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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
1997 1
1998 2
1999 1
2000 1
2001 2
2003 2
2004 3
2005 2
2006 3
2007 4
2008 7
2009 3
2010 7
2011 8
2012 7
2013 9
2014 7
2015 6
2016 6
2017 9
2018 5
2019 3
2020 4
2021 7
2022 5
2023 2
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112 results
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Page 1
Loss of epigenetic information as a cause of mammalian aging.
Yang JH, Hayano M, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, Chew YC, Guo W, Yang X, Maybury-Lewis S, Tian X, Ross JM, Coppotelli G, Meer MV, Rogers-Hammond R, Vera DL, Lu YR, Pippin JW, Creswell ML, Dou Z, Xu C, Mitchell SJ, Das A, O'Connell BL, Thakur S, Kane AE, Su Q, Mohri Y, Nishimura EK, Schaevitz L, Garg N, Balta AM, Rego MA, Gregory-Ksander M, Jakobs TC, Zhong L, Wakimoto H, El Andari J, Grimm D, Mostoslavsky R, Wagers AJ, Tsubota K, Bonasera SJ, Palmeira CM, Seidman JG, Seidman CE, Wolf NS, Kreiling JA, Sedivy JM, Murphy GF, Green RE, Garcia BA, Berger SL, Oberdoerffer P, Shankland SJ, Gladyshev VN, Ksander BR, Pfenning AR, Rajman LA, Sinclair DA. Yang JH, et al. Cell. 2023 Jan 19;186(2):305-326.e27. doi: 10.1016/j.cell.2022.12.027. Epub 2023 Jan 12. Cell. 2023. PMID: 36638792
SIRT6, a Mammalian Deacylase with Multitasking Abilities.
Chang AR, Ferrer CM, Mostoslavsky R. Chang AR, et al. Physiol Rev. 2020 Jan 1;100(1):145-169. doi: 10.1152/physrev.00030.2018. Epub 2019 Aug 22. Physiol Rev. 2020. PMID: 31437090 Free PMC article. Review.
SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ.
Khan D, Ara T, Ravi V, Rajagopal R, Tandon H, Parvathy J, Gonzalez EA, Asirvatham-Jeyaraj N, Krishna S, Mishra S, Raghu S, Bhati AS, Tamta AK, Dasgupta S, Kolthur-Seetharam U, Etchegaray JP, Mostoslavsky R, Rao PSM, Srinivasan N, Sundaresan NR. Khan D, et al. Cell Rep. 2021 Jun 1;35(9):109190. doi: 10.1016/j.celrep.2021.109190. Cell Rep. 2021. PMID: 34077730 Free PMC article.
NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer.
Guo H, Golczer G, Wittner BS, Langenbucher A, Zachariah M, Dubash TD, Hong X, Comaills V, Burr R, Ebright RY, Horwitz E, Vuille JA, Hajizadeh S, Wiley DF, Reeves BA, Zhang JM, Niederhoffer KL, Lu C, Wesley B, Ho U, Nieman LT, Toner M, Vasudevan S, Zou L, Mostoslavsky R, Maheswaran S, Lawrence MS, Haber DA. Guo H, et al. Mol Cell. 2021 Oct 7;81(19):4041-4058.e15. doi: 10.1016/j.molcel.2021.09.016. Mol Cell. 2021. PMID: 34624217 Free PMC article.
Here, we find that the orphan nuclear receptor NR4A1 localizes across the gene body and 3' UTR of IEGs, where it inhibits transcriptional elongation by RNA Pol II, generating R-loops and accessible chromatin domains. Acute replication stress causes immediate dissociation o …
Here, we find that the orphan nuclear receptor NR4A1 localizes across the gene body and 3' UTR of IEGs, where it inhibits transcriptional el …
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b.
Kugel S, Sebastián C, Fitamant J, Ross KN, Saha SK, Jain E, Gladden A, Arora KS, Kato Y, Rivera MN, Ramaswamy S, Sadreyev RI, Goren A, Deshpande V, Bardeesy N, Mostoslavsky R. Kugel S, et al. Cell. 2016 Jun 2;165(6):1401-1415. doi: 10.1016/j.cell.2016.04.033. Epub 2016 May 12. Cell. 2016. PMID: 27180906 Free PMC article.
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.
Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME. Brunet A, et al. Science. 2004 Mar 26;303(5666):2011-5. doi: 10.1126/science.1094637. Epub 2004 Feb 19. Science. 2004. PMID: 14976264
Liquid biopsy reveals collateral tissue damage in cancer.
Lubotzky A, Zemmour H, Neiman D, Gotkine M, Loyfer N, Piyanzin S, Ochana BL, Lehmann-Werman R, Cohen D, Moss J, Magenheim J, Loftus MF, Brais L, Ng K, Mostoslavsky R, Wolpin BM, Zick A, Maoz M, Grinshpun A, Kustanovich A, Makranz C, Cohen JE, Peretz T, Hubert A, Temper M, Salah A, Avniel-Polak S, Grozinsky-Glasberg S, Spalding KL, Rokach A, Kaplan T, Glaser B, Shemer R, Dor Y. Lubotzky A, et al. JCI Insight. 2022 Jan 25;7(2):e153559. doi: 10.1172/jci.insight.153559. JCI Insight. 2022. PMID: 35076021 Free PMC article.
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.
Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R. Zhong L, et al. Cell. 2010 Jan 22;140(2):280-93. doi: 10.1016/j.cell.2009.12.041. Cell. 2010. PMID: 20141841 Free PMC article.
112 results