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Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA.
Arragain S, Handelman SK, Forouhar F, Wei FY, Tomizawa K, Hunt JF, Douki T, Fontecave M, Mulliez E, Atta M. Arragain S, et al. J Biol Chem. 2010 Sep 10;285(37):28425-33. doi: 10.1074/jbc.M110.106831. Epub 2010 Jun 28. J Biol Chem. 2010. PMID: 20584901 Free PMC article.
Bacterial and eukaryotic transfer RNAs have been shown to contain hypermodified adenosine, 2-methylthio-N(6)-threonylcarbamoyladenosine, at position 37 (A(37)) adjacent to the 3'-end of the anticodon, which is essential for efficient and highly accurate protein tran …
Bacterial and eukaryotic transfer RNAs have been shown to contain hypermodified adenosine, 2-methylthio-N(6)-threonylcarbamoyl …
MiaB protein is a bifunctional radical-S-adenosylmethionine enzyme involved in thiolation and methylation of tRNA.
Pierrel F, Douki T, Fontecave M, Atta M. Pierrel F, et al. J Biol Chem. 2004 Nov 12;279(46):47555-63. doi: 10.1074/jbc.M408562200. Epub 2004 Aug 30. J Biol Chem. 2004. PMID: 15339930 Free article.
The last biosynthetic step for 2-methylthio-N(6)-isopentenyl-adenosine (ms(2)i(6)A), present at position 37 in some tRNAs, consists of the methylthiolation of the isopentenyl-adenosine (i(6)A) precursor. In this work we have reconstituted in vitro the conversion of …
The last biosynthetic step for 2-methylthio-N(6)-isopentenyl-adenosine (ms(2)i(6)A), present at position 37 in some tRNAs, con …
Gene ssfg_01967 (miaB) for tRNA modification influences morphogenesis and moenomycin biosynthesis in Streptomyces ghanaensis ATCC14672.
Sehin Y, Koshla O, Dacyuk Y, Zhao R, Ross R, Myronovskyi M, Limbach PA, Luzhetskyy A, Walker S, Fedorenko V, Ostash B. Sehin Y, et al. Microbiology (Reading). 2019 Feb;165(2):233-245. doi: 10.1099/mic.0.000747. Epub 2018 Dec 13. Microbiology (Reading). 2019. PMID: 30543507 Free PMC article.
HIM5 carried the Tn insertion within gene ssfg_01967 for putative tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase, or MiaB, and led to a reduced level of thiomethylation at position 37 in the anticodon of S. ghanaensis transfer ribonucleic acid (tRNA). ...
HIM5 carried the Tn insertion within gene ssfg_01967 for putative tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase, or MiaB
Ferredoxins as interchangeable redox components in support of MiaB, a radical S-adenosylmethionine methylthiotransferase.
Arcinas AJ, Maiocco SJ, Elliott SJ, Silakov A, Booker SJ. Arcinas AJ, et al. Protein Sci. 2019 Jan;28(1):267-282. doi: 10.1002/pro.3548. Protein Sci. 2019. PMID: 30394621 Free PMC article.
MiaB is a member of the methylthiotransferase subclass of the radical S-adenosylmethionine (SAM) superfamily of enzymes, catalyzing the methylthiolation of C2 of adenosines bearing an N(6) -isopentenyl (i(6) A) group found at position 37 in several tRNAs to afford 2
MiaB is a member of the methylthiotransferase subclass of the radical S-adenosylmethionine (SAM) superfamily of enzymes, catalyzing t
Structural basis for tRNA methylthiolation by the radical SAM enzyme MiaB.
Esakova OA, Grove TL, Yennawar NH, Arcinas AJ, Wang B, Krebs C, Almo SC, Booker SJ. Esakova OA, et al. Nature. 2021 Sep;597(7877):566-570. doi: 10.1038/s41586-021-03904-6. Epub 2021 Sep 15. Nature. 2021. PMID: 34526715 Free PMC article.
Numerous post-transcriptional modifications of transfer RNAs have vital roles in translation. The 2-methylthio-N(6)-isopentenyladenosine (ms(2)i(6)A) modification occurs at position 37 (A37) in transfer RNAs that contain adenine in position 36 of the anticodon, and …
Numerous post-transcriptional modifications of transfer RNAs have vital roles in translation. The 2-methylthio-N(6)-isopenteny …
MiaB protein from Thermotoga maritima. Characterization of an extremely thermophilic tRNA-methylthiotransferase.
Pierrel F, Hernandez HL, Johnson MK, Fontecave M, Atta M. Pierrel F, et al. J Biol Chem. 2003 Aug 8;278(32):29515-24. doi: 10.1074/jbc.M301518200. Epub 2003 May 24. J Biol Chem. 2003. PMID: 12766153 Free article.
In Escherichia coli, the MiaB protein catalyzes the methylthiolation of N-6-isopentenyl adenosine in tRNAs, the last reaction step during biosynthesis of 2-methylthio-N-6-isopentenyl adenosine (ms2i6A-37). ...Its amino acid sequence shares the CysXXX-CysXXCys …
In Escherichia coli, the MiaB protein catalyzes the methylthiolation of N-6-isopentenyl adenosine in tRNAs, the last reaction step du …
Functional characterization of the YmcB and YqeV tRNA methylthiotransferases of Bacillus subtilis.
Anton BP, Russell SP, Vertrees J, Kasif S, Raleigh EA, Limbach PA, Roberts RJ. Anton BP, et al. Nucleic Acids Res. 2010 Oct;38(18):6195-205. doi: 10.1093/nar/gkq364. Epub 2010 May 14. Nucleic Acids Res. 2010. PMID: 20472640 Free PMC article.
Members of two of the four known subgroups of MTTases have been characterized, typified by MiaB, which modifies N(6)-isopentenyladenosine (i(6)A) to 2-methylthio-N(6)-isopentenyladenosine (ms(2)i(6)A) in tRNA, and RimO, which modifies a specific aspartate res …
Members of two of the four known subgroups of MTTases have been characterized, typified by MiaB, which modifies N(6)-isopentenyladeno …
Host mutations (miaA and rpsL) reduce tetracycline resistance mediated by Tet(O) and Tet(M).
Taylor DE, Trieber CA, Trescher G, Bekkering M. Taylor DE, et al. Antimicrob Agents Chemother. 1998 Jan;42(1):59-64. doi: 10.1128/AAC.42.1.59. Antimicrob Agents Chemother. 1998. PMID: 9449261 Free PMC article.
., respectively, were investigated by using mutants of Salmonella typhimurium and Escherichia coli. The miaA, miaB, and miaAB double mutants of S. typhimurium specify enzymes for tRNA modification at the adenosine at position 37, adjacent to the anticodon in tRNA. In S. ty …
., respectively, were investigated by using mutants of Salmonella typhimurium and Escherichia coli. The miaA, miaB, and miaAB double …
Role of tRNA modification in translational fidelity.
Hagervall TG, Ericson JU, Esberg KB, Li JN, Björk GR. Hagervall TG, et al. Biochim Biophys Acta. 1990 Aug 27;1050(1-3):263-6. doi: 10.1016/0167-4781(90)90178-5. Biochim Biophys Acta. 1990. PMID: 2207153
In this region, pseudouridine (psi) is found in positions 38, 39 or 40 in a subset of tRNA species, 2-methylthio-6-hydroxyisopentenyladenosine (ms2io6A) is found in position 37 in tRNAs that read codons starting with U and 1-methylguanosine (m1G) is found in positio …
In this region, pseudouridine (psi) is found in positions 38, 39 or 40 in a subset of tRNA species, 2-methylthio-6-hydroxyisop …