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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 8
1997 22
1998 41
1999 91
2000 106
2001 160
2002 144
2003 179
2004 233
2005 278
2006 302
2007 314
2008 343
2009 341
2010 305
2011 357
2012 422
2013 393
2014 372
2015 349
2016 318
2017 267
2018 232
2019 226
2020 128
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5,258 results
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Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases.
Liew SC, Gupta ED. Liew SC, et al. Eur J Med Genet. 2015 Jan;58(1):1-10. doi: 10.1016/j.ejmg.2014.10.004. Epub 2014 Nov 4. Eur J Med Genet. 2015. PMID: 25449138 Review.
The Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with various diseases (vascular, cancers, neurology, diabetes, psoriasis, etc) with the epidemiology of the polymorphism of the C677T that varies dependent on the g …
The Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with various diseases (vascular …
Genetic polymorphism of MTHFR C677T with preterm birth and low birth weight susceptibility: a meta-analysis.
Wu H, Zhu P, Geng X, Liu Z, Cui L, Gao Z, Jiang B, Yang L. Wu H, et al. Arch Gynecol Obstet. 2017 May;295(5):1105-1118. doi: 10.1007/s00404-017-4322-z. Epub 2017 Mar 10. Arch Gynecol Obstet. 2017. PMID: 28283826 Review.
PURPOSE: This study aimed at clarifying the association of maternal and neonatal methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms with preterm birth (PTB) and low birth weight (LBW) susceptibility, respectively. ...No associations betwee …
PURPOSE: This study aimed at clarifying the association of maternal and neonatal methylenetetrahydrofolate reductase (MTHFR …
MTHFR: Addressing Genetic Counseling Dilemmas Using Evidence-Based Literature.
Levin BL, Varga E. Levin BL, et al. J Genet Couns. 2016 Oct;25(5):901-11. doi: 10.1007/s10897-016-9956-7. Epub 2016 Apr 30. J Genet Couns. 2016. PMID: 27130656 Review.
The 5, 10 methylenetetrahydrofolate reductase (MTHFR) enzyme is a catalyst in the folate metabolism pathway, the byproducts of which are involved in the remethylation of homocysteine to methionine. ...Given this wide spectrum of purported clinical implication …
The 5, 10 methylenetetrahydrofolate reductase (MTHFR) enzyme is a catalyst in the folate metabolism pathway, the byprod …
Association of methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism with autism: evidence of genetic susceptibility.
Rai V. Rai V. Metab Brain Dis. 2016 Aug;31(4):727-35. doi: 10.1007/s11011-016-9815-0. Epub 2016 Mar 8. Metab Brain Dis. 2016. PMID: 26956130 Review.
Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme of this pathway and MTHFR C677T polymorphism reported as risk factor for autism in several case control studies. ...Meta-analysis using all four genetic models showed signif …
Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme of this pathway and MTHFR C677T polymorphism …
MTHFR genetic testing: Controversy and clinical implications.
Long S, Goldblatt J. Long S, et al. Aust Fam Physician. 2016 Apr;45(4):237-40. Aust Fam Physician. 2016. PMID: 27052143 Free article. Review.
BACKGROUND: A polymorphism is a variant within a gene that does not necessarily affect its function, unlike a pathogenic mutation. Genetic testing for two common polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR), 677C& …
BACKGROUND: A polymorphism is a variant within a gene that does not necessarily affect its function, unlike a pathogenic mutation. …
Investigation of MTHFR gene C677T polymorphism in cardiac syndrome X patients.
Kandaz C, Önal B, Özen D, Demir B, Akkan AG, Özyazgan S. Kandaz C, et al. J Clin Lab Anal. 2018 Feb;32(2):e22247. doi: 10.1002/jcla.22247. Epub 2017 May 8. J Clin Lab Anal. 2018. PMID: 28481466 Free PMC article.
Some polymorphisms observed on the MTHFR gene cause inactivation of the MTHFR enzyme, leading to hyperhomocysteinemia and homocysteinuria, which are prominent risk factors of cardiovascular and cerebrovascular diseases. It was aimed to explain the association …
Some polymorphisms observed on the MTHFR gene cause inactivation of the MTHFR enzyme, leading to hyperhomocysteinemia a …
Cumulative review and meta-analyses on the association between MTHFR rs1801133 polymorphism and breast cancer risk: a pooled analysis of 83 studies with 74,019 participants.
Zhang Y, Jia H, Wang S, Jiang D. Zhang Y, et al. Minerva Med. 2017 Feb;108(1):57-73. doi: 10.23736/S0026-4806.16.04759-5. Epub 2016 Nov 8. Minerva Med. 2017. PMID: 27824246 Review.
BACKGROUND: The association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and breast cancer risk has been extensively explored, but their results are conflicting rather than conclusive. ...Overall, MTHFR rs1801133 gene …
BACKGROUND: The association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and breast ca …
Polymorphism of MTHFR 1298A>C in relation to adverse pregnancy outcomes in Chinese populations.
Mo H, Rao M, Wang G, Long YX, Wang HW, Tang L. Mo H, et al. Mol Genet Genomic Med. 2019 May;7(5):e642. doi: 10.1002/mgg3.642. Epub 2019 Mar 22. Mol Genet Genomic Med. 2019. PMID: 30900398 Free PMC article.
Polymorphism of methylenetetrahydrofolate reductase gene (MTHFR, 607093) is one of the main genetic causes of APO. However, there is still debate on whether MTHFR 1298A>C, rs1801131, polymorphism is related to APO. ...CONCLUSION …
Polymorphism of methylenetetrahydrofolate reductase gene (MTHFR, 607093) is one of the main genetic cause …
Correlations between plasma homocysteine and MTHFR gene polymorphism and white matter lesions.
Li M, Fu B, Dong W. Li M, et al. Folia Neuropathol. 2018;56(4):301-307. doi: 10.5114/fn.2018.80863. Folia Neuropathol. 2018. PMID: 30786667 Free article.
This study aims to investigate the correlation between the plasma homocysteine (Hcy) level and methylenetetrahydro-folate reductase (MTHFR) C677T polymorphism, and white matter lesions (WML). ...The severity of white matter lesions is not correlated with M …
This study aims to investigate the correlation between the plasma homocysteine (Hcy) level and methylenetetrahydro-folate reductase ( …
Effects of MTHFR A1298C polymorphism on peripheral blood folate concentration in healthy populations: a meta-analysis of observational studies.
Xin Y, Wu L, Lu X, Shangguan S, Wang Z, Chang S, Yin J, Piao W, Zhang T, Wang L. Xin Y, et al. Asia Pac J Clin Nutr. 2018;27(3):718-727. doi: 10.6133/apjcn.122017.02. Asia Pac J Clin Nutr. 2018. PMID: 29737822 Free article.
BACKGROUND AND OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR) irreversibly converts 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, which is the main form of folate used in the body. Previous studies suggest that MTHFR p …
BACKGROUND AND OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR) irreversibly converts 5,10- methylenetetrahyd …
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