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HRT optimization, using transdermal estradiol plus micronized progesterone, a safer HRT.
L'Hermite M. L'Hermite M. Climacteric. 2013 Aug;16 Suppl 1:44-53. doi: 10.3109/13697137.2013.808563. Climacteric. 2013. PMID: 23848491 Review.
The increased occurrence of all these events can be prevented by the use of the transdermal route of estradiol administration; this route seems also advantageous for women with diabetes, hypertension and other cardiovascular risk factors, and also especially with advancing age. …
The increased occurrence of all these events can be prevented by the use of the transdermal route of estradiol administration; this route se …
Breast and endometrial safety of micronised progesterone versus norethisterone acetate in menopausal hormone therapy (PROBES): study protocol of a double-blind randomised controlled trial.
Lundell C, Stergiopoulos N, Blomberg L, Ujvari D, Schuppe-Koistinen I, Kopp-Kallner H, Iliadis SI, Skalkidou A, Hirschberg AL. Lundell C, et al. BMJ Open. 2024 Oct 23;14(10):e082749. doi: 10.1136/bmjopen-2023-082749. BMJ Open. 2024. PMID: 39448218 Free PMC article.
INTRODUCTION: Data suggest that micronised progesterone (mP) in menopausal hormone therapy is safer for the breast than synthetic progestins, while protection of the endometrium appears to be less effective. However, comparative randomised trial data are lack …
INTRODUCTION: Data suggest that micronised progesterone (mP) in menopausal hormone therapy is safer for the breast than synthe …
Micronized progesterone and its impact on the endometrium and breast vs. progestogens.
Gompel A. Gompel A. Climacteric. 2012 Apr;15 Suppl 1:18-25. doi: 10.3109/13697137.2012.669584. Climacteric. 2012. PMID: 22432812 Review.
Therefore, micronized progesterone and progestogens are recommended as part of combined HRT in women with an intact uterus. ...Therefore, for women with an intact uterus, micronized progesterone may be the optimal choice as part of combined H …
Therefore, micronized progesterone and progestogens are recommended as part of combined HRT in women with an intact ute …
Endometrial response to a cyclic regimen of percutaneous 17beta-estradiol and low-dose vaginal micronized progesterone in women with mild-to-moderate hypertension.
Vilodre LC, Osório Wender MC, Sisson de Castro JA, dos Reis FM, Ruschel S, Magalhães JA, Spritzer PM. Vilodre LC, et al. Gynecol Endocrinol. 2003 Aug;17(4):323-8. Gynecol Endocrinol. 2003. PMID: 14503977 Clinical Trial.
Endometrial response to natural estradiol and low-dose vaginal progesterone replacement therapy was evaluated in 20 postmenopausal women with chronic, mild-to-moderate hypertension. A cyclic hormone replacement therapy (HRT) regimen was used (21/28 days) with …
Endometrial response to natural estradiol and low-dose vaginal progesterone replacement therapy was evaluated in 20 postmenopa …
Endometrial carcinoma on continuous combined HRT: case report and literature review.
Di Spiezio Sardo A, Radhakrishnan S. Di Spiezio Sardo A, et al. Maturitas. 2004 Jun 15;48(2):171-5. doi: 10.1016/j.maturitas.2004.02.002. Maturitas. 2004. PMID: 15172092 Review.
Moreover, when given on a daily basis, progestin is thought to be more protective against the development of endometrial carcinoma. CASE REPORT: We describe the case of a 59-year-old woman, diagnosed with endometrial carcinoma while on continuous combined …
Moreover, when given on a daily basis, progestin is thought to be more protective against the development of endometrial carci …
Position paper of the expert panel of the Polish Society of Menopause and Andropause on the use of Oestrogel® in menopausal hormone therapy.
Bińkowska M, Paszkowski T, Skrzypulec-Plinta V, Zgliczyński W. Bińkowska M, et al. Prz Menopauzalny. 2025 Jun;24(2):131-136. doi: 10.5114/pm.2025.152241. Epub 2025 Jun 23. Prz Menopauzalny. 2025. PMID: 40777875 Free PMC article. Review.
This position paper of the expert panel presents a comprehensive review of the efficacy, safety, and clinical application of bioidentical hormone replacement therapy (HRT), with particular focus on transdermal 17beta-oestradiol gel (Oestrogel( )). Bioidentical hormones - c …
This position paper of the expert panel presents a comprehensive review of the efficacy, safety, and clinical application of bioidentical ho …
[Authors' experience with transvaginal administration of progestagens].
Cataldi U, Tridente V, Pazienza S, Brizzi C, Serrao L, Proia L, Quattrini MJ. Cataldi U, et al. Clin Ter. 1997 Apr;148(4):165-72. Clin Ter. 1997. PMID: 9377851 Italian.
The authors, after a short introducing on the most used kinds of progestins in Hormonal Replacement Therapy (HRT), report this own clinical experience on the efficacy of a micronized progestin treatment given by the vaginal route in comparison with oral somministrat …
The authors, after a short introducing on the most used kinds of progestins in Hormonal Replacement Therapy (HRT), report this own cl …
Estradiol and Micronized Progesterone: A Narrative Review About Their Use as Hormone Replacement Therapy.
Foschi M, Groccia G, Rusce ML, Medaglia C, Aio C, Sponzilli A, Setti V, Battipaglia C, Genazzani AD. Foschi M, et al. J Clin Med. 2025 Oct 16;14(20):7328. doi: 10.3390/jcm14207328. J Clin Med. 2025. PMID: 41156198 Free PMC article. Review.
Standard regimens generally combine 17beta-estradiol (E2) or conjugated equine estrogens (CEEs) with micronized progesterone (P4) or synthetic progestins. While synthetic progestins ensure endometrial protection against estrogen-induced stimulation of …
Standard regimens generally combine 17beta-estradiol (E2) or conjugated equine estrogens (CEEs) with micronized progesterone ( …
Can endometrial protection be inferred from the bleeding pattern on combined cyclical hormone replacement therapy.
Burch D, Bieshuevel E, Smith S, Fox H. Burch D, et al. Maturitas. 2000 Feb 15;34(2):155-60. doi: 10.1016/s0378-5122(99)00101-2. Maturitas. 2000. PMID: 10714910 Clinical Trial.
INTERVENTIONS: Administration of six 28-day treatment cycles of a continuous daily dose of 2 mg of micronised 17beta oestradiol with a randomly allocated dose of 5-20 mg of dydrogesterone added for the last 14 days of each. ...There were two cases of proliferative and one …
INTERVENTIONS: Administration of six 28-day treatment cycles of a continuous daily dose of 2 mg of micronised 17beta oestradiol with …