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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 8
1997 22
1998 41
1999 91
2000 106
2001 160
2002 144
2003 179
2004 233
2005 278
2006 302
2007 314
2008 343
2009 341
2010 305
2011 357
2012 423
2013 393
2014 374
2015 349
2016 320
2017 267
2018 236
2019 238
2020 246
2021 229
2022 74
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5,623 results
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Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases.
Liew SC, Gupta ED. Liew SC, et al. Eur J Med Genet. 2015 Jan;58(1):1-10. doi: 10.1016/j.ejmg.2014.10.004. Epub 2014 Nov 4. Eur J Med Genet. 2015. PMID: 25449138 Review.
The Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with various diseases (vascular, cancers, neurology, diabetes, psoriasis, etc) with the epidemiology of the polymorphism of the C677T that varies dependent on the g …
The Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with various diseases (vascular …
MTHFR C677T polymorphism and hypertension.
Sookaromdee P, Wiwanitkit V. Sookaromdee P, et al. J Clin Hypertens (Greenwich). 2020 Feb;22(2):308. doi: 10.1111/jch.13811. Epub 2020 Jan 19. J Clin Hypertens (Greenwich). 2020. PMID: 31955498 Free PMC article. No abstract available.
MTHFR: Addressing Genetic Counseling Dilemmas Using Evidence-Based Literature.
Levin BL, Varga E. Levin BL, et al. J Genet Couns. 2016 Oct;25(5):901-11. doi: 10.1007/s10897-016-9956-7. Epub 2016 Apr 30. J Genet Couns. 2016. PMID: 27130656 Review.
The 5, 10 methylenetetrahydrofolate reductase (MTHFR) enzyme is a catalyst in the folate metabolism pathway, the byproducts of which are involved in the remethylation of homocysteine to methionine. ...Given this wide spectrum of purported clinical implication …
The 5, 10 methylenetetrahydrofolate reductase (MTHFR) enzyme is a catalyst in the folate metabolism pathway, the byprod …
MTHFR genetic testing: Controversy and clinical implications.
Long S, Goldblatt J. Long S, et al. Aust Fam Physician. 2016 Apr;45(4):237-40. Aust Fam Physician. 2016. PMID: 27052143 Free article. Review.
Genetic testing for two common polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR), 677C>T and 1298A>C, is being accessed by general practitioners (GPs) and alternative medicine practitioners (based on in-house records fr
Genetic testing for two common polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR), 677
Polymorphism of MTHFR 1298A>C in relation to adverse pregnancy outcomes in Chinese populations.
Mo H, Rao M, Wang G, Long YX, Wang HW, Tang L. Mo H, et al. Mol Genet Genomic Med. 2019 May;7(5):e642. doi: 10.1002/mgg3.642. Epub 2019 Mar 22. Mol Genet Genomic Med. 2019. PMID: 30900398 Free PMC article.
BACKGROUND: Adverse pregnancy outcomes (APOs) are involved in a series of abnormal pregnancies like embryo growth arrest, spontaneous abortion, premature birth, stillbirth, fetal malformation, birth defects and other pathological pregnancy, and childbirth complications. Polymo
BACKGROUND: Adverse pregnancy outcomes (APOs) are involved in a series of abnormal pregnancies like embryo growth arrest, spontaneous aborti …
Genetic polymorphism of MTHFR C677T with preterm birth and low birth weight susceptibility: a meta-analysis.
Wu H, Zhu P, Geng X, Liu Z, Cui L, Gao Z, Jiang B, Yang L. Wu H, et al. Arch Gynecol Obstet. 2017 May;295(5):1105-1118. doi: 10.1007/s00404-017-4322-z. Epub 2017 Mar 10. Arch Gynecol Obstet. 2017. PMID: 28283826 Review.
PURPOSE: This study aimed at clarifying the association of maternal and neonatal methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms with preterm birth (PTB) and low birth weight (LBW) susceptibility, respectively. ...No associations betwee …
PURPOSE: This study aimed at clarifying the association of maternal and neonatal methylenetetrahydrofolate reductase (MTHFR
Association between MTHFR C677T/A1298C and susceptibility to autism spectrum disorders: a meta-analysis.
Li Y, Qiu S, Shi J, Guo Y, Li Z, Cheng Y, Liu Y. Li Y, et al. BMC Pediatr. 2020 Sep 24;20(1):449. doi: 10.1186/s12887-020-02330-3. BMC Pediatr. 2020. PMID: 32972375 Free PMC article.
BACKGROUND: Autism spectrum disorder (ASD) is becoming increasingly prevalent of late. Methylenetetrahydrofolate reductase (MTHFR) has a significant role in folate metabolism. ...However, the MTHFR A1298C polymorphism was not found to be signifi …
BACKGROUND: Autism spectrum disorder (ASD) is becoming increasingly prevalent of late. Methylenetetrahydrofolate reductase ( …
MTHFR gene polymorphism and diabetic retinopathy.
Maeda M, Fujio Y, Azuma J. Maeda M, et al. Curr Diabetes Rev. 2006 Nov;2(4):467-76. doi: 10.2174/1573399810602040467. Curr Diabetes Rev. 2006. PMID: 18220649 Review.
A polymorphic mutation (C677T) in the MTHFR gene leads to impaired enzyme activity, resulting in hyper- homocysteinemia as an independent risk factor for macroangiopathy. ...We also propose the possibility of personalized medicine for diabetes mellitus based on a be …
A polymorphic mutation (C677T) in the MTHFR gene leads to impaired enzyme activity, resulting in hyper- homocysteinemia as an …
Association of methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism with autism: evidence of genetic susceptibility.
Rai V. Rai V. Metab Brain Dis. 2016 Aug;31(4):727-35. doi: 10.1007/s11011-016-9815-0. Epub 2016 Mar 8. Metab Brain Dis. 2016. PMID: 26956130 Review.
Numerous articles reported that dysfunctional folate-methionine pathway enzymes may play an important role in the pathophysiology of autism. Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme of this pathway and MTHFR C677T polymorphis
Numerous articles reported that dysfunctional folate-methionine pathway enzymes may play an important role in the pathophysiology of autism. …
Association between MTHFR C677T polymorphism and primary open-angle glaucoma: a meta-analysis.
Huo Y, Zou H, Lang M, Ji SX, Yin XL, Zheng Z, Liu W, Chen CL, Yuan RD, Ye J. Huo Y, et al. Gene. 2013 Jan 10;512(2):179-84. doi: 10.1016/j.gene.2012.10.067. Epub 2012 Nov 1. Gene. 2013. PMID: 23123730 Review.
Epidemiological studies have evaluated the association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and primary open-angle glaucoma (POAG) risk. ...The aim of this study was to investigate the association between MTHFRC677T …
Epidemiological studies have evaluated the association between methylenetetrahydrofolate reductase (MTHFR) C677T pol
5,623 results