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MicroRNA-23a promotes myelination in the central nervous system.
Lin ST, Huang Y, Zhang L, Heng MY, Ptácek LJ, Fu YH. Lin ST, et al. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17468-73. doi: 10.1073/pnas.1317182110. Epub 2013 Oct 7. Proc Natl Acad Sci U S A. 2013. PMID: 24101522 Free PMC article.
Demyelinating disorders including leukodystrophies are devastating conditions that are still in need of better understanding, and both oligodendrocyte differentiation and myelin synthesis pathways are potential avenues for developing treatment. Overexpression of lamin B1 l …
Demyelinating disorders including leukodystrophies are devastating conditions that are still in need of better understanding, and both oligo …
Exosomal miR-23a-3p derived from human umbilical cord mesenchymal stem cells promotes remyelination in central nervous system demyelinating diseases by targeting Tbr1/Wnt pathway.
Qin D, Wang C, Li D, Guo S. Qin D, et al. J Biol Chem. 2024 Jan;300(1):105487. doi: 10.1016/j.jbc.2023.105487. Epub 2023 Nov 22. J Biol Chem. 2024. PMID: 37995941 Free PMC article.
Oligodendrocyte precursor cells are present in the adult central nervous system, and their impaired ability to differentiate into myelinating oligodendrocytes can lead to demyelination in patients with multiple sclerosis, accompanied by neurological de …
Oligodendrocyte precursor cells are present in the adult central nervous system, and their impaired ability to differen …
M2 microglia-derived extracellular vesicles promote white matter repair and functional recovery via miR-23a-5p after cerebral ischemia in mice.
Li Y, Liu Z, Song Y, Pan JJ, Jiang Y, Shi X, Liu C, Ma Y, Luo L, Mamtilahun M, Shi Z, Khan H, Xie Q, Wang Y, Tang Y, Zhang Z, Yang GY. Li Y, et al. Theranostics. 2022 Apr 24;12(7):3553-3573. doi: 10.7150/thno.68895. eCollection 2022. Theranostics. 2022. PMID: 35547763 Free PMC article.
Results: M2-EVs reduced brain atrophy volume, promoted functional recovery, oligodendrogenesis and white matter repair in vivo, increased OPC proliferation, survival and differentiation in vitro. miR-23a-5p was enriched in M2-EVs and could promote OPC …
Results: M2-EVs reduced brain atrophy volume, promoted functional recovery, oligodendrogenesis and white matter repair in vivo, incre …