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Evidence-Based Review of BioBran/MGN-3 Arabinoxylan Compound as a Complementary Therapy for Conventional Cancer Treatment.
Ooi SL, McMullen D, Golombick T, Nut D, Pak SC. Ooi SL, et al. Integr Cancer Ther. 2018 Jun;17(2):165-178. doi: 10.1177/1534735417735379. Epub 2017 Oct 17. Integr Cancer Ther. 2018. PMID: 29037071 Free PMC article. Review.
MGN-3 has been shown to possess immunomodulating anticancer effects and can work synergistically with chemotherapeutic agents, in vitro. ...However, more well-designed RCTs on MGN-3 are needed to strengthen the evidence base....
MGN-3 has been shown to possess immunomodulating anticancer effects and can work synergistically with chemotherapeutic agents,
Arabinoxylan rice bran (MGN-3/Biobran) alleviates radiation-induced intestinal barrier dysfunction of mice in a mitochondrion-dependent manner.
Zhao Z, Cheng W, Qu W, Wang K. Zhao Z, et al. Biomed Pharmacother. 2020 Apr;124:109855. doi: 10.1016/j.biopha.2020.109855. Epub 2020 Jan 24. Biomed Pharmacother. 2020. PMID: 31986410 Free article.
MGN-3 is an arabinoxylan from rice bran that has been shown to be an excellent antioxidant and radioprotector. This study examined the protective effects of MGN-3 on radiation-induced intestinal injury. Mice were treated with MGN-3 prior
MGN-3 is an arabinoxylan from rice bran that has been shown to be an excellent antioxidant and radioprotector. This study exam
MGN-3 arabinoxylan rice bran modulates innate immunity in multiple myeloma patients.
Cholujova D, Jakubikova J, Czako B, Martisova M, Hunakova L, Duraj J, Mistrik M, Sedlak J. Cholujova D, et al. Cancer Immunol Immunother. 2013 Mar;62(3):437-45. doi: 10.1007/s00262-012-1344-z. Epub 2012 Sep 2. Cancer Immunol Immunother. 2013. PMID: 22941038 Clinical Trial.
We have performed a randomized, placebo-controlled study to examine the effects of MGN-3 on innate immune system parameters in 48 multiple myeloma patients. ...The present study suggests that MGN-3 may represent an immunologically relevant product for …
We have performed a randomized, placebo-controlled study to examine the effects of MGN-3 on innate immune system parameters in …
Mgn-3/biobran enhances generation of cytotoxic CD8+ T cells via upregulation of dec-205 expression on dendritic cells.
Ghoneum M, Agrawal S. Ghoneum M, et al. Int J Immunopathol Pharmacol. 2014 Oct-Dec;27(4):523-30. doi: 10.1177/039463201402700408. Int J Immunopathol Pharmacol. 2014. PMID: 25572732 Free article.
Human monocyte-derived DCs were treated with MGN-3 (20 and 40 μg/ml). Results indicate that treatment with MGN-3 caused DCs to prime higher granzyme B-expressing CD8+ T cells. ...This was associated with: i) increased expression of DEC-205 in …
Human monocyte-derived DCs were treated with MGN-3 (20 and 40 μg/ml). Results indicate that treatment with MGN
Biobran/MGN-3, an Arabinoxylan Rice Bran, Exerts Anti-COVID-19 Effects and Boosts Immunity in Human Subjects.
Agrawal S, Agrawal A, Ghoneum M. Agrawal S, et al. Nutrients. 2024 Mar 19;16(6):881. doi: 10.3390/nu16060881. Nutrients. 2024. PMID: 38542792 Free PMC article.
We here investigate Biobran/MGN-3's potential to enhance an antiviral immune response in humans. ...Results showed that PBMCs from subjects supplemented with Biobran/MGN-3 had significantly increased activation of plasmacytoid dendritic cells (pDCs) co …
We here investigate Biobran/MGN-3's potential to enhance an antiviral immune response in humans. ...Results showed that PBMCs …
Dietary Supplementation with Biobran/MGN-3 Increases Innate Resistance and Reduces the Incidence of Influenza-like Illnesses in Elderly Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Clinical Trial.
Elsaid AF, Agrawal S, Agrawal A, Ghoneum M. Elsaid AF, et al. Nutrients. 2021 Nov 19;13(11):4133. doi: 10.3390/nu13114133. Nutrients. 2021. PMID: 34836388 Free PMC article. Clinical Trial.
Furthermore, Biobran/MGN-3 ingestion significantly enhanced NK activity compared to the basal levels and to the placebo group. In addition, Biobran/MGN-3 significantly upregulated the expression levels of RIG-1, MDA5, ISG15, and MX1 in the human pulmon …
Furthermore, Biobran/MGN-3 ingestion significantly enhanced NK activity compared to the basal levels and to the placebo group. …
Biobran/MGN-3, an Arabinoxylan Rice Bran, Protects against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An In Vitro and In Silico Study.
Ghoneum M, Abdulmalek S, Fadel HH. Ghoneum M, et al. Nutrients. 2023 Jan 15;15(2):453. doi: 10.3390/nu15020453. Nutrients. 2023. PMID: 36678324 Free PMC article.
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus Disease 2019 (COVID-19), poses a serious global public health threat for which there is currently no satisfactory treatment. This study examines the efficacy of Biobran/MGN- …
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus Disease 2019 (COVID-19), poses a serious gl …
MGN-3/Biobran, modified arabinoxylan from rice bran, sensitizes human breast cancer cells to chemotherapeutic agent, daunorubicin.
Gollapudi S, Ghoneum M. Gollapudi S, et al. Cancer Detect Prev. 2008;32(1):1-6. doi: 10.1016/j.cdp.2008.02.006. Epub 2008 Apr 11. Cancer Detect Prev. 2008. PMID: 18406070
MGN-3 sensitizes human T cell leukemia cells to death receptor (CD95)-induced apoptosis. ...The sensitizing effect of MGN-3 was associated with increased accumulation of DNR in cancer cells. ...
MGN-3 sensitizes human T cell leukemia cells to death receptor (CD95)-induced apoptosis. ...The sensitizing effect of MGN
Biobran/MGN-3, an arabinoxylan rice bran, enhances NK cell activity in geriatric subjects: A randomized, double-blind, placebo-controlled clinical trial.
Elsaid AF, Shaheen M, Ghoneum M. Elsaid AF, et al. Exp Ther Med. 2018 Mar;15(3):2313-2320. doi: 10.3892/etm.2018.5713. Epub 2018 Jan 8. Exp Ther Med. 2018. PMID: 29456638 Free PMC article.
A total of six subjects served as control and six subjects ingested Biobran/MGN-3 (500 mg/day) for 30 days. The effect of Biobran/MGN-3 supplementation on NK/NKT cell activity was assessed using the degranulation assay. ...Furthermore, there were no si …
A total of six subjects served as control and six subjects ingested Biobran/MGN-3 (500 mg/day) for 30 days. The effect of Biob …
Arabinoxylan rice bran (MGN-3/Biobran) enhances natural killer cell-mediated cytotoxicity against neuroblastoma in vitro and in vivo.
Pérez-Martínez A, Valentín J, Fernández L, Hernández-Jiménez E, López-Collazo E, Zerbes P, Schwörer E, Nuñéz F, Martín IG, Sallis H, Díaz MÁ, Handgretinger R, Pfeiffer MM. Pérez-Martínez A, et al. Cytotherapy. 2015 May;17(5):601-12. doi: 10.1016/j.jcyt.2014.11.001. Epub 2014 Dec 23. Cytotherapy. 2015. PMID: 25541298
This study evaluated the effect of MGN-3/Biobran on NK cell activation, expansion and cytotoxicity against neuroblastoma cells. ...The mechanism is not mediated by lipopolysaccharide contamination in MGN-3/Biobran. Furthermore, the addition of MGN
This study evaluated the effect of MGN-3/Biobran on NK cell activation, expansion and cytotoxicity against neuroblastoma cells …
55 results