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Page 1
Levodopa reverses cytokine-induced reductions in striatal dopamine release.
Felger JC, Hernandez CR, Miller AH. Felger JC, et al. Among authors: miller ah. Int J Neuropsychopharmacol. 2015 Jan 31;18(4):pyu084. doi: 10.1093/ijnp/pyu084. Int J Neuropsychopharmacol. 2015. PMID: 25638816 Free PMC article.
METHODS: Herein, we examined whether reduced striatal dopamine release in rhesus monkeys chronically treated with interferon-alpha can be restored by administration of the dopamine precursor levodopa via reverse in vivo microdialysis. RESULTS: Levodopa completely reversed …
METHODS: Herein, we examined whether reduced striatal dopamine release in rhesus monkeys chronically treated with interferon-alpha ca …
Transcriptomic signatures of psychomotor slowing in peripheral blood of depressed patients: evidence for immunometabolic reprogramming.
Bekhbat M, Goldsmith DR, Woolwine BJ, Haroon E, Miller AH, Felger JC. Bekhbat M, et al. Among authors: miller ah, felger jc. Mol Psychiatry. 2021 Dec;26(12):7384-7392. doi: 10.1038/s41380-021-01258-z. Epub 2021 Sep 17. Mol Psychiatry. 2021. PMID: 34535767 Free PMC article.
Unsupervised clustering in the primary cohort revealed two psychomotor slowing-associated gene co-expression modules that were enriched for interferon, interleukin-6, aerobic glycolysis, and oxidative phosphorylation pathways (p < 0.05, q < 0.1). ...
Unsupervised clustering in the primary cohort revealed two psychomotor slowing-associated gene co-expression modules that were enriched for …
Tyrosine metabolism during interferon-alpha administration: association with fatigue and CSF dopamine concentrations.
Felger JC, Li L, Marvar PJ, Woolwine BJ, Harrison DG, Raison CL, Miller AH. Felger JC, et al. Among authors: miller ah. Brain Behav Immun. 2013 Jul;31:153-60. doi: 10.1016/j.bbi.2012.10.010. Epub 2012 Oct 13. Brain Behav Immun. 2013. PMID: 23072726 Free PMC article.
Chronic exposure to interferon (IFN)-alpha, an innate immune cytokine, produces high rates of behavioral disturbances, including depression and fatigue. ...
Chronic exposure to interferon (IFN)-alpha, an innate immune cytokine, produces high rates of behavioral disturbances, including depr …
Interferon-alpha-induced inflammation is associated with reduced glucocorticoid negative feedback sensitivity and depression in patients with hepatitis C virus.
Felger JC, Haroon E, Woolwine BJ, Raison CL, Miller AH. Felger JC, et al. Among authors: miller ah. Physiol Behav. 2016 Nov 1;166:14-21. doi: 10.1016/j.physbeh.2015.12.013. Epub 2015 Dec 17. Physiol Behav. 2016. PMID: 26703235 Free PMC article.
We previously reported that patients with hepatitis C virus chronically administered interferon (IFN)-alpha develop increased evening plasma cortisol concentrations and a flattened diurnal cortisol slope, which correlated with increased tumor necrosis factor (TNF) and its …
We previously reported that patients with hepatitis C virus chronically administered interferon (IFN)-alpha develop increased evening …
Effects of interferon-alpha on rhesus monkeys: a nonhuman primate model of cytokine-induced depression.
Felger JC, Alagbe O, Hu F, Mook D, Freeman AA, Sanchez MM, Kalin NH, Ratti E, Nemeroff CB, Miller AH. Felger JC, et al. Among authors: miller ah. Biol Psychiatry. 2007 Dec 1;62(11):1324-33. doi: 10.1016/j.biopsych.2007.05.026. Epub 2007 Aug 2. Biol Psychiatry. 2007. PMID: 17678633 Free PMC article.
BACKGROUND: Interferon (IFN)-alpha is an innate immune cytokine that causes high rates of depression in humans and therefore has been used to study the impact of cytokines on the brain and behavior. ...
BACKGROUND: Interferon (IFN)-alpha is an innate immune cytokine that causes high rates of depression in humans and therefore has been …
Molecular signatures of peripheral blood mononuclear cells during chronic interferon-alpha treatment: relationship with depression and fatigue.
Felger JC, Cole SW, Pace TW, Hu F, Woolwine BJ, Doho GH, Raison CL, Miller AH. Felger JC, et al. Among authors: miller ah. Psychol Med. 2012 Aug;42(8):1591-603. doi: 10.1017/S0033291711002868. Epub 2011 Dec 9. Psychol Med. 2012. PMID: 22152193 Free PMC article. Clinical Trial.
BACKGROUND: Interferon-alpha (IFN-alpha) treatment for infectious disease and cancer causes high rates of depression and fatigue, and has been used to investigate the impact of inflammatory cytokines on brain and behavior. ...
BACKGROUND: Interferon-alpha (IFN-alpha) treatment for infectious disease and cancer causes high rates of depression and fatigue, and …
Early activation of p38 mitogen activated protein kinase is associated with interferon-alpha-induced depression and fatigue.
Felger JC, Alagbe O, Pace TW, Woolwine BJ, Hu F, Raison CL, Miller AH. Felger JC, et al. Among authors: miller ah. Brain Behav Immun. 2011 Aug;25(6):1094-8. doi: 10.1016/j.bbi.2011.02.015. Epub 2011 Feb 26. Brain Behav Immun. 2011. PMID: 21356304 Free PMC article. Clinical Trial.
Cytokine-induced stimulation of p38 mitogen activated protein kinase (MAPK) has been shown to influence behaviorally-relevant pathophysiologic pathways including monoamine neurotransmission and neuroendocrine function and thus may contribute to behavioral changes that occur durin …
Cytokine-induced stimulation of p38 mitogen activated protein kinase (MAPK) has been shown to influence behaviorally-relevant pathophysiolog …
Chronic interferon-alpha decreases dopamine 2 receptor binding and striatal dopamine release in association with anhedonia-like behavior in nonhuman primates.
Felger JC, Mun J, Kimmel HL, Nye JA, Drake DF, Hernandez CR, Freeman AA, Rye DB, Goodman MM, Howell LL, Miller AH. Felger JC, et al. Among authors: miller ah. Neuropsychopharmacology. 2013 Oct;38(11):2179-87. doi: 10.1038/npp.2013.115. Epub 2013 May 9. Neuropsychopharmacology. 2013. PMID: 23657438 Free PMC article.
To further examine cytokine effects on striatal DA function, eight rhesus monkeys (four male, four female) were administered interferon (IFN)-alpha (20 MIU/m(2) s.c.) or saline for 4 weeks. In vivo microdialysis was used to investigate IFN-alpha effects on DA release in th …
To further examine cytokine effects on striatal DA function, eight rhesus monkeys (four male, four female) were administered interferon …
12 results