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Year Number of Results
1992 1
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2003 1
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2005 2
2006 1
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Page 1
mRNA Vaccine Era-Mechanisms, Drug Platform and Clinical Prospection.
Xu S, Yang K, Li R, Zhang L. Xu S, et al. Int J Mol Sci. 2020 Sep 9;21(18):6582. doi: 10.3390/ijms21186582. Int J Mol Sci. 2020. PMID: 32916818 Free PMC article. Review.
Messenger ribonucleic acid (mRNA)-based drugs, notably mRNA vaccines, have been widely proven as a promising treatment strategy in immune therapeutics. ...Applications of mRNA vaccines in some infectious diseases and cancers are introduced. ...
Messenger ribonucleic acid (mRNA)-based drugs, notably mRNA vaccines, have been widely proven as a promising treatment …
Lipid nanoparticle-mediated lymph node-targeting delivery of mRNA cancer vaccine elicits robust CD8(+) T cell response.
Chen J, Ye Z, Huang C, Qiu M, Song D, Li Y, Xu Q. Chen J, et al. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2207841119. doi: 10.1073/pnas.2207841119. Epub 2022 Aug 15. Proc Natl Acad Sci U S A. 2022. PMID: 35969778 Free PMC article.
For mRNA vaccines, the targeted delivery to the lymph node (LN) is predicted to reduce side effects and increase the immune response. ...As a result, the protective and therapeutic effect of the OVA-encoding mRNA vaccine on the OVA-antigen-beari …
For mRNA vaccines, the targeted delivery to the lymph node (LN) is predicted to reduce side effects and increase the im …
Side effects of BNT162b2 mRNA COVID-19 vaccine: A randomized, cross-sectional study with detailed self-reported symptoms from healthcare workers.
Kadali RAK, Janagama R, Peruru S, Malayala SV. Kadali RAK, et al. Int J Infect Dis. 2021 May;106:376-381. doi: 10.1016/j.ijid.2021.04.047. Epub 2021 Apr 15. Int J Infect Dis. 2021. PMID: 33866000 Free PMC article. Clinical Trial.
INTRODUCTION: Concerns are prevailing about the safety and side effects of the BNT162b2 mRNA vaccine for coronavirus disease 2019 (COVID-19). ...RESULTS: Of all HCWs, 87.98% (1245/1415) completed the survey. Of them, 64.5% (803/1245) received the BNT162b2 …
INTRODUCTION: Concerns are prevailing about the safety and side effects of the BNT162b2 mRNA vaccine for coronavirus di …
mRNA vaccine in cancer therapy: Current advance and future outlook.
Li Y, Wang M, Peng X, Yang Y, Chen Q, Liu J, She Q, Tan J, Lou C, Liao Z, Li X. Li Y, et al. Clin Transl Med. 2023 Aug;13(8):e1384. doi: 10.1002/ctm2.1384. Clin Transl Med. 2023. PMID: 37612832 Free PMC article. Review.
In the past 2 years, SARS-CoV-2 mRNA vaccines have contributed tremendously against SARS-CoV2, which has prompted the arrival of the mRNA vaccine research boom, especially in the research of cancer vaccines. Compared with conventional cancer …
In the past 2 years, SARS-CoV-2 mRNA vaccines have contributed tremendously against SARS-CoV2, which has prompted the arrival …
The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory.
Ndeupen S, Qin Z, Jacobsen S, Bouteau A, Estanbouli H, Igyártó BZ. Ndeupen S, et al. iScience. 2021 Dec 17;24(12):103479. doi: 10.1016/j.isci.2021.103479. Epub 2021 Nov 20. iScience. 2021. PMID: 34841223 Free PMC article.
Vaccines based on mRNA-containing lipid nanoparticles (LNPs) are a promising new platform used by two leading vaccines against COVID-19. ...Here we present evidence that Acuitas' LNPs used in preclinical nucleoside-modified mRNA vaccine studies …
Vaccines based on mRNA-containing lipid nanoparticles (LNPs) are a promising new platform used by two leading vaccines …
Vaccines' New Era-RNA Vaccine.
Zhou W, Jiang L, Liao S, Wu F, Yang G, Hou L, Liu L, Pan X, Jia W, Zhang Y. Zhou W, et al. Viruses. 2023 Aug 18;15(8):1760. doi: 10.3390/v15081760. Viruses. 2023. PMID: 37632102 Free PMC article. Review.
RNA vaccines, including conventional messenger RNA (mRNA) vaccines, circular RNA (circRNA) vaccines, and self-amplifying RNA (saRNA) vaccines, have ushered in a promising future and revolutionized vaccine development. The success of mR …
RNA vaccines, including conventional messenger RNA (mRNA) vaccines, circular RNA (circRNA) vaccines, and self-am …
Cardiovascular Manifestation of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents.
Mansanguan S, Charunwatthana P, Piyaphanee W, Dechkhajorn W, Poolcharoen A, Mansanguan C. Mansanguan S, et al. Trop Med Infect Dis. 2022 Aug 19;7(8):196. doi: 10.3390/tropicalmed7080196. Trop Med Infect Dis. 2022. PMID: 36006288 Free PMC article.
This study focuses on cardiovascular manifestation, particularly myocarditis and pericarditis events, after BNT162b2 mRNA COVID-19 vaccine injection in Thai adolescents. This prospective cohort study enrolled students aged 13-18 years from two schools, who received …
This study focuses on cardiovascular manifestation, particularly myocarditis and pericarditis events, after BNT162b2 mRNA COVID-19 …
Future prospects in mRNA vaccine development.
Mbatha LS, Akinyelu J, Maiyo F, Kudanga T. Mbatha LS, et al. Biomed Mater. 2023 Aug 17;18(5). doi: 10.1088/1748-605X/aceceb. Biomed Mater. 2023. PMID: 37589309 Review.
The recent advancements in messenger ribonucleic acid (mRNA) vaccine development have vastly enhanced their use as alternatives to conventional vaccines in the prevention of various infectious diseases and treatment of several types of cancers. This is mainly …
The recent advancements in messenger ribonucleic acid (mRNA) vaccine development have vastly enhanced their use as alternative …
Short-term Side Effects of mRNA-based COVID-19 Vaccine Among Jordanian Population; a Cross-sectional Study.
Nassar RI. Nassar RI. Arch Acad Emerg Med. 2023 Feb 12;11(1):e22. doi: 10.22037/aaem.v11i1.1850. eCollection 2023. Arch Acad Emerg Med. 2023. PMID: 36919138 Free PMC article.
INTRODUCTION: One type of the developed COVID-19 vaccines that received emergency permission and was approved by the food and drug administration (FDA) is the mRNA-based vaccine. ...RESULTS: Among the study's participants (n= 533), about 56% experienced si …
INTRODUCTION: One type of the developed COVID-19 vaccines that received emergency permission and was approved by the food and drug ad …
An Integrated Polymeric mRNA Vaccine without Inflammation Side Effects for Cellular Immunity Mediated Cancer Therapy.
Huang P, Jiang L, Pan H, Ding L, Zhou B, Zhao M, Zou J, Li B, Qi M, Deng H, Zhou Y, Chen X. Huang P, et al. Adv Mater. 2023 Jan;35(3):e2207471. doi: 10.1002/adma.202207471. Epub 2022 Dec 16. Adv Mater. 2023. PMID: 36326183
Unlike LNPs exhibiting high levels of inflammation, the PHTA-based PNPs show negligible inflammatory side effects in vivo. Importantly, the top candidate PHTA-C18 enables successful mRNA cancer vaccine delivery in vivo and leads to a robust CD8(+) T cell medi …
Unlike LNPs exhibiting high levels of inflammation, the PHTA-based PNPs show negligible inflammatory side effects in vivo. Importantl …
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