Chlorhexidine is the preferred agent for vaginal antisepsis prior to cesarean delivery: a systematic review and network meta-analysis.
McKinney JA, Sanchez-Ramos L, Duncan J, Lin L, Rhoades C, Mateus J, Dussan LE, Nino G, Hansen A, Messiah C, Pomputius A.
McKinney JA, et al.
Am J Obstet Gynecol. 2026 Jan;233(6S):S504.e1-S504.e41. doi: 10.1016/j.ajog.2025.09.046.
Am J Obstet Gynecol. 2026.
PMID: 41485838
RESULTS: Fifty trials (14,515 participants) evaluated povidone-iodine, chlorhexidine (0.05% to 5%), cetrimide, metronidazole, clindamycin, saline, water, and no vaginal preparation. ...In concentration-stratified analyses, chlorhexidine 0.2% achieved the high …
RESULTS: Fifty trials (14,515 participants) evaluated povidone-iodine, chlorhexidine (0.05% to 5%), cetrimide, metronidazole, …