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Page 1
Iron superoxide dismutase contributes to miltefosine resistance in Leishmania donovani.
Veronica J, Chandrasekaran S, Dayakar A, Devender M, Prajapati VK, Sundar S, Maurya R. Veronica J, et al. FEBS J. 2019 Sep;286(17):3488-3503. doi: 10.1111/febs.14923. Epub 2019 Jun 1. FEBS J. 2019. PMID: 31087522 Free article.
The present study used high-throughput proteomics to determine whether proteins are differentially expressed in miltefosine-resistant (BHU875) and -sensitive (DD8) Leishmania donovani strains. Comparative proteomic analysis revealed up-regulation of ir …
The present study used high-throughput proteomics to determine whether proteins are differentially expressed in miltefosine-resist …
Leishmania donovani chaperonin TCP1gamma subunit protects miltefosine induced oxidative damage.
Yadav S, Ali V, Singh Y, Kanojia S, Goyal N. Yadav S, et al. Int J Biol Macromol. 2020 Dec 15;165(Pt B):2607-2620. doi: 10.1016/j.ijbiomac.2020.10.134. Epub 2020 Oct 22. Int J Biol Macromol. 2020. PMID: 33736277
T-complex protein-1 (TCP1) is a chaperonin protein known to fold various proteins like actin and tubulin. In Leishmania donovani only one subunit of TCP1 that is gamma subunit (LdTCP1gamma) has been functionally characterized. ...The present work demonstrates that L …
T-complex protein-1 (TCP1) is a chaperonin protein known to fold various proteins like actin and tubulin. In Leishmania donovani …
The drug resistance mechanisms in Leishmania donovani are independent of immunosuppression.
Saha B, Pai K, Sundar S, Bhattacharyya M, Bodhale NP. Saha B, et al. Cytokine. 2021 Sep;145:155300. doi: 10.1016/j.cyto.2020.155300. Epub 2020 Sep 23. Cytokine. 2021. PMID: 32978033
As immuno-suppression characterizes the disease, we examined whether eliciting immunosuppressive cytokines is a mechanism of manifestation of drug-resistance. We infected BALB/c mice with the clinical isolates of L. donovani- BHU1066 (sensitive), NS2 (antimony-re …
As immuno-suppression characterizes the disease, we examined whether eliciting immunosuppressive cytokines is a mechanism of manifestation o …
Natural Resistance of Leishmania infantum to Miltefosine Contributes to the Low Efficacy in the Treatment of Visceral Leishmaniasis in Brazil.
Carnielli JBT, Monti-Rocha R, Costa DL, Molina Sesana A, Pansini LNN, Segatto M, Mottram JC, Costa CHN, Carvalho SFG, Dietze R. Carnielli JBT, et al. Am J Trop Med Hyg. 2019 Oct;101(4):789-794. doi: 10.4269/ajtmh.18-0949. Am J Trop Med Hyg. 2019. PMID: 31436148 Free PMC article. Clinical Trial.
In India, visceral leishmaniasis (VL) caused by Leishmania donovani has been successfully treated with miltefosine with a cure rate of > 90%. ...The finding of L. infantum amastigotes resistant to miltefosine in isolates from patients who eve …
In India, visceral leishmaniasis (VL) caused by Leishmania donovani has been successfully treated with miltefosine with …
Phenotypic adaptations of Leishmania donovani to recurrent miltefosine exposure and impact on sand fly infection.
Hendrickx S, Van Bockstal L, Bulté D, Mondelaers A, Aslan H, Rivas L, Maes L, Caljon G. Hendrickx S, et al. Parasit Vectors. 2020 Feb 22;13(1):96. doi: 10.1186/s13071-020-3972-z. Parasit Vectors. 2020. PMID: 32087758 Free PMC article.
BACKGROUND: Since the introduction of miltefosine (MIL) as first-line therapy in the kala-azar elimination programme in the Indian subcontinent, treatment failure rates have been increasing. Since parasite infectivity and virulence may become altered upon treatment relapse …
BACKGROUND: Since the introduction of miltefosine (MIL) as first-line therapy in the kala-azar elimination programme in the Indian su …
A mitochondrial HSP70 (HSPA9B) is linked to miltefosine resistance and stress response in Leishmania donovani.
Vacchina P, Norris-Mullins B, Carlson ES, Morales MA. Vacchina P, et al. Parasit Vectors. 2016 Dec 1;9(1):621. doi: 10.1186/s13071-016-1904-8. Parasit Vectors. 2016. PMID: 27906059 Free PMC article.
Visceral leishmaniasis (VL), caused by Leishmania donovani, is the most severe form of leishmaniasis with high rates of mortality if left untreated. ...METHODS: 2D-DIGE quantitative proteomics comparing the soluble proteomes of sensitive and HePC resistant L. …
Visceral leishmaniasis (VL), caused by Leishmania donovani, is the most severe form of leishmaniasis with high rates of mortal …
A Novel Bioimpedance-Based Detection of Miltefosine Susceptibility Among Clinical Leishmania donovani Isolates of the Indian Subcontinent Exhibiting Resistance to Multiple Drugs.
Ghosh S, Biswas S, Mukherjee S, Pal A, Saxena A, Sundar S, Dujardin JC, Das S, Roy S, Mukhopadhyay R, Mukherjee B. Ghosh S, et al. Front Cell Infect Microbiol. 2021 Nov 29;11:768830. doi: 10.3389/fcimb.2021.768830. eCollection 2021. Front Cell Infect Microbiol. 2021. PMID: 34912730 Free PMC article.
The extent of susceptibility towards miltefosine (Mil), amphotericin B (AmpB), and paromomycin (Paro) was measured among 19 clinical isolates of Leishmania donovani (LD). ...Impedance spectra analysis, which quantifies membrane resistance, revealed low …
The extent of susceptibility towards miltefosine (Mil), amphotericin B (AmpB), and paromomycin (Paro) was measured among 19 clinical …
Leishmania donovani resistance to miltefosine involves a defective inward translocation of the drug.
Pérez-Victoria FJ, Castanys S, Gamarro F. Pérez-Victoria FJ, et al. Antimicrob Agents Chemother. 2003 Aug;47(8):2397-403. doi: 10.1128/AAC.47.8.2397-2403.2003. Antimicrob Agents Chemother. 2003. PMID: 12878496 Free PMC article.
As part of a study on the mechanisms of action of this drug and on the rates of resistance to this drug, we have been working in vitro with an Leishmania donovani line that was previously shown to be 15-fold more resistant to HePC. We have studied the …
As part of a study on the mechanisms of action of this drug and on the rates of resistance to this drug, we have been working in vitr …
Miltefosine resistance in Leishmania donovani involves suppression of oxidative stress-induced programmed cell death.
Mishra J, Singh S. Mishra J, et al. Exp Parasitol. 2013 Oct;135(2):397-406. doi: 10.1016/j.exppara.2013.08.004. Epub 2013 Aug 19. Exp Parasitol. 2013. PMID: 23968687
But due to its long half-life, miltefosine is highly vulnerable for resistance. Hence it is important to understand the mechanism of resistance and to elucidate its action on Leishmania. Here we investigate the miltefosine induced process of pro …
But due to its long half-life, miltefosine is highly vulnerable for resistance. Hence it is important to understand the mechan …
In Vivo Selection of Paromomycin and Miltefosine Resistance in Leishmania donovani and L. infantum in a Syrian Hamster Model.
Hendrickx S, Mondelaers A, Eberhardt E, Delputte P, Cos P, Maes L. Hendrickx S, et al. Antimicrob Agents Chemother. 2015 Aug;59(8):4714-8. doi: 10.1128/AAC.00707-15. Epub 2015 May 26. Antimicrob Agents Chemother. 2015. PMID: 26014955 Free PMC article.
In 2002 and 2006, respectively, miltefosine (MIL) and paromomycin (PMM) were licensed in the Indian subcontinent for treatment of visceral leishmaniasis; however, their future routine use might become jeopardized by the development of drug resistance. ...To corrobor …
In 2002 and 2006, respectively, miltefosine (MIL) and paromomycin (PMM) were licensed in the Indian subcontinent for treatment of vis …
169 results