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Year Number of Results
2015 4
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2023 36
2024 10

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MOTS-c Functionally Prevents Metabolic Disorders.
Gao Y, Wei X, Wei P, Lu H, Zhong L, Tan J, Liu H, Liu Z. Gao Y, et al. Metabolites. 2023 Jan 13;13(1):125. doi: 10.3390/metabo13010125. Metabolites. 2023. PMID: 36677050 Free PMC article. Review.
MOTS-c plays these physiological functions mainly through activating the AICAR-AMPK signaling pathways by disrupting the folate-methionine cycle in cells. ...However, there is a lack of articles summarizing the genes and pathways involved in the physiological activi
MOTS-c plays these physiological functions mainly through activating the AICAR-AMPK signaling pathways by disrupting the folat
MOTS-c reduces myostatin and muscle atrophy signaling.
Kumagai H, Coelho AR, Wan J, Mehta HH, Yen K, Huang A, Zempo H, Fuku N, Maeda S, Oliveira PJ, Cohen P, Kim SJ. Kumagai H, et al. Am J Physiol Endocrinol Metab. 2021 Apr 1;320(4):E680-E690. doi: 10.1152/ajpendo.00275.2020. Epub 2021 Feb 8. Am J Physiol Endocrinol Metab. 2021. PMID: 33554779 Free PMC article.
Although MOTS-c improves insulin sensitivity in skeletal muscle, whether MOTS-c impacts muscle atrophy is not known. ...We further demonstrated that MOTS-c prevents palmitic acid-induced atrophy in differentiated C2C12 myotubes, whereas …
Although MOTS-c improves insulin sensitivity in skeletal muscle, whether MOTS-c impacts muscle atrophy is not kn …
MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.
Zheng Y, Wei Z, Wang T. Zheng Y, et al. Front Endocrinol (Lausanne). 2023 Jan 25;14:1120533. doi: 10.3389/fendo.2023.1120533. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 36761202 Free PMC article. Review.
Nevertheless, MOTS-c has been used less frequently in disease treatment, and no effective method of applying MOTS-c in the clinic has been developed. Throughout this paper, we discussed the discovery and physiological function of mitochondrial-derived …
Nevertheless, MOTS-c has been used less frequently in disease treatment, and no effective method of applying MOTS-c
MOTS-c: A potential anti-pulmonary fibrosis factor derived by mitochondria.
Zhang Z, Chen D, Du K, Huang Y, Li X, Li Q, Lv X. Zhang Z, et al. Mitochondrion. 2023 Jul;71:76-82. doi: 10.1016/j.mito.2023.06.002. Epub 2023 Jun 10. Mitochondrion. 2023. PMID: 37307934 Review.
Additionally, dynamic expression changes of MOTS-c have been closely linked to ageing and ageing-related diseases, indicating its potential as an exercise mimetic. Therefore, the review aims to comprehensively analyze the available literature on the potential role o …
Additionally, dynamic expression changes of MOTS-c have been closely linked to ageing and ageing-related diseases, indicating …
MOTS-c: A Mitochondrial-Encoded Regulator of the Nucleus.
Benayoun BA, Lee C. Benayoun BA, et al. Bioessays. 2019 Sep;41(9):e1900046. doi: 10.1002/bies.201900046. Epub 2019 Aug 5. Bioessays. 2019. PMID: 31378979 Free PMC article. Review.
On the contrary, no mitochondrial-encoded factors are known to actively regulate nuclear gene expression. MOTS-c (mitochondrial open reading frame of the 12S ribosomal RNA type-c) is a recently identified peptide encoded within the mitochondrial 12S ribosomal RNA ge …
On the contrary, no mitochondrial-encoded factors are known to actively regulate nuclear gene expression. MOTS-c (mitochondria …
Role of MOTS-c in the regulation of bone metabolism.
Yi X, Hu G, Yang Y, Li J, Jin J, Chang B. Yi X, et al. Front Physiol. 2023 May 2;14:1149120. doi: 10.3389/fphys.2023.1149120. eCollection 2023. Front Physiol. 2023. PMID: 37200834 Free PMC article. Review.
Recent studies have revealed that MOTS-c promotes osteoblast proliferation, differentiation, and mineralization. Furthermore, it inhibits osteoclast production and mediates the regulation of bone metabolism and bone remodeling. Exercise effectively upregulates the e …
Recent studies have revealed that MOTS-c promotes osteoblast proliferation, differentiation, and mineralization. Furthermore, …
Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases.
Kong BS, Lee C, Cho YM. Kong BS, et al. Diabetes Metab J. 2023 May;47(3):315-324. doi: 10.4093/dmj.2022.0333. Epub 2023 Feb 24. Diabetes Metab J. 2023. PMID: 36824008 Free PMC article. Review.
This review focuses mainly on recent advances in MOTS-c research with regards to diabetes, including both type 1 and type 2. The emerging understanding of MOTS-c in diabetes may provide insight into the development of new therapies for diabetes and oth …
This review focuses mainly on recent advances in MOTS-c research with regards to diabetes, including both type 1 and type 2. T …
The mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitus.
Yin Y, Pan Y, He J, Zhong H, Wu Y, Ji C, Liu L, Cui X. Yin Y, et al. Pharmacol Res. 2022 Jan;175:105987. doi: 10.1016/j.phrs.2021.105987. Epub 2021 Nov 17. Pharmacol Res. 2022. PMID: 34798268 Free article.
Here, we demonstrate that MOTS-c can be an effective treatment for GDM. A GDM mouse model was established by short term high-fat diet combined with low-dose streptozotocin (STZ) treatment while MOTS-c was administrated daily during pregnancy. ...In add …
Here, we demonstrate that MOTS-c can be an effective treatment for GDM. A GDM mouse model was established by short term high-f …
MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases.
Mohtashami Z, Singh MK, Salimiaghdam N, Ozgul M, Kenney MC. Mohtashami Z, et al. Int J Mol Sci. 2022 Oct 9;23(19):11991. doi: 10.3390/ijms231911991. Int J Mol Sci. 2022. PMID: 36233287 Free PMC article. Review.
MOTS-c, a 16 amino acid mitochondrial derived peptide, is encoded from the 12S rRNA region of the mitochondrial genome. ...Aging is characterized by gradual loss of (mitochondrial) metabolic balance, decreased muscle homeostasis and eventual diminished physical capa
MOTS-c, a 16 amino acid mitochondrial derived peptide, is encoded from the 12S rRNA region of the mitochondrial genome. ...Agi
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.
Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P. Lee C, et al. Cell Metab. 2015 Mar 3;21(3):443-54. doi: 10.1016/j.cmet.2015.02.009. Cell Metab. 2015. PMID: 25738459 Free PMC article.
Here we report a sORF within the mitochondrial 12S rRNA encoding a 16-amino-acid peptide named MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) that regulates insulin sensitivity and metabolic homeostasis. Its primary target organ appears to be the skelet …
Here we report a sORF within the mitochondrial 12S rRNA encoding a 16-amino-acid peptide named MOTS-c (mitochondrial open read …
145 results