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Evidence-Based Review of BioBran/MGN-3 Arabinoxylan Compound as a Complementary Therapy for Conventional Cancer Treatment.
Ooi SL, McMullen D, Golombick T, Nut D, Pak SC. Ooi SL, et al. Integr Cancer Ther. 2018 Jun;17(2):165-178. doi: 10.1177/1534735417735379. Epub 2017 Oct 17. Integr Cancer Ther. 2018. PMID: 29037071 Free PMC article. Review.
There are no reports on adverse events on MGN-3. Most of the clinical trials are small studies with short duration. CONCLUSION: There is sufficient evidence suggesting MGN-3 to be an effective immunomodulator that can complement conventional cancer tre …
There are no reports on adverse events on MGN-3. Most of the clinical trials are small studies with short duration. CONCLUSION …
Arabinoxylan rice bran (MGN-3/Biobran) alleviates radiation-induced intestinal barrier dysfunction of mice in a mitochondrion-dependent manner.
Zhao Z, Cheng W, Qu W, Wang K. Zhao Z, et al. Biomed Pharmacother. 2020 Apr;124:109855. doi: 10.1016/j.biopha.2020.109855. Epub 2020 Jan 24. Biomed Pharmacother. 2020. PMID: 31986410 Free article.
MGN-3 is an arabinoxylan from rice bran that has been shown to be an excellent antioxidant and radioprotector. This study examined the protective effects of MGN-3 on radiation-induced intestinal injury. Mice were treated with MGN-3 prior …
MGN-3 is an arabinoxylan from rice bran that has been shown to be an excellent antioxidant and radioprotector. This study exam …
Mgn-3/biobran enhances generation of cytotoxic CD8+ T cells via upregulation of dec-205 expression on dendritic cells.
Ghoneum M, Agrawal S. Ghoneum M, et al. Int J Immunopathol Pharmacol. 2014 Oct-Dec;27(4):523-30. doi: 10.1177/039463201402700408. Int J Immunopathol Pharmacol. 2014. PMID: 25572732 Free article.
Human monocyte-derived DCs were treated with MGN-3 (20 and 40 μg/ml). Results indicate that treatment with MGN-3 caused DCs to prime higher granzyme B-expressing CD8+ T cells. Tumor lysate-pulsed MGN-3 DC also increased tumor cel …
Human monocyte-derived DCs were treated with MGN-3 (20 and 40 μg/ml). Results indicate that treatment with MGN …
Dietary Supplementation with Biobran/MGN-3 Increases Innate Resistance and Reduces the Incidence of Influenza-like Illnesses in Elderly Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Clinical Trial.
Elsaid AF, Agrawal S, Agrawal A, Ghoneum M. Elsaid AF, et al. Nutrients. 2021 Nov 19;13(11):4133. doi: 10.3390/nu13114133. Nutrients. 2021. PMID: 34836388 Free PMC article. Clinical Trial.
Furthermore, Biobran/MGN-3 ingestion significantly enhanced NK activity compared to the basal levels and to the placebo group. In addition, Biobran/MGN-3 significantly upregulated the expression levels of RIG-1, MDA5, ISG15, and MX1 in the human pulmon …
Furthermore, Biobran/MGN-3 ingestion significantly enhanced NK activity compared to the basal levels and to the placebo group. …
Biobran/MGN-3, an Arabinoxylan Rice Bran, Exerts Anti-COVID-19 Effects and Boosts Immunity in Human Subjects.
Agrawal S, Agrawal A, Ghoneum M. Agrawal S, et al. Nutrients. 2024 Mar 19;16(6):881. doi: 10.3390/nu16060881. Nutrients. 2024. PMID: 38542792 Free PMC article.
We here investigate Biobran/MGN-3's potential to enhance an antiviral immune response in humans. Peripheral blood mononuclear cells (PBMCs) derived from eight subjects taking Biobran/MGN-3 (age 55-65 years) and eight age-matched control subjects were s …
We here investigate Biobran/MGN-3's potential to enhance an antiviral immune response in humans. Peripheral blood mononuclear …
MGN-3/Biobran, modified arabinoxylan from rice bran, sensitizes human breast cancer cells to chemotherapeutic agent, daunorubicin.
Gollapudi S, Ghoneum M. Gollapudi S, et al. Cancer Detect Prev. 2008;32(1):1-6. doi: 10.1016/j.cdp.2008.02.006. Epub 2008 Apr 11. Cancer Detect Prev. 2008. PMID: 18406070
BACKGROUND: MGN-3/Biobran, a modified form of arabinoxylan from rice bran, is a potent biological response modifier (BRM). ...MGN-3 sensitizes human T cell leukemia cells to death receptor (CD95)-induced apoptosis. ...
BACKGROUND: MGN-3/Biobran, a modified form of arabinoxylan from rice bran, is a potent biological response modifier (BRM). ... …
Biobran/MGN-3, an Arabinoxylan Rice Bran, Protects against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An In Vitro and In Silico Study.
Ghoneum M, Abdulmalek S, Fadel HH. Ghoneum M, et al. Nutrients. 2023 Jan 15;15(2):453. doi: 10.3390/nu15020453. Nutrients. 2023. PMID: 36678324 Free PMC article.
This study examines the efficacy of Biobran/MGN-3 against SARS-CoV-2. Biobran is an arabinoxylan rice bran that has been shown to significantly inhibit the related influenza virus in geriatric subjects. ...
This study examines the efficacy of Biobran/MGN-3 against SARS-CoV-2. Biobran is an arabinoxylan rice bran that has been shown …
MGN-3 arabinoxylan rice bran modulates innate immunity in multiple myeloma patients.
Cholujova D, Jakubikova J, Czako B, Martisova M, Hunakova L, Duraj J, Mistrik M, Sedlak J. Cholujova D, et al. Cancer Immunol Immunother. 2013 Mar;62(3):437-45. doi: 10.1007/s00262-012-1344-z. Epub 2012 Sep 2. Cancer Immunol Immunother. 2013. PMID: 22941038 Free PMC article. Clinical Trial.
The results demonstrate a clear increase in NK activity in MGN-3-treated patients compared to the placebo group, an increased level of myeloid DCs in peripheral blood, and augmented concentrations of T helper cell type 1-related cytokines. The present study suggests …
The results demonstrate a clear increase in NK activity in MGN-3-treated patients compared to the placebo group, an increased …
Efficiency of Biobran/MGN-3, an Arabinoxylan Rice Bran, in Attenuating Diabetes-Induced Cognitive Impairment of the Hippocampus via Oxidative Stress and IR/Akt/NF-kappaB in Rats.
Abdou HM, Hamaad FA, Abd Elmageed GM, Ghoneum MH. Abdou HM, et al. Evid Based Complement Alternat Med. 2023 Jul 19;2023:8248576. doi: 10.1155/2023/8248576. eCollection 2023. Evid Based Complement Alternat Med. 2023. PMID: 37501860 Free PMC article.
Type 2 diabetes mellitus (T2DM) is a common metabolic disease accompanied by cognitive impairment, hippocampal malfunctioning, and inflammation. Biobran/MGN-3, an arabinoxylan rice bran, has been shown to have an antidiabetic effect in streptozotocin-induced diabeti …
Type 2 diabetes mellitus (T2DM) is a common metabolic disease accompanied by cognitive impairment, hippocampal malfunctioning, and inflammat …
Biobran/MGN-3, an arabinoxylan rice bran, enhances NK cell activity in geriatric subjects: A randomized, double-blind, placebo-controlled clinical trial.
Elsaid AF, Shaheen M, Ghoneum M. Elsaid AF, et al. Exp Ther Med. 2018 Mar;15(3):2313-2320. doi: 10.3892/etm.2018.5713. Epub 2018 Jan 8. Exp Ther Med. 2018. PMID: 29456638 Free PMC article.
A total of six subjects served as control and six subjects ingested Biobran/MGN-3 (500 mg/day) for 30 days. The effect of Biobran/MGN-3 supplementation on NK/NKT cell activity was assessed using the degranulation assay. ...Furthermore, there were no si …
A total of six subjects served as control and six subjects ingested Biobran/MGN-3 (500 mg/day) for 30 days. The effect of Biob …
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