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2,835 results

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Page 1
Microtubule nucleation: beyond the template.
Roostalu J, Surrey T. Roostalu J, et al. Nat Rev Mol Cell Biol. 2017 Nov;18(11):702-710. doi: 10.1038/nrm.2017.75. Epub 2017 Aug 23. Nat Rev Mol Cell Biol. 2017. PMID: 28831203 Review.
Consequently, cells need to exert tight control over when, where and how many microtubules are being made. Whereas the regulation of microtubule dynamics is well studied, the molecular mechanisms of microtubule nucleation are still poorly understood. N …
Consequently, cells need to exert tight control over when, where and how many microtubules are being made. Whereas the regulation of …
Centrosome-microtubule nucleation.
Pereira G, Schiebel E. Pereira G, et al. J Cell Sci. 1997 Feb;110 ( Pt 3):295-300. doi: 10.1242/jcs.110.3.295. J Cell Sci. 1997. PMID: 9057082 Review.
In many cell types the formation of microtubules from tubulin subunits is initiated at defined nucleation sites at the centrosome. ...While the structure and composition of a microtubule nucleation site is becoming clearer, it is still unknown how the …
In many cell types the formation of microtubules from tubulin subunits is initiated at defined nucleation sites at the centros …
Assaying Microtubule Nucleation.
Ezquerra A, Viais R, Lüders J. Ezquerra A, et al. Methods Mol Biol. 2020;2101:163-178. doi: 10.1007/978-1-0716-0219-5_11. Methods Mol Biol. 2020. PMID: 31879904
Assaying microtubule nucleation is essential to understand the organization of microtubule networks in any cell type. In this chapter we describe methods for measuring nucleation activity at centrosomes and at mitotic chromatin in cell lines, to study …
Assaying microtubule nucleation is essential to understand the organization of microtubule networks in any cell type. I …
Microtubule nucleation: The waltz between gamma-tubulin ring complex and associated proteins.
Liu P, Würtz M, Zupa E, Pfeffer S, Schiebel E. Liu P, et al. Curr Opin Cell Biol. 2021 Feb;68:124-131. doi: 10.1016/j.ceb.2020.10.004. Epub 2020 Nov 12. Curr Opin Cell Biol. 2021. PMID: 33190097 Review.
In high eukaryotes, microtubule nucleation, the de novo assembly of a microtubule from its minus end, is initiated by the gamma-tubulin ring complex (gamma-TuRC). ...In vitro assays further deciphered the spatial and temporal cooperation between gamma-TuRC an …
In high eukaryotes, microtubule nucleation, the de novo assembly of a microtubule from its minus end, is initiated by t …
Microtubule nucleation.
Job D, Valiron O, Oakley B. Job D, et al. Curr Opin Cell Biol. 2003 Feb;15(1):111-7. doi: 10.1016/s0955-0674(02)00003-0. Curr Opin Cell Biol. 2003. PMID: 12517712 Review.
Microtubule nucleation is the process in which several tubulin molecules interact to form a microtubule seed. Microtubule nucleation occurs spontaneously in purified tubulin solutions, and molecular intermediates between tubulin dimers and mi …
Microtubule nucleation is the process in which several tubulin molecules interact to form a microtubule seed. Microt …
CAMSAPs and nucleation-promoting factors control microtubule release from gamma-TuRC.
Rai D, Song Y, Hua S, Stecker K, Monster JL, Yin V, Stucchi R, Xu Y, Zhang Y, Chen F, Katrukha EA, Altelaar M, Heck AJR, Wieczorek M, Jiang K, Akhmanova A. Rai D, et al. Nat Cell Biol. 2024 Mar;26(3):404-420. doi: 10.1038/s41556-024-01366-2. Epub 2024 Feb 29. Nat Cell Biol. 2024. PMID: 38424271 Free PMC article.
gamma-Tubulin ring complex (gamma-TuRC) is the major microtubule-nucleating factor. After nucleation, microtubules can be released from gamma-TuRC and stabilized by other proteins, such as CAMSAPs, but the biochemical cross-talk between minus-end regul …
gamma-Tubulin ring complex (gamma-TuRC) is the major microtubule-nucleating factor. After nucleation, microtubules …
Centrosomal and acentrosomal microtubule nucleation during neuronal development.
Vinopal S, Bradke F. Vinopal S, et al. Curr Opin Neurobiol. 2025 Jun;92:103016. doi: 10.1016/j.conb.2025.103016. Epub 2025 Mar 26. Curr Opin Neurobiol. 2025. PMID: 40147111 Free article. Review.
We review recent progress in understanding the molecular concepts of microtubule nucleation, how these concepts underlie neurodevelopmental processes, and pinpoint the open questions. Since microtubules play a pivotal role in axon regeneration within the adul …
We review recent progress in understanding the molecular concepts of microtubule nucleation, how these concepts underlie neuro …
Microtubule nucleation and establishment of the mitotic spindle in vascular plant cells.
Masoud K, Herzog E, Chabouté ME, Schmit AC. Masoud K, et al. Plant J. 2013 Jul;75(2):245-57. doi: 10.1111/tpj.12179. Epub 2013 May 7. Plant J. 2013. PMID: 23521421 Free article. Review.
The microtubular cytoskeleton plays a major role in cellular organization and proliferation. The first step in construction of a microtubule is microtubule nucleation. Individual microtubules then participate in organization of more complex microtub …
The microtubular cytoskeleton plays a major role in cellular organization and proliferation. The first step in construction of a microtub …
Regulation of microtubule nucleation mediated by gamma-tubulin complexes.
Sulimenko V, Hájková Z, Klebanovych A, Dráber P. Sulimenko V, et al. Protoplasma. 2017 May;254(3):1187-1199. doi: 10.1007/s00709-016-1070-z. Epub 2017 Jan 10. Protoplasma. 2017. PMID: 28074286 Review.
The nucleation of new microtubules is typically restricted to microtubule organizing centers (MTOCs) and requires gamma-tubulin that assembles into multisubunit complexes of various sizes. gamma-Tubulin ring complexes (TuRCs) are efficient microtubule …
The nucleation of new microtubules is typically restricted to microtubule organizing centers (MTOCs) and requires gamma …
Microtubule nucleation from the fibrous corona by LIC1-pericentrin promotes chromosome congression.
Wu J, Larreategui-Aparicio A, Lambers MLA, Bodor DL, Klaasen SJ, Tollenaar E, de Ruijter-Villani M, Kops GJPL. Wu J, et al. Curr Biol. 2023 Mar 13;33(5):912-925.e6. doi: 10.1016/j.cub.2023.01.010. Epub 2023 Jan 30. Curr Biol. 2023. PMID: 36720222 Free PMC article.
Microtubules sprout from nucleation sites such as centrosomes, but kinetochores can also promote microtubule formation. ...The fibrous corona is essential for the nucleation of kinetochore-derived microtubules, and when dissociated from the core …
Microtubules sprout from nucleation sites such as centrosomes, but kinetochores can also promote microtubule formation. …
2,835 results