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Genome engineering with CRISPR-Cas9 in the mosquito Aedes aegypti.
Kistler KE, Vosshall LB, Matthews BJ. Kistler KE, et al. Cell Rep. 2015 Apr 7;11(1):51-60. doi: 10.1016/j.celrep.2015.03.009. Epub 2015 Mar 26. Cell Rep. 2015. PMID: 25818303 Free PMC article.
The mosquito Aedes aegypti is a potent vector of the chikungunya, yellow fever, and dengue viruses, responsible for hundreds of millions of infections and over 50,000 human deaths per year. ...This work offers a detailed exploration into the use of CRISPR-Cas9 in Ae …
The mosquito Aedes aegypti is a potent vector of the chikungunya, yellow fever, and dengue viruses, responsible for hundreds of milli …
How to turn an organism into a model organism in 10 'easy' steps.
Matthews BJ, Vosshall LB. Matthews BJ, et al. J Exp Biol. 2020 Feb 7;223(Pt Suppl 1):jeb218198. doi: 10.1242/jeb.218198. J Exp Biol. 2020. PMID: 32034051 Free PMC article. Review.
In this review, we chart a 10-step path to this goal, using our own experience with the Aedes aegypti mosquito, which we built into a model organism for neurobiology in one decade. Insights into the biology of this deadly disease vector require that we work with the mos …
In this review, we chart a 10-step path to this goal, using our own experience with the Aedes aegypti mosquito, which we built into a …
Fruitless mutant male mosquitoes gain attraction to human odor.
Basrur NS, De Obaldia ME, Morita T, Herre M, von Heynitz RK, Tsitohay YN, Vosshall LB. Basrur NS, et al. Elife. 2020 Dec 7;9:e63982. doi: 10.7554/eLife.63982. Elife. 2020. PMID: 33284111 Free PMC article.
However, there are a few species where behavioral differences between the sexes are not connected to mating. Mosquitoes are an example: while female mosquitoes feed on humans, and are attracted to a person's body heat and odor, male mosquitoes have lit …
However, there are a few species where behavioral differences between the sexes are not connected to mating. Mosquitoes are an exampl …
Small-Molecule Agonists of Ae. aegypti Neuropeptide Y Receptor Block Mosquito Biting.
Duvall LB, Ramos-Espiritu L, Barsoum KE, Glickman JF, Vosshall LB. Duvall LB, et al. Cell. 2019 Feb 7;176(4):687-701.e5. doi: 10.1016/j.cell.2018.12.004. Cell. 2019. PMID: 30735632 Free PMC article.
Female Aedes aegypti mosquitoes bite humans to obtain blood to develop their eggs. Remarkably, their strong attraction to humans is suppressed for days after the blood meal by an unknown mechanism. ...To obtain small-molecule agonists selective for NPYLR7, we performed a h …
Female Aedes aegypti mosquitoes bite humans to obtain blood to develop their eggs. Remarkably, their strong attraction to humans is s …
The ion channel ppk301 controls freshwater egg-laying in the mosquito Aedes aegypti.
Matthews BJ, Younger MA, Vosshall LB. Matthews BJ, et al. Elife. 2019 May 21;8:e43963. doi: 10.7554/eLife.43963. Elife. 2019. PMID: 31112133 Free PMC article.
Female Aedes aegypti mosquitoes are deadly vectors of arboviral pathogens and breed in containers of freshwater associated with human habitation. ...Water is a key resource for insect survival and understanding how mosquitoes interact with water to control different …
Female Aedes aegypti mosquitoes are deadly vectors of arboviral pathogens and breed in containers of freshwater associated with human …