Multi-omics analysis identifies a microbiota-bile acid-TLR signaling axis driving bladder injury in interstitial cystitis.
Peng L, Chen JW, Chen YZ, Di XP, Lin LD, Li BY, Zhang C, Wang W, Gao XS, Ma YC, Shen SH, Li HR, Xu XF, Zeng X, Shen H, Sun Q, Jin T, Luo DY.
Peng L, et al.
Nat Commun. 2025 Dec 29;17(1):1299. doi: 10.1038/s41467-025-68060-1.
Nat Commun. 2025.
PMID: 41457077
Free PMC article.
Hunner-type interstitial cystitis/bladder pain syndrome (HIC) is a debilitating condition defined by bladder pain and urinary urgency, yet its upstream drivers remain poorly understood. ...Single-cell analysis indicates that these changes converge on Toll-like receptor 3 ( …
Hunner-type interstitial cystitis/bladder pain syndrome (HIC) is a debilitating condition defined by bladder pain and urinary urgency …