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1965 3
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1976 5
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1978 16
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2000 191
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2002 206
2003 222
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2005 311
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2008 314
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8,380 results

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Page 1
Microtubule-Organizing Centers.
Wu J, Akhmanova A. Wu J, et al. Annu Rev Cell Dev Biol. 2017 Oct 6;33:51-75. doi: 10.1146/annurev-cellbio-100616-060615. Epub 2017 Jun 23. Annu Rev Cell Dev Biol. 2017. PMID: 28645217 Review.
Such sites are often clustered into structures known as microtubule-organizing centers, which include the centrosomes in animals and spindle pole bodies in fungi. In addition, other microtubules, as well as membrane compartments such as the cell nucleus, the Golgi a …
Such sites are often clustered into structures known as microtubule-organizing centers, which include the centrosomes in anima …
Anatomy of the fungal microtubule organizing center, the spindle pole body.
Jaspersen SL. Jaspersen SL. Curr Opin Struct Biol. 2021 Feb;66:22-31. doi: 10.1016/j.sbi.2020.09.008. Epub 2020 Oct 25. Curr Opin Struct Biol. 2021. PMID: 33113389 Free PMC article. Review.
This nuclear envelope embedded structure, which is essential for microtubule nucleation, shows dramatically different morphologies between different fungi. ...Here, I review the organization of the most well-studied SPBs and describe how advances in genomics, genetics and …
This nuclear envelope embedded structure, which is essential for microtubule nucleation, shows dramatically different morphologies be …
Microtubule-organizing center-mediated structural atypia in low- and high-grade urothelial carcinoma.
Murata SI, Kuroda M, Kawamura N, Warigaya K, Musangile FY, Matsuzaki I, Kojima F. Murata SI, et al. Virchows Arch. 2021 Feb;478(2):327-334. doi: 10.1007/s00428-020-02895-5. Epub 2020 Jul 24. Virchows Arch. 2021. PMID: 32710188
The mechanisms responsible for maintaining structural atypia, such as the disturbance of nuclear polarity, remain unclear. In this study, we studied microtubule-organizing center (MTOC)-mediated nuclear polarity in UC subtypes. We evaluated six cases with nor …
The mechanisms responsible for maintaining structural atypia, such as the disturbance of nuclear polarity, remain unclear. In this study, we …
The centrosome in vertebrates: more than a microtubule-organizing center.
Rieder CL, Faruki S, Khodjakov A. Rieder CL, et al. Trends Cell Biol. 2001 Oct;11(10):413-9. doi: 10.1016/s0962-8924(01)02085-2. Trends Cell Biol. 2001. PMID: 11567874 Review.
For years, the functions of the centrosome were thought to revolve around its ability to nucleate and organize the various microtubule arrays seen in interphase and mitosis. But the centrosome is more than just a microtubule-organizing center. ...
For years, the functions of the centrosome were thought to revolve around its ability to nucleate and organize the various microtubule …
Microtubule-organizing centres: a re-evaluation.
Lüders J, Stearns T. Lüders J, et al. Nat Rev Mol Cell Biol. 2007 Feb;8(2):161-7. doi: 10.1038/nrm2100. Nat Rev Mol Cell Biol. 2007. PMID: 17245416 Review.
The number, length, distribution and polarity of microtubules are largely controlled by microtubule-organizing centres, which nucleate and anchor microtubule minus ends in a process that requires gamma-tubulin. Here we discuss recent evidence indicating that …
The number, length, distribution and polarity of microtubules are largely controlled by microtubule-organizing centres, which …
The mechanism of acentrosomal spindle assembly in human oocytes.
Wu T, Dong J, Fu J, Kuang Y, Chen B, Gu H, Luo Y, Gu R, Zhang M, Li W, Dong X, Sun X, Sang Q, Wang L. Wu T, et al. Science. 2022 Nov 18;378(6621):eabq7361. doi: 10.1126/science.abq7361. Epub 2022 Nov 18. Science. 2022. PMID: 36395215
We used three-dimensional high-resolution imaging of more than 2000 human oocytes to identify a structure that we named the human oocyte microtubule organizing center (huoMTOC). The proteins TACC3, CCP110, CKAP5, and DISC1 were found to be essential component …
We used three-dimensional high-resolution imaging of more than 2000 human oocytes to identify a structure that we named the human oocyte …
Growth cone-localized microtubule organizing center establishes microtubule orientation in dendrites.
Liang X, Kokes M, Fetter RD, Sallee MD, Moore AW, Feldman JL, Shen K. Liang X, et al. Elife. 2020 Jul 13;9:e56547. doi: 10.7554/eLife.56547. Elife. 2020. PMID: 32657271 Free PMC article.
A polarized arrangement of neuronal microtubule arrays is the foundation of membrane trafficking and subcellular compartmentalization. ...Here we show that in Caenorhabditis elegans the dendritic growth cone contains a non-centrosomal microtubule organizing …
A polarized arrangement of neuronal microtubule arrays is the foundation of membrane trafficking and subcellular compartmentalization …
Regulation of microtubule-organizing center orientation and actomyosin cytoskeleton rearrangement during immune interactions.
Sancho D, Vicente-Manzanares M, Mittelbrunn M, Montoya MC, Gordón-Alonso M, Serrador JM, Sánchez-Madrid F. Sancho D, et al. Immunol Rev. 2002 Nov;189:84-97. doi: 10.1034/j.1600-065x.2002.18908.x. Immunol Rev. 2002. PMID: 12445267 Review.
In early T cell-APC cognate interactions, the microtubular cytoskeleton undergoes drastic changes that lead to microtubule-organizing center (MTOC) reorientation to the vicinity of the cell-cell contact area. ...
In early T cell-APC cognate interactions, the microtubular cytoskeleton undergoes drastic changes that lead to microtubule-organiz …
Consecutive palmitoylation and phosphorylation orchestrates NLRP3 membrane trafficking and inflammasome activation.
Nie L, Fei C, Fan Y, Dang F, Zhao Z, Zhu T, Wu X, Dai T, Balasubramanian A, Pan J, Hu Y, Luo HR, Wei W, Chen J. Nie L, et al. Mol Cell. 2024 Sep 5;84(17):3336-3353.e7. doi: 10.1016/j.molcel.2024.08.001. Epub 2024 Aug 21. Mol Cell. 2024. PMID: 39173637 Free article.
Upon stimulation, NLRP3 undergoes subcellular membrane trafficking and conformational rearrangements, preparing itself for inflammasome assembly at the microtubule-organizing center (MTOC). Here, we elucidate an orchestrated mechanism underlying these ordered …
Upon stimulation, NLRP3 undergoes subcellular membrane trafficking and conformational rearrangements, preparing itself for inflammasome asse …
Mechanism of spindle pole organization and instability in human oocytes.
So C, Menelaou K, Uraji J, Harasimov K, Steyer AM, Seres KB, Bucevičius J, Lukinavičius G, Möbius W, Sibold C, Tandler-Schneider A, Eckel H, Moltrecht R, Blayney M, Elder K, Schuh M. So C, et al. Science. 2022 Feb 11;375(6581):eabj3944. doi: 10.1126/science.abj3944. Epub 2022 Feb 11. Science. 2022. PMID: 35143306
We found that NUMA (nuclear mitotic apparatus protein)-mediated clustering of microtubule minus ends focused the spindle poles in human, bovine, and porcine oocytes and in mouse oocytes depleted of acentriolar microtubule-organizing centers (aMTOCs). ...
We found that NUMA (nuclear mitotic apparatus protein)-mediated clustering of microtubule minus ends focused the spindle poles in hum …
8,380 results