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Unified synthesis and assessment of tumor cell migration inhibitory activity of optically active UTKO1, originally designed moverastin analog.
Ogura Y, Kobayashi H, Imoto M, Watanabe H, Takikawa H. Ogura Y, et al. Biosci Biotechnol Biochem. 2021 Jan 7;85(1):160-167. doi: 10.1093/bbb/zbaa062. Biosci Biotechnol Biochem. 2021. PMID: 33577660 Free article.
UTKO1 is a synthetic analog of a natural tumor cell migration inhibitor, moverastin, isolated from microbial extracts of Aspergillus sp. 7720. UTKO1 was initially developed as a mixture of the stereoisomers. ...
UTKO1 is a synthetic analog of a natural tumor cell migration inhibitor, moverastin, isolated from microbial extracts of Aspergillus …
Synthesis and anti-migrative evaluation of moverastin derivatives.
Sawada M, Kubo S, Matsumura K, Takemoto Y, Kobayashi H, Tashiro E, Kitahara T, Watanabe H, Imoto M. Sawada M, et al. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1385-9. doi: 10.1016/j.bmcl.2011.01.028. Epub 2011 Jan 11. Bioorg Med Chem Lett. 2011. PMID: 21306898
Inhibition of the cell migration involved in the invasion process represents a potential therapeutic approach to the treatment of tumor metastasis; therefore, a novel series of derivatives of moverastins (moverastins A and B), an inhibitor of tumor cell migration, was designed an …
Inhibition of the cell migration involved in the invasion process represents a potential therapeutic approach to the treatment of tumor meta …
Chemistry and biology of the compounds that modulate cell migration.
Tashiro E, Imoto M. Tashiro E, et al. J Ind Microbiol Biotechnol. 2016 Mar;43(2-3):213-9. doi: 10.1007/s10295-015-1654-1. Epub 2015 Jul 15. J Ind Microbiol Biotechnol. 2016. PMID: 26173498 Free article. Review.
In this mini-review, we introduce our chemical and biological studies of three cell migration inhibitors: moverastin, UTKO1, and BU-4664L....
In this mini-review, we introduce our chemical and biological studies of three cell migration inhibitors: moverastin, UTKO1, and BU-4 …
Chemistry and biology of moverastins, inhibitors of cancer cell migration, produced by Aspergillus.
Takemoto Y, Watanabe H, Uchida K, Matsumura K, Nakae K, Tashiro E, Shindo K, Kitahara T, Imoto M. Takemoto Y, et al. Chem Biol. 2005 Dec;12(12):1337-47. doi: 10.1016/j.chembiol.2005.09.017. Chem Biol. 2005. PMID: 16356851
We screened for inhibitors of cancer cell migration of microbial origin, and obtained moverastin, a member of the cylindrol family, from Aspergillus sp. F7720. However, the results of an NMR spectroscopic analysis raised the possibility that moverastin is a mixture …
We screened for inhibitors of cancer cell migration of microbial origin, and obtained moverastin, a member of the cylindrol family, f …