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1946 1
1947 2
1948 2
1950 4
1951 6
1952 12
1953 47
1954 47
1955 58
1956 84
1957 86
1958 94
1959 132
1960 144
1961 170
1962 140
1963 108
1964 332
1965 525
1966 839
1967 1148
1968 1370
1969 1628
1970 1807
1971 2063
1972 2285
1973 2467
1974 2491
1975 2609
1976 2348
1977 2254
1978 2180
1979 2371
1980 2332
1981 2174
1982 2412
1983 2511
1984 2708
1985 2707
1986 2698
1987 2617
1988 2681
1989 3033
1990 3115
1991 3078
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1994 3346
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1996 3752
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1998 4319
1999 4494
2000 5322
2001 6079
2002 6466
2003 6981
2004 7926
2005 8439
2006 9098
2007 9848
2008 10220
2009 10808
2010 11919
2011 12510
2012 13666
2013 14752
2014 16101
2015 16563
2016 17297
2017 16083
2018 16430
2019 17319
2020 18615
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2022 18717
2023 18200
2024 20053
2025 493

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381,271 results

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Page 1
Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction.
Monzel AS, Enríquez JA, Picard M. Monzel AS, et al. Nat Metab. 2023 Apr;5(4):546-562. doi: 10.1038/s42255-023-00783-1. Epub 2023 Apr 26. Nat Metab. 2023. PMID: 37100996 Free PMC article. Review.
Mitochondria have cell-type specific phenotypes, perform dozens of interconnected functions and undergo dynamic and often reversible physiological recalibrations. Given their multifunctional and malleable nature, the frequently used terms 'mitochondrial fu …
Mitochondria have cell-type specific phenotypes, perform dozens of interconnected functions and undergo dynamic and often reve …
Mitochondrial proteins: from biogenesis to functional networks.
Pfanner N, Warscheid B, Wiedemann N. Pfanner N, et al. Nat Rev Mol Cell Biol. 2019 May;20(5):267-284. doi: 10.1038/s41580-018-0092-0. Nat Rev Mol Cell Biol. 2019. PMID: 30626975 Free PMC article. Review.
Recent functional and proteomic studies have revealed the remarkable complexity of mitochondrial protein organization. ...The preprotein translocases that reside on the mitochondrial membranes not only function during organelle biogenesis to deliver ne …
Recent functional and proteomic studies have revealed the remarkable complexity of mitochondrial protein organization. ...The …
Mitochondrial dysfunction in diabetic kidney disease.
Forbes JM, Thorburn DR. Forbes JM, et al. Nat Rev Nephrol. 2018 May;14(5):291-312. doi: 10.1038/nrneph.2018.9. Epub 2018 Feb 19. Nat Rev Nephrol. 2018. PMID: 29456246 Review.
These complex organelles have a broad range of functions, including the generation of ATP. The kidneys are mitochondrially rich, highly metabolic organs that require vast amounts of ATP for their normal function. ...Inherited factors including mutations in ge …
These complex organelles have a broad range of functions, including the generation of ATP. The kidneys are mitochondrially ric …
Mitochondrial dynamics and their potential as a therapeutic target.
Whitley BN, Engelhart EA, Hoppins S. Whitley BN, et al. Mitochondrion. 2019 Nov;49:269-283. doi: 10.1016/j.mito.2019.06.002. Epub 2019 Jun 19. Mitochondrion. 2019. PMID: 31228566 Free PMC article. Review.
Mitochondrial dynamics shape the mitochondrial network and contribute to mitochondrial function and quality control. Mitochondrial fusion and division are integrated into diverse cellular functions and respond to changes in cell physio …
Mitochondrial dynamics shape the mitochondrial network and contribute to mitochondrial function and quality cont …
Mitochondrial-derived vesicles in metabolism, disease, and aging.
König T, McBride HM. König T, et al. Cell Metab. 2024 Jan 2;36(1):21-35. doi: 10.1016/j.cmet.2023.11.014. Cell Metab. 2024. PMID: 38171335 Free article. Review.
The dynamic plasticity of mitochondria to fuse, divide, and contact other organelles to flux metabolites is central to their function. To ensure bona fide functionality and signaling interconnectivity, diverse molecular mechanisms evolved. An ancient and long …
The dynamic plasticity of mitochondria to fuse, divide, and contact other organelles to flux metabolites is central to their funct …
Mitochondrial Function and Dysfunction in White Adipocytes and Therapeutic Implications.
Wang F, Huynh PM, An YA. Wang F, et al. Compr Physiol. 2024 Oct 9;14(4):5581-5640. doi: 10.1002/cphy.c230009. Compr Physiol. 2024. PMID: 39382163 Review.
However, recent discoveries have highlighted the critical role of white adipocytes in maintaining energy homeostasis and contributing to obesity and related metabolic diseases. These physiological and pathological functions depend heavily on the mitochondria that re …
However, recent discoveries have highlighted the critical role of white adipocytes in maintaining energy homeostasis and contributing to obe …
Mitochondrial quality control in human health and disease.
Liu BH, Xu CZ, Liu Y, Lu ZL, Fu TL, Li GR, Deng Y, Luo GQ, Ding S, Li N, Geng Q. Liu BH, et al. Mil Med Res. 2024 May 29;11(1):32. doi: 10.1186/s40779-024-00536-5. Mil Med Res. 2024. PMID: 38812059 Free PMC article. Review.
In response to various physiological signals or external stimuli, a sophisticated mitochondrial quality control (MQC) mechanism has evolved, encompassing key processes like mitochondrial biogenesis, mitochondrial dynamics, and mitophagy, which have garnered i …
In response to various physiological signals or external stimuli, a sophisticated mitochondrial quality control (MQC) mechanism has e …
Mitochondrial Function, Dynamics, and Permeability Transition: A Complex Love Triangle as A Possible Target for the Treatment of Brain Aging and Alzheimer's Disease.
Stockburger C, Eckert S, Eckert GP, Friedland K, Müller WE. Stockburger C, et al. J Alzheimers Dis. 2018;64(s1):S455-S467. doi: 10.3233/JAD-179915. J Alzheimers Dis. 2018. PMID: 29504539 Review.
Accordingly, improving mitochondrial function as an alternative strategy for new drug development became of increasing interest and many different compounds have been identified which improve mitochondrial function in preclinical in vitro and in vivo e …
Accordingly, improving mitochondrial function as an alternative strategy for new drug development became of increasing interes …
Mitochondria in Health and Disease.
Annesley SJ, Fisher PR. Annesley SJ, et al. Cells. 2019 Jul 5;8(7):680. doi: 10.3390/cells8070680. Cells. 2019. PMID: 31284394 Free PMC article.
They have their own genome but the great majority of the mitochondrial proteins are encoded by the nuclear genome and are imported into the mitochondria. The mitochondria participate in critical central metabolic pathways and they are fully integrated into th …
They have their own genome but the great majority of the mitochondrial proteins are encoded by the nuclear genome and are imported in …
Structure, function, and regulation of mitofusin-2 in health and disease.
Chandhok G, Lazarou M, Neumann B. Chandhok G, et al. Biol Rev Camb Philos Soc. 2018 May;93(2):933-949. doi: 10.1111/brv.12378. Epub 2017 Oct 25. Biol Rev Camb Philos Soc. 2018. PMID: 29068134 Free PMC article. Review.
Mitochondria are highly dynamic organelles that constantly migrate, fuse, and divide to regulate their shape, size, number, and bioenergetic function. Mitofusins (Mfn1/2), optic atrophy 1 (OPA1), and dynamin-related protein 1 (Drp1), are key regulators of mitocho …
Mitochondria are highly dynamic organelles that constantly migrate, fuse, and divide to regulate their shape, size, number, and bioen …
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