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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1954 1
1955 1
1960 1
1961 1
1963 2
1964 1
1965 1
1986 2
1987 1
1988 1
1989 2
1990 3
1991 6
1992 3
1993 10
1994 9
1995 10
1996 11
1997 11
1998 24
1999 20
2000 25
2001 29
2002 47
2003 54
2004 75
2005 84
2006 95
2007 111
2008 124
2009 124
2010 148
2011 105
2012 130
2013 115
2014 117
2015 115
2016 108
2017 101
2018 101
2019 99
2020 105
2021 120
2022 94
2023 88
2024 52

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2,206 results

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Page 1
Cognitive enhancement effects of stimulants: a randomized controlled trial testing methylphenidate, modafinil, and caffeine.
Repantis D, Bovy L, Ohla K, Kühn S, Dresler M. Repantis D, et al. Psychopharmacology (Berl). 2021 Feb;238(2):441-451. doi: 10.1007/s00213-020-05691-w. Epub 2020 Nov 17. Psychopharmacology (Berl). 2021. PMID: 33201262 Free PMC article. Clinical Trial.
Widely available stimulants such as caffeine, but also prescription substances such as methylphenidate and modafinil, are being used by healthy individuals to enhance cognitive performance. ...METHODS: We conducted a pilot study with three arms in which male participants r …
Widely available stimulants such as caffeine, but also prescription substances such as methylphenidate and modafinil, are being used …
Modafinil protects hippocampal neurons by suppressing excessive autophagy and apoptosis in mice with sleep deprivation.
Cao Y, Li Q, Liu L, Wu H, Huang F, Wang C, Lan Y, Zheng F, Xing F, Zhou Q, Li Q, Shi H, Zhang B, Wang Z, Wu X. Cao Y, et al. Br J Pharmacol. 2019 May;176(9):1282-1297. doi: 10.1111/bph.14626. Epub 2019 Apr 2. Br J Pharmacol. 2019. PMID: 30767208 Free PMC article.
These effects of modafinil were abolished by rapamycin. In addition, modafinil suppressed the aberrant autophagy and apoptosis induced by rapamycin and reactivated PI3K/Akt/mTOR/P70S6K signals in HT-22 cells. ...This novel mechanism may add to our knowledge of mo
These effects of modafinil were abolished by rapamycin. In addition, modafinil suppressed the aberrant autophagy and apoptosis …
Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial.
Nourbakhsh B, Revirajan N, Morris B, Cordano C, Creasman J, Manguinao M, Krysko K, Rutatangwa A, Auvray C, Aljarallah S, Jin C, Mowry E, McCulloch C, Waubant E. Nourbakhsh B, et al. Lancet Neurol. 2021 Jan;20(1):38-48. doi: 10.1016/S1474-4422(20)30354-9. Epub 2020 Nov 23. Lancet Neurol. 2021. PMID: 33242419 Free PMC article. Clinical Trial.
FINDINGS: Between Oct 4, 2017, and Feb 27, 2019, of 169 patients screened, 141 patients were enrolled and randomly assigned to one of four medication administration sequences: 35 (25%) patients to the amantadine, placebo, modafinil, and methylphenidate sequence; 34 (24%) p …
FINDINGS: Between Oct 4, 2017, and Feb 27, 2019, of 169 patients screened, 141 patients were enrolled and randomly assigned to one of four m …
Modafinil and orexin system: interactions and medico-legal considerations.
Salerno M, Villano I, Nicolosi D, Longhitano L, Loreto C, Lovino A, Sessa F, Polito AN, Monda V, Chieffi S, Messina A, Monda M, Zammit C, Tafuri D, Messina G, Carotenuto M. Salerno M, et al. Front Biosci (Landmark Ed). 2019 Jan 1;24(3):564-575. doi: 10.2741/4736. Front Biosci (Landmark Ed). 2019. PMID: 30468674 Free article. Review.
Modafinil (Mo) is increasingly being used as an enhancement drug rather than for its therapeutic effects. ...
Modafinil (Mo) is increasingly being used as an enhancement drug rather than for its therapeutic effects. ...
Cognitive enhancement: Effects of methylphenidate, modafinil, and caffeine on latent memory and resting state functional connectivity in healthy adults.
Becker M, Repantis D, Dresler M, Kühn S. Becker M, et al. Hum Brain Mapp. 2022 Oct 1;43(14):4225-4238. doi: 10.1002/hbm.25949. Epub 2022 Jun 7. Hum Brain Mapp. 2022. PMID: 35670369 Free PMC article. Clinical Trial.
Stimulants like methylphenidate, modafinil, and caffeine have repeatedly shown to enhance cognitive processes such as attention and memory. ...Here, we utilized behavioral and resting-state fMRI data from a double-blind randomized placebocontrolled study of methylphenidate …
Stimulants like methylphenidate, modafinil, and caffeine have repeatedly shown to enhance cognitive processes such as attention and m …
Modafinil Treatment of Cocaine Dependence: A Systematic Review and Meta-Analysis.
Sangroula D, Motiwala F, Wagle B, Shah VC, Hagi K, Lippmann S. Sangroula D, et al. Subst Use Misuse. 2017 Aug 24;52(10):1292-1306. doi: 10.1080/10826084.2016.1276597. Epub 2017 Mar 28. Subst Use Misuse. 2017. PMID: 28350194 Review.
In addition, no evidence suggested modafinil-related discontinuation or specific adverse events than placebo. CONCLUSIONS: Overall, there is no evidence to conclude superiority of modafinil in increasing cocaine abstinence and treatment retention rate. ...
In addition, no evidence suggested modafinil-related discontinuation or specific adverse events than placebo. CONCLUSIONS: Overall, t …
Modafinil Induced Spontaneous Ejaculation Without Orgasm: A Case Report.
Aras N. Aras N. Clin Neuropharmacol. 2021 Jan-Feb 01;44(1):27-28. doi: 10.1097/WNF.0000000000000423. Clin Neuropharmacol. 2021. PMID: 33252371
The addition of modafinil to antidepressant treatment may provide positive effects on sexual dysfunction. ...Although venlafaxine treatment continued after the discontinuation of modafinil, spontaneous ejaculation did not continue. It should be kept in mind that age …
The addition of modafinil to antidepressant treatment may provide positive effects on sexual dysfunction. ...Although venlafaxine tre …
Modafinil, an atypical CNS stimulant?
Hersey M, Tanda G. Hersey M, et al. Adv Pharmacol. 2024;99:287-326. doi: 10.1016/bs.apha.2023.10.006. Epub 2023 Nov 22. Adv Pharmacol. 2024. PMID: 38467484
Modafinil is a central nervous system stimulant approved for the treatment of narcolepsy and sleep disorders. ...However, modafinil is unique in that only a few cases of dependence on this drug have been reported, as compared to other psychostimulants. ...
Modafinil is a central nervous system stimulant approved for the treatment of narcolepsy and sleep disorders. ...However, modafini
HYPERSEXUALITY ASSOCIATED WITH MODAFINIL USE.
Sancaktar M, Demir B, Altındag A. Sancaktar M, et al. Psychiatr Danub. 2023 Summer;35(2):272-273. doi: 10.24869/psyd.2023.272. Psychiatr Danub. 2023. PMID: 37480319 Free article. No abstract available.
Modafinil and its structural analogs as atypical dopamine uptake inhibitors and potential medications for psychostimulant use disorder.
Tanda G, Hersey M, Hempel B, Xi ZX, Newman AH. Tanda G, et al. Curr Opin Pharmacol. 2021 Feb;56:13-21. doi: 10.1016/j.coph.2020.07.007. Epub 2020 Sep 11. Curr Opin Pharmacol. 2021. PMID: 32927246 Free PMC article. Review.
Pharmacotherapeutics for treatment of psychostimulant use disorder are still an unmet medical goal. Recently, off label use of modafinil (MOD), an approved medication for treatment of sleep disturbances, has been tested as a therapeutic for cocaine and methamphetamine use …
Pharmacotherapeutics for treatment of psychostimulant use disorder are still an unmet medical goal. Recently, off label use of modafinil
2,206 results