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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
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1988 7
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2002 41
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2,192 results

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Page 1
Cilia oscillations.
Man Y, Ling F, Kanso E. Man Y, et al. Philos Trans R Soc Lond B Biol Sci. 2020 Feb 17;375(1792):20190157. doi: 10.1098/rstb.2019.0157. Epub 2019 Dec 30. Philos Trans R Soc Lond B Biol Sci. 2020. PMID: 31884917 Free PMC article.
Several theories suggest that geometric feedback control from cilium deformations to molecular activity is needed. Here, we implement a recent sliding control model, where the unbinding of molecular motors is dictated by the sliding motion between microtubule double …
Several theories suggest that geometric feedback control from cilium deformations to molecular activity is needed. Here, we implement …
HURP regulates Kif18A recruitment and activity to synergistically control microtubule dynamics.
Perez-Bertoldi JM, Zhao Y, Thawani A, Yildiz A, Nogales E. Perez-Bertoldi JM, et al. Nat Commun. 2024 Nov 8;15(1):9687. doi: 10.1038/s41467-024-53691-7. Nat Commun. 2024. PMID: 39516196 Free PMC article.
While sparse decoration of HURP activates the motor, higher concentrations hinder processive motility. To shed light on this behavior, we determine the binding mode of HURP to microtubules using cryo-EM. The structure helps rationalize why HURP functions as a mic …
While sparse decoration of HURP activates the motor, higher concentrations hinder processive motility. To shed light on this behavior …
Coupling of ATPase activity, microtubule binding, and mechanics in the dynein motor domain.
Niekamp S, Coudray N, Zhang N, Vale RD, Bhabha G. Niekamp S, et al. EMBO J. 2019 Jul 1;38(13):e101414. doi: 10.15252/embj.2018101414. Epub 2019 May 31. EMBO J. 2019. PMID: 31268607 Free PMC article.
We identified mutations in the stalk that disrupt directional motion, have microtubule-independent hyperactive ATPase activity, and nucleotide-independent low affinity for microtubules. ...These results demonstrate an essential role of the stalk in regulating …
We identified mutations in the stalk that disrupt directional motion, have microtubule-independent hyperactive ATPase activity …
Observation of microtubule-based motor protein activity.
Sloboda RD. Sloboda RD. Cold Spring Harb Protoc. 2015 Feb 2;2015(2):205-9. doi: 10.1101/pdb.prot081224. Cold Spring Harb Protoc. 2015. PMID: 25646501
It is possible to detect the presence of motor proteins that have the ability to translocate particles along microtubules. The two procedures described here were developed to detect microtubule-dependent motor protein activity in cell lysates or …
It is possible to detect the presence of motor proteins that have the ability to translocate particles along microtubules. The …
Potent microtubule-depolymerizing activity of a mitotic Kif18b-MCAK-EB network.
McHugh T, Welburn JPI. McHugh T, et al. J Cell Sci. 2023 Mar 1;136(5):jcs260144. doi: 10.1242/jcs.260144. Epub 2022 May 31. J Cell Sci. 2023. PMID: 35502670 Free PMC article.
The kinesin-13 Kif2C or MCAK acts as a potent microtubule depolymerase that diffuses short distances on microtubules, whereas the kinesin-8 Kif18b is a processive motor with weak depolymerase activity. ...We find that Kif18b can transport EB3 and MCAK …
The kinesin-13 Kif2C or MCAK acts as a potent microtubule depolymerase that diffuses short distances on microtubules, whereas …
Motor usage imprints microtubule stability along the shaft.
Andreu-Carbó M, Fernandes S, Velluz MC, Kruse K, Aumeier C. Andreu-Carbó M, et al. Dev Cell. 2022 Jan 10;57(1):5-18.e8. doi: 10.1016/j.devcel.2021.11.019. Epub 2021 Dec 8. Dev Cell. 2022. PMID: 34883065 Free article.
Tubulin dimers assemble into dynamic microtubules, which are used by molecular motors as tracks for intracellular transport. Organization and dynamics of the microtubule network are commonly thought to be regulated at the polymer ends, where tubulin dimers can be ad …
Tubulin dimers assemble into dynamic microtubules, which are used by molecular motors as tracks for intracellular transport. Organiza …
Motor processivity and speed determine structure and dynamics of microtubule-motor assemblies.
Banks RA, Galstyan V, Lee HJ, Hirokawa S, Ierokomos A, Ross TD, Bryant Z, Thomson M, Phillips R. Banks RA, et al. Elife. 2023 Feb 8;12:e79402. doi: 10.7554/eLife.79402. Elife. 2023. PMID: 36752605 Free PMC article.
These active systems are prevalent in living matter; for example, in cells, the cytoskeleton is organized into structures such as the mitotic spindle through the coordinated activity of many motor proteins walking along microtubules. Here, we investigate how …
These active systems are prevalent in living matter; for example, in cells, the cytoskeleton is organized into structures such as the mitoti …
The ubiquitous microtubule-associated protein 4 (MAP4) controls organelle distribution by regulating the activity of the kinesin motor.
Nabti I, Reddy BJN, Rezgui R, Wang W, Gross SP, Shubeita GT. Nabti I, et al. Proc Natl Acad Sci U S A. 2022 Oct 11;119(41):e2206677119. doi: 10.1073/pnas.2206677119. Epub 2022 Oct 3. Proc Natl Acad Sci U S A. 2022. PMID: 36191197 Free PMC article.
Regulation of organelle transport by molecular motors along the cytoskeletal microtubules is central to maintaining cellular functions. Here, we show that the ubiquitous tau-related microtubule-associated protein 4 (MAP4) can bias the bidirectional transport of orga …
Regulation of organelle transport by molecular motors along the cytoskeletal microtubules is central to maintaining cellular function …
The motor domain of the kinesin Kip2 promotes microtubule polymerization at microtubule tips.
Chen X, Portran D, Widmer LA, Stangier MM, Czub MP, Liakopoulos D, Stelling J, Steinmetz MO, Barral Y. Chen X, et al. J Cell Biol. 2023 Jul 3;222(7):e202110126. doi: 10.1083/jcb.202110126. Epub 2023 Apr 24. J Cell Biol. 2023. PMID: 37093124 Free PMC article.
Kinesins are microtubule-dependent motor proteins, some of which moonlight as microtubule polymerases, such as the yeast protein Kip2. Here, we show that the CLIP-170 ortholog Bik1 stabilizes Kip2 at microtubule ends where the motor domain of Ki …
Kinesins are microtubule-dependent motor proteins, some of which moonlight as microtubule polymerases, such as the yeas …
A kinesin-1 variant reveals motor-induced microtubule damage in cells.
Budaitis BG, Badieyan S, Yue Y, Blasius TL, Reinemann DN, Lang MJ, Cianfrocco MA, Verhey KJ. Budaitis BG, et al. Curr Biol. 2022 Jun 6;32(11):2416-2429.e6. doi: 10.1016/j.cub.2022.04.020. Epub 2022 May 2. Curr Biol. 2022. PMID: 35504282 Free PMC article.
Here, we describe a kinesin-1 KIF5C mutant with an increased ability to generate damage sites in the microtubule lattice as compared with the wild-type motor. The expression of the mutant motor in cultured cells resulted in microtubule breakage and fra …
Here, we describe a kinesin-1 KIF5C mutant with an increased ability to generate damage sites in the microtubule lattice as compared …
2,192 results