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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1913 1
1914 1
1915 1
1916 1
1918 2
1920 1
1921 3
1922 1
1923 3
1924 3
1925 2
1926 1
1927 2
1929 1
1930 1
1931 3
1932 1
1933 3
1935 2
1937 1
1939 1
1943 1
1944 1
1945 4
1946 6
1947 9
1948 12
1949 15
1950 23
1951 36
1952 49
1953 107
1954 90
1955 104
1956 167
1957 173
1958 161
1959 219
1960 275
1961 288
1962 346
1963 597
1964 945
1965 965
1966 1207
1967 1618
1968 1914
1969 2237
1970 2484
1971 2851
1972 3199
1973 3354
1974 3216
1975 3304
1976 2941
1977 2822
1978 2671
1979 2873
1980 2866
1981 2656
1982 2906
1983 2994
1984 3158
1985 3172
1986 3108
1987 3030
1988 3107
1989 3482
1990 3575
1991 3515
1992 3551
1993 3695
1994 3710
1995 3958
1996 4138
1997 4182
1998 4738
1999 4898
2000 5721
2001 6518
2002 6935
2003 7393
2004 8474
2005 8889
2006 9592
2007 10428
2008 10838
2009 11534
2010 12697
2011 13417
2012 14783
2013 15974
2014 17515
2015 18310
2016 19878
2017 19217
2018 19830
2019 21591
2020 23809
2021 25581
2022 24802
2023 24362
2024 26568
2025 32362
2026 18167

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32,362 results

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Page 1
Mitochondrial diseases: from molecular mechanisms to therapeutic advances.
Wen H, Deng H, Li B, Chen J, Zhu J, Zhang X, Yoshida S, Zhou Y. Wen H, et al. Signal Transduct Target Ther. 2025 Jan 10;10(1):9. doi: 10.1038/s41392-024-02044-3. Signal Transduct Target Ther. 2025. PMID: 39788934 Free PMC article. Review.
These genetic defects can lead to a breakdown of mitochondrial function and metabolism, such as the collapse of oxidative phosphorylation, one of the mitochondria's most critical functions. ...However, recent advancements in research and technology have significantl …
These genetic defects can lead to a breakdown of mitochondrial function and metabolism, such as the collapse of oxidative phosphoryla …
Mitochondrial metabolism and cancer therapeutic innovation.
Du H, Xu T, Yu S, Wu S, Zhang J. Du H, et al. Signal Transduct Target Ther. 2025 Aug 4;10(1):245. doi: 10.1038/s41392-025-02311-x. Signal Transduct Target Ther. 2025. PMID: 40754534 Free PMC article. Review.
Advances in mitochondrial genome editing, proteomics, and circulating mitochondrial DNA analysis have enhanced tumor diagnostic precision. This review synthesizes the developmental landscape of mitochondrial research in cancer, comprehensively summarizing …
Advances in mitochondrial genome editing, proteomics, and circulating mitochondrial DNA analysis have enhanced tumor diagnosti …
Mitochondrial Dysfunction in Cardiovascular Diseases.
Yang HM. Yang HM. Int J Mol Sci. 2025 Feb 23;26(5):1917. doi: 10.3390/ijms26051917. Int J Mol Sci. 2025. PMID: 40076543 Free PMC article. Review.
Emerging therapeutic strategies targeting mitochondrial dysfunction, such as mitochondrial antioxidants, metabolic modulators, and gene therapy, are also discussed. By synthesizing recent advances in mitochondrial biology and cardiovascular research, this rev …
Emerging therapeutic strategies targeting mitochondrial dysfunction, such as mitochondrial antioxidants, metabolic modulators, …
Mitochondrial genetics, signalling and stress responses.
Liu YJ, Sulc J, Auwerx J. Liu YJ, et al. Nat Cell Biol. 2025 Mar;27(3):393-407. doi: 10.1038/s41556-025-01625-w. Epub 2025 Mar 10. Nat Cell Biol. 2025. PMID: 40065146 Review.
Genome-editing techniques have been adapted to target mtDNA, further propelling the functional analysis of mitochondrial genes. Mitochondria are finely tuned signalling hubs, a concept that has been expanded by advances in methodologies for studying the function of …
Genome-editing techniques have been adapted to target mtDNA, further propelling the functional analysis of mitochondrial genes. Mi …
Mitochondrial Dysfunction in Genetic and Non-Genetic Parkinson's Disease.
Lucchesi M, Biso L, Bonaso M, Longoni B, Buchignani B, Battini R, Santorelli FM, Doccini S, Scarselli M. Lucchesi M, et al. Int J Mol Sci. 2025 May 7;26(9):4451. doi: 10.3390/ijms26094451. Int J Mol Sci. 2025. PMID: 40362688 Free PMC article. Review.
Atypical juvenile genetic syndromes also exhibit mitochondrial abnormalities. In idiopathic PD, environmental neurotoxins such as pesticides and MPTP act as mitochondrial inhibitors, disrupting complex I activity and increasing reactive oxygen species. These converg …
Atypical juvenile genetic syndromes also exhibit mitochondrial abnormalities. In idiopathic PD, environmental neurotoxins such as pes …
Principles of cotranslational mitochondrial protein import.
Zhu Z, Mallik S, Stevens TA, Huang R, Levy ED, Shan SO. Zhu Z, et al. Cell. 2025 Oct 2;188(20):5605-5617.e14. doi: 10.1016/j.cell.2025.07.021. Epub 2025 Aug 11. Cell. 2025. PMID: 40795856 Free PMC article.
Nearly all mitochondrial proteins are translated on cytosolic ribosomes. How these proteins are subsequently delivered to mitochondria remains poorly understood. Using selective ribosome profiling, we show that nearly 20% of mitochondrial proteins can be impo …
Nearly all mitochondrial proteins are translated on cytosolic ribosomes. How these proteins are subsequently delivered to mitochon …
Mitochondrial DNA damage, repair, and replacement in cancer.
Vodicka P, Vodenkova S, Danesova N, Vodickova L, Zobalova R, Tomasova K, Boukalova S, Berridge MV, Neuzil J. Vodicka P, et al. Trends Cancer. 2025 Jan;11(1):62-73. doi: 10.1016/j.trecan.2024.09.010. Epub 2024 Oct 21. Trends Cancer. 2025. PMID: 39438191 Review.
Mitochondria are vital organelles with their own DNA (mtDNA). mtDNA is circular and composed of heavy and light chains that are structurally more accessible than nuclear DNA (nDNA). ...In this review, we discuss the various forms of mtDNA damage and repair and their associ …
Mitochondria are vital organelles with their own DNA (mtDNA). mtDNA is circular and composed of heavy and light chains that are struc …
Mitochondrial fission - changing perspectives for future progress.
Kamerkar SC, Liu A, Higgs HN. Kamerkar SC, et al. J Cell Sci. 2025 May 1;138(9):jcs263640. doi: 10.1242/jcs.263640. Epub 2025 Mar 19. J Cell Sci. 2025. PMID: 40104946 Free PMC article. Review.
Mitochondrial fission is important for many aspects of cellular homeostasis, including mitochondrial distribution, stress response, mitophagy, mitochondrially derived vesicle production and metabolic regulation. ...First, how do we quantify mitochondrial …
Mitochondrial fission is important for many aspects of cellular homeostasis, including mitochondrial distribution, stress resp …
Mitochondrial Quality Control and Cell Death.
Zhang Z, Zhang M, Jin H, Lv S, Li Y, Li Y. Zhang Z, et al. Int J Mol Sci. 2025 Nov 16;26(22):11084. doi: 10.3390/ijms262211084. Int J Mol Sci. 2025. PMID: 41303566 Free PMC article. Review.
Mitochondrial quality control includes mitochondrial biogenesis, fusion, fission (to maintain mitochondrial function), and mitochondrial autophagy (for removing damaged mitochondria). This is a highly delicate and complex process involving many …
Mitochondrial quality control includes mitochondrial biogenesis, fusion, fission (to maintain mitochondrial function), …
Phase separation in mitochondrial fate and mitochondrial diseases.
Chen Q, An S, Wang C, Zhou Y, Liu X, Ren W. Chen Q, et al. Proc Natl Acad Sci U S A. 2025 May 27;122(21):e2422255122. doi: 10.1073/pnas.2422255122. Epub 2025 May 9. Proc Natl Acad Sci U S A. 2025. PMID: 40344006 Free PMC article. Review.
Mitochondria are central metabolic organelles that control cell fate and the development of mitochondrial diseases. ...Recent studies show that phase separation regulates cell functions and diseases through the regulation of subcellular organelles, particularly m …
Mitochondria are central metabolic organelles that control cell fate and the development of mitochondrial diseases. ...Recent …
32,362 results
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