h transient middle cerebral artery occlusion (tMCAO), and MB was injected intravenously following reperfusion (3 mg/kg). …
Methylene blue (MB) was found to exert neuroprotective effect on different brain diseases, such as ischemic stroke. ...Rats we …
Comparison of salpingectomy and tubal detorsion procedures after experimental ischemia-reperfusion injury in a rat fallopian tube model: biochemical and histopathological evaluation.
Koyan Karadeniz GN, Karadeniz O, Bulutlar E, Yilmaz B, Gedikbasi A, Arslan HS, Cetin BA, Polat İ. Koyan Karadeniz GN, et al. F S Sci. 2024 May;5(2):195-203. doi: 10.1016/j.xfss.2024.03.003. Epub 2024 Apr 4. F S Sci. 2024. PMID: 38580179
A 22-gauge catheter was administered before and after surgery using methylene blue through the uterine horn of the rat to evaluate tubal patency. MAIN OUTCOME MEASURE(S): Preoperative and postoperative serum antimullerian hormone (AMH) levels, histopathological exam …
A 22-gauge catheter was administered before and after surgery using methylene blue through the uterine horn of the rat to eval …
Cardiotoxic Effects Produced by Omeprazole and Methylene Blue in an Animal Model of Cardiac Ischemia and Reperfusion and Potential Implications for the Pharmacological Strategy for Vasoplegic Syndrome.
de Araújo EA, Tallo FS, Oliveira ASF, Toghlobi GSSE, Arantes RA, Balsimelli R, Kehrwald-Balsimelli B, de Almeida Viana BL, Matuda FS, Nicolau LAD, Medeiros JVR, Caixeta A, Taha MO, Gomes WJ, Caricati-Neto A, Menezes-Rodrigues FS. de Araújo EA, et al. Biomedicines. 2024 Mar 6;12(3):582. doi: 10.3390/biomedicines12030582. Biomedicines. 2024. PMID: 38540195 Free PMC article.
Although vasopressors such as norepinephrine and vasopressin are the first-choice drugs for VS treatment, several other drugs such as methylene blue (MB) can be used as adjuvant therapy including rescue therapy. To develop new pharmacological strategies to reduce th …
Although vasopressors such as norepinephrine and vasopressin are the first-choice drugs for VS treatment, several other drugs such as met …
Methylene blue and its potential in the treatment of traumatic brain injury, brain ischemia, and Alzheimer's disease.
Isaev NK, Genrikhs EE, Stelmashook EV. Isaev NK, et al. Rev Neurosci. 2024 Mar 27;35(5):585-595. doi: 10.1515/revneuro-2024-0007. Print 2024 Jul 26. Rev Neurosci. 2024. PMID: 38530227 Review.
Traumatic brain injury (TBI) and brain ischemia/reperfusion cause neurodegenerative processes that can continue after the acute stage with the development of severe brain atrophy with dementia. ...One of such substances that can be used in multi-purpose therapeutic strateg …
Traumatic brain injury (TBI) and brain ischemia/reperfusion cause neurodegenerative processes that can continue after the acute stage …
Methylene blue as an adjuvant during cardiopulmonary resuscitation: an experimental study in rats.
Xavier MS, Vane MF, Vieira RF, Oliveira CC, Maia DRR, de Castro LUC, Carmona MJC, Costa Auler JO Jr, Otsuki DA. Xavier MS, et al. Braz J Anesthesiol. 2024 Mar-Apr;74(2):744470. doi: 10.1016/j.bjane.2023.10.003. Epub 2023 Nov 4. Braz J Anesthesiol. 2024. PMID: 37926365 Free PMC article.
INTRODUCTION: Methylene Blue (MB) has been shown to attenuate oxidative, inflammatory, myocardial, and neurological lesions during ischemia-reperfusion and has great potential during cardiac arrest. ...
INTRODUCTION: Methylene Blue (MB) has been shown to attenuate oxidative, inflammatory, myocardial, and neurological lesions du …
Hydrogen Sulfide-Releasing Indomethacin-Derivative (ATB-344) Prevents the Development of Oxidative Gastric Mucosal Injuries.
Głowacka U, Magierowski M, Śliwowski Z, Cieszkowski J, Szetela M, Wójcik-Grzybek D, Chmura A, Brzozowski T, Wallace JL, Magierowska K. Głowacka U, et al. Antioxidants (Basel). 2023 Aug 2;12(8):1545. doi: 10.3390/antiox12081545. Antioxidants (Basel). 2023. PMID: 37627540 Free PMC article.
Next, animals were exposed to microsurgical gastric ischemia-reperfusion (I/R). Gastric damage was assessed micro- and macroscopically. The volatile H(2)S level was assessed in the gastric mucosa using the modified methylene blue method. ...
Next, animals were exposed to microsurgical gastric ischemia-reperfusion (I/R). Gastric damage was assessed micro- and macroscopicall …
Vasoplegic Syndrome after Cardiopulmonary Bypass in Cardiovascular Surgery: Pathophysiology and Management in Critical Care.
Ltaief Z, Ben-Hamouda N, Rancati V, Gunga Z, Marcucci C, Kirsch M, Liaudet L. Ltaief Z, et al. J Clin Med. 2022 Oct 29;11(21):6407. doi: 10.3390/jcm11216407. J Clin Med. 2022. PMID: 36362635 Free PMC article. Review.
Surgical trauma, exposure to the elements of the CPB circuit and ischemia-reperfusion promote a systemic inflammatory response with the release of cytokines (IL-1beta, IL-6, IL-8, and TNF-alpha) with vasodilating properties, both direct and indirect through the expression …
Surgical trauma, exposure to the elements of the CPB circuit and ischemia-reperfusion promote a systemic inflammatory response with t …
Aquaporins: Important players in the cardiovascular pathophysiology.
Shangzu Z, Dingxiong X, ChengJun M, Yan C, Yangyang L, Zhiwei L, Ting Z, Zhiming M, Yiming Z, Liying Z, Yongqi L. Shangzu Z, et al. Pharmacol Res. 2022 Sep;183:106363. doi: 10.1016/j.phrs.2022.106363. Epub 2022 Jul 26. Pharmacol Res. 2022. PMID: 35905892 Free article. Review.
The aberrant expression of AQPs highly correlates with the onset of ischemic heart disease, myocardial ischemia-reperfusion injury, heart failure, etc. Despite much attention to the regulatory role of AQPs in the cardiovascular system, the translation of AQPs into clinical …
The aberrant expression of AQPs highly correlates with the onset of ischemic heart disease, myocardial ischemia-reperfusion injury, h …
Methylene Blue Reduces Fluid Loading and Norepinephrine Requirements for Post-Resuscitation Syndrome in a Pig Model of Refractory Cardiac Arrest Resuscitated with Veno-Arterial ECMO.
Pequignot B, Lescroart M, Orlowski S, Reynette N, Martini B, Albuisson E, Pina H, Tran N, Grandmougin D, Levy B. Pequignot B, et al. J Clin Med. 2022 Apr 29;11(9):2515. doi: 10.3390/jcm11092515. J Clin Med. 2022. PMID: 35566640 Free PMC article.
After a low flow period of 30 min, VA-ECMO was initiated and the pigs were randomly assigned to the standard care group (norepinephrine + crystalloids) or methylene blue group (IV 2 mg.kg(-1) bolus of methylene blue over 30 min + norepinephrine and cry …
After a low flow period of 30 min, VA-ECMO was initiated and the pigs were randomly assigned to the standard care group (norepinephrine + cr …
Upregulation of hemeoxygenase enzymes HO-1 and HO-2 following ischemia-reperfusion injury in connection with experimental cardiac arrest and cardiopulmonary resuscitation: Neuroprotective effects of methylene blue.
Wiklund L, Sharma A, Patnaik R, Muresanu DF, Sahib S, Tian ZR, Castellani RJ, Nozari A, Lafuente JV, Sharma HS. Wiklund L, et al. Prog Brain Res. 2021;265:317-375. doi: 10.1016/bs.pbr.2021.06.009. Epub 2021 Aug 12. Prog Brain Res. 2021. PMID: 34560924 Review.
In this review involvement of HO-1 and HO-2 enzymes in the porcine brain following cardiac arrest and resuscitation is discussed based on our own observations. In addition, neuroprotective role of methylene blue- an antioxidant dye on alterations in HO under in card …
In this review involvement of HO-1 and HO-2 enzymes in the porcine brain following cardiac arrest and resuscitation is discussed based on ou …
The Use of Methylene Blue during Liver Transplantation for Vasoplegia.
Harding P, Nicholas T, Kassel C. Harding P, et al. Case Rep Anesthesiol. 2021 Jun 23;2021:6610754. doi: 10.1155/2021/6610754. eCollection 2021. Case Rep Anesthesiol. 2021. PMID: 34258070 Free PMC article.
The use of methylene blue for vasoplegia in cardiac cases with cardiopulmonary bypass, septic shock, and acute liver failure is well documented. ...We describe three separate liver transplantation patients with significant hypotension following reperfusion. A …
The use of methylene blue for vasoplegia in cardiac cases with cardiopulmonary bypass, septic shock, and acute liver failure i …
Pharmacologic neuroprotection in ischemic brain injury after cardiac arrest.
Katz A, Brosnahan SB, Papadopoulos J, Parnia S, Lam JQ. Katz A, et al. Ann N Y Acad Sci. 2022 Jan;1507(1):49-59. doi: 10.1111/nyas.14613. Epub 2021 May 31. Ann N Y Acad Sci. 2022. PMID: 34060087 Review.
Few interventions have been shown to improve return of spontaneous circulation (ROSC) and long-term outcomes after cardiac arrest. Ischemic-reperfusion injury upon achieving ROSC creates an imbalance between oxygen supply and demand. ...Pharmacologic therapies most relevan …
Few interventions have been shown to improve return of spontaneous circulation (ROSC) and long-term outcomes after cardiac arrest. Ischemic- …
Selective Imaging of HClO in the Liver Tissue In Vivo Using a Near-infrared Hepatocyte-specific Fluorescent Probe.
Jia X, Wei C, Li Z, Liu L, Wang M, Zhang P, Li X. Jia X, et al. Chem Asian J. 2021 Jul 19;16(14):1967-1972. doi: 10.1002/asia.202100476. Epub 2021 Jun 7. Chem Asian J. 2021. PMID: 34036742
It is important that probe NHF is the first NIR hepatocyte-specific fluorescent probe, which successfully visualized the up-regulation of endogenous HClO in the oxygen-glucose deprivation/reperfusion (OGD/R) model HepG2 cells and dynamically monitored APAP-induced endogeno …
It is important that probe NHF is the first NIR hepatocyte-specific fluorescent probe, which successfully visualized the up-regulation of en …
Intravenous Interferon-beta1a for the Treatment of Ischemia-Reperfusion Injury in Acute Myocardial Infarct in Pigs.
Deomic Niittynen S, Liikamaa L, Jalkanen J, Jalkanen S, Savunen T, Gunn J, Anttila V, Virtanen L, Taimen P, Hollmén M, Pan E, Saura E, Malmberg M. Deomic Niittynen S, et al. Heart Surg Forum. 2021 Apr 27;24(2):E409-E413. doi: 10.1532/hsf.3639. Heart Surg Forum. 2021. PMID: 33973512
IR injury was induced by occluding the distal left descending coronary artery for 30 minutes, with a reperfusion period of 6 h. In the IFN group, the animals received 12.5 g IFN-beta1a intravenously repeatedly; the control group received saline solution. The levels of inte …
IR injury was induced by occluding the distal left descending coronary artery for 30 minutes, with a reperfusion period of 6 h. In th …
A case report of acquired methemoglobinemia rescued by veno-venous extracorporeal membrane oxygenation.
Lien YH, Lin YC, Chen RJ. Lien YH, et al. Medicine (Baltimore). 2021 Apr 16;100(15):e25522. doi: 10.1097/MD.0000000000025522. Medicine (Baltimore). 2021. PMID: 33847673 Free PMC article.
INTERVENTIONS: Because of recovered and normal cardiac function, we placed veno-venous extracorporeal membrane oxygenation (VV-ECMO) for tissue hypoxemia in addition to exchange transfusion, vitamin C, and methylene blue. OUTCOMES: Met-Hb blood level dropped rapidly …
INTERVENTIONS: Because of recovered and normal cardiac function, we placed veno-venous extracorporeal membrane oxygenation (VV-ECMO) for tis …
Effect of Methylene Blue on White Matter Injury after Ischemic Stroke.
Cheng Q, Chen X, Ma J, Jiang X, Chen J, Zhang M, Wu Y, Zhang W, Chen C. Cheng Q, et al. Oxid Med Cell Longev. 2021 Feb 2;2021:6632411. doi: 10.1155/2021/6632411. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 33603949 Free PMC article.
Methylene blue, the FDA-grandfathered drug was proved to be neuroprotective in ischemic stroke in rat. ...Middle cerebral artery occlusion and reperfusion (MCAO) and photothrombotic middle cerebral artery occlusion (PT-MCAO) models were used. ...
Methylene blue, the FDA-grandfathered drug was proved to be neuroprotective in ischemic stroke in rat. ...Middle cerebral arte …
Methylene blue ameliorates brain edema in rats with experimental ischemic stroke via inhibiting aquaporin 4 expression.
Shi ZF, Fang Q, Chen Y, Xu LX, Wu M, Jia M, Lu Y, Wang XX, Wang YJ, Yan X, Dong LP, Yuan F. Shi ZF, et al. Acta Pharmacol Sin. 2021 Mar;42(3):382-392. doi: 10.1038/s41401-020-0468-5. Epub 2020 Jul 14. Acta Pharmacol Sin. 2021. PMID: 32665706 Free PMC article.
Brain edema is a common and serious complication of ischemic stroke with limited effective treatment. We previously reported that methylene blue (MB) attenuated ischemic brain edema in rats, but the underlying mechanisms remained unknown. ...Rats were subjected to t …
Brain edema is a common and serious complication of ischemic stroke with limited effective treatment. We previously reported that methyle …
Effects of Methylene Blue on Ovarian Torsion-Detorsion Injury in a Rat Model.
Ilgen O, Hortu I, Ozceltik G, Yigitturk G, Erbas O, Karadadas N. Ilgen O, et al. J Pediatr Adolesc Gynecol. 2020 Oct;33(5):506-510. doi: 10.1016/j.jpag.2020.06.010. Epub 2020 Jun 25. J Pediatr Adolesc Gynecol. 2020. PMID: 32593749
STUDY OBJECTIVES: Methylene blue (MB) is an antioxidant that ameliorates ischemia-reperfusion injury in several tissues. ...Group 4 was the torsion-detorsion group, with 3 hours of ischemia and reperfusion. Finally, group 5 was the torsion-detorsion + …
STUDY OBJECTIVES: Methylene blue (MB) is an antioxidant that ameliorates ischemia-reperfusion injury in several tissues …
Amputation in crush syndrome: A case report.
Arango-Granados MC, Cruz Mendoza DF, Salcedo Cadavid AE, García Marín AF. Arango-Granados MC, et al. Int J Surg Case Rep. 2020;72:346-350. doi: 10.1016/j.ijscr.2020.05.087. Epub 2020 Jun 12. Int J Surg Case Rep. 2020. PMID: 32563818 Free PMC article.
INTRODUCTION: Crush syndrome (CS) is a condition with a high morbidity and mortality due to severe electrolyte disorders, circulatory dysfunction and multiple organ failure, secondary to severe rhabdomyolysis and reperfusion injuries. There is controversy about the role of …
INTRODUCTION: Crush syndrome (CS) is a condition with a high morbidity and mortality due to severe electrolyte disorders, circulatory dysfun …
Comparative Study Regarding the Properties of Methylene Blue and Proflavine and Their Optimal Concentrations for In Vitro and In Vivo Applications.
Nedu ME, Tertis M, Cristea C, Georgescu AV. Nedu ME, et al. Diagnostics (Basel). 2020 Apr 15;10(4):223. doi: 10.3390/diagnostics10040223. Diagnostics (Basel). 2020. PMID: 32326607 Free PMC article. Review.
Methylene blue and proflavine are fluorescent dyes used to stain nucleic acid from the molecular level to the tissue level. ...At the tissue level, the anti-inflammatory effects of methylene blue protect against pulmonary, renal, cardiac, pancreatic, i …
Methylene blue and proflavine are fluorescent dyes used to stain nucleic acid from the molecular level to the tissue level. .. …
Assessment of effects of methylene blue on intestinal ischemia and reperfusion in a rabbit model: hemodynamic, histological and immunohistochemical study.
Morgaz J, Ventura S, Muñoz-Rascón P, Navarrete R, Pérez J, Granados MDM, Fernández-Sarmiento JA, Domínguez JM, Molina V, Gómez-Villamandos RJ, Zafra R. Morgaz J, et al. BMC Vet Res. 2020 Feb 12;16(1):54. doi: 10.1186/s12917-020-02279-6. BMC Vet Res. 2020. PMID: 32050965 Free PMC article.
During reperfusion, methylene blue (MB) infusion generated an increase in cardiac output due to a positive chronotropic effect, an elevation of preload, and an intense positive inotropic effect. The changes in heart rate and blood pressure were significantly …
During reperfusion, methylene blue (MB) infusion generated an increase in cardiac output due to a positive chronotropic …
Facile Ratiometric Electrochemical Sensor for In Vivo/Online Repetitive Measurements of Cerebral Ascorbic Acid in Brain Microdiaysate.
Jiang Y, Xiao X, Li C, Luo Y, Chen S, Shi G, Han K, Gu H. Jiang Y, et al. Anal Chem. 2020 Mar 3;92(5):3981-3989. doi: 10.1021/acs.analchem.9b05484. Epub 2020 Feb 20. Anal Chem. 2020. PMID: 32037799
The sensor were constructed by careful electrodeposition of graphene oxide (GO) onto glassy carbon (GC) electrodes. Methylene blue (MB) was electrostatically adsorbed onto the GO surface as a built-in reference to achieve ratiometric detection of AA. ...As a result, …
The sensor were constructed by careful electrodeposition of graphene oxide (GO) onto glassy carbon (GC) electrodes. Methylene blue …
Methylene blue and the NO/cGMP pathway in solid organs transplants.
Miranda LE, Mente ED, Fernandes Molina CA, Sumarelli Albuquerque AA, Rubens de Nadai T, Arcêncio L, Basile-Filho A, Barbosa Evora PR. Miranda LE, et al. Minerva Anestesiol. 2020 Apr;86(4):423-432. doi: 10.23736/S0375-9393.20.13841-0. Epub 2020 Jan 27. Minerva Anestesiol. 2020. PMID: 31994368 Free article.
The nitric oxide/cyclic guanosine monophosphate (NO/cGMP) pathway has a significative influence in hemodynamic changes that occur in transplants. Classically, the ischemia-reperfusion syndrome (IRS) is characterized by hypotension and low vascular resistance, when cGMP and …
The nitric oxide/cyclic guanosine monophosphate (NO/cGMP) pathway has a significative influence in hemodynamic changes that occur in transpl …
The H2S-Nrf2-Antioxidant Proteins Axis Protects Renal Tubular Epithelial Cells of the Native Hibernator Syrian Hamster from Reoxygenation-Induced Cell Death.
Eleftheriadis T, Pissas G, Nikolaou E, Liakopoulos V, Stefanidis I. Eleftheriadis T, et al. Biology (Basel). 2019 Sep 30;8(4):74. doi: 10.3390/biology8040074. Biology (Basel). 2019. PMID: 31574983 Free PMC article.
During hibernation, repeated cycles of ischemia-reperfusion (I-R) leave vital organs without injury. Studying this phenomenon may reveal pathways applicable to improving outcomes in I-R injury-induced human diseases. ...Whenever required, the H(2)S-producing enzymes inhibi …
During hibernation, repeated cycles of ischemia-reperfusion (I-R) leave vital organs without injury. Studying this phenomenon may rev …
Prophylactic Use of Laser Light and Methylene Blue on Ischemia and Liver Reperfusion Injury.
Albuquerque FP, Laureano E, Jordani-Gomes MC, Fina CF, Vanni C, Mente ED, Vollet Filho JD, Bagnato VS, Dálbuquerque LAC, Évora PRB, Castro E Silva O. Albuquerque FP, et al. Transplant Proc. 2019 Jun;51(5):1549-1554. doi: 10.1016/j.transproceed.2019.02.018. Transplant Proc. 2019. PMID: 31155190
OBJECTIVE: This study aimed to evaluate the effect of hepatic preconditioning with laser light in the presence of methylene blue (MB) in the liver ischemia-reperfusion injury process. METHOD: Forty male Wistar rats were divided into 8 experimental groups (n = …
OBJECTIVE: This study aimed to evaluate the effect of hepatic preconditioning with laser light in the presence of methylene blue …
Evaluation of the therapeutic effect of methylene blue on the liver of rats submitted to ischemia and reperfusion.
Castro-E-Silva O, D'Albuquerque LAC, Silveira MRG, Zorzi P, Liu JB, Campos DTQ, Victorino JP, Jordani MC, Mendes KDS, Évora PRB. Castro-E-Silva O, et al. Acta Cir Bras. 2018 Dec;33(12):1043-1051. doi: 10.1590/s0102-865020180120000001. Acta Cir Bras. 2018. PMID: 30624509 Free article.
PURPOSE: To analyze the effect of methylene blue (MB) therapy during the liver ischemia-reperfusion injury (I/R) process. ...AST levels were increased in all ischemic with or without MB. CONCLUSIONS: The methylene blue was not able to restore th …
PURPOSE: To analyze the effect of methylene blue (MB) therapy during the liver ischemia-reperfusion injury (I/R) proces …
Catecholamine Vasopressor Support Sparing Strategies in Vasodilatory Shock.
Buckley MS, Barletta JF, Smithburger PL, Radosevich JJ, Kane-Gill SL. Buckley MS, et al. Pharmacotherapy. 2019 Mar;39(3):382-398. doi: 10.1002/phar.2199. Epub 2019 Jan 2. Pharmacotherapy. 2019. PMID: 30506565 Review.
Hemodynamic support is typically initiated with fluid resuscitation strategies and administration of adrenergic vasopressor agents in nonresponsive patients to restore arterial pressure with subsequent adequate organ reperfusion. Unfortunately, high catecholamine dosing re …
Hemodynamic support is typically initiated with fluid resuscitation strategies and administration of adrenergic vasopressor agents in nonres …
Does methylene blue attenuate inflammation in nonischemic lungs after lung transplantation?
Abreu MDM, Almeida FM, Santos KBD, Assis EACP, Hamada RKF, Jatene FB, Pêgo-Fernandes PM, Pazetti R. Abreu MDM, et al. J Bras Pneumol. 2018 Sep-Oct;44(5):378-382. doi: 10.1590/S1806-37562017000000172. J Bras Pneumol. 2018. PMID: 30517338 Free PMC article.
OBJECTIVE: To evaluate whether methylene blue (MB) could minimize the effects of ischemia-reperfusion injury in the nonischemic lung on a lung transplantation rodent model. ...Recipients received 2 mL of saline or MB intraperitoneally prior to transplantation …
OBJECTIVE: To evaluate whether methylene blue (MB) could minimize the effects of ischemia-reperfusion injury in the non …
Methylene blue attenuates renal ischemia-reperfusion injury by negative regulation of NLRP3 signaling pathway.
Liu JJ, Lu L, Hu FQ, Yuan H, Xu Q, Qin YF, Gong JH. Liu JJ, et al. Eur Rev Med Pharmacol Sci. 2018 May;22(9):2847-2853. doi: 10.26355/eurrev_201805_14986. Eur Rev Med Pharmacol Sci. 2018. PMID: 29771438 Free article.
OBJECTIVE: To investigate the effect of methylene blue (MB) on renal ischemia-reperfusion (IR) injury in mice and its possible relevant mechanisms. ...Mice in MB group were treated with gavage continuously using methylene blue solution (dosage: …
OBJECTIVE: To investigate the effect of methylene blue (MB) on renal ischemia-reperfusion (IR) injury in mice and its p …
Methylene Blue Attenuates Lung Injury Induced by Hindlimb Ischemia Reperfusion in Rats.
Wang L, Chen B, Lin B, Ye Y, Bao C, Zhao X, Jin L, Xiong X. Wang L, et al. Mediators Inflamm. 2018 Mar 11;2018:2508620. doi: 10.1155/2018/2508620. eCollection 2018. Mediators Inflamm. 2018. PMID: 29713238 Free PMC article.
OBJECTIVE: This study was aimed to investigate the protective effect of methylene blue against lung injury induced by reperfusion of ischemic hindlimb in a rat model. ...Treatment with 1% methylene blue (50 mg/kg) was administrated intraperitone …
OBJECTIVE: This study was aimed to investigate the protective effect of methylene blue against lung injury induced by reper …
Effect of Hepatic Preconditioning with the Use of Methylene Blue on the Liver of Wistar Rats Submitted to Ischemia and Reperfusion.
de Almeida TN, Victorino JP, Bistafa Liu J, Tófoli Queiroz Campos D, Graf C, Jordani MC, Carneiro d'Albuquerque LA, Mendes KDS, Castro-E-Silva O. de Almeida TN, et al. Transplant Proc. 2018 Apr;50(3):841-847. doi: 10.1016/j.transproceed.2018.02.002. Transplant Proc. 2018. PMID: 29661450
The aim of this work was to analyze the effect of ischemic preconditioning with the use of methylene blue (MB; 15 mg/kg) 5 or 15 minutes before I/R (IRMB5' and IRMB15', respectively) on the hepatic injury occurring after I/R. ...The respiratory control ratio was red …
The aim of this work was to analyze the effect of ischemic preconditioning with the use of methylene blue (MB; 15 mg/kg) 5 or …
Case report of high-dose hydroxocobalamin in the treatment of vasoplegic syndrome during liver transplantation.
An SS, Henson CP, Freundlich RE, McEvoy MD. An SS, et al. Am J Transplant. 2018 Jun;18(6):1552-1555. doi: 10.1111/ajt.14736. Epub 2018 Apr 2. Am J Transplant. 2018. PMID: 29573551 Free PMC article.
There was minimal response to a 2 mg/kg i.v. bolus of methylene blue. Following the administration of 5 g of i.v.hydroxocobalamin, the patient had a profound improvement in arterial blood pressure, with subsequent discontinuation of the vasopressin infusion and rapi …
There was minimal response to a 2 mg/kg i.v. bolus of methylene blue. Following the administration of 5 g of i.v.hydroxocobala …
Methylene Blue Protects the Isolated Rat Lungs from Ischemia-Reperfusion Injury by Attenuating Mitochondrial Oxidative Damage.
Tian WF, Zeng S, Sheng Q, Chen JL, Weng P, Zhang XT, Yuan JJ, Pang QF, Wang ZQ. Tian WF, et al. Lung. 2018 Feb;196(1):73-82. doi: 10.1007/s00408-017-0072-8. Epub 2017 Dec 4. Lung. 2018. PMID: 29204685
INTRODUCTION: Impaired mitochondrial function is a key factor attributing to the lung ischemia reperfusion injury (LIRI). Methylene blue (MB) has been reported to attenuate brain and renal ischemia-reperfusion injury. ...CONCLUSION: MB protects the iso …
INTRODUCTION: Impaired mitochondrial function is a key factor attributing to the lung ischemia reperfusion injury (LIRI). Methylen …
Intraoperative vasoplegia: methylene blue to the rescue!
McCartney SL, Duce L, Ghadimi K. McCartney SL, et al. Curr Opin Anaesthesiol. 2018 Feb;31(1):43-49. doi: 10.1097/ACO.0000000000000548. Curr Opin Anaesthesiol. 2018. PMID: 29176374 Review.
PURPOSE OF REVIEW: To evaluate the efficacy, dosing, and safety of methylene blue (MTB) in perioperative vasoplegic syndrome (VS). RECENT FINDINGS: Vasoplegic syndrome is a state of persistent hypotension with elevated cardiac output, low filling pressures, and low …
PURPOSE OF REVIEW: To evaluate the efficacy, dosing, and safety of methylene blue (MTB) in perioperative vasoplegic syndrome ( …
Chronic oral methylene blue treatment in a rat model of focal cerebral ischemia/reperfusion.
Huang L, Lu J, Cerqueira B, Liu Y, Jiang Z, Duong TQ. Huang L, et al. Brain Res. 2018 Jan 1;1678:322-329. doi: 10.1016/j.brainres.2017.10.033. Epub 2017 Nov 8. Brain Res. 2018. PMID: 29108817 Clinical Trial.
A single acute low-dose methylene blue (MB), an FDA-grandfathered drug, has been shown to ameliorate behavioral deficits and reduces MRI-defined infarct volume in experimental ischemic stroke when administered intravenously or intraperitoneally. ...
A single acute low-dose methylene blue (MB), an FDA-grandfathered drug, has been shown to ameliorate behavioral deficits and r …
Cerebral Tissue Oxidative Ischemia-Reperfusion Injury in Connection with Experimental Cardiac Arrest and Cardiopulmonary Resuscitation: Effect of Mild Hypothermia and Methylene Blue.
Wiklund L, Patnaik R, Sharma A, Miclescu A, Sharma HS. Wiklund L, et al. Mol Neurobiol. 2018 Jan;55(1):115-121. doi: 10.1007/s12035-017-0723-z. Mol Neurobiol. 2018. PMID: 28895060 Free PMC article.
A 30-min postponement of induction of hypothermia results in a cerebral oxidative injury comparable to that of "standard CPR" or the oxidative injury found after 5 min of untreated CA. Intravenous administration of methylene blue (MB) during and immediately after CP …
A 30-min postponement of induction of hypothermia results in a cerebral oxidative injury comparable to that of "standard CPR" or the oxidati …
Exogenous and Endogenous Hydrogen Sulfide Protects Gastric Mucosa against the Formation and Time-Dependent Development of Ischemia/Reperfusion-Induced Acute Lesions Progressing into Deeper Ulcerations.
Magierowski M, Magierowska K, Hubalewska-Mazgaj M, Sliwowski Z, Pajdo R, Ginter G, Kwiecien S, Brzozowski T. Magierowski M, et al. Molecules. 2017 Feb 15;22(2):295. doi: 10.3390/molecules22020295. Molecules. 2017. PMID: 28212299 Free PMC article.
The mechanism(s) involved in H2S-gastroprotection against ischemia/reperfusion (I/R) lesions and their time-dependent progression into deeper gastric ulcerations have been little studied. ...Expression of mRNA for CSE, CBS, 3-MST, HIF-1alpha, glutathione peroxidase (GPx)-1 …
The mechanism(s) involved in H2S-gastroprotection against ischemia/reperfusion (I/R) lesions and their time-dependent progression int …
Use of Methylene Blue to Treat Hypovolemic Shock Followed by Ischemia-Reperfusion Injury in the Postoperative Orthotopic Liver Transplant Patient: A Case Report.
Vilalva KH, Mumic FT, Silveira MRG, Mente ED, Evora PRB, Castro E Silva O. Vilalva KH, et al. Exp Clin Transplant. 2018 Aug;16(4):511-514. doi: 10.6002/ect.2016.0041. Epub 2016 Aug 24. Exp Clin Transplant. 2018. PMID: 27561907 Free article.
On the basis of the hypothesis of vasoplegic syndrome, the patient received methylene blue intravenously (100 mg bolus for 12 h/1.5 mg/kg). The catastrophic situation was controlled. ...
On the basis of the hypothesis of vasoplegic syndrome, the patient received methylene blue intravenously (100 mg bolus for 12 …
Direct intraperitoneal resuscitation with lidocaine, methylene blue and pentoxiphylline combination does not decreases inflammation after intestinal ischemia-reperfusion injury in rats.
Gandini M, Cerri S, Pregel P, Giusto G, Vercelli C, Iussich S, Tursi M, Farca AM. Gandini M, et al. Acta Cir Bras. 2016 May;31(5):333-7. doi: 10.1590/S0102-865020160050000007. Acta Cir Bras. 2016. PMID: 27275855 Free article.
PURPOSE: To evaluate the effects of an intraperitoneal solution of methylene blue (MB), lidocaine and pentoxyphylline (PTX) on intestinal ischemic and reperfusion injury. ...CONCLUSION: The combination of lidocaine, methylene blue and pentoxyphy …
PURPOSE: To evaluate the effects of an intraperitoneal solution of methylene blue (MB), lidocaine and pentoxyphylline (PTX) on …
Capsulotomy of Ischemically Damaged Donor Kidneys: A Pig Study.
van Smaalen TC, Mestrom MG, Kox JJ, Winkens B, van Heurn LW. van Smaalen TC, et al. Eur Surg Res. 2016;57(1-2):89-99. doi: 10.1159/000445432. Epub 2016 May 5. Eur Surg Res. 2016. PMID: 27160678 Free article.
During perfusion, machine flow (Q), renal resistance (RR), renovascular circulating volume (RCV), intraparenchymal pressure (IPP) and weight were recorded. Parenchymal injury was examined with methylene blue infusion. RESULTS: Mean Q and RCV increased directly after …
During perfusion, machine flow (Q), renal resistance (RR), renovascular circulating volume (RCV), intraparenchymal pressure (IPP) and weight …
Methylene Blue Ameliorates Ischemia/Reperfusion-Induced Cerebral Edema: An MRI and Transmission Electron Microscope Study.
Fang Q, Yan X, Li S, Sun Y, Xu L, Shi Z, Wu M, Lu Y, Dong L, Liu R, Yuan F, Yang SH. Fang Q, et al. Acta Neurochir Suppl. 2016;121:227-36. doi: 10.1007/978-3-319-18497-5_41. Acta Neurochir Suppl. 2016. PMID: 26463954
The neuroprotective effect of methylene blue (MB) has been identified against various brain disorders, including ischemic stroke. ...Adult male rats were subjected to transient focal cerebral ischemia induced by 1 h middle cerebral artery occlusion (MCAO), followed …
The neuroprotective effect of methylene blue (MB) has been identified against various brain disorders, including ischemic stro …
Neuroprotective and Functional Improvement Effects of Methylene Blue in Global Cerebral Ischemia.
Lu Q, Tucker D, Dong Y, Zhao N, Zhang Q. Lu Q, et al. Mol Neurobiol. 2016 Oct;53(8):5344-55. doi: 10.1007/s12035-015-9455-0. Epub 2015 Oct 3. Mol Neurobiol. 2016. PMID: 26433378 Free PMC article.
Transient global cerebral ischemia (GCI) causes delayed neuronal cell death in the vulnerable hippocampus CA1 subfield, as well as behavioral deficits. Ischemia reperfusion (I/R) produces excessive reactive oxygen species and plays a key role in brain injury. ...The aim of …
Transient global cerebral ischemia (GCI) causes delayed neuronal cell death in the vulnerable hippocampus CA1 subfield, as well as behaviora …
Investigation of the role of nitric oxide/soluble guanylyl cyclase pathway in ascorbic acid-mediated protection against acute kidney injury in rats.
Koul V, Kaur A, Singh AP. Koul V, et al. Mol Cell Biochem. 2015 Aug;406(1-2):1-7. doi: 10.1007/s11010-015-2392-4. Epub 2015 Jul 5. Mol Cell Biochem. 2015. PMID: 26142728
In separate groups, the nitric oxide synthase inhibitor, L-NAME (20 mg/kg, i.p.) and sGC inhibitor, methylene blue (50 mg/kg, i.p.) was administered prior to AA treatment in rats. The significant decrease in CrCl and increase in BUN, plasma uric acid, potassium, FeN …
In separate groups, the nitric oxide synthase inhibitor, L-NAME (20 mg/kg, i.p.) and sGC inhibitor, methylene blue (50 mg/kg, …
The Effects of Methylene Blue on Autophagy and Apoptosis in MRI-Defined Normal Tissue, Ischemic Penumbra and Ischemic Core.
Jiang Z, Watts LT, Huang S, Shen Q, Rodriguez P, Chen C, Zhou C, Duong TQ. Jiang Z, et al. PLoS One. 2015 Jun 29;10(6):e0131929. doi: 10.1371/journal.pone.0131929. eCollection 2015. PLoS One. 2015. PMID: 26121129 Free PMC article.
Methylene blue (MB) USP, which has energy-enhancing and antioxidant properties, is currently used to treat methemoglobinemia and cyanide poisoning in humans. ...Multimodal MRI during the acute phase and at 24 hrs were used to define three regions of interest (ROIs): …
Methylene blue (MB) USP, which has energy-enhancing and antioxidant properties, is currently used to treat methemoglobinemia a …
Methylene blue-induced neuronal protective mechanism against hypoxia-reoxygenation stress.
Ryou MG, Choudhury GR, Li W, Winters A, Yuan F, Liu R, Yang SH. Ryou MG, et al. Neuroscience. 2015 Aug 20;301:193-203. doi: 10.1016/j.neuroscience.2015.05.064. Epub 2015 Jun 3. Neuroscience. 2015. PMID: 26047733 Free PMC article.
Brain ischemia and reperfusion (I/R) injury occurs in various pathological conditions, but there is no effective treatment currently available in clinical practice. Methylene blue (MB) is a century-old drug with a newly discovered protective function in the i …
Brain ischemia and reperfusion (I/R) injury occurs in various pathological conditions, but there is no effective treatment currently …
The inflammatory response in cardiac surgery: an overview of the pathophysiology and clinical implications.
Corral-Velez V, Lopez-Delgado JC, Betancur-Zambrano NL, Lopez-Suñe N, Rojas-Lora M, Torrado H, Ballus J. Corral-Velez V, et al. Inflamm Allergy Drug Targets. 2015;13(6):367-70. doi: 10.2174/1871528114666150529120801. Inflamm Allergy Drug Targets. 2015. PMID: 26021321 Review.
During cardiac surgery different factors, such as the aortic clamp, the extracorporeal circulation and the surgical injury itself, produce complex inflammatory responses which can lead to varying degrees of ischemia-reperfusion injury and/or systemic inflammatory response. …
During cardiac surgery different factors, such as the aortic clamp, the extracorporeal circulation and the surgical injury itself, produce c …
Methylene Blue Reduces Acute Cerebral Ischemic Injury via the Induction of Mitophagy.
Di Y, He YL, Zhao T, Huang X, Wu KW, Liu SH, Zhao YQ, Fan M, Wu LY, Zhu LL. Di Y, et al. Mol Med. 2015 May 19;21(1):420-9. doi: 10.2119/molmed.2015.00038. Mol Med. 2015. PMID: 25998511 Free PMC article.
The treatment of stroke is limited by a short therapeutic window and a lack of effective clinical drugs. Methylene blue (MB) has been used in laboratories and clinics since the 1890s. Few studies have reported the neuroprotective role of MB in cerebral ischemia-r …
The treatment of stroke is limited by a short therapeutic window and a lack of effective clinical drugs. Methylene blue (MB) h …
The Effect of Ischemia and Reperfusion on Enteric Glial Cells and Contractile Activity in the Ileum.
Mendes CE, Palombit K, Vieira C, Silva I, Correia-de-Sá P, Castelucci P. Mendes CE, et al. Dig Dis Sci. 2015 Sep;60(9):2677-89. doi: 10.1007/s10620-015-3663-3. Epub 2015 Apr 28. Dig Dis Sci. 2015. PMID: 25917048
BACKGROUND: We investigated the effects of ischemia followed by different periods of reperfusion (I/R) on immunoreactive S100beta-positive glial and Hu-immunoreactive neurons co-expressing the P2X2 receptor in the myenteric plexus of the rat ileum. ...The area of S100beta- …
BACKGROUND: We investigated the effects of ischemia followed by different periods of reperfusion (I/R) on immunoreactive S100beta-pos …
Methylene blue attenuates renal ischemia-reperfusion injury in rats.
Sarac F, Kilincaslan H, Kilic E, Koldas M, Terzi EH, Aydogdu I. Sarac F, et al. J Pediatr Surg. 2015 Jun;50(6):1067-71. doi: 10.1016/j.jpedsurg.2014.06.018. Epub 2014 Aug 13. J Pediatr Surg. 2015. PMID: 25783339
BACKGROUND AND PURPOSE: In our study, we investigated the effects of methylene blue (MB) on histopathological changes in renal ischemia/reperfusion (I/R) injury rat model. ...In Groups 2 (untreated group) and 3 (MB treatment), the renal arteries were clamped, …
BACKGROUND AND PURPOSE: In our study, we investigated the effects of methylene blue (MB) on histopathological changes in renal …
Pterostilbene attenuates the inflammatory reaction induced by ischemia/reperfusion in rat heart.
Lv M, Liu K, Fu S, Li Z, Yu X. Lv M, et al. Mol Med Rep. 2015 Jan;11(1):724-8. doi: 10.3892/mmr.2014.2719. Epub 2014 Oct 21. Mol Med Rep. 2015. PMID: 25333895
The role of pterostilbene (Pte) in inflammation induced by ischemia/reperfusion is not well understood. The aim of this study was to investigate whether Pte modulates neutrophil accumulation and the induction of tumor necrosis factor-alpha (TNF-alpha) in an ischemia/rep …
The role of pterostilbene (Pte) in inflammation induced by ischemia/reperfusion is not well understood. The aim of this study was to …
Methylene blue attenuates ischemia--reperfusion injury in lung transplantation.
Abreu Mda M, Pazetti R, Almeida FM, Correia AT, Parra ER, Silva LP, Vieira RP, Pêgo-Fernandes PM, Jatene FB. Abreu Mda M, et al. J Surg Res. 2014 Dec;192(2):635-41. doi: 10.1016/j.jss.2014.07.043. Epub 2014 Jul 24. J Surg Res. 2014. PMID: 25151469
BACKGROUND: Ischemia-reperfusion injury (IRI) is one of the principal obstacles for the lung transplantation (LTx) success. Several strategies have been adopted to minimize the effects of IRI in lungs, including ex vivo conditioning of the grafts and the use of antioxidant …
BACKGROUND: Ischemia-reperfusion injury (IRI) is one of the principal obstacles for the lung transplantation (LTx) success. Several s …
Resveratrol attenuates the inflammatory reaction induced by ischemia/reperfusion in the rat heart.
Cong X, Li Y, Lu N, Dai Y, Zhang H, Zhao X, Liu Y. Cong X, et al. Mol Med Rep. 2014 Jun;9(6):2528-32. doi: 10.3892/mmr.2014.2090. Epub 2014 Mar 28. Mol Med Rep. 2014. PMID: 24682318
The role of resveratrol (Res) in inflammation induced by ischemia/reperfusion is not well understood. The aim of the present study was to investigate whether Res modulates neutrophil accumulation and tumor necrosis factor-alpha (TNF-alpha) induction in an ischemia/reper …
The role of resveratrol (Res) in inflammation induced by ischemia/reperfusion is not well understood. The aim of the present study wa …
Calculus Bovis-Fel Uris-Moschus Pharmacopuncture's Effect on Regional Cerebral Blood Flow and Mean Arterial Blood Pressure in Rats.
Park SJ, Lee HY, Choi NR, Kwon YM, Joo JC. Park SJ, et al. J Pharmacopuncture. 2013 Dec;16(4):30-5. doi: 10.3831/KPI.2013.16.028. J Pharmacopuncture. 2013. PMID: 25780680 Free PMC article.
The effect on the rCBF was significantly inhibited by pretreatment with methylene blue (0.01 mg/kg, intraperitoneal), an inhibitor of guanylate cyclase, but was not affected by pretreatment with indomethacin (1 mg/kg, intraperitoneal), an inhibitor of cyclooxygenase …
The effect on the rCBF was significantly inhibited by pretreatment with methylene blue (0.01 mg/kg, intraperitoneal), an inhib …
Neuroprotective efficacy of methylene blue in ischemic stroke: an MRI study.
Shen Q, Du F, Huang S, Rodriguez P, Watts LT, Duong TQ. Shen Q, et al. PLoS One. 2013 Nov 21;8(11):e79833. doi: 10.1371/journal.pone.0079833. eCollection 2013. PLoS One. 2013. PMID: 24278191 Free PMC article.
Methylene blue (MB) has unique energy-enhancing and antioxidant properties and is FDA-approved drug to treat methemoglobinemia and cyanide poisoning. ...In a randomized double-blinded design, vehicle or MB was administered after reperfusion. The initial lesio …
Methylene blue (MB) has unique energy-enhancing and antioxidant properties and is FDA-approved drug to treat methemoglobinemia …
Clinical update in liver transplantation.
Valentine E, Gregorits M, Gutsche JT, Al-Ghofaily L, Augoustides JG. Valentine E, et al. J Cardiothorac Vasc Anesth. 2013 Aug;27(4):809-15. doi: 10.1053/j.jvca.2013.03.031. J Cardiothorac Vasc Anesth. 2013. PMID: 23849528 Review.
The postreperfusion syndrome has clearly defined and typically responds to vasopressin and/or methylene blue when refractory to catecholamine therapy. Diastolic dysfunction and cirrhotic cardiomyopathy are prevalent and important in LTX recipients. ...
The postreperfusion syndrome has clearly defined and typically responds to vasopressin and/or methylene blue when refractory t …
Methylene blue protects against paraquat-induced acute lung injury in rats.
Tian ZG, Ji Y, Yan WJ, Xu CY, Kong QY, Han F, Zhao Y, Pang QF. Tian ZG, et al. Int Immunopharmacol. 2013 Oct;17(2):309-13. doi: 10.1016/j.intimp.2013.06.022. Epub 2013 Jul 8. Int Immunopharmacol. 2013. PMID: 23845394
Methylene blue (MB) attenuates acute lung injury (ALI) induced by liver or pancreas ischemia-reperfusion. ...
Methylene blue (MB) attenuates acute lung injury (ALI) induced by liver or pancreas ischemia-reperfusion. ...
Methylene blue protects liver oxidative capacity after gut ischaemia-reperfusion in the rat.
Collange O, Charles AL, Bouitbir J, Chenard MP, Zoll J, Diemunsch P, Thaveau F, Chakfé N, Piquard F, Geny B. Collange O, et al. Eur J Vasc Endovasc Surg. 2013 Feb;45(2):168-75. doi: 10.1016/j.ejvs.2012.11.011. Epub 2012 Dec 14. Eur J Vasc Endovasc Surg. 2013. PMID: 23246335 Free article.
OBJECTIVES: Mesenteric ischaemia/reperfusion (IR) may lead to liver mitochondrial dysfunction and multiple organ failure. We determined whether gut IR induces early impairment of liver mitochondrial oxidative activity and whether methylene blue (MB) might aff …
OBJECTIVES: Mesenteric ischaemia/reperfusion (IR) may lead to liver mitochondrial dysfunction and multiple organ failure. We determin …
Pre-conditioned mesenchymal stem cells ameliorate renal ischemic injury in rats by augmented survival and engraftment.
Masoud MS, Anwar SS, Afzal MZ, Mehmood A, Khan SN, Riazuddin S. Masoud MS, et al. J Transl Med. 2012 Dec 5;10:243. doi: 10.1186/1479-5876-10-243. J Transl Med. 2012. PMID: 23217165 Free PMC article.
METHODS: MSCs were cultured in four groups SNAP (S-nitroso N-acetyl penicillamine), SNAP + Methylene Blue (MB), MB and a control for in vitro analysis. Cultured MSCs were pre-conditioned with either SNAP (100 muM) or MB (1 muM) or both for 6 hours. ...CONCLUSION: Th …
METHODS: MSCs were cultured in four groups SNAP (S-nitroso N-acetyl penicillamine), SNAP + Methylene Blue (MB), MB and a contr …
Central nervous tissue damage after hypoxia and reperfusion in conjunction with cardiac arrest and cardiopulmonary resuscitation: mechanisms of action and possibilities for mitigation.
Wiklund L, Martijn C, Miclescu A, Semenas E, Rubertsson S, Sharma HS. Wiklund L, et al. Int Rev Neurobiol. 2012;102:173-87. doi: 10.1016/B978-0-12-386986-9.00007-7. Int Rev Neurobiol. 2012. PMID: 22748830 Review.
One of the most important causes for this low survival rate is the ischemia-reperfusion injury that hits the brain. This review summarizes some of the more important mechanisms causing cerebral injury. ...In order to shed some light on therapeutic opportunities, our findin …
One of the most important causes for this low survival rate is the ischemia-reperfusion injury that hits the brain. This review summa …
Effect of methylene blue on the hemodynamic instability resulting from liver ischemia and reperfusion in rabbits.
Rosique RG, Rosique MJ, Rosique IA, Tirapelli LF, Castro e Silva O Jr, dos Santos JS, Evora PR. Rosique RG, et al. Transplant Proc. 2011 Dec;43(10):3643-51. doi: 10.1016/j.transproceed.2011.08.108. Transplant Proc. 2011. PMID: 22172820 Free article.
The experimental investigation was performed to study the effects of methylene blue (MB) on hemodynamic, biochemical, and tissue changes among rabbits undergoing liver ischemia and reperfusion (IR). Twenty-four rabbits were randomized into 5 groups: 1, SHAM, …
The experimental investigation was performed to study the effects of methylene blue (MB) on hemodynamic, biochemical, and tiss …
Alternative mitochondrial electron transfer as a novel strategy for neuroprotection.
Wen Y, Li W, Poteet EC, Xie L, Tan C, Yan LJ, Ju X, Liu R, Qian H, Marvin MA, Goldberg MS, She H, Mao Z, Simpkins JW, Yang SH. Wen Y, et al. J Biol Chem. 2011 May 6;286(18):16504-15. doi: 10.1074/jbc.M110.208447. Epub 2011 Mar 18. J Biol Chem. 2011. PMID: 21454572 Free PMC article.
In the current study, we demonstrated that methylene blue (MB) functions as an alternative electron carrier, which accepts electrons from NADH and transfers them to cytochrome c and bypasses complex I/III blockage. ...In addition, MB significantly reduced cerebral i …
In the current study, we demonstrated that methylene blue (MB) functions as an alternative electron carrier, which accepts ele …
The effect of methylene blue during orthotopic liver transplantation on post reperfusion syndrome and postoperative graft function.
Fukazawa K, Pretto EA. Fukazawa K, et al. J Hepatobiliary Pancreat Sci. 2011 May;18(3):406-13. doi: 10.1007/s00534-010-0344-7. J Hepatobiliary Pancreat Sci. 2011. PMID: 21104279
Methylene blue (MB) is an inhibitor of inducible NO synthase and an NO scavenger that has been shown to attenuate reperfusion hypotension. ...CONCLUSIONS: In our study, the administration of MB at 1-1.5 mg/kg immediately prior to reperfusion did not pr …
Methylene blue (MB) is an inhibitor of inducible NO synthase and an NO scavenger that has been shown to attenuate reperfusi …
[Protective effect of Na2SeO3 against cerebral ischemia-reperfusion injury to the hippocampal neurons in rats].
Wang GS, Geng DQ, Wang YW, Chen XD, Yang TH, Chang CH. Wang GS, et al. Nan Fang Yi Ke Da Xue Xue Bao. 2010 Oct;30(10):2336-9. Nan Fang Yi Ke Da Xue Xue Bao. 2010. PMID: 20965840 Chinese.
OBJECTIVE: To investigate the protective effects of selenium on rat hippocampal neurons against ischemia-reperfusion (IR) injury. METHODS: Thirty-two rats were randomly divided into sham-operated group, IR group and selenium-treated group, and in the latter two groups, cer …
OBJECTIVE: To investigate the protective effects of selenium on rat hippocampal neurons against ischemia-reperfusion (IR) injury. MET …
Adjuvant therapy with methylene blue in the treatment of right ventricular failure after pulmonary embolectomy.
Raikhelkar JK, Milla F, Darrow B, Scurlock C. Raikhelkar JK, et al. Heart Lung Circ. 2011 Apr;20(4):234-6. doi: 10.1016/j.hlc.2010.08.018. Epub 2010 Oct 16. Heart Lung Circ. 2011. PMID: 20952252
Severe pulmonary embolism often leads to right ventricular failure after surgical embolectomy secondary to ischaemia reperfusion injury and acute lung injury (ALI). Acute right ventricular dysfunction is traditionally treated with inotropes and vasopressors to maintain car …
Severe pulmonary embolism often leads to right ventricular failure after surgical embolectomy secondary to ischaemia reperfusion inju …
Methylene blue protects the cortical blood-brain barrier against ischemia/reperfusion-induced disruptions.
Miclescu A, Sharma HS, Martijn C, Wiklund L. Miclescu A, et al. Crit Care Med. 2010 Nov;38(11):2199-206. doi: 10.1097/CCM.0b013e3181f26b0c. Crit Care Med. 2010. PMID: 20711066
OBJECTIVES: To investigate the effects of cardiac arrest and the reperfusion syndrome on blood-brain barrier permeability and evaluate whether methylene blue counteracts blood-brain barrier disruption in a pig model of controlled cardiopulmonary resuscitation …
OBJECTIVES: To investigate the effects of cardiac arrest and the reperfusion syndrome on blood-brain barrier permeability and evaluat …
Effect of methylene blue on the genomic response to reperfusion injury induced by cardiac arrest and cardiopulmonary resuscitation in porcine brain.
Martijn C, Wiklund L. Martijn C, et al. BMC Med Genomics. 2010 Jul 1;3:27. doi: 10.1186/1755-8794-3-27. BMC Med Genomics. 2010. PMID: 20594294 Free PMC article.
BACKGROUND: Cerebral ischemia/reperfusion injury is a common secondary effect of cardiac arrest which is largely responsible for postresuscitative mortality. Therefore development of therapies which restore and protect the brain function after cardiac arrest is essential. …
BACKGROUND: Cerebral ischemia/reperfusion injury is a common secondary effect of cardiac arrest which is largely responsible for post …
The influence of methylene blue on the healing of intestinal anastomoses subjected to ischemia and reperfusion in rats.
Miranda EF, Greca FH, Noronha L, Kotze LR, Rubin MR. Miranda EF, et al. Acta Cir Bras. 2010 Feb;25(1):63-70. doi: 10.1590/s0102-86502010000100015. Acta Cir Bras. 2010. PMID: 20126891 Free article.
PURPOSE: To investigate the influence of methylene blue, on the healing of intestinal anastomoses subjected to ischemia and reperfusion in rats. METHODS: Forty-five rats divided into the following three groups were used: control (G1); ischemia without meth …
PURPOSE: To investigate the influence of methylene blue, on the healing of intestinal anastomoses subjected to ischemia and …
The use of methylene blue in abdominal aortic surgery: a case report.
Piraccini E, Agnoletti V, Corso R, Maitan S, Gambale G. Piraccini E, et al. HSR Proc Intensive Care Cardiovasc Anesth. 2010;2(3):215-8. HSR Proc Intensive Care Cardiovasc Anesth. 2010. PMID: 23440623 Free PMC article.
The massive production of NO by the inducible isoform of NO synthase could be partially responsible for the profound vasodilatation and myocardial dysfunction. The dye methylene blue (MB) has been used as to prevent vasodilatation in other clinical situations like s …
The massive production of NO by the inducible isoform of NO synthase could be partially responsible for the profound vasodilatation and myoc …
Sex differences in cerebral injury after severe haemorrhage and ventricular fibrillation in pigs.
Semenas E, Nozari A, Sharma HS, Basu S, Rubertsson S, Wiklund L. Semenas E, et al. Acta Anaesthesiol Scand. 2010 Mar;54(3):343-53. doi: 10.1111/j.1399-6576.2009.02125.x. Epub 2009 Sep 17. Acta Anaesthesiol Scand. 2010. PMID: 19764903
METHODS: Thirty-two sexually immature piglets (14 males and 18 females) were subjected to 5 min of haemorrhagic shock followed by 2 min of ventricular fibrillation and 8 min of cardiopulmonary resuscitation, using three resuscitation fluid regimens (whole blood, hypertonic saline …
METHODS: Thirty-two sexually immature piglets (14 males and 18 females) were subjected to 5 min of haemorrhagic shock followed by 2 min of v …
Methylene blue attenuates pancreas ischemia-reperfusion (IR)-induced lung injury: a dose response study in a rat model.
Weinbroum AA. Weinbroum AA. J Gastrointest Surg. 2009 Sep;13(9):1683-91. doi: 10.1007/s11605-009-0945-0. Epub 2009 Jul 1. J Gastrointest Surg. 2009. PMID: 19568820
Such damage has recently been demonstrated in the presence of pancreas ischemia-reperfusion (IR). We now investigated whether methylene blue (MB), a clinically used coloring agent and antioxidant in itself, protected the lung exposed to pancreas IR. MATERIALS …
Such damage has recently been demonstrated in the presence of pancreas ischemia-reperfusion (IR). We now investigated whether meth …
Serendipitous findings while researching oxygen free radicals.
Floyd RA. Floyd RA. Free Radic Biol Med. 2009 Apr 15;46(8):1004-13. doi: 10.1016/j.freeradbiomed.2009.02.003. Epub 2009 Feb 12. Free Radic Biol Med. 2009. PMID: 19439210 Free PMC article. Review.
This technology led to the pioneering use of salicylate to trap hydroxyl free radicals and show increased flux in ischemia/reperfused brain regions and also to first sensitively detect 8-hydroxyl-2-deoxyguanosine in oxidatively damaged DNA and help assess its role in cance …
This technology led to the pioneering use of salicylate to trap hydroxyl free radicals and show increased flux in ischemia/reperfused …
Physiologically relevant online electrochemical method for continuous and simultaneous monitoring of striatum glucose and lactate following global cerebral ischemia/reperfusion.
Lin Y, Zhu N, Yu P, Su L, Mao L. Lin Y, et al. Anal Chem. 2009 Mar 15;81(6):2067-74. doi: 10.1021/ac801946s. Anal Chem. 2009. PMID: 19281258
The dehydrogenase-based electrochemical biosensors are developed onto the dual split-disk plastic carbon film (SPCF) electrodes with methylene green (MG) adsorbed onto single-walled carbon nanotubes (SWNTs) as the electrocatalyst for the oxidation of dihydronicotiamide ade …
The dehydrogenase-based electrochemical biosensors are developed onto the dual split-disk plastic carbon film (SPCF) electrodes with meth …
Nitroglycerin protects small intestine from ischemia-reperfusion injury via NO-cGMP pathway and upregulation of alpha-CGRP.
Li J, Zhang M, Yang C, Dun Y, Zhang Y, Hao Y. Li J, et al. J Gastrointest Surg. 2009 Mar;13(3):478-85. doi: 10.1007/s11605-008-0728-z. Epub 2008 Nov 11. J Gastrointest Surg. 2009. PMID: 19002537
RESULTS: Pretreatment with NTG (0.12 mg/kg i.v.) 24 h before ischemia-reperfusion (I/R) of super mesenteric artery significantly reduced histologic lesions and serum LDH with elevated blood levels of NO and CGRP. Inhibition of guanylate cyclase by methylene blue …
RESULTS: Pretreatment with NTG (0.12 mg/kg i.v.) 24 h before ischemia-reperfusion (I/R) of super mesenteric artery significantly redu …
In vivo myocardial infarct area at risk assessment in the rat using manganese enhanced magnetic resonance imaging (MEMRI) at 1.5T.
Daire JL, Hyacinthe JN, Tatar I, Montet-Abou K, Ivancevic MK, Masterson K, Jorge-Costa M, Morel DR, Vallée JP. Daire JL, et al. Magn Reson Med. 2008 Jun;59(6):1422-30. doi: 10.1002/mrm.21493. Magn Reson Med. 2008. PMID: 18506788 Free article.
A total of 15 adult rats underwent a single 30-min episode of coronary occlusion followed by reperfusion. MnCl2 was injected (25 micromol/kg) at the beginning of the occlusion for 11 rats (group 1) and 6 h after reperfusion for four animals (group 2). ...Hypoenhance …
A total of 15 adult rats underwent a single 30-min episode of coronary occlusion followed by reperfusion. MnCl2 was injected (25 micr …
Thymosin beta4 is an essential paracrine factor of embryonic endothelial progenitor cell-mediated cardioprotection.
Hinkel R, El-Aouni C, Olson T, Horstkotte J, Mayer S, Müller S, Willhauck M, Spitzweg C, Gildehaus FJ, Münzing W, Hannappel E, Bock-Marquette I, DiMaio JM, Hatzopoulos AK, Boekstegers P, Kupatt C. Hinkel R, et al. Circulation. 2008 Apr 29;117(17):2232-40. doi: 10.1161/CIRCULATIONAHA.107.758904. Epub 2008 Apr 21. Circulation. 2008. PMID: 18427126 Free PMC article.
We have reported that retrograde application of embryonic endothelial progenitor cells (eEPCs) provides rapid paracrine protection against ischemia-reperfusion injury. Here, we investigated the role of thymosin beta4 (Tbeta4) as a mediator of eEPC-mediated cardioprotection …
We have reported that retrograde application of embryonic endothelial progenitor cells (eEPCs) provides rapid paracrine protection against i …
The protective effect of methylene blue in lungs, small bowel and kidney after intestinal ischemia and reperfusion.
Greca FH, Gonçalves NM, Souza Filho ZA, Noronha Ld, Silva RF, Rubin MR. Greca FH, et al. Acta Cir Bras. 2008 Mar-Apr;23(2):149-56. doi: 10.1590/s0102-86502008000200007. Acta Cir Bras. 2008. PMID: 18372960 Free article.
In the animals of the control group, 2 ml of saline were injected in the peritoneal cavity and in the animals of the experimental group, 2 ml of methylene blue were injected in the peritoneal cavity. After reperfusion for 4 hours, the animals were then sacrif …
In the animals of the control group, 2 ml of saline were injected in the peritoneal cavity and in the animals of the experimental group, 2 m …
Neuro- and cardioprotective effects of blockade of nitric oxide action by administration of methylene blue.
Wiklund L, Basu S, Miclescu A, Wiklund P, Ronquist G, Sharma HS. Wiklund L, et al. Ann N Y Acad Sci. 2007 Dec;1122:231-44. doi: 10.1196/annals.1403.016. Ann N Y Acad Sci. 2007. PMID: 18077576 Review.
Methylene blue (MB), generic name methylthioninium (C(16)H(18)ClN(3) S . 3H(2)O), is a blue dye synthesized in 1876 by Heinrich Caro for use as a textile dye and used in the laboratory and clinically since the 1890s, with well-known toxicity and pharmacokinet …
Methylene blue (MB), generic name methylthioninium (C(16)H(18)ClN(3) S . 3H(2)O), is a blue dye synthesized in 1876 by …
Methylene blue increases contralateral testicular ischaemia-reperfusion injury after unilateral testicular torsion.
Inan M, Basaran UN, Dokmeci D, Yalcin O, Aydogdu N, Turan N. Inan M, et al. Clin Exp Pharmacol Physiol. 2008 Jan;35(1):50-4. doi: 10.1111/j.1440-1681.2007.04736.x. Clin Exp Pharmacol Physiol. 2008. PMID: 18047627
It is has been reported that methylene blue has a positive effect in the reparation of ischaemia-reperfusion injury in different tissues. Therefore, we hypothesized that methylene blue may prevent the hazardous effects of ischaemia-reperfusio …
It is has been reported that methylene blue has a positive effect in the reparation of ischaemia-reperfusion injury in …
In vitro pharmacological study of femoral artery vascular reactivity after inferior canine hindlimb ischemia/reperfusion: effects of in vivo nitric oxide blocker infusion.
Joviliano EE, Piccinato CE, Cherri J, Viaro F, Moryia T, Celotto AC, Bonaventura D, Evora PR. Joviliano EE, et al. Ann Vasc Surg. 2007 Sep;21(5):618-28. doi: 10.1016/j.avsg.2007.07.004. Ann Vasc Surg. 2007. PMID: 17823044
The experimental model tested herein was the inferior canine hindlimb global ischemia induced by infrarenal abdominal aortic cross-clamping followed by reperfusion. The NO blockers employed in the tests were N(G)-nitro-l-arginine methyl ester (L-NAME), aminoguanidine (AMG) …
The experimental model tested herein was the inferior canine hindlimb global ischemia induced by infrarenal abdominal aortic cross-clamping …
[Cardioprotection and mechanisms of exogenous carbon monoxide releaser CORM-2 against ischemia/reperfusion injury in isolated rat hearts].
Mei DS, Du YA, Wang Y. Mei DS, et al. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2007 May;36(3):291-7. doi: 10.3785/j.issn.1008-9292.2007.03.014. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2007. PMID: 17571314 Chinese.
Pretreatment of a NOS inhibitor L-NAME and a HO-1 inhibitor ZnPP partly abolished the protection effect of CORM-2(25 micromol/L) on LVEDP, and L-NAME and a GC inhibitor methylene blue could also cancel the enhance of LVDP and +dp/dt(max) incuced by CORM-2. All of th …
Pretreatment of a NOS inhibitor L-NAME and a HO-1 inhibitor ZnPP partly abolished the protection effect of CORM-2(25 micromol/L) on LVEDP, a …
Cardio-cerebral and metabolic effects of methylene blue in hypertonic sodium lactate during experimental cardiopulmonary resuscitation.
Miclescu A, Basu S, Wiklund L. Miclescu A, et al. Resuscitation. 2007 Oct;75(1):88-97. doi: 10.1016/j.resuscitation.2007.03.014. Epub 2007 May 4. Resuscitation. 2007. PMID: 17482336
BACKGROUND: Methylene blue (MB) administered with a hypertonic-hyperoncotic solution reduces the myocardial and cerebral damage due to ischaemia and reperfusion injury after experimental cardiac arrest and also increases short-term survival. As MB precipitate …
BACKGROUND: Methylene blue (MB) administered with a hypertonic-hyperoncotic solution reduces the myocardial and cerebral damag …
The guanylyl cyclase inhibition by MB as vasoplegic circulatory shock therapeutical target.
Evora PR, Viaro F. Evora PR, et al. Curr Drug Targets. 2006 Sep;7(9):1195-204. doi: 10.2174/138945006778226679. Curr Drug Targets. 2006. PMID: 17017895 Review.
Other forms of shock associated to anaphylaxis (anaphylactic shock, SIRS) and ischemia reperfusion injury (cardiogenic shock, organ transplants), may involve nitric oxide overproduction. ...
Other forms of shock associated to anaphylaxis (anaphylactic shock, SIRS) and ischemia reperfusion injury (cardiogenic shock, organ t …
Methylene blue decreases ischemia-reperfusion (I/R)-induced spinal cord injury: an in vivo study in an I/R rabbit model.
Bardakci H, Kaplan S, Karadeniz U, Ozer C, Bardakci Y, Ozogul C, Birincioglu CL, Cobanoglu A. Bardakci H, et al. Eur Surg Res. 2006;38(5):482-8. doi: 10.1159/000096007. Epub 2006 Sep 29. Eur Surg Res. 2006. PMID: 17016050
OBJECTIVES: To evaluate the effects of intravenous methylene blue (MB) administration on ischemia-reperfusion (I/R) injury of the spinal cord (SC). ...
OBJECTIVES: To evaluate the effects of intravenous methylene blue (MB) administration on ischemia-reperfusion (I/R) inj …
Methylene blue added to a hypertonic-hyperoncotic solution increases short-term survival in experimental cardiac arrest.
Miclescu A, Basu S, Wiklund L. Miclescu A, et al. Crit Care Med. 2006 Nov;34(11):2806-13. doi: 10.1097/01.CCM.0000242517.23324.27. Crit Care Med. 2006. PMID: 16957637
OBJECTIVE: Methylene blue (MB), a free-radical scavenger inhibiting the production and actions of nitric oxide, may counteract excessive vasodilatation induced by nitric oxide during cardiac arrest. ...
OBJECTIVE: Methylene blue (MB), a free-radical scavenger inhibiting the production and actions of nitric oxide, may counteract …
Retroinfusion of embryonic endothelial progenitor cells attenuates ischemia-reperfusion injury in pigs: role of phosphatidylinositol 3-kinase/AKT kinase.
Kupatt C, Hinkel R, Lamparter M, von Brühl ML, Pohl T, Horstkotte J, Beck H, Müller S, Delker S, Gildehaus FJ, Büning H, Hatzopoulos AK, Boekstegers P. Kupatt C, et al. Circulation. 2005 Aug 30;112(9 Suppl):I117-22. doi: 10.1161/CIRCULATIONAHA.104.524801. Circulation. 2005. PMID: 16159802
Here, we assessed the potential of eEPCs to limit organ dysfunction after ischemia and reperfusion in a preclinical pig model. METHODS AND RESULTS: Pigs were subjected to ischemia (60-minute left anterior descending [LAD] artery occlusion) and reperfusion (7 days). …
Here, we assessed the potential of eEPCs to limit organ dysfunction after ischemia and reperfusion in a preclinical pig model. METHOD …
Carbon monoxide protects against cardiac ischemia--reperfusion injury in vivo via MAPK and Akt--eNOS pathways.
Fujimoto H, Ohno M, Ayabe S, Kobayashi H, Ishizaka N, Kimura H, Yoshida K, Nagai R. Fujimoto H, et al. Arterioscler Thromb Vasc Biol. 2004 Oct;24(10):1848-53. doi: 10.1161/01.ATV.0000142364.85911.0e. Epub 2004 Aug 12. Arterioscler Thromb Vasc Biol. 2004. PMID: 15308554
We investigated the role of CO in amelioration of cardiac ischemia-reperfusion injury in vivo and the mechanisms involved in it. METHODS AND RESULTS: Rats inhaled CO (250 ppm, 500 ppm, or 1000 ppm) for 24 hours in a chamber after myocardial ischemia-reperfusion indu …
We investigated the role of CO in amelioration of cardiac ischemia-reperfusion injury in vivo and the mechanisms involved in it. METH …
Methylene blue attenuates lung injury after mesenteric artery clamping/unclamping.
Weinbroum AA. Weinbroum AA. Eur J Clin Invest. 2004 Jun;34(6):436-42. doi: 10.1111/j.1365-2362.2004.01361.x. Eur J Clin Invest. 2004. PMID: 15200496
BACKGROUND: This controlled, experimental study was designed to assess the effects of intratracheal and intravenous methylene blue on reperfusion lung injury following superior mesenteric artery clamping/unclamping. ...This finding is a novel potential use of …
BACKGROUND: This controlled, experimental study was designed to assess the effects of intratracheal and intravenous methylene blue …
Selective retroinfusion of GSH and cariporide attenuates myocardial ischemia-reperfusion injury in a preclinical pig model.
Kupatt C, Hinkel R, Horstkotte J, Deiss M, von Brühl ML, Bilzer M, Boekstegers P. Kupatt C, et al. Cardiovasc Res. 2004 Feb 15;61(3):530-7. doi: 10.1016/j.cardiores.2003.11.012. Cardiovasc Res. 2004. PMID: 14962483
OBJECTIVE: Reperfusion after ischemia may contribute to loss of myocardial function and increase in infarct size. ...Seven days later, subendocardial segment shortening (SES) was analyzed by sonomicrometry. Infarct size was determined by methylene-blue staini …
OBJECTIVE: Reperfusion after ischemia may contribute to loss of myocardial function and increase in infarct size. ...Seven days later …
Effects of the anti-ICAM-1 monoclonal antibody, allopurinol, and methylene blue on intestinal reperfusion injury.
Ilhan H, Alatas O, Tokar B, çOlak O, Paşaoĝlu O, Koku N. Ilhan H, et al. J Pediatr Surg. 2003 Nov;38(11):1591-5. doi: 10.1016/s0022-3468(03)00568-2. J Pediatr Surg. 2003. PMID: 14614706
PURPOSE: The aim of this study was to evaluate the effect of allopurinol, methylene blue, and a monoclonal antibody to the adhesion molecule ICAM-1 in intestinal ischemia and reperfusion injury. ...Methylene blue was not effective to prevent or …
PURPOSE: The aim of this study was to evaluate the effect of allopurinol, methylene blue, and a monoclonal antibody to the adh …
Preischemic infusion of alpha-human atrial natriuretic peptide elicits myoprotective effects against ischemia reperfusion in isolated rat hearts.
Okawa H, Horimoto H, Mieno S, Nomura Y, Yoshida M, Shinjiro S. Okawa H, et al. Mol Cell Biochem. 2003 Jun;248(1-2):171-7. doi: 10.1023/a:1024148621505. Mol Cell Biochem. 2003. PMID: 12870670
Six hearts received 0.1 microM of carperitide for 10 min, 6 hearts received 1 mM of a NO synthetase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) for 5 min before the infusion of carperitide, 6 hearts received 0.02 microM of a PKC synthetase inhibitor chelerythrine chlori …
Six hearts received 0.1 microM of carperitide for 10 min, 6 hearts received 1 mM of a NO synthetase inhibitor N(G)-nitro-L-arginine methyl e …
Warm retrograde blood cardioplegia saves more ischemic myocardium but may cause a functional impairment compared to cold crystalloid.
Elvenes OP, Korvald C, Myklebust R, Sørlie D. Elvenes OP, et al. Eur J Cardiothorac Surg. 2002 Sep;22(3):402-9. doi: 10.1016/s1010-7940(02)00338-x. Eur J Cardiothorac Surg. 2002. PMID: 12204731
All animals were put on cardiopulmonary bypass. After 1h of cardioplegia and 1 h of reperfusion the perfused left ventricle was colored with methylene blue. After excision of the hearts a standard planimetri technique was used to determine the area at risk an …
All animals were put on cardiopulmonary bypass. After 1h of cardioplegia and 1 h of reperfusion the perfused left ventricle was color …
Studies on the signal cascade mechanism mediating the cardioprotective actions of bradykinin.
Akula A, Veeravalli KK, Potharaju S, Kota MK. Akula A, et al. Pharmazie. 2002 May;57(5):332-6. Pharmazie. 2002. PMID: 12061258
The signal cascade mechanism mediating the cardioprotective actions of bradykinin was evaluated by administering aspirin and methylene blue prior to lisinopril and 2-mercaptoethanol combined treatment. Myocardial infarction was produced by occlusion of the left ante …
The signal cascade mechanism mediating the cardioprotective actions of bradykinin was evaluated by administering aspirin and methylene …
Methylene blue in preventing hemodynamic and metabolic derangement following superior mesenteric artery clamping/unclamping: an intratracheal vs. intraperitoneal dose-response study.
Weinbroum AA, Goldin I, Kluger Y, Szold A. Weinbroum AA, et al. Shock. 2002 May;17(5):372-6. doi: 10.1097/00024382-200205000-00005. Shock. 2002. PMID: 12022756
Intestinal ischemia-reperfusion affects hemodynamics. We studied intratracheal vs. intraperitoneal methylene blue (MB) attenuation of hemodynamic and metabolic deterioration following superior mesenteric artery (SMA) clamping/unclamping. ...
Intestinal ischemia-reperfusion affects hemodynamics. We studied intratracheal vs. intraperitoneal methylene blue (MB) …
Complementary role of extracellular ATP and adenosine in ischemic preconditioning in the rat heart.
Ninomiya H, Otani H, Lu K, Uchiyama T, Kido M, Imamura H. Ninomiya H, et al. Am J Physiol Heart Circ Physiol. 2002 May;282(5):H1810-20. doi: 10.1152/ajpheart.00760.2001. Am J Physiol Heart Circ Physiol. 2002. PMID: 11959647 Free article.
Isolated and buffer-perfused rat hearts underwent IPC by three cycles of 5-min ischemia and 5-min reperfusion before 25 min of global ischemia. The rate-pressure product (RPP) 30 min after reperfusion was taken as an endpoint of functional protection. ...The improve …
Isolated and buffer-perfused rat hearts underwent IPC by three cycles of 5-min ischemia and 5-min reperfusion before 25 min of global …
Delayed cardioprotection induced by nitroglycerin is mediated by alpha-calcitonin gene-related peptide.
Zhou ZH, Peng J, Ye F, Li NS, Deng HW, Li YJ. Zhou ZH, et al. Naunyn Schmiedebergs Arch Pharmacol. 2002 Apr;365(4):253-9. doi: 10.1007/s00210-002-0537-y. Epub 2002 Mar 6. Naunyn Schmiedebergs Arch Pharmacol. 2002. PMID: 11919648
The left main coronary artery was occluded for 60 min, followed by 3 h reperfusion. Infarct size, serum creatine kinase activity, serum levels of NO and CGRP and the expression of alpha- and beta-CGRP isoform mRNA in lumbar dorsal root ganglia were measured. ...The effects …
The left main coronary artery was occluded for 60 min, followed by 3 h reperfusion. Infarct size, serum creatine kinase activity, ser …
The effect of methylene blue on the hemodynamic changes during ischemia reperfusion injury in orthotopic liver transplantation.
Koelzow H, Gedney JA, Baumann J, Snook NJ, Bellamy MC. Koelzow H, et al. Anesth Analg. 2002 Apr;94(4):824-9, table of contents. doi: 10.1097/00000539-200204000-00009. Anesth Analg. 2002. PMID: 11916779 Clinical Trial.
Methylene blue (MB) has been used as a vasopressor in sepsis and acute liver failure. We investigated the effect of MB on IRS during OLT. ...MB attenuated the hemodynamic changes of IRS in OLT acting via guanylate cyclase inhibition. IMPLICATIONS: Methylene …
Methylene blue (MB) has been used as a vasopressor in sepsis and acute liver failure. We investigated the effect of MB on IRS …
14 C-deoxyglucose imaging overestimates myocardial viability in subacute infarction of rats.
Hasegawa S, Kusuoka H, Fukuchi K, Yutani K, Maruyama K, Hori M, Nishimura T. Hasegawa S, et al. Nucl Med Commun. 2002 Mar;23(3):209-17. doi: 10.1097/00006231-200203000-00003. Nucl Med Commun. 2002. PMID: 11891478
Autoradiography with 14C-deoxyglucose was performed in fasting rats whose left coronary artery was occluded for 60 min and then reperfused. 14C-deoxyglucose was injected 30 min after the reperfusion (acute; n=10) or 1 week later (subacute; n=9). Infarction and risk …
Autoradiography with 14C-deoxyglucose was performed in fasting rats whose left coronary artery was occluded for 60 min and then reperfuse …
Heme oxygenase-1 pathway is involved in delayed protection induced by heat stress against cardiac ischemia-reperfusion injury.
Lu R, Peng J, Xiao L, Deng HW, Li YJ. Lu R, et al. Int J Cardiol. 2002 Feb;82(2):133-40. doi: 10.1016/s0167-5273(01)00612-x. Int J Cardiol. 2002. PMID: 11853899
Pretreatment with hyperthemia significantly reduced infarct size and CK release during reperfusion, which was completely blocked by pretreatment with ZnPP-9, an inhibitor of HO and methylene blue, an inhibitor of soluble guanylate cyclase. Heat stress also si …
Pretreatment with hyperthemia significantly reduced infarct size and CK release during reperfusion, which was completely blocked by p …
Improvement of preservation with cardioplegic solution by nitroglycerin-induced delayed preconditioning is mediated by calcitonin gene-related peptide.
Zhou ZH, Deng HW, Li YJ. Zhou ZH, et al. Int J Cardiol. 2001 Dec;81(2-3):211-8. doi: 10.1016/s0167-5273(01)00569-1. Int J Cardiol. 2001. PMID: 11744139
The isolated rat heart was arrested using St. Thomas Hospital solution, and then reperfused with normothermic Krebs-Henseleit solution for 40 min after a 4-h hypothermic ischemic period. ...After pretreatment with capsaicin, which depletes neurotransmitters in sensory nerv …
The isolated rat heart was arrested using St. Thomas Hospital solution, and then reperfused with normothermic Krebs-Henseleit solutio …
Selective attenuation of acute lung ventilatory injury by methylene blue after liver ischemia-reperfusion: a drug response study in an isolated perfused double organ model.
Weinbroum AA, Paret G, Szold O, Rudick V, Krupitzky L. Weinbroum AA, et al. Transplantation. 2001 Aug 15;72(3):385-92. doi: 10.1097/00007890-200108150-00006. Transplantation. 2001. PMID: 11502965
BACKGROUND: Liver transplantation-related ischemia-reperfusion (IR) is associated with the generation of stress oxidants that can spread damage remotely. Methylene blue (MB) had been shown to reduce lung neutrophils sequestration after in vivo intestinal IR a …
BACKGROUND: Liver transplantation-related ischemia-reperfusion (IR) is associated with the generation of stress oxidants that can spr …
The effect of methylene blue on histological damage after spermatic cord torsion in a rat model.
Greenstein A, Schreiber L, Matzkin H. Greenstein A, et al. BJU Int. 2001 Jul;88(1):90-2. doi: 10.1046/j.1464-410x.2001.02192.x. BJU Int. 2001. PMID: 11446854
OBJECTIVE: To investigate, in a rat model, whether methylene blue (a free-radical scavenger) is effective in alleviating the histological testicular damage caused by reperfusion after spermatic cord torsion. ...CONCLUSION: Anti-oxidant treatment with methy …
OBJECTIVE: To investigate, in a rat model, whether methylene blue (a free-radical scavenger) is effective in alleviating the h …
Chronic extrinsic denervation after small bowel transplantation in rat jejunum: Effects and adaptation in nitrergic and non-nitrergic neuromuscular inhibitory mechanisms.
Balsiger BM, Ohtani N, Anding WJ, Duenes JA, Sarr MG. Balsiger BM, et al. Surgery. 2001 Apr;129(4):478-89. doi: 10.1067/msy.2001.112070. Surgery. 2001. PMID: 11283540
We evaluated the effects of exogenous nitric oxide, increasing doses of cholinergic and adrenergic agonists, and electrical field stimulation (EFS) in the presence or absence of N(G)-monomethyl-l-arginine, methylene blue, tetraethylammonium, or tetrodotoxin. RESULTS …
We evaluated the effects of exogenous nitric oxide, increasing doses of cholinergic and adrenergic agonists, and electrical field stimulatio …
Norepinephrine release after acute brain death abolishes the cardioprotective effects of ischemic preconditioning in rabbit.
Farhat F, Loisance D, Garnier JP, Kirsch M. Farhat F, et al. Eur J Cardiothorac Surg. 2001 Mar;19(3):313-20. doi: 10.1016/s1010-7940(00)00659-x. Eur J Cardiothorac Surg. 2001. PMID: 11251272
In control group (CTRL), anaesthetized rabbits were subjected to 30 min left coronary marginal branch occlusion and 90 min reperfusion. In CTRL+IP group, anaesthetized rabbits were preconditioned with a 5-min ischemia and 5-min reperfusion sequence before coronary o …
In control group (CTRL), anaesthetized rabbits were subjected to 30 min left coronary marginal branch occlusion and 90 min reperfusion …
Methylene blue abolishes aortal tone impairment induced by liver ischemia-reperfusion in a dose response manner: an isolated-perfused double-organ rat model study.
Weinbroum AA, Kluger Y, Shapira I, Rudick V. Weinbroum AA, et al. Shock. 2001 Mar;15(3):226-30. doi: 10.1097/00024382-200115030-00011. Shock. 2001. PMID: 11236907
Liver ischemia-reperfusion (IR) generates remote organ reperfusion injury attributable to oxidative mediators. We tested the protective properties of methylene blue (MB) on aortal dysfunction. An ex vivo rat liver-aortal ring model was used to study th …
Liver ischemia-reperfusion (IR) generates remote organ reperfusion injury attributable to oxidative mediators. We tested the p …
Estimation of the area at risk in myocardial infarction of rats by means of I-123 beta-methyliodophenyl pentadecanoic acid imaging.
Hasegawa S, Kusuoka H, Fukuchi K, Hori M, Nishimura T. Hasegawa S, et al. Ann Nucl Med. 2000 Oct;14(5):347-52. doi: 10.1007/BF02988694. Ann Nucl Med. 2000. PMID: 11108163
To elucidate whether I-123 BMIPP can indicate the area at risk of ischemia, ex-vivo autoradiography was performed in rats whose left coronary artery was occluded for 60 min and then reperfused. I-123 BMIPP was injected at the acute stage (n = 10), or the subacute stage (7 …
To elucidate whether I-123 BMIPP can indicate the area at risk of ischemia, ex-vivo autoradiography was performed in rats whose left coronar …
The role of nitric oxide, K(+)(ATP) channels, and cGMP in the preconditioning response of the rabbit.
Horimoto H, Gaudette GR, Saltman AE, Krukenkamp IB. Horimoto H, et al. J Surg Res. 2000 Jul;92(1):56-63. doi: 10.1006/jsre.2000.5845. J Surg Res. 2000. PMID: 10864483
MATERIAL AND METHODS: Isolated rabbit hearts were pretreated with the NO precursor L-arginine (L-Arg), both alone and after infusion of the NO synthetase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME). Guanylate cyclase inhibitor methylene blue (MB) was infus …
MATERIAL AND METHODS: Isolated rabbit hearts were pretreated with the NO precursor L-arginine (L-Arg), both alone and after infusion of the …
Acute brain death abolishes the cardioprotective effects of ischemic preconditioning in the rabbit.
Kirsch M, Farhat F, Garnier JP, Loisance D. Kirsch M, et al. Transplantation. 2000 May 27;69(10):2013-9. doi: 10.1097/00007890-200005270-00007. Transplantation. 2000. PMID: 10852589
In the control group (CTRL), anaesthetized rabbits were subjected to 30 min of left coronary marginal branch occlusion and 90 min of reperfusion without any pretreatment. In the CTRL+IP group, anaesthetized rabbits were preconditioned with a 3-min ischemia and 3-min rep …
In the control group (CTRL), anaesthetized rabbits were subjected to 30 min of left coronary marginal branch occlusion and 90 min of repe …
Multiple organ dysfunction after remote circulatory arrest: common pathway of radical oxygen species?
Weinbroum AA, Hochhauser E, Rudick V, Kluger Y, Karchevsky E, Graf E, Vidne BA. Weinbroum AA, et al. J Trauma. 1999 Oct;47(4):691-8. doi: 10.1097/00005373-199910000-00013. J Trauma. 1999. PMID: 10528603
Then, pairs of liver plus heart, lung, or ring were reperfused in series (15 minutes), and then the second organ circulated alone for 45 minutes. Remote organ protection against the pro-oxidant hepatic-induced toxicity was evaluated by using allopurinol (1 mmol/L, heart), …
Then, pairs of liver plus heart, lung, or ring were reperfused in series (15 minutes), and then the second organ circulated alone for …
EP receptor-mediated inhibition by prostaglandin E(1) of cardiac L-type Ca(2+) current of rabbits.
Yamamoto T, Habuchi Y, Tanaka H, Suto F, Morikawa J, Kashima K, Yoshimura M. Yamamoto T, et al. Am J Physiol. 1999 Oct;277(4):H1369-74. doi: 10.1152/ajpheart.1999.277.4.H1369. Am J Physiol. 1999. PMID: 10516171
Prostaglandin E(1) (PGE(1)) has cardioprotective effects on the ischemic-reperfused heart. To clarify the mechanisms underlying the protective action of PGE(1) on myocardium, we examined the effect of PGE(1) on the L-type Ca(2+) current (I(Ca)) using single atrial cells fr …
Prostaglandin E(1) (PGE(1)) has cardioprotective effects on the ischemic-reperfused heart. To clarify the mechanisms underlying the p …
Cardioprotective effect of angiotensin-converting enzyme inhibition against hypoxia/reoxygenation injury in cultured rat cardiac myocytes.
Matoba S, Tatsumi T, Keira N, Kawahara A, Akashi K, Kobara M, Asayama J, Nakagawa M. Matoba S, et al. Circulation. 1999 Feb 16;99(6):817-22. doi: 10.1161/01.cir.99.6.817. Circulation. 1999. PMID: 9989969
The protective effect of cilazaprilat was significantly inhibited by Hoe 140 (a bradykinin B2 receptor antagonist), NG-monomethyl-L-arginine monoacetate (L-NMMA) (an NO synthase inhibitor), and methylene blue (a soluble guanylate cyclase inhibitor) but not by stauro …
The protective effect of cilazaprilat was significantly inhibited by Hoe 140 (a bradykinin B2 receptor antagonist), NG-monomethyl-L-arginine …
Functional changes in nonadrenergic, noncholinergic inhibitory neurons in ileal circular smooth muscle after small bowel transplantation in rats.
Shibata C, Balsiger BM, Anding WJ, Duenes JA, Miller VM, Sarr MG. Shibata C, et al. Dig Dis Sci. 1998 Nov;43(11):2446-54. doi: 10.1023/a:1026630115009. Dig Dis Sci. 1998. PMID: 9824132
In all groups, exogenous NO, NG-monomethyl-L-arginine (L-NMMA, an NO synthase inhibitor), and methylene blue (soluble guanylate cyclase inhibitor) had no effect on spontaneous activity, while 8-bromocyclic guanosine monophosphate (8Br-cGMP) inhibited contractile act …
In all groups, exogenous NO, NG-monomethyl-L-arginine (L-NMMA, an NO synthase inhibitor), and methylene blue (soluble guanylat …
Methylene blue prevents pulmonary injury after intestinal ischemia-reperfusion.
Galili Y, Ben-Abraham R, Weinbroum A, Marmur S, Iaina A, Volman Y, Peer G, Szold O, Soffer D, Klausner J, Rabau M, Kluger Y. Galili Y, et al. J Trauma. 1998 Aug;45(2):222-5; discussion 225-6. doi: 10.1097/00005373-199808000-00004. J Trauma. 1998. PMID: 9715176
OBJECTIVE: To investigate the effect of methylene blue, an inhibitor of oxygen radicals, on lung injury caused by reperfusion of ischemic tissue. ...CONCLUSION: Methylene blue attenuated lung injury after intestinal ischemia-reperfusion. …
OBJECTIVE: To investigate the effect of methylene blue, an inhibitor of oxygen radicals, on lung injury caused by reperfusi …
Cold storage induces an endothelium-independent relaxation to hypoxia/reoxygenation in porcine coronary arteries.
Shimizu S, Shimizu K, Paul RJ. Shimizu S, et al. J Vasc Res. 1997 Sep-Oct;34(5):399-407. doi: 10.1159/000159248. J Vasc Res. 1997. PMID: 9349733
However, after overnight cold storage (4 degrees C), H/R elicited a transient relaxation with peak relaxation of 56 +/- 8% (n = 8), which was reproducible after 2 days of cold storage. The H/R relaxation was inhibited by methylene blue (10 microM) and LY83583 (10 mi …
However, after overnight cold storage (4 degrees C), H/R elicited a transient relaxation with peak relaxation of 56 +/- 8% (n = 8), which wa …
Bradykinin and endothelial-cardiac myocyte interactions in ischemic preconditioning.
Parratt JR, Vegh A, Zeitlin IJ, Ahmad M, Oldroyd K, Kaszala K, Papp JG. Parratt JR, et al. Am J Cardiol. 1997 Aug 4;80(3A):124A-131A. doi: 10.1016/s0002-9149(97)00467-0. Am J Cardiol. 1997. PMID: 9293965 Review.
Evidence for early bradykinin release has come from clinical studies involving patients undergoing coronary angioplasty where, in 4 of 5 patients, there was evidence for elevated kinin levels in coronary sinus blood either during balloon inflation (i.e., ischemia) or deflation ( …
Evidence for early bradykinin release has come from clinical studies involving patients undergoing coronary angioplasty where, in 4 of 5 pat …
Losartan attenuates myocardial ischemia-induced ventricular arrythmias and reperfusion injury in spontaneously hypertensive rats.
Lee YM, Peng YY, Ding YA, Yen MH. Lee YM, et al. Am J Hypertens. 1997 Aug;10(8):852-8. doi: 10.1016/s0895-7061(97)00119-2. Am J Hypertens. 1997. PMID: 9270079
The animals underwent 45 min of left coronary artery occlusion and 1 h of reperfusion and were randomly assigned to control and losartan-treated groups (2, 5, and 10 mg/kg, intravenously). ...To assess the anti-infarct effect of losartan, the area at risk was determined by …
The animals underwent 45 min of left coronary artery occlusion and 1 h of reperfusion and were randomly assigned to control and losar …
Local inotropic stimulation by methylene blue does not improve mechanical dysfunction due to myocardial stunning.
Naim KL, Weiss HR, Guo X, Sadoff J, Scholz P, Kedem J. Naim KL, et al. Res Exp Med (Berl). 1997;197(1):23-35. doi: 10.1007/s004330050052. Res Exp Med (Berl). 1997. PMID: 9226760
We tested the hypothesis that reduction of intramyocardial cyclic guanosine monophosphate (GMP) by methylene blue (MB) would improve mechanical dysfunction in stunned myocardium. Regional stunning was produced in nine open-chest anesthetized dogs by a 12-min left an …
We tested the hypothesis that reduction of intramyocardial cyclic guanosine monophosphate (GMP) by methylene blue (MB) would i …
Nitric oxide/carbon monoxide. A molecular switch for myocardial preservation during ischemia.
Maulik N, Engelman DT, Watanabe M, Engelman RM, Rousou JA, Flack JE 3rd, Deaton DW, Gorbunov NV, Elsayed NM, Kagan VE, Das DK. Maulik N, et al. Circulation. 1996 Nov 1;94(9 Suppl):II398-406. Circulation. 1996. PMID: 8901781
METHODS AND RESULTS: To test this hypothesis, isolated rat hearts were perfused for 10 minutes with one of the following: (1) buffer alone; (2) 3 mmol/L L-arginine, a precursor for NO; (3) 650 mumol/L zinc protoporphyrin, a heme oxygenase inhibitor; (4) 3 mmol/L L-arginine plus 6 …
METHODS AND RESULTS: To test this hypothesis, isolated rat hearts were perfused for 10 minutes with one of the following: (1) buffer alone; …
Infarct size-reducing effect of nicorandil is mediated by the KATP channel but not by its nitrate-like properties in dogs.
Mizumura T, Nithipatikom K, Gross GJ. Mizumura T, et al. Cardiovasc Res. 1996 Aug;32(2):274-85. doi: 10.1016/0008-6363(96)00061-2. Cardiovasc Res. 1996. PMID: 8796114
In the next three groups, glibenclamide (0.3 mg/kg) was administered 15 min before drug infusion. In the final three groups, methylene blue (80 microM) was given intracoronarily 5 min before nicorandil or glyceryl trinitrate and continued until 15 min following r …
In the next three groups, glibenclamide (0.3 mg/kg) was administered 15 min before drug infusion. In the final three groups, methylene …
Salvage of ischemic myocardium with simplified and even delayed coronary sinus retroperfusion.
Aldea GS, Zhang X, Rivers S, Shemin RJ. Aldea GS, et al. Ann Thorac Surg. 1996 Jul;62(1):9-15. doi: 10.1016/0003-4975(96)00257-3. Ann Thorac Surg. 1996. PMID: 8678691 Free article.
All animals were then placed on cardiopulmonary bypass and, after a 60-minute cardioplegic arrest, the coronary artery obstructions were removed, to simulate surgical revascularization. This was followed by 3 hours of reperfusion. The area of myocardium at risk and the are …
All animals were then placed on cardiopulmonary bypass and, after a 60-minute cardioplegic arrest, the coronary artery obstructions were rem …
An endogenous protectant effect of cardiac cyclic GMP against reperfusion-induced ventricular fibrillation in the rat heart.
Pabla R, Bland-Ward P, Moore PK, Curtis MJ. Pabla R, et al. Br J Pharmacol. 1995 Dec;116(7):2923-30. doi: 10.1111/j.1476-5381.1995.tb15946.x. Br J Pharmacol. 1995. PMID: 8680726 Free PMC article.
Rat isolated hearts were subjected to 60 min left regional ischaemia followed by reperfusion (n = 10 per group). Methylene blue (20 microM), a soluble guanylate cyclase inhibitor, raised the incidence of reperfusion-induced ventricular fibrillation (VF …
Rat isolated hearts were subjected to 60 min left regional ischaemia followed by reperfusion (n = 10 per group). Methylene …
[Methylene blue as an endocrine modulator: interactions with thyroid hormones].
Schreiber V. Schreiber V. Bratisl Lek Listy. 1995 Nov;96(11):586-7. Bratisl Lek Listy. 1995. PMID: 8624735 Czech.
Methylene blue (MB) is a thiazine dye used in the treatment of methemoglobinemia. Since it was shown to scavenge free radicals, it is now being examined clinically in reperfusion syndrome and septic shock. We tested methylene blue in a series of …
Methylene blue (MB) is a thiazine dye used in the treatment of methemoglobinemia. Since it was shown to scavenge free radicals …
Methylene blue--an endocrine modulator.
Haluzík M, Nedvídková J, Schreiber V. Haluzík M, et al. Sb Lek. 1995;96(4):319-22. Sb Lek. 1995. PMID: 8711376
Methylene blue (MB) is a thiazine dye used in the treatment of methemoglobinemia. It may represent a new class of anti-oxidant drugs which competitively inhibit the reduction of molecular oxygen to superoxide by acting as an alternative electron acceptor for tissue …
Methylene blue (MB) is a thiazine dye used in the treatment of methemoglobinemia. It may represent a new class of anti-oxidant …
The applicability of color-labeled microspheres in a rabbit model of ischemia-reperfusion.
Hasdai D, Fuchs L, Ohad D, Battler A. Hasdai D, et al. Angiology. 1994 Jun;45(6):461-7. doi: 10.1177/000331979404500608. Angiology. 1994. PMID: 8203773
The snare was loosened, and yellow-labeled microspheres (500/g body wt) were injected before (n = 5) or after (n = 3) methylene blue injection. In animals belonging to the "sham" group (n = 4 and n = 2, respectively), the sequence of injections was similar, but the …
The snare was loosened, and yellow-labeled microspheres (500/g body wt) were injected before (n = 5) or after (n = 3) methylene bl …
Prevention of acute regional ischemia with endocardial laser channels.
Yano OJ, Bielefeld MR, Jeevanandam V, Treat MR, Marboe CC, Spotnitz HM, Smith CR. Yano OJ, et al. Ann Thorac Surg. 1993 Jul;56(1):46-53. doi: 10.1016/0003-4975(93)90401-3. Ann Thorac Surg. 1993. PMID: 8328875 Free article.
Twelve mongrel dogs (6 controls, 6 laser myocardial revascularizations) underwent 90 minutes of LAD ligation followed by 6 hours of reperfusion. The ischemic region was determined by methylene blue injection during brief LAD occlusion. ...In control dogs, the …
Twelve mongrel dogs (6 controls, 6 laser myocardial revascularizations) underwent 90 minutes of LAD ligation followed by 6 hours of reper …
Omental pedicle graft to improve ischemic anastomoses.
Dockendorf BL, Frazee RC, Matheny RG. Dockendorf BL, et al. South Med J. 1993 Jun;86(6):628-32. doi: 10.1097/00007611-199306000-00007. South Med J. 1993. PMID: 7685127
The remaining animals had strictures of various degrees. Injection of methylene blue into the omental vessels showed perfusion to the mucosa from the omentum. ...The anastomotic stricturing was due to ischemic injury before reperfusion by ingrowth of omental …
The remaining animals had strictures of various degrees. Injection of methylene blue into the omental vessels showed perfusion …
Evidence that NADPH-dependent methemoglobin reductase and administered riboflavin protect tissues from oxidative injury.
Hultquist DE, Xu F, Quandt KS, Shlafer M, Mack CP, Till GO, Seekamp A, Betz AL, Ennis SR. Hultquist DE, et al. Am J Hematol. 1993 Jan;42(1):13-8. doi: 10.1002/ajh.2830420105. Am J Hematol. 1993. PMID: 8416288
NADPH-dependent methemoglobin reductase, first detected in erythrocytes sixty years ago, has subsequently been purified and characterized as a methylene blue reductase and a flavin reductase. The reductase plays no role in methemoglobin reduction under normal condit …
NADPH-dependent methemoglobin reductase, first detected in erythrocytes sixty years ago, has subsequently been purified and characterized as …
Cardiac venous endothelial dysfunction after myocardial ischemia and reperfusion in dogs.
Lefer DJ, Nakanishi K, Vinten-Johansen J, Ma XL, Lefer AM. Lefer DJ, et al. Am J Physiol. 1992 Sep;263(3 Pt 2):H850-6. doi: 10.1152/ajpheart.1992.263.3.H850. Am J Physiol. 1992. PMID: 1415612
Endothelial dysfunction is a prominent occurrence in coronary arteries after myocardial ischemia and reperfusion. However, this has not been studied in coronary veins. Endothelium-dependent vasorelaxation was studied in cardiac venous rings obtained from dogs subjected to …
Endothelial dysfunction is a prominent occurrence in coronary arteries after myocardial ischemia and reperfusion. However, this has n …
2,6-Dichlorophenolindophenol is a competitive inhibitor for xanthine oxidase and is therefore not usable as an electron acceptor in the fluorometric assay.
Mest SJ, Kosted PJ, van Kuijk FJ. Mest SJ, et al. Free Radic Biol Med. 1992;12(3):189-92. doi: 10.1016/0891-5849(92)90026-d. Free Radic Biol Med. 1992. PMID: 1563644
Xanthine oxidase has been recognized as an important source of oxygen free radicals in ischemia-reperfusion injury. In order to study this enzyme in biological tissues, the conversion of pterin (2-amino-4-hydroxypteridine) to isoxanthopterin provides the basis for a very s …
Xanthine oxidase has been recognized as an important source of oxygen free radicals in ischemia-reperfusion injury. In order to study …
Endothelial superoxide production in buffer perfused rat lungs, demonstrated by a new histochemical technique.
Babbs CF, Cregor MD, Turek JJ, Badylak SF. Babbs CF, et al. Lab Invest. 1991 Oct;65(4):484-96. Lab Invest. 1991. PMID: 1656143
The histochemical reaction was not prevented by the xanthine oxidase inhibitors allopurinol or methylene blue. The high manganese/diamine technique provides direct visual evidence of a calcium dependent mechanism by which pulmonary vascular endothelial cells can gen …
The histochemical reaction was not prevented by the xanthine oxidase inhibitors allopurinol or methylene blue. The high mangan …
Oxidative modification by low levels of HOOH can transform myoglobin to an oxidase.
Osawa Y, Korzekwa K. Osawa Y, et al. Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7081-5. doi: 10.1073/pnas.88.16.7081. Proc Natl Acad Sci U S A. 1991. PMID: 1871123 Free PMC article.
In the presence of an enzymatic metmyoglobin reducing system containing diaphorase and methylene blue with excess NADH, this HOOH-altered myoglobin catalyzed NADH oxidation and oxygen consumption; the overall stoichiometry indicated a two-electron reduction of oxyge …
In the presence of an enzymatic metmyoglobin reducing system containing diaphorase and methylene blue with excess NADH, this H …
Methylene blue as an inhibitor of superoxide generation by xanthine oxidase. A potential new drug for the attenuation of ischemia/reperfusion injury.
Salaris SC, Babbs CF, Voorhees WD 3rd. Salaris SC, et al. Biochem Pharmacol. 1991 Jul 15;42(3):499-506. doi: 10.1016/0006-2952(91)90311-r. Biochem Pharmacol. 1991. PMID: 1650213
Previous work has indicated that methylene blue accepts electrons from xanthine oxidase at the iron-sulfur center. Initial experiments in our laboratory demonstrated that (1) pairs of electrons from each enzymatic oxidation are transferred to methylene blu …
Previous work has indicated that methylene blue accepts electrons from xanthine oxidase at the iron-sulfur center. Initial exp …
Renal ischemia and reperfusion impair endothelium-dependent vascular relaxation.
Lieberthal W, Wolf EF, Rennke HG, Valeri CR, Levinsky NG. Lieberthal W, et al. Am J Physiol. 1989 May;256(5 Pt 2):F894-900. doi: 10.1152/ajprenal.1989.256.5.F894. Am J Physiol. 1989. PMID: 2785768
In contrast, acetylcholine and the calcium ionophore A23187, two vasodilators that act by releasing endothelium-derived relaxing factor (EDRF), had no effect on the increased RVR that occurs on reflow. Two inhibitors of EDRF, methylene blue and gossypol, increased R …
In contrast, acetylcholine and the calcium ionophore A23187, two vasodilators that act by releasing endothelium-derived relaxing factor (EDR …
Infarct-sparing effect of propranolol in an occlusion-reperfusion dog model.
Chagas AC, Da-Luz PL, Pileggi F. Chagas AC, et al. Braz J Med Biol Res. 1989;22(11):1337-45. Braz J Med Biol Res. 1989. PMID: 2638925
To test the hypothesis that early pharmacological protection of the ischemic myocardium can enhance the effects of late reperfusion, 32 mongrel dogs were submitted to 6 h of left anterior descending coronary (LAD) occlusion and 18 h of reperfusion. 2. Arterial press …
To test the hypothesis that early pharmacological protection of the ischemic myocardium can enhance the effects of late reperfusion, …
Potential of methylene blue to block oxygen radical generation in reperfusion injury.
Kelner MJ, Bagnell R, Hale B, Alexander NM. Kelner MJ, et al. Basic Life Sci. 1988;49:895-8. doi: 10.1007/978-1-4684-5568-7_146. Basic Life Sci. 1988. PMID: 2855011
Since the electron affinity constants of xanthine oxidase for electron acceptors are FAD greater than iron/sulfide greater than molybdenum, methylene blue falls between the FAD and iron-sulfide site. Thus, methylene blue effectively inhibits superoxide …
Since the electron affinity constants of xanthine oxidase for electron acceptors are FAD greater than iron/sulfide greater than molybdenum, …
Ultrastructural alterations to myocytes and associated microvascular functional changes at lateral margins of developing experimental myocardial infarcts.
Sage MD. Sage MD. J Mol Cell Cardiol. 1986 Oct;18 Suppl 4:17-21. doi: 10.1016/s0022-2828(86)80020-7. J Mol Cell Cardiol. 1986. PMID: 3783737
Provided this zone does not advance with time, ischaemic myocardium potentially "salvageable" by reperfusion appears confined to the subepicardial zone in rabbit hearts. The advantages of SEM in assessing the extent of ischaemic injury are compared with those of previously …
Provided this zone does not advance with time, ischaemic myocardium potentially "salvageable" by reperfusion appears confined to the …
The effect of tricyclic antidepressants on ventricular fibrillation and collateral blood supply following acute coronary occlusion.
Manoach M, Netz H, Varon D, Ben-Ze'ev Z. Manoach M, et al. Heart Vessels. 1986;2(1):36-40. doi: 10.1007/BF02060242. Heart Vessels. 1986. PMID: 2873124
The LAD was occluded at its origin in 43 cats, 28 of which were treated either with D or with 5-iminodibenzyl HCl; the remaining 15 were untreated controls. Two hours after the occlusion, methylene blue was injected into the left atrium to determine color demarcatio …
The LAD was occluded at its origin in 43 cats, 28 of which were treated either with D or with 5-iminodibenzyl HCl; the remaining 15 were unt …
Early recovery of regional performance in salvaged ischemic myocardium following coronary artery occlusion in the dog.
Darsee JR, Kloner RA, Braunwald E. Darsee JR, et al. J Clin Invest. 1981 Jul;68(1):225-39. doi: 10.1172/jci110239. J Clin Invest. 1981. Retraction in: J Clin Invest. 1982 Oct;70(4):following 915. PMID: 7019244 Free PMC article. Retracted.
The ischemic myocardium-at-risk for necrosis was determined by injecting methylene blue dye into the left atrium with the coronary artery reoccluded at the end of the reperfusion period, slicing the left ventricle into thin transverse sections, and measuring …
The ischemic myocardium-at-risk for necrosis was determined by injecting methylene blue dye into the left atrium with the coro …
The no reflow phenomenon: a time-limiting factor for reperfusion after coronary occlusion?
Darsee JR, Kloner RA. Darsee JR, et al. Am J Cardiol. 1980 Nov;46(5):800-6. doi: 10.1016/0002-9149(80)90431-2. Am J Cardiol. 1980. Retraction in: Am J Cardiol. 1982 Oct;50(4):929. doi: 10.1016/0002-9149(82)91256-5. PMID: 7435390 Retracted.
The area of "no reflow" was determined by injecting a fluorescent dye into the left atrium at the end of 6 hours with the coronary artery patent, and the ischemic area at risk by injecting methylene blue dye into the left atrium with the coronary artery reoccluded. …
The area of "no reflow" was determined by injecting a fluorescent dye into the left atrium at the end of 6 hours with the coronary artery pa …