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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
1991 6
1992 12
1993 17
1994 13
1995 23
1996 16
1997 28
1998 20
1999 21
2000 39
2001 29
2002 27
2003 33
2004 34
2005 41
2006 44
2007 45
2008 44
2009 39
2010 41
2011 46
2012 45
2013 54
2014 59
2015 55
2016 52
2017 51
2018 37
2019 44
2020 56
2021 18
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999 results
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Midkine (MDK) growth factor: a key player in cancer progression and a promising therapeutic target.
Filippou PS, Karagiannis GS, Constantinidou A. Filippou PS, et al. Oncogene. 2020 Mar;39(10):2040-2054. doi: 10.1038/s41388-019-1124-8. Epub 2019 Dec 4. Oncogene. 2020. PMID: 31801970 Review.
Midkine is abnormally expressed at high levels in various human malignancies and acts as a mediator for the acquisition of critical hallmarks of cancer, including cell growth, survival, metastasis, migration, and angiogenesis. Several studies have investigated the role of
Midkine is abnormally expressed at high levels in various human malignancies and acts as a mediator for the acquisition of critical h
Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state.
Cerezo-Wallis D, Contreras-Alcalde M, Troulé K, Catena X, Mucientes C, Calvo TG, Cañón E, Tejedo C, Pennacchi PC, Hogan S, Kölblinger P, Tejero H, Chen AX, Ibarz N, Graña-Castro O, Martinez L, Muñoz J, Ortiz-Romero P, Rodriguez-Peralto JL, Gómez-López G, Al-Shahrour F, Rabadán R, Levesque MP, Olmeda D, Soengas MS. Cerezo-Wallis D, et al. Nat Med. 2020 Dec;26(12):1865-1877. doi: 10.1038/s41591-020-1073-3. Epub 2020 Oct 19. Nat Med. 2020. PMID: 33077955
An open question in aggressive cancers such as melanoma is how malignant cells can shift the immune system to pro-tumorigenic functions. Here we identify midkine (MDK) as a melanoma-secreted driver of an inflamed, but immune evasive, microenvironment that defines poor pati …
An open question in aggressive cancers such as melanoma is how malignant cells can shift the immune system to pro-tumorigenic functions. Her …
Midkine-a Is Required for Cell Cycle Progression of Muller Glia during Neuronal Regeneration in the Vertebrate Retina.
Nagashima M, D'Cruz TS, Danku AE, Hesse D, Sifuentes C, Raymond PA, Hitchcock PF. Nagashima M, et al. J Neurosci. 2020 Feb 5;40(6):1232-1247. doi: 10.1523/JNEUROSCI.1675-19.2019. Epub 2019 Dec 27. J Neurosci. 2020. PMID: 31882403 Free PMC article.
However, transition from G(1) to S phase is blocked in the absence of Midkine-a, resulting in significantly reduced proliferation and selective failure to regenerate cone photoreceptors. ...The absence of Midkine-a suspends proliferation and neuronal regeneration. W …
However, transition from G(1) to S phase is blocked in the absence of Midkine-a, resulting in significantly reduced proliferation and …
Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis.
Weckbach LT, Grabmaier U, Uhl A, Gess S, Boehm F, Zehrer A, Pick R, Salvermoser M, Czermak T, Pircher J, Sorrelle N, Migliorini M, Strickland DK, Klingel K, Brinkmann V, Abu Abed U, Eriksson U, Massberg S, Brunner S, Walzog B. Weckbach LT, et al. J Exp Med. 2019 Feb 4;216(2):350-368. doi: 10.1084/jem.20181102. Epub 2019 Jan 15. J Exp Med. 2019. PMID: 30647120 Free PMC article.
Inhibition of NET formation in experimental autoimmune myocarditis (EAM) of mice substantially reduces inflammation in the acute phase of the disease. Targeting the cytokine midkine (MK), which mediates NET formation in vitro, not only attenuates NET formation in vivo and …
Inhibition of NET formation in experimental autoimmune myocarditis (EAM) of mice substantially reduces inflammation in the acute phase of th …
[Investigation of cytokine and midkine responses of human THP-1 leukemia cells induced by phorbol-12-Myristate-13-Acetate (PMA) at different concentrations and times].
Biriken D, Yazıhan N, Yılmaz Ş. Biriken D, et al. Mikrobiyol Bul. 2018 Apr;52(2):147-155. doi: 10.5578/mb.66745. Mikrobiyol Bul. 2018. PMID: 29933732 Free article. Turkish.
PMA caused cytotoxicity in the cells when the dosages were increased (> 20 ng/ml). THP-1 cells have a basal secretion of midkine and are increased by dosage dependent with PMA stimulation. Midkine secretion has shown changes dependent with dosage and time. ...
PMA caused cytotoxicity in the cells when the dosages were increased (> 20 ng/ml). THP-1 cells have a basal secretion of midkine a …
Diagnostic accuracy of midkine for hepatocellular carcinoma: A meta-analysis.
Zhang Y, Tang J, Zhou X, Zhu SL, Li LQ. Zhang Y, et al. Mol Genet Genomic Med. 2020 Feb;8(2):e1071. doi: 10.1002/mgg3.1071. Epub 2019 Nov 27. Mol Genet Genomic Med. 2020. PMID: 31777190 Free PMC article. Review.
BACKGROUND: There have been many reports on midkine as a promising marker in the diagnosis of hepatocellular carcinoma (HCC). ...The area under curve value was 0.9266 in the overall SROC curve. CONCLUSION: Midkine has moderate diagnostic accuracy for HCC. Due to the …
BACKGROUND: There have been many reports on midkine as a promising marker in the diagnosis of hepatocellular carcinoma (HCC). ...The …
Midkine promotes NETosis in myocarditis.
Lim GB. Lim GB. Nat Rev Cardiol. 2019 Mar;16(3):132. doi: 10.1038/s41569-019-0163-8. Nat Rev Cardiol. 2019. PMID: 30700861 No abstract available.
Disruption of Midkine gene reduces traumatic brain injury through the modulation of neuroinflammation.
Takada S, Sakakima H, Matsuyama T, Otsuka S, Nakanishi K, Norimatsu K, Itashiki Y, Tani A, Kikuchi K. Takada S, et al. J Neuroinflammation. 2020 Jan 29;17(1):40. doi: 10.1186/s12974-020-1709-8. J Neuroinflammation. 2020. PMID: 31996236 Free PMC article.
BACKGROUND: Midkine (MK) is a multifunctional cytokine found upregulated in the brain in the presence of different disorders characterized by neuroinflammation, including neurodegenerative disorders and ischemia. ...
BACKGROUND: Midkine (MK) is a multifunctional cytokine found upregulated in the brain in the presence of different disorders characte …
Involvement of midkine in autoimmune and autoinflammatory diseases.
Aynacıoğlu AŞ, Bilir A, Tuna MY. Aynacıoğlu AŞ, et al. Mod Rheumatol. 2019 Jul;29(4):567-571. doi: 10.1080/14397595.2018.1523701. Epub 2018 Oct 25. Mod Rheumatol. 2019. PMID: 30217121 Review.
Midkine (MK) is a heparin-binding growth factor that markedly expressed during embryogenesis but downregulated to inconsiderable levels in healthy adults. ...
Midkine (MK) is a heparin-binding growth factor that markedly expressed during embryogenesis but downregulated to inconsiderable leve
The CD151-midkine pathway regulates the immune microenvironment in inflammatory breast cancer.
Hayward S, Gachehiladze M, Badr N, Andrijes R, Molostvov G, Paniushkina L, Sopikova B, Slobodová Z, Mgebrishvili G, Sharma N, Horimoto Y, Burg D, Robertson G, Hanby A, Hoar F, Rea D, Eckhardt BL, Ueno NT, Nazarenko I, Long HM, van Laere S, Shaaban AM, Berditchevski F. Hayward S, et al. J Pathol. 2020 May;251(1):63-73. doi: 10.1002/path.5415. Epub 2020 Mar 24. J Pathol. 2020. PMID: 32129471
Profiling of chemokines secreted by IBC cells demonstrated that CD151 increases production of midkine. Purified midkine specifically stimulated migration of monocytes, but not other immune cells. ...Therefore, a CD151-midkine pathway can be considered as a no …
Profiling of chemokines secreted by IBC cells demonstrated that CD151 increases production of midkine. Purified midkine specif …
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