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The Clinical Use of Monolaurin as a Dietary Supplement: A Review of the Literature.
Barker LA, Bakkum BW, Chapman C. Barker LA, et al. J Chiropr Med. 2019 Dec;18(4):305-310. doi: 10.1016/j.jcm.2019.02.004. Epub 2020 Sep 3. J Chiropr Med. 2019. PMID: 32952476 Free PMC article.
RESULTS: Twenty-eight articles were found that appeared to address the clinical use of monolaurin. CONCLUSION: There are many articles that address the antimicrobial effects of monolaurin in vitro. Only 3 peer-reviewed papers that evidence in vivo antimicr
RESULTS: Twenty-eight articles were found that appeared to address the clinical use of monolaurin. CONCLUSION: There are many article …
Antimicrobial synergy of monolaurin lipid nanocapsules with adsorbed antimicrobial peptides against Staphylococcus aureus biofilms in vitro is absent in vivo.
Rozenbaum RT, Su L, Umerska A, Eveillard M, Håkansson J, Mahlapuu M, Huang F, Liu J, Zhang Z, Shi L, van der Mei HC, Busscher HJ, Sharma PK. Rozenbaum RT, et al. J Control Release. 2019 Jan 10;293:73-83. doi: 10.1016/j.jconrel.2018.11.018. Epub 2018 Nov 19. J Control Release. 2019. PMID: 30465823
In-vitro, monolaurin lipid nanocapsules (ML-LNCs) carrying adsorbed antimicrobial peptides (AMPs) displayed synergistic efficacy against planktonic Staphylococcus aureus, but it has not been demonstrated, neither in-vitro nor in-vivo, that such ML-LNCs penetrate int …
In-vitro, monolaurin lipid nanocapsules (ML-LNCs) carrying adsorbed antimicrobial peptides (AMPs) displayed synergistic effica …
In Vivo Antifungal Activity of Monolaurin against Candida albicans Biofilms.
Seleem D, Freitas-Blanco VS, Noguti J, Zancope BR, Pardi V, Murata RM. Seleem D, et al. Biol Pharm Bull. 2018;41(8):1299-1302. doi: 10.1248/bpb.b18-00256. Biol Pharm Bull. 2018. PMID: 30068882 Free article.
Monolaurin is a natural compound that has been known for its broad antimicrobial activities. ...Oral fungal infection in vivo was performed using bioluminescent engineered C. albicans (SKCa23-ActgLUC) biofilms on Balb/c mice. The antifungal activity of monolaurin
Monolaurin is a natural compound that has been known for its broad antimicrobial activities. ...Oral fungal infection in vivo
Effects of Monolaurin on Oral Microbe-Host Transcriptome and Metabolome.
Silva VO, Pereira LJ, Pasetto S, da Silva MP, Meyers JC, Murata RM. Silva VO, et al. Front Microbiol. 2018 Nov 6;9:2638. doi: 10.3389/fmicb.2018.02638. eCollection 2018. Front Microbiol. 2018. PMID: 30467497 Free PMC article.
The production of glycerol and pyruvic acid increased, and the 2-deoxytetronic acid NIST, 4-aminobutyric acid, pinitol and glyceric acid, presented lower concentrations because of the treatment with 25 and/or 50 muM of Monolaurin. Use of monolaurin modulated the imm …
The production of glycerol and pyruvic acid increased, and the 2-deoxytetronic acid NIST, 4-aminobutyric acid, pinitol and glyceric acid, pr …
The 1-monolaurin inhibit growth and eradicate the biofilm formed by clinical isolates of Staphylococcus epidermidis.
Krislee A, Fadly C, Nugrahaningsih DAA, Nuryastuti T, Nitbani FO, Jumina, Sholikhah EN. Krislee A, et al. BMC Proc. 2019 Dec 16;13(Suppl 11):19. doi: 10.1186/s12919-019-0174-9. eCollection 2019. BMC Proc. 2019. PMID: 31890012 Free PMC article.
One of the biofilm-producing bacteria is Staphylococcus epidermidis which has been proven to infect long-term users of urinary catheters and implant devices. The 1-monolaurin compound has been known to have an antimicrobial effect. ...BIC50 and BIC80 of 1-monolau
One of the biofilm-producing bacteria is Staphylococcus epidermidis which has been proven to infect long-term users of urinary catheters and …
Five Percent Monolaurin Vaginal Gel for the Treatment of Bacterial Vaginosis: A Randomized Placebo-Controlled Trial.
Mancuso AC, Widdice LE, Hughes BL, Schlievert P, Swamy GK, Stockdale CK, Bernstein DI, Winokur PL. Mancuso AC, et al. J Low Genit Tract Dis. 2020 Jul;24(3):277-283. doi: 10.1097/LGT.0000000000000543. J Low Genit Tract Dis. 2020. PMID: 32379102 Clinical Trial.
OBJECTIVE: The aim of the study was to test the hypothesis that 5% monolaurin vaginal gel, a naturally occurring monoglyceride shown to have antimicrobial effects on vaginal pathogens without affecting Lactobacillus species, cures bacterial vaginosis (BV). ...Future …
OBJECTIVE: The aim of the study was to test the hypothesis that 5% monolaurin vaginal gel, a naturally occurring monoglyceride shown …
In Vitro Antimicrobial Activities of Organic Acids and Their Derivatives on Several Species of Gram-Negative and Gram-Positive Bacteria.
Kovanda L, Zhang W, Wei X, Luo J, Wu X, Atwill ER, Vaessen S, Li X, Liu Y. Kovanda L, et al. Molecules. 2019 Oct 19;24(20):3770. doi: 10.3390/molecules24203770. Molecules. 2019. PMID: 31635062 Free PMC article.
The MIC tests indicated that organic acids and their derivatives exhibit promising antimicrobial effects in vitro against G- and G+ bacteria that are resistant to antimicrobial drugs. The acid forms had stronger in vitro antimicrobial activities than ester fo …
The MIC tests indicated that organic acids and their derivatives exhibit promising antimicrobial effects in vitro against G- and G+ b …
Coconut Oil and Immunity: What do we really know about it so far?
Joshi S, Kaushik V, Gode V, Mhaskar S. Joshi S, et al. J Assoc Physicians India. 2020 Jul;68(7):67-72. J Assoc Physicians India. 2020. PMID: 32602684 Review.
The information discussed in this review explains that coconut oil, either topically applied or ingested, gets broken down to release Lauric Acid and Monolaurin - known anti-microbial agents. The studies reported in literature are discussed to evaluate the an …
The information discussed in this review explains that coconut oil, either topically applied or ingested, gets broken down to release Lauric …
Antibacterial interactions of monolaurin with commonly used antimicrobials and food components.
Zhang H, Wei H, Cui Y, Zhao G, Feng F. Zhang H, et al. J Food Sci. 2009 Sep;74(7):M418-21. doi: 10.1111/j.1750-3841.2009.01300.x. J Food Sci. 2009. PMID: 19895490
Monolaurin is a nontraditional antimicrobial agent that possesses better antimicrobial activities but causes no health problems to consumers, but the use of monolaurin in the food industry as a preservative is still limited. ...The interaction with com
Monolaurin is a nontraditional antimicrobial agent that possesses better antimicrobial activities but causes no health
Design and characterization of monolaurin loaded electrospun shellac nanofibers with antimicrobial activity.
Chinatangkul N, Limmatvapirat C, Nunthanid J, Luangtana-Anan M, Sriamornsak P, Limmatvapirat S. Chinatangkul N, et al. Asian J Pharm Sci. 2018 Sep;13(5):459-471. doi: 10.1016/j.ajps.2017.12.006. Epub 2017 Dec 27. Asian J Pharm Sci. 2018. PMID: 32104420 Free PMC article.
The aim of this study was to elucidate the optimized fabrication factors influencing the formation and properties of shellac (SHL) nanofibers loaded with an antimicrobial monolaurin (ML). The main and interaction effects of formulation and process parameters includi …
The aim of this study was to elucidate the optimized fabrication factors influencing the formation and properties of shellac (SHL) nanofiber …
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