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2,324 results

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Page 1
Effect of a U:G mispair on the water around DNA.
Mardt A, Gorriz RF, Ferraro F, Ulrich P, Zahran M, Imhof P. Mardt A, et al. Biophys Chem. 2022 Apr;283:106779. doi: 10.1016/j.bpc.2022.106779. Epub 2022 Feb 17. Biophys Chem. 2022. PMID: 35217480
To investigate detectable characteristics of one specific lesion, we compare statistical results from molecular dynamics simulations of two different DNA in water, one with an intact C:G pair and one that contains a U:G mispair, and perform a comparative analysis of the wa …
To investigate detectable characteristics of one specific lesion, we compare statistical results from molecular dynamics simulations of two …
Redundant mispair excision mechanisms in eukaryotic DNA mismatch repair.
Putnam CD, Kolodner RD. Putnam CD, et al. Nucleus. 2026 Dec;17(1):2741514. doi: 10.1080/19491034.2026.2741514. Epub 2026 Oct 4. Nucleus. 2026. PMID: 42830602 Free PMC article. Review.
In the first excision pathway identified, Saccharomyces cerevisiae Msh2-Msh6 (or Msh2-Msh3) and/or Mlh1-Pms1 (human MLH1-PMS2) recruit Exo1 to 5' nicks, and 5'-to-3' excision by Exo1 excises the daughter strand containing the mispair to generate a single-stranded gap. The …
In the first excision pathway identified, Saccharomyces cerevisiae Msh2-Msh6 (or Msh2-Msh3) and/or Mlh1-Pms1 (human MLH1-PMS2) recruit Exo1 …
Mispair formation in DNA can involve rare tautomeric forms in the template.
Strazewski P. Strazewski P. Nucleic Acids Res. 1988 Oct 25;16(20):9377-98. doi: 10.1093/nar/16.20.9377. Nucleic Acids Res. 1988. PMID: 3054806 Free PMC article. Review.
The formation of pyridine-pyrimidine- and pyrimidine-pyrimidine base pairs after in vitro DNA replication with the large fragment of Escherichia coli DNA polymerase I indicates that Watson-Crick-like base pairing between pyrimidine bases can occur in the enzyme due to the presenc …
The formation of pyridine-pyrimidine- and pyrimidine-pyrimidine base pairs after in vitro DNA replication with the large fragment of Escheri …
Mispair-bound human MutS-MutL complex triggers DNA incisions and activates mismatch repair.
Ortega J, Lee GS, Gu L, Yang W, Li GM. Ortega J, et al. Cell Res. 2021 May;31(5):542-553. doi: 10.1038/s41422-021-00468-y. Epub 2021 Jan 28. Cell Res. 2021. PMID: 33510387 Free PMC article.
DNA mismatch repair (MMR) relies on MutS and MutL ATPases for mismatch recognition and strand-specific nuclease recruitment to remove mispaired bases in daughter strands. However, whether the MutS-MutL complex coordinates MMR by ATP-dependent sliding on DNA or protein-prot …
DNA mismatch repair (MMR) relies on MutS and MutL ATPases for mismatch recognition and strand-specific nuclease recruitment to remove mis …
Mispair-specific recruitment of the Mlh1-Pms1 complex identifies repair substrates of the Saccharomyces cerevisiae Msh2-Msh3 complex.
Srivatsan A, Bowen N, Kolodner RD. Srivatsan A, et al. J Biol Chem. 2014 Mar 28;289(13):9352-64. doi: 10.1074/jbc.M114.552190. Epub 2014 Feb 18. J Biol Chem. 2014. PMID: 24550389 Free PMC article.
Msh2-Msh3 formed sliding clamps and recruited Mlh1-Pms1 on +1, +2, +3, and +4 insertion/deletions and CC, AA, and possibly GG mispairs, whereas Msh2-Msh6 formed mispair-dependent sliding clamps and recruited Mlh1-Pms1 on 7 of the 8 possible base:base mispairs …
Msh2-Msh3 formed sliding clamps and recruited Mlh1-Pms1 on +1, +2, +3, and +4 insertion/deletions and CC, AA, and possibly GG mispairs …
Mispair specificity of methyl-directed DNA mismatch correction in vitro.
Su SS, Lahue RS, Au KG, Modrich P. Su SS, et al. J Biol Chem. 1988 May 15;263(14):6829-35. J Biol Chem. 1988. PMID: 2834393 Free article.
G-T was corrected most efficiently, with A-C, C-T, A-A, T-T, and G-G being repaired at rates 40-80% of that of the G-T mispair. Correction of each of these six mispairs occurred in a methyl-directed manner in a reaction requiring mutH, mutL, and mutS gene products. …
G-T was corrected most efficiently, with A-C, C-T, A-A, T-T, and G-G being repaired at rates 40-80% of that of the G-T mispair. Corre …
Postreplicative mismatch repair.
Jiricny J. Jiricny J. Cold Spring Harb Perspect Biol. 2013 Apr 1;5(4):a012633. doi: 10.1101/cshperspect.a012633. Cold Spring Harb Perspect Biol. 2013. PMID: 23545421 Free PMC article. Review.
The mismatch repair (MMR) system detects non-Watson-Crick base pairs and strand misalignments arising during DNA replication and mediates their removal by catalyzing excision of the mispair-containing tract of nascent DNA and its error-free resynthesis. In this way, MMR im …
The mismatch repair (MMR) system detects non-Watson-Crick base pairs and strand misalignments arising during DNA replication and mediates th …
Environmental Effects on Guanine-Thymine Mispair Tautomerization Explored with Quantum Mechanical/Molecular Mechanical Free Energy Simulations.
Li P, Rangadurai A, Al-Hashimi HM, Hammes-Schiffer S. Li P, et al. J Am Chem Soc. 2020 Jun 24;142(25):11183-11191. doi: 10.1021/jacs.0c03774. Epub 2020 Jun 11. J Am Chem Soc. 2020. PMID: 32459476 Free PMC article.
Previous NMR and computational studies have indicated that the population of WC-like guanine-thymine (G-T) mispairs depends on the environment, such as the local nucleic acid sequence and solvation. ...These studies highlight the impact of the environment on the thermodyna …
Previous NMR and computational studies have indicated that the population of WC-like guanine-thymine (G-T) mispairs depends on the en …
Fidelity of mispair formation and mispair extension is dependent on the interaction between the minor groove of the primer terminus and Arg668 of DNA polymerase I of Escherichia coli.
McCain MD, Meyer AS, Schultz SS, Glekas A, Spratt TE. McCain MD, et al. Biochemistry. 2005 Apr 19;44(15):5647-59. doi: 10.1021/bi047460f. Biochemistry. 2005. PMID: 15823023
The G to 3DG substitution at the primer terminus also decreased the formation of correct base pairs as well as incorrect base pairs. However, in all but two mispairs, the effect on correct base pairs was much greater than that of mispairs. These results indicate tha …
The G to 3DG substitution at the primer terminus also decreased the formation of correct base pairs as well as incorrect base pairs. However …
Non-canonical actions of mismatch repair.
Crouse GF. Crouse GF. DNA Repair (Amst). 2016 Feb;38:102-109. doi: 10.1016/j.dnarep.2015.11.020. Epub 2015 Dec 2. DNA Repair (Amst). 2016. PMID: 26698648 Free PMC article. Review.
When such mispairs are generated during replication or recombination, MMR will direct removal of an incorrectly paired base or block recombination between nonidentical sequences. However, when mispairs are recognized outside the context of replication, proper strand …
When such mispairs are generated during replication or recombination, MMR will direct removal of an incorrectly paired base or block …
2,324 results