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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 2
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2008 3
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2010 3
2011 1
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2013 5
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562 results

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Page 1
Neuroinflammation and Central Sensitization in Chronic and Widespread Pain.
Ji RR, Nackley A, Huh Y, Terrando N, Maixner W. Ji RR, et al. Anesthesiology. 2018 Aug;129(2):343-366. doi: 10.1097/ALN.0000000000002130. Anesthesiology. 2018. PMID: 29462012 Free PMC article. Review.
Sustained increase of cytokines and chemokines in the central nervous system also promotes chronic widespread pain that affects multiple body sites. Thus, neuroinflammation drives widespread chronic pain via central sensitization. We also discus …
Sustained increase of cytokines and chemokines in the central nervous system also promotes chronic widespread pain that affect …
Chronic pain and neuroinflammation.
Vergne-Salle P, Bertin P. Vergne-Salle P, et al. Joint Bone Spine. 2021 Dec;88(6):105222. doi: 10.1016/j.jbspin.2021.105222. Epub 2021 May 19. Joint Bone Spine. 2021. PMID: 34022418
In rheumatology, chronic pain most often sets in after a musculoskeletal injury. Its persistence is not always due to the progression of the initial injury, but in some cases to the onset of central sensitization. ...The aim of this update is to describe the pathoph …
In rheumatology, chronic pain most often sets in after a musculoskeletal injury. Its persistence is not always due to the prog …
Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain.
Chen G, Zhang YQ, Qadri YJ, Serhan CN, Ji RR. Chen G, et al. Neuron. 2018 Dec 19;100(6):1292-1311. doi: 10.1016/j.neuron.2018.11.009. Neuron. 2018. PMID: 30571942 Free PMC article. Review.
Numerous signaling molecules are altered in microglia and contribute to the pathogenesis of pain. Here, we discuss how microglial signaling regulates spinal cord synaptic plasticity in acute and chronic pain conditions with different degrees and variat …
Numerous signaling molecules are altered in microglia and contribute to the pathogenesis of pain. Here, we discuss how microgl …
Huc-MSCs-derived exosomes attenuate inflammatory pain by regulating microglia pyroptosis and autophagy via the miR-146a-5p/TRAF6 axis.
Hua T, Yang M, Song H, Kong E, Deng M, Li Y, Li J, Liu Z, Fu H, Wang Y, Yuan H. Hua T, et al. J Nanobiotechnology. 2022 Jul 14;20(1):324. doi: 10.1186/s12951-022-01522-6. J Nanobiotechnology. 2022. PMID: 35836229 Free PMC article.
BACKGROUND: Chronic inflammatory pain significantly reduces the quality of life and lacks effective interventions. ...In this study, we investigated the therapeutic effect and related mechanisms of huc-MSCs-derived exosomes in a chronic inflammatory pain …
BACKGROUND: Chronic inflammatory pain significantly reduces the quality of life and lacks effective interventions. ...In this …
Pain-resolving immune mechanisms in neuropathic pain.
Fiore NT, Debs SR, Hayes JP, Duffy SS, Moalem-Taylor G. Fiore NT, et al. Nat Rev Neurol. 2023 Apr;19(4):199-220. doi: 10.1038/s41582-023-00777-3. Epub 2023 Mar 1. Nat Rev Neurol. 2023. PMID: 36859719 Review.
Interactions between the immune and nervous systems are of central importance in neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or disease affecting the somatosensory system. ...Indeed, immune cells and their mediators are …
Interactions between the immune and nervous systems are of central importance in neuropathic pain, a common and debilitating form of …
Spinal microglia-neuron interactions in chronic pain.
Ho IHT, Chan MTV, Wu WKK, Liu X. Ho IHT, et al. J Leukoc Biol. 2020 Nov;108(5):1575-1592. doi: 10.1002/JLB.3MR0520-695R. Epub 2020 Jun 23. J Leukoc Biol. 2020. PMID: 32573822 Review.
Current deficiency in our understanding of acute-to-chronic pain transition remains a hurdle for developing effective treatments against chronic pain. ...This narrative review summerizes the longitudinal alterations of spinal microglia-neuron in …
Current deficiency in our understanding of acute-to-chronic pain transition remains a hurdle for developing effective treatmen …
Pain regulation by gut microbiota: molecular mechanisms and therapeutic potential.
Guo R, Chen LH, Xing C, Liu T. Guo R, et al. Br J Anaesth. 2019 Nov;123(5):637-654. doi: 10.1016/j.bja.2019.07.026. Epub 2019 Sep 21. Br J Anaesth. 2019. PMID: 31551115 Free article. Review.
The relationship between gut microbiota and neurological diseases, including chronic pain, has received increasing attention. The gut microbiome is a crucial modulator of visceral pain, whereas recent evidence suggests that gut microbiota may also play …
The relationship between gut microbiota and neurological diseases, including chronic pain, has received increasing atte …
Microglia TREM1-mediated neuroinflammation contributes to central sensitization via the NF-kappaB pathway in a chronic migraine model.
Sun S, Fan Z, Liu X, Wang L, Ge Z. Sun S, et al. J Headache Pain. 2024 Jan 5;25(1):3. doi: 10.1186/s10194-023-01707-w. J Headache Pain. 2024. PMID: 38177990 Free PMC article.
BACKGROUND: Neuroinflammation, mediated by the activation of microglia, contributes to central sensitization, which is associated with the development of chronic migraine (CM). ...CONCLUSIONS: Our findings suggest that TREM1 regulates microglia and NLR …
BACKGROUND: Neuroinflammation, mediated by the activation of microglia, contributes to central sensitization, which is associa …
IDO1 modulates pain sensitivity and comorbid anxiety in chronic migraine through microglial activation and synaptic pruning.
Hu J, Ji WJ, Liu GY, Su XH, Zhu JM, Hong Y, Xiong YF, Zhao YY, Li WP, Xie W. Hu J, et al. J Neuroinflammation. 2025 Feb 18;22(1):42. doi: 10.1186/s12974-025-03367-w. J Neuroinflammation. 2025. PMID: 39966822 Free PMC article.
Indoleamine 2,3-dioxygenase 1 (IDO1) has been implicated in inflammatory processes, including neuroinflammation and pain. However, its role as a link between neuroinflammation and pain sensitization in chronic migraine is not well defined. ...CO …
Indoleamine 2,3-dioxygenase 1 (IDO1) has been implicated in inflammatory processes, including neuroinflammation and pain. Howe …
Activation of locus coeruleus-spinal cord noradrenergic neurons alleviates neuropathic pain in mice via reducing neuroinflammation from astrocytes and microglia in spinal dorsal horn.
Li J, Wei Y, Zhou J, Zou H, Ma L, Liu C, Xiao Z, Liu X, Tan X, Yu T, Cao S. Li J, et al. J Neuroinflammation. 2022 May 27;19(1):123. doi: 10.1186/s12974-022-02489-9. J Neuroinflammation. 2022. PMID: 35624514 Free PMC article.
This study aimed to explore the analgesic effects and the anti-neuroinflammation mechanism of LC-spinal cord noradrenergic pathway (LC:SC) in neuropathic pain (NP) mice with sciatic chronic constriction injury. ...Noradrenergic neuron-specific retro-adeno-ass …
This study aimed to explore the analgesic effects and the anti-neuroinflammation mechanism of LC-spinal cord noradrenergic pathway (L …
562 results