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Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism.
Boss O, Hagen T, Lowell BB. Boss O, et al. Diabetes. 2000 Feb;49(2):143-56. doi: 10.2337/diabetes.49.2.143. Diabetes. 2000. PMID: 10868929 Review.
Mitochondria use energy derived from fuel combustion to create a proton electrochemical gradient across the mitochondrial inner membrane. This intermediate form of energy is then used by ATP synthase to synthesize ATP. Uncoupling protein-1 …
Mitochondria use energy derived from fuel combustion to create a proton electrochemical gradient across the mitochondrial inne …
UCP1: the original uncoupling protein--and perhaps the only one? New perspectives on UCP1, UCP2, and UCP3 in the light of the bioenergetics of the UCP1-ablated mice.
Nedergaard J, Matthias A, Golozoubova V, Jacobsson A, Cannon B. Nedergaard J, et al. J Bioenerg Biomembr. 1999 Oct;31(5):475-91. doi: 10.1023/a:1005400507802. J Bioenerg Biomembr. 1999. PMID: 10653476 Review.
The availability of a UCP1-ablated mouse has enabled critical studies of the function of UCP1, UCP2, and UCP3. Concerning UCP1, its presence in brown-fat mitochondria is associated with innate uncoupling, high GDP-binding capacity, and GDP-inhibitable Cl- permeabili …
The availability of a UCP1-ablated mouse has enabled critical studies of the function of UCP1, UCP2, and UCP3. Concerning UCP1, its presence …
Cloning and functional characterization of an uncoupling protein homolog in hummingbirds.
Vianna CR, Hagen T, Zhang CY, Bachman E, Boss O, Gereben B, Moriscot AS, Lowell BB, Bicudo JE, Bianco AC. Vianna CR, et al. Physiol Genomics. 2001 Apr 2;5(3):137-45. doi: 10.1152/physiolgenomics.2001.5.3.137. Physiol Genomics. 2001. PMID: 11285367
The uncoupling activity of this novel protein was characterized in yeast. ...Similarly to rat UCP1, HmUCP decreased the mitochondrial membrane potential as measured in whole yeast by uptake of the fluorescent potential-sensitive dye 3 …
The uncoupling activity of this novel protein was characterized in yeast. ...Similarly to rat UCP1, HmUCP decreased the mit …
Respiration under control of uncoupling proteins: Clinical perspective.
Nübel T, Ricquier D. Nübel T, et al. Horm Res. 2006;65(6):300-10. doi: 10.1159/000092847. Horm Res. 2006. PMID: 16641553 Free article. Review.
The term 'uncoupling protein' was originally used for the mitochondrial membrane protein UCP1, which is uniquely present in mitochondria of brown adipocytes, thermogenic cells that regulate body temperature in small rodents, hibernators a …
The term 'uncoupling protein' was originally used for the mitochondrial membrane protein UCP1, which is u …
[Role of novel mitochondrial proteins in energy balance].
Zorzano A, Bach D, Pich S, Palacín M. Zorzano A, et al. Rev Med Univ Navarra. 2004 Apr-Jun;48(2):30-5. Rev Med Univ Navarra. 2004. PMID: 15382611 Review. Spanish.
Mitochondrial activity plays a key role in the control of thermogenesis and energy expenditure in homeothermic organisms. ...The demonstration that mitofusin-2, a protein involved in mitochondrial fusion, stimulates the mitochondrial oxidation o …
Mitochondrial activity plays a key role in the control of thermogenesis and energy expenditure in homeothermic organisms. ...T …
Perspectives on the biology of uncoupling protein (UCP) homologues.
Adams SH, Pan G, Yu XX. Adams SH, et al. Biochem Soc Trans. 2001 Nov;29(Pt 6):798-802. doi: 10.1042/0300-5127:0290798. Biochem Soc Trans. 2001. PMID: 11709077 Review.
In mammals, it is believed that a portion of tissue metabolic rate is driven by counteraction of uncoupling, in which the energetically inefficient process of proton leak acts to diminish the mitochondrial electrochemical membrane potential. It is prop …
In mammals, it is believed that a portion of tissue metabolic rate is driven by counteraction of uncoupling, in which the energetical …
Differential regulation of uncoupling protein gene homologues in multiple tissues of hibernating ground squirrels.
Boyer BB, Barnes BM, Lowell BB, Grujic D. Boyer BB, et al. Am J Physiol. 1998 Oct;275(4):R1232-8. doi: 10.1152/ajpregu.1998.275.4.R1232. Am J Physiol. 1998. PMID: 9756555
Nonshivering thermogenesis in brown adipose tissue (BAT) provides heat through activation of a mitochondrial uncoupling protein (UCP1), which causes futile electron transport cycles without the production of ATP. ...Here we report significant increases …
Nonshivering thermogenesis in brown adipose tissue (BAT) provides heat through activation of a mitochondrial uncoupling …
Cold tolerance of UCP1-ablated mice: a skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects.
Shabalina IG, Hoeks J, Kramarova TV, Schrauwen P, Cannon B, Nedergaard J. Shabalina IG, et al. Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):968-80. doi: 10.1016/j.bbabio.2010.02.033. Epub 2010 Mar 19. Biochim Biophys Acta. 2010. PMID: 20227385 Free article.
Mice lacking the thermogenic mitochondrial membrane protein UCP1 (uncoupling protein 1)--and thus all heat production from brown adipose tissue--can still adapt to a cold environment (4 degrees C) if successively transferred to the cold. …
Mice lacking the thermogenic mitochondrial membrane protein UCP1 (uncoupling protein 1)--and thus …
Thermogenic responses in brown fat cells are fully UCP1-dependent. UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty scid-induced thermogenesis.
Matthias A, Ohlson KB, Fredriksson JM, Jacobsson A, Nedergaard J, Cannon B. Matthias A, et al. J Biol Chem. 2000 Aug 18;275(33):25073-81. doi: 10.1074/jbc.M000547200. J Biol Chem. 2000. PMID: 10825155 Free article.
To examine the thermogenic significance of the classical uncoupling protein-1 (UCP1), the thermogenic potential of brown adipocytes isolated from UCP1-ablated mice was investigated. ...Thus, UCP1 remains the only physiologically potent thermogenic u …
To examine the thermogenic significance of the classical uncoupling protein-1 (UCP1), the thermogenic potential …