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Year Number of Results
1977 1
1978 1
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1980 2
1981 1
1984 3
1985 1
1986 1
1987 2
1989 2
1990 1
1993 2
1994 2
1997 3
1998 2
1999 1
2000 2
2001 4
2002 1
2003 2
2004 1
2005 1
2006 5
2007 10
2008 4
2009 3
2010 1
2012 6
2013 7
2014 4
2015 4
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2017 9
2018 3
2019 4
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107 results

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Page 1
Methylphenidate and brain dopamine neurotoxicity.
Yuan J, McCann U, Ricaurte G. Yuan J, et al. Brain Res. 1997 Aug 29;767(1):172-5. doi: 10.1016/s0006-8993(97)00771-3. Brain Res. 1997. PMID: 9365033 Free article.
To further evaluate the dopamine (DA) neurotoxic potential of the widely prescribed psychostimulant, methylphenidate, mice were treated with various doses (range: 10-120 mg/kg) and treatment schedules of methylphenidate (every 2 h x 4 or twice daily x 4). ... …
To further evaluate the dopamine (DA) neurotoxic potential of the widely prescribed psychostimulant, methylphenidate, mice wer …
Methamphetamine-Related Disorders.
Gouzoulis-Mayfrank E, Härtel-Petri R, Hamdorf W, Havemann-Reinecke U, Mühlig S, Wodarz N. Gouzoulis-Mayfrank E, et al. Dtsch Arztebl Int. 2017 Jun 30;114(26):455-461. doi: 10.3238/arztebl.2017.0455. Dtsch Arztebl Int. 2017. PMID: 28705298 Free PMC article.
BACKGROUND: Methamphetamine is considered more dangerous than other stimulants because of its acute complications, long-term neurotoxicity, and potential for drug dependence. Until now, there have been no evidence-based guidelines for the treatment of methamphetamine-relat …
BACKGROUND: Methamphetamine is considered more dangerous than other stimulants because of its acute complications, long-term neurotoxicit …
Investigation of the Protective Effects of Aripiprazole on Methylphenidate-induced Neurotoxicity in Rats.
Mohammadgholi-Beiki A, Aghamiri H, Rashidian R, Jafari-Sabet M, Motevalian M, Rahimi-Moghaddam P, Sheibani M. Mohammadgholi-Beiki A, et al. Mol Neurobiol. 2025 Sep;62(9):11581-11595. doi: 10.1007/s12035-025-04994-3. Epub 2025 Apr 29. Mol Neurobiol. 2025. PMID: 40299297
Methylphenidate (MPH) serves as a frequently utilized stimulant in the treatment of attention deficit hyperactivity disorder (ADHD). However, long-term administration of this medication has been linked to neurotoxic sequels such as cognitive decline and increased ox …
Methylphenidate (MPH) serves as a frequently utilized stimulant in the treatment of attention deficit hyperactivity disorder (ADHD). …
Acute and sub-chronic functional neurotoxicity of methylphenidate on neural networks in vitro.
Gopal KV, Miller BR, Gross GW. Gopal KV, et al. J Neural Transm (Vienna). 2007;114(11):1365-75. doi: 10.1007/s00702-007-0759-8. Epub 2007 Jun 18. J Neural Transm (Vienna). 2007. PMID: 17576514
Methylphenidate (MPH) is the drug of choice in the treatment of attention deficit and hyperactivity disorders. ...This study used spontaneously active neuronal networks growing on microelectrode arrays (MEA) to investigate functional neurotoxicity of MPH by assessin …
Methylphenidate (MPH) is the drug of choice in the treatment of attention deficit and hyperactivity disorders. ...This study used spo …
Methylphenidate and Its Impact on Redox Balance and Behavior.
Jîtcă G, Mehelean IE, Maier AN, Jîtcă CM. Jîtcă G, et al. J Xenobiot. 2025 Sep 30;15(5):157. doi: 10.3390/jox15050157. J Xenobiot. 2025. PMID: 41149743 Free PMC article. Review.
Methylphenidate (MPH) and its active enantiomer, dexmethylphenidate, are widely prescribed as first-line therapies for attention deficit hyperactivity disorder (ADHD), yet their increasing non-medical use highlights significant clinical and toxicological challenges. ...Whi …
Methylphenidate (MPH) and its active enantiomer, dexmethylphenidate, are widely prescribed as first-line therapies for attention defi …
Methylphenidate effects in the young brain: friend or foe?
Loureiro-Vieira S, Costa VM, de Lourdes Bastos M, Carvalho F, Capela JP. Loureiro-Vieira S, et al. Int J Dev Neurosci. 2017 Aug;60:34-47. doi: 10.1016/j.ijdevneu.2017.04.002. Epub 2017 Apr 13. Int J Dev Neurosci. 2017. PMID: 28412445 Review.
Attention deficit hyperactivity disorder (ADHD) is one of the most prevalent neuropsychiatry disorders in children and adolescents, and methylphenidate (MPH) is a first-line stimulant drug available worldwide for its treatment. ...
Attention deficit hyperactivity disorder (ADHD) is one of the most prevalent neuropsychiatry disorders in children and adolescents, and m …
The neurobiology of relapse in schizophrenia.
Remington G, Foussias G, Agid O, Fervaha G, Takeuchi H, Hahn M. Remington G, et al. Schizophr Res. 2014 Feb;152(2-3):381-90. doi: 10.1016/j.schres.2013.10.009. Epub 2013 Oct 24. Schizophr Res. 2014. PMID: 24206930 Review.
This link is reflected in early work examining neurotransmitter metabolite and drug (e.g. amphetamine, methylphenidate) challenge studies as a means of better understanding relapse and predictors. ...Similarly, it has been suggested that relapse is 'neurotoxic', yet …
This link is reflected in early work examining neurotransmitter metabolite and drug (e.g. amphetamine, methylphenidate) challenge stu …
[Neurotoxicity of psychostimulants].
Numachi Y, Yoshida S, Matsuoka H, Sato M. Numachi Y, et al. Ryoikibetsu Shokogun Shirizu. 1999;(27 Pt 2):523-6. Ryoikibetsu Shokogun Shirizu. 1999. PMID: 10434714 Review. Japanese. No abstract available.
Methylphenidate and Rosmarinus officinalis improves cognition and regulates inflammation and synaptic gene expression in AlCl(3)-induced neurotoxicity mouse model.
Khalid A, Abbasi UA, Amber S, Sumera, Mirza FJ, Asif M, Javed A, Zahid S. Khalid A, et al. Mol Biol Rep. 2020 Oct;47(10):7861-7870. doi: 10.1007/s11033-020-05864-y. Epub 2020 Oct 4. Mol Biol Rep. 2020. PMID: 33011892
Methylphenidate (MPH), a psychotropic medication is commonly used for children with attention deficit hyperactivity disorder (ADHD). ...Briefly, six groups of mice (n = 8 each group), were specified for the study and behavioral analysis was performed to analyze spatial mem …
Methylphenidate (MPH), a psychotropic medication is commonly used for children with attention deficit hyperactivity disorder (ADHD). …
Methylphenidate-induced rabbit syndrome.
Mendhekar DN, Duggal HS. Mendhekar DN, et al. Ann Pharmacother. 2006 Nov;40(11):2076. doi: 10.1345/aph.1H086. Epub 2006 Oct 17. Ann Pharmacother. 2006. PMID: 17047143 No abstract available.
107 results