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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1948 2
1954 1
1955 1
1959 1
1962 2
1963 2
1965 1
1968 2
1969 4
1971 2
1972 3
1974 3
1975 9
1976 13
1977 6
1978 6
1979 7
1980 12
1981 14
1982 10
1983 21
1984 24
1985 33
1986 25
1987 35
1988 37
1989 54
1990 46
1991 53
1992 55
1993 61
1994 74
1995 60
1996 61
1997 77
1998 86
1999 84
2000 87
2001 92
2002 90
2003 89
2004 79
2005 65
2006 75
2007 82
2008 64
2009 74
2010 76
2011 64
2012 78
2013 77
2014 77
2015 73
2016 64
2017 53
2018 53
2019 53
2020 70
2021 61
2022 55
2023 54
2024 47
2025 42
2026 54
2027 2

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2,676 results

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Page 1
BRCA1 safeguards genome integrity by activating chromosome asynapsis checkpoint to eliminate recombination-defective oocytes.
Bai L, Li P, Xiang Y, Jiao X, Chen J, Song L, Liang Z, Liu Y, Zhu Y, Lu LY. Bai L, et al. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2401386121. doi: 10.1073/pnas.2401386121. Epub 2024 May 2. Proc Natl Acad Sci U S A. 2024. PMID: 38696471 Free PMC article.
Mechanistically, BRCA1 activates chromosome asynapsis checkpoint by promoting ATR activity at unsynapsed chromosome axes in Dmc1 KO oocytes. ...Collectively, our study not only unveils an unappreciated role of chromosome asynapsis in eliminating recombination-defect …
Mechanistically, BRCA1 activates chromosome asynapsis checkpoint by promoting ATR activity at unsynapsed chromosome axes in Dmc1 KO o …
Speedy A governs non-homologous XY chromosome desynapsis as a unique prerequisite for XY loop-axis organization.
Liu D, Zhang Y, Li D, Jiang B, Zhao X, Li Y, Lin Z, Zhao Y, Hu Z, Deng S, Li Z, Lu H, Chan KKL, Yeung WSB, Kaldis P, Yao C, Wang H, Chow LT, Liu K. Liu D, et al. EMBO J. 2025 Oct;44(19):5509-5536. doi: 10.1038/s44318-025-00528-8. Epub 2025 Aug 18. EMBO J. 2025. PMID: 40826181 Free PMC article.
Mechanistic studies revealed that Serine 48 of SUN1 is a key SpdyA/CDK2 phosphorylation site required for Y-X NH desynapsis. We propose that SpdyA governs Y-X NH desynapsis by stabilizing the linkage between the X-Y non-PAR telomeres and their LINC complexes, and th …
Mechanistic studies revealed that Serine 48 of SUN1 is a key SpdyA/CDK2 phosphorylation site required for Y-X NH desynapsis. We propo …
Postreplicative mismatch repair.
Jiricny J. Jiricny J. Cold Spring Harb Perspect Biol. 2013 Apr 1;5(4):a012633. doi: 10.1101/cshperspect.a012633. Cold Spring Harb Perspect Biol. 2013. PMID: 23545421 Free PMC article. Review.
The mismatch repair (MMR) system detects non-Watson-Crick base pairs and strand misalignments arising during DNA replication and mediates their removal by catalyzing excision of the mispair-containing tract of nascent DNA and its error-free resynthesis. In this way, MMR im …
The mismatch repair (MMR) system detects non-Watson-Crick base pairs and strand misalignments arising during DNA replication and mediates th …
Aberrant activation of chromosome asynapsis checkpoint triggers oocyte elimination.
Jiao X, Liang Z, Li J, Bai L, Xu J, Liu Y, Lu LY. Jiao X, et al. Nat Commun. 2025 Mar 6;16(1):2260. doi: 10.1038/s41467-025-57702-z. Nat Commun. 2025. PMID: 40050306 Free PMC article.
HORMAD1 and HORMAD2, which monitor chromosome asynapsis by localizing to unsynapsed chromosome axes, are removed from synapsed chromosome axes by TRIP13, though the biological significance of this process remains unclear. ...Collectively, the TRIP13-dependent removal of HO …
HORMAD1 and HORMAD2, which monitor chromosome asynapsis by localizing to unsynapsed chromosome axes, are removed from synapsed chromo …
Thymine DNA glycosylase.
Hardeland U, Bentele M, Lettieri T, Steinacher R, Jiricny J, Schär P. Hardeland U, et al. Prog Nucleic Acid Res Mol Biol. 2001;68:235-53. doi: 10.1016/s0079-6603(01)68103-0. Prog Nucleic Acid Res Mol Biol. 2001. PMID: 11554300 Review.
This deamination process gives rise to G.T mispairs that need to be repaired to G.C in order to avoid C-->T mutation. Similarly, deamination of cytosine generates G.U mispairs that also produce C-->T transitions if not repaired. ...Human TDG was discovered as …
This deamination process gives rise to G.T mispairs that need to be repaired to G.C in order to avoid C-->T mutation. Similarly, d …
Non-canonical actions of mismatch repair.
Crouse GF. Crouse GF. DNA Repair (Amst). 2016 Feb;38:102-109. doi: 10.1016/j.dnarep.2015.11.020. Epub 2015 Dec 2. DNA Repair (Amst). 2016. PMID: 26698648 Free PMC article. Review.
When such mispairs are generated during replication or recombination, MMR will direct removal of an incorrectly paired base or block recombination between nonidentical sequences. However, when mispairs are recognized outside the context of replication, proper strand …
When such mispairs are generated during replication or recombination, MMR will direct removal of an incorrectly paired base or block …
The consequences of asynapsis for mammalian meiosis.
Burgoyne PS, Mahadevaiah SK, Turner JM. Burgoyne PS, et al. Nat Rev Genet. 2009 Mar;10(3):207-16. doi: 10.1038/nrg2505. Nat Rev Genet. 2009. PMID: 19188923 Review.
Recently it was discovered that the chromatin of asynapsed chromosome segments is transcriptionally silenced, providing new insights into the connection between asynapsis and meiotic impairment....
Recently it was discovered that the chromatin of asynapsed chromosome segments is transcriptionally silenced, providing new insights into th …
Msh2-Msh3 DNA-binding is not sufficient to promote trinucleotide repeat expansions in Saccharomyces cerevisiae.
Casazza KM, Williams GM, Johengen L, Twoey G, Surtees JA. Casazza KM, et al. Genetics. 2025 Mar 17;229(3):iyae222. doi: 10.1093/genetics/iyae222. Genetics. 2025. PMID: 39790027 Free PMC article.
Mismatch repair (MMR) is a highly conserved DNA repair pathway that recognizes mispairs that occur spontaneously during DNA replication and coordinates their repair. In Saccharomyces cerevisiae, Msh2-Msh3 and Msh2-Msh6 initiate MMR by recognizing and binding insertion or d …
Mismatch repair (MMR) is a highly conserved DNA repair pathway that recognizes mispairs that occur spontaneously during DNA replicati …
Exonuclease 1-dependent and independent mismatch repair.
Goellner EM, Putnam CD, Kolodner RD. Goellner EM, et al. DNA Repair (Amst). 2015 Aug;32:24-32. doi: 10.1016/j.dnarep.2015.04.010. Epub 2015 Apr 30. DNA Repair (Amst). 2015. PMID: 25956862 Free PMC article. Review.
DNA mismatch repair (MMR) acts to repair mispaired bases resulting from misincorporation errors during DNA replication and also recognizes mispaired bases in recombination (HR) intermediates. ...Exo1 was identified as an exonuclease that participates in Saccharomyce …
DNA mismatch repair (MMR) acts to repair mispaired bases resulting from misincorporation errors during DNA replication and also recog …
A Role for N6-Methyladenine in DNA Damage Repair.
Zhang X, Blumenthal RM, Cheng X. Zhang X, et al. Trends Biochem Sci. 2021 Mar;46(3):175-183. doi: 10.1016/j.tibs.2020.09.007. Epub 2020 Oct 16. Trends Biochem Sci. 2021. PMID: 33077363 Free PMC article. Review.
The leading cause of mutation due to oxidative damage is 8-oxo-2'-deoxyguanosine (8-oxoG) mispairing with adenine (Ade), which can occur in two ways. First, guanine of a G:C DNA base pair can be oxidized. If not repaired in time, DNA polymerases can mispair Ade with …
The leading cause of mutation due to oxidative damage is 8-oxo-2'-deoxyguanosine (8-oxoG) mispairing with adenine (Ade), which can oc …
2,676 results