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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1956 2
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1958 1
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1964 3
1965 10
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1967 32
1968 36
1969 52
1970 52
1971 70
1972 103
1973 138
1974 175
1975 162
1976 155
1977 161
1978 151
1979 222
1980 220
1981 210
1982 234
1983 271
1984 316
1985 315
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1987 388
1988 459
1989 519
1990 601
1991 746
1992 811
1993 965
1994 1095
1995 1247
1996 1353
1997 1355
1998 1531
1999 1641
2000 1917
2001 2217
2002 2316
2003 2382
2004 2783
2005 2921
2006 3051
2007 3245
2008 3292
2009 3522
2010 3797
2011 3946
2012 4392
2013 4754
2014 5561
2015 5534
2016 6636
2017 5036
2018 4785
2019 5459
2020 5524
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112,333 results

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Page 1
Mitochondrial DNA Integrity: Role in Health and Disease.
Sharma P, Sampath H. Sharma P, et al. Cells. 2019 Jan 29;8(2):100. doi: 10.3390/cells8020100. Cells. 2019. PMID: 30700008 Free PMC article. Review.
Yet, by virtue of this very function of respiration, mitochondria are subject to constant oxidative stress that can damage one of the unique features of this organelle, its distinct genome. Damage to mitochondrial DNA (mtDNA) and loss of mitochondrial genome …
Yet, by virtue of this very function of respiration, mitochondria are subject to constant oxidative stress that can damage one of the unique …
Mitochondrial DNA Analysis.
Cooley AM. Cooley AM. Methods Mol Biol. 2023;2685:331-349. doi: 10.1007/978-1-0716-3295-6_20. Methods Mol Biol. 2023. PMID: 37439991
Mitochondrial DNA (mtDNA) is a 16,569 base pair (bp) circular genome that is passed from generation to generation through the maternal line. mtDNA analysis in the context of the forensic science field usually involves unidentified human remains or missing persons. . …
Mitochondrial DNA (mtDNA) is a 16,569 base pair (bp) circular genome that is passed from generation to generation through the …
Structure, mechanism, and regulation of mitochondrial DNA transcription initiation.
Basu U, Bostwick AM, Das K, Dittenhafer-Reed KE, Patel SS. Basu U, et al. J Biol Chem. 2020 Dec 25;295(52):18406-18425. doi: 10.1074/jbc.REV120.011202. Epub 2020 Oct 30. J Biol Chem. 2020. PMID: 33127643 Free PMC article. Review.
The mitochondrial transcriptional machinery is different from nuclear machinery. The in vitro re-constituted transcriptional complexes of Saccharomyces cerevisiae (yeast) and humans, aided with high-resolution structures and biochemical characterizations, have provided a d …
The mitochondrial transcriptional machinery is different from nuclear machinery. The in vitro re-constituted transcriptional complexe …
Mitochondrial DNA replication and repair defects: Clinical phenotypes and therapeutic interventions.
Roy A, Kandettu A, Ray S, Chakrabarty S. Roy A, et al. Biochim Biophys Acta Bioenerg. 2022 Jun 1;1863(5):148554. doi: 10.1016/j.bbabio.2022.148554. Epub 2022 Mar 24. Biochim Biophys Acta Bioenerg. 2022. PMID: 35341749 Free article. Review.
This semi-autonomous organelle contains its circular genome - mtDNA (mitochondrial DNA), that undergoes continuous cycles of replication and repair to maintain the mitochondrial genome integrity. ...Here, we review the mechanism of mitochondrial DNA …
This semi-autonomous organelle contains its circular genome - mtDNA (mitochondrial DNA), that undergoes continuous cycles of r …
Mitochondrial DNA signals driving immune responses: Why, How, Where?
Giordano L, Ware SA, Lagranha CJ, Kaufman BA. Giordano L, et al. Cell Commun Signal. 2025 Apr 22;23(1):192. doi: 10.1186/s12964-025-02042-0. Cell Commun Signal. 2025. PMID: 40264103 Free PMC article. Review.
There has been a recent expansion in our understanding of DNA-sensing mechanisms. Mitochondrial dysfunction, oxidative and proteostatic stresses, instability and impaired disposal of nucleoids cause the release of mitochondrial DNA (mtDNA) from the mit …
There has been a recent expansion in our understanding of DNA-sensing mechanisms. Mitochondrial dysfunction, oxidative and pro …
Mitochondrial DNA damage, repair, and replacement in cancer.
Vodicka P, Vodenkova S, Danesova N, Vodickova L, Zobalova R, Tomasova K, Boukalova S, Berridge MV, Neuzil J. Vodicka P, et al. Trends Cancer. 2025 Jan;11(1):62-73. doi: 10.1016/j.trecan.2024.09.010. Epub 2024 Oct 21. Trends Cancer. 2025. PMID: 39438191 Review.
Mitochondria are vital organelles with their own DNA (mtDNA). mtDNA is circular and composed of heavy and light chains that are structurally more accessible than nuclear DNA (nDNA). ...In this review, we discuss the various forms of mtDNA damage and repair and their …
Mitochondria are vital organelles with their own DNA (mtDNA). mtDNA is circular and composed of heavy and light chains that are struc …
Mitochondrial DNA Methylation and Related Disease.
Gao D, Zhu B, Sun H, Wang X. Gao D, et al. Adv Exp Med Biol. 2017;1038:117-132. doi: 10.1007/978-981-10-6674-0_9. Adv Exp Med Biol. 2017. PMID: 29178073 Review.
Most researchers focused on methylation of genomic DNA, while methylation of mitochondrial DNA (mtDNA) is rarely tauched, and there is still controversy about the existence of mtDNA methylation. ...The mtDNA was recently found to exist CpG hypomethylation, an …
Most researchers focused on methylation of genomic DNA, while methylation of mitochondrial DNA (mtDNA) is rarely tauche …
Enzymology of mitochondrial DNA repair.
Alencar RR, Batalha CMPF, Freire TS, de Souza-Pinto NC. Alencar RR, et al. Enzymes. 2019;45:257-287. doi: 10.1016/bs.enz.2019.06.002. Epub 2019 Jul 15. Enzymes. 2019. PMID: 31627879 Review.
Maintaining mitochondrial DNA stability is critical for cellular function and organismal fitness, and several pathways contribute to that, including damage tolerance and bypass, degradation of damaged genomes and DNA repair. ...In this chapter, we review what …
Maintaining mitochondrial DNA stability is critical for cellular function and organismal fitness, and several pathways contrib …
Mitochondrial DNA variants in colorectal carcinogenesis: Drivers or passengers?
Errichiello E, Venesio T. Errichiello E, et al. J Cancer Res Clin Oncol. 2017 Oct;143(10):1905-1914. doi: 10.1007/s00432-017-2418-2. Epub 2017 Apr 9. J Cancer Res Clin Oncol. 2017. PMID: 28393270 Free PMC article. Review.
INTRODUCTION: Mitochondrial DNA alterations have widely been reported in many age-related degenerative diseases and tumors, including colorectal cancer. ...Furthermore, the biological impact of mitochondrial DNA variants may vary tremendously, dependin …
INTRODUCTION: Mitochondrial DNA alterations have widely been reported in many age-related degenerative diseases and tumors, in …
Role of Mitochondrial DNA in Yeast Replicative Aging.
Azbarova AV, Knorre DA. Azbarova AV, et al. Biochemistry (Mosc). 2023 Dec;88(12):1997-2006. doi: 10.1134/S0006297923120040. Biochemistry (Mosc). 2023. PMID: 38462446 Free article. Review.
With age, yeast mother cells start to experience a decrease in mitochondrial transmembrane potential and, consequently, a decrease in mitochondrial protein import efficiency. This induces mitochondrial protein precursors in the cytoplasm, the loss of mitoc …
With age, yeast mother cells start to experience a decrease in mitochondrial transmembrane potential and, consequently, a decrease in …
112,333 results
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