Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy.
You Y, Tian Y, Yang Z, Shi J, Kwak KJ, Tong Y, Estania AP, Cao J, Hsu WH, Liu Y, Chiang CL, Schrank BR, Huntoon K, Lee D, Li Z, Zhao Y, Zhang H, Gallup TD, Ha J, Dong S, Li X, Wang Y, Lu WJ, Bahrani E, Lee LJ, Teng L, Jiang W, Lan F, Kim BYS, Lee AS.
You Y, et al.
Nat Biomed Eng. 2023 Jul;7(7):887-900. doi: 10.1038/s41551-022-00989-w. Epub 2023 Jan 12.
Nat Biomed Eng. 2023.
PMID: 36635419
We also show that the intradermal delivery of the mRNA-loaded EVs via a microneedle array led to the prolonged and more uniform synthesis and replacement of collagen in the dermis of the animals. The intradermal delivery of EV-based COL1A1 mRNA may mak …
We also show that the intradermal delivery of the mRNA-loaded EVs via a microneedle array led to the prolonged and more unifor …