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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1925 1
1952 2
1953 6
1954 1
1955 4
1956 6
1957 4
1958 15
1959 14
1960 11
1961 15
1962 22
1963 34
1964 34
1965 35
1966 42
1967 59
1968 65
1969 71
1970 87
1971 69
1972 80
1973 87
1974 60
1975 204
1976 196
1977 165
1978 122
1979 142
1980 180
1981 146
1982 185
1983 188
1984 222
1985 218
1986 212
1987 205
1988 244
1989 300
1990 299
1991 303
1992 288
1993 307
1994 327
1995 367
1996 330
1997 414
1998 440
1999 395
2000 461
2001 529
2002 552
2003 577
2004 626
2005 648
2006 689
2007 784
2008 823
2009 919
2010 941
2011 1025
2012 1195
2013 1195
2014 1193
2015 1303
2016 1356
2017 1332
2018 1395
2019 1505
2020 1702
2021 1891
2022 1802
2023 1656
2024 1740
2025 1966
2026 791

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34,228 results

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Page 1
Inhibitors of cytochrome c biogenesis pathways.
Mendez DL, Childs PL, Martinie AJ, Huynh JQ, Zhu AF, McKee SR, Ghabrial GS, Stallings CL, Kranz RG. Mendez DL, et al. mBio. 2026 Apr 20:e0027326. doi: 10.1128/mbio.00273-26. Online ahead of print. mBio. 2026. PMID: 42007688
Notably, bacterial cytochrome c (cyt c) biogenesis systems-Systems I and II-are absent in mammalian mitochondria, which utilize System III. This divergence suggests that cyt c biosynthesis pathways may serve as novel antibiotic targets. ...Importantly, the manuscript highl …
Notably, bacterial cytochrome c (cyt c) biogenesis systems-Systems I and II-are absent in mammalian mitochondria, which utilize Syste …
Self-assembled nanoparticles from Xiexin Decoction attenuate ulcerative colitis by targeting VDAC1-Mediated NLRP3 inflammasome activation.
Chu Z, Yang T, Zhang Y, Zhu Q, Wang D, Tang H, Zhang G, Jiang M, Zhou L, Xu L, Fan T, Zhang J, Ma A, Xu C, Wang J, Tang H. Chu Z, et al. Mater Today Bio. 2026 Mar 27;38:103078. doi: 10.1016/j.mtbio.2026.103078. eCollection 2026 Jun. Mater Today Bio. 2026. PMID: 42006725 Free PMC article.
Binding to VDAC1 inhibits its oligomerization, preventing the cytosolic release of oxidized mitochondrial DNA and subsequent activation of the NLRP3 inflammasome in macrophages. Co-assembly with rhein further enhances cellular uptake and bioavailability, amplifying anti-in …
Binding to VDAC1 inhibits its oligomerization, preventing the cytosolic release of oxidized mitochondrial DNA and subsequent activati …
Maternal obesity alters adipogenic potential and mitochondrial maximal respiration in infant mesenchymal stem cells.
Paz HA, Zhong Y, Williams DK, Shankar K, Andres A, Wankhade UD. Paz HA, et al. Front Endocrinol (Lausanne). 2026 Apr 2;17:1786389. doi: 10.3389/fendo.2026.1786389. eCollection 2026. Front Endocrinol (Lausanne). 2026. PMID: 42006275 Free PMC article.
OBJECTIVE: To assess the adipogenic potential and mitochondrial bioenergetics of umbilical cord mesenchymal stem cells (UC-MSCs) derived from infants born to mothers with divergent body mass index and to evaluate the associations between maternal BMI and adipogenic gene ex …
OBJECTIVE: To assess the adipogenic potential and mitochondrial bioenergetics of umbilical cord mesenchymal stem cells (UC-MSCs) deri …
Phytoestrogenic Isoflavone Formononetin Attenuates Motor Deficits and Mitochondrial Impairment by Regulating SIRT1/PGC-1alpha/NRF1/TFAM Axis in Parkinson's Disease.
Kaur J, Naqvi S. Kaur J, et al. Biofactors. 2026 Mar-Apr;52(2):e70098. doi: 10.1002/biof.70098. Biofactors. 2026. PMID: 42002934
An essential early hallmark of PD is disrupted mitochondrial dynamics driven by impaired cellular energy homeostasis. Therapeutic interventions restoring mitochondrial function and biogenesis hold promise for neuroprotection in PD. ...Our results demonstrated that F …
An essential early hallmark of PD is disrupted mitochondrial dynamics driven by impaired cellular energy homeostasis. Therapeutic int …
Targeting ATP11B-YAP axis repairs mitochondrial function and inhibits neuronal ferroptosis to attenuate age-related cognitive decline.
Qi W, Liu Q, Dong N, Sun X, Wu P, Zhou J, Sun R, Liu Y, Zhao RC, Wang J. Qi W, et al. Signal Transduct Target Ther. 2026 Apr 20;11(1):141. doi: 10.1038/s41392-026-02652-1. Signal Transduct Target Ther. 2026. PMID: 42002550
We found that ATP11B deficiency facilitates the transport of Fe2+ from ependymal cells to hippocampal neurons, activating the Hippo signaling pathway and inducing mitochondrial respiratory dysfunction and dynamic imbalance, which results in neuronal ferroptosis and …
We found that ATP11B deficiency facilitates the transport of Fe2+ from ependymal cells to hippocampal neurons, activating the Hippo signalin …
Molecular analysis of a new patient COX15 mutation provides insight into the etiology of fatal infantile cardioencephalopathy.
Carroll-Deaton JA, Bohovych I, Emetu FT, Dietz JV, Rivett ED, Stanley E, Hegg EL, Fox JL, Khalimonchuk O. Carroll-Deaton JA, et al. J Biol Chem. 2026 Apr 17:111475. doi: 10.1016/j.jbc.2026.111475. Online ahead of print. J Biol Chem. 2026. PMID: 42001949
Mitochondrial disease can result from mutations in the enzymes responsible for biosynthesis of heme a and hemylation of respiratory complex IV of the electron transport chain, also known as cytochrome c oxidase (CcO). ...Our results provide insights into the etiolog
Mitochondrial disease can result from mutations in the enzymes responsible for biosynthesis of heme a and hemylation of respirator
Mitochondrial respiration supports cancer growth independent of OXPHOS.
Chinopoulos C. Chinopoulos C. Biochim Biophys Acta Rev Cancer. 2026 Apr 17:189593. doi: 10.1016/j.bbcan.2026.189593. Online ahead of print. Biochim Biophys Acta Rev Cancer. 2026. PMID: 42001904 Review.
Furthermore, even with oxygen present and ETC active, ATP synthesis requires surpassing defined thresholds; thus, respiration is not equivalent to phosphorylation. This review surveys mitochondrial pathways that use the ETC with oxygen as the terminal electron acceptor yet …
Furthermore, even with oxygen present and ETC active, ATP synthesis requires surpassing defined thresholds; thus, respiration is not equival …
Advanced materials for non-alcoholic fatty liver disease and cardiovascular disease comorbidity therapeutics.
Na J, Huang L, Wang L, Ni Y, Chen Y, Luo Q, Li Y. Na J, et al. Biomaterials. 2026 Apr 7;333:124209. doi: 10.1016/j.biomaterials.2026.124209. Online ahead of print. Biomaterials. 2026. PMID: 42001540 Review.
We synthesize three major pathological axes, including lipid overflow and impaired reverse cholesterol transport, inflammation-oxidative stress amplification driven by Kupffer cell-NLRP3 and mitochondrial ROS/MAPK signaling, as well as gut-liver-vascular dysregulation invo …
We synthesize three major pathological axes, including lipid overflow and impaired reverse cholesterol transport, inflammation-oxidative str …
A multifunctional ICAM1-directed MnO₂@ZIF8 nanoplatform with Tanshinone IIA synergistically reverses senescence and restores alveolar regeneration in septic lung injury.
Lin S, Ding X, Dang X, Luo D, Cao D, Gong Z, Zhan Q. Lin S, et al. J Nanobiotechnology. 2026 Apr 18. doi: 10.1186/s12951-026-04362-w. Online ahead of print. J Nanobiotechnology. 2026. PMID: 42001182 Free article.
Proteomic and metabolomic analyses further confirmed improved mitochondrial metabolism, SASP modulation, and inflammatory resolution. Functionally, Anti-ICAM1-MnO(2)@ZIF8@TSA restored alveolar structure, boosted oxygenation, and markedly increased survival in CLP-induced s …
Proteomic and metabolomic analyses further confirmed improved mitochondrial metabolism, SASP modulation, and inflammatory resolution. …
Glutathione peroxidase 4 alleviates chronic obstructive pulmonary disease by inhibition of ferroptosis.
Bai N, Jin P, Yao X, Zhao W, Zhu L, Chen D, Fang Y, Pan B, Yang Z. Bai N, et al. Biochem Biophys Res Commun. 2026 Apr 14;818:153769. doi: 10.1016/j.bbrc.2026.153769. Online ahead of print. Biochem Biophys Res Commun. 2026. PMID: 42000629
Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder characterized by persistent inflammation, oxidative stress, and lung function decline. ...Overexpression of GPX4 in COPD mice significantly restored mitochondrial morphology, reduced …
Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder characterized by persistent inflammation, oxidativ …
34,228 results
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