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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 1
1995 1
1996 1
2002 2
2003 2
2004 4
2005 1
2006 3
2007 2
2008 2
2009 5
2010 4
2011 10
2012 11
2013 13
2014 13
2015 16
2016 11
2017 17
2018 7
2019 15
2020 9
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131 results
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Safety and efficacy of helminth treatment in relapsing-remitting multiple sclerosis: Results of the HINT 2 clinical trial.
Fleming J, Hernandez G, Hartman L, Maksimovic J, Nace S, Lawler B, Risa T, Cook T, Agni R, Reichelderfer M, Luzzio C, Rolak L, Field A, Fabry Z. Fleming J, et al. Mult Scler. 2019 Jan;25(1):81-91. doi: 10.1177/1352458517736377. Epub 2017 Oct 24. Mult Scler. 2019. PMID: 29064315 Free PMC article. Clinical Trial.
Nevertheless, the results of helminth treatment, including in multiple sclerosis (MS), have been inconclusive. OBJECTIVE: To assess safety and brain magnetic resonance imaging (MRI) activity in subjects with relapsing-remitting multiple sclerosis
Nevertheless, the results of helminth treatment, including in multiple sclerosis (MS), have been inconclusive. OBJECTIV …
Immune-Regulatory Mechanisms of Classical and Experimental Multiple Sclerosis Drugs: A Special Focus on Helminth-Derived Treatments.
Peón AN, Terrazas LI. Peón AN, et al. Curr Med Chem. 2016;23(11):1152-70. doi: 10.2174/0929867323666160311114110. Curr Med Chem. 2016. PMID: 26947777 Review.
Multiple sclerosis (MS) is the most prevalent autoimmune disease affecting the central nervous system (CNS). Its pathophysiology is centered on neuron myelin sheath destruction in a manner largely dependent upon CD4+/CD8+ T-cell autoreactivity against myelin antigen
Multiple sclerosis (MS) is the most prevalent autoimmune disease affecting the central nervous system (CNS). Its pathophysiolo
A critical analysis of helminth immunotherapy in multiple sclerosis.
Charabati M, Donkers SJ, Kirkland MC, Osborne LC. Charabati M, et al. Mult Scler. 2020 Jan 23:1352458519899040. doi: 10.1177/1352458519899040. Online ahead of print. Mult Scler. 2020. PMID: 31971074
Helminthic worms are ancestral members of the intestinal ecosystem that have been largely eradicated from the general population in industrialized countries. ...This concept and the geographic discrepancy between global burdens of chronic inflammatory diseases and helmi
Helminthic worms are ancestral members of the intestinal ecosystem that have been largely eradicated from the general population in i
Novel Therapeutics for Multiple Sclerosis Designed by Parasitic Worms.
Dixit A, Tanaka A, Greer JM, Donnelly S. Dixit A, et al. Int J Mol Sci. 2017 Oct 13;18(10):2141. doi: 10.3390/ijms18102141. Int J Mol Sci. 2017. PMID: 29027962 Free PMC article. Review.
The evolutionary response to endemic infections with parasitic worms (helminth) was the development of a distinct regulatory immune profile arising from the need to encapsulate the helminths while simultaneously repairing tissue damage. According to the old friend's …
The evolutionary response to endemic infections with parasitic worms (helminth) was the development of a distinct regulatory immune p …
Perspectives of People with Multiple Sclerosis About Helminth Immunotherapy.
Donkers SJ, Kirkland MC, Charabati M, Osborne LC. Donkers SJ, et al. Int J MS Care. 2020 Jan-Feb;22(1):43-51. doi: 10.7224/1537-2073.2019-044. Int J MS Care. 2020. PMID: 32123528 Free PMC article.
BACKGROUND: Due to the chronic and incurable nature of the autoimmune disease multiple sclerosis (MS), some people with MS will seek out alternative therapeutic approaches. Helminth immunotherapy, the deliberate inoculation with helminthic parasites as …
BACKGROUND: Due to the chronic and incurable nature of the autoimmune disease multiple sclerosis (MS), some people with MS wil …
Helminth therapy and multiple sclerosis.
Fleming JO. Fleming JO. Int J Parasitol. 2013 Mar;43(3-4):259-74. doi: 10.1016/j.ijpara.2012.10.025. Epub 2013 Jan 5. Int J Parasitol. 2013. PMID: 23298637 Review.
Multiple sclerosis is a common and frequently disabling neurological disease of young adults. It is characterised by recurrent areas of focal inflammation (plaques) in the CNS which give rise to episodic neurological signs and symptoms. ...Helminths have been
Multiple sclerosis is a common and frequently disabling neurological disease of young adults. It is characterised by recurrent
Therapeutic potential of helminths in autoimmune diseases: helminth-derived immune-regulators and immune balance.
Wang M, Wu L, Weng R, Zheng W, Wu Z, Lv Z. Wang M, et al. Parasitol Res. 2017 Aug;116(8):2065-2074. doi: 10.1007/s00436-017-5544-5. Epub 2017 Jun 29. Parasitol Res. 2017. PMID: 28664463 Review.
Helminths have accompanied human throughout history by releasing immune-evasion molecules that could counteract an aberrant immune response within the host. ...Special attentions are paid on the booming animal models and clinical trials that are to detect the efficiency of
Helminths have accompanied human throughout history by releasing immune-evasion molecules that could counteract an aberrant immune re
Does helminth activation of toll-like receptors modulate immune response in multiple sclerosis patients?
Correale J, Farez MF. Correale J, et al. Front Cell Infect Microbiol. 2012 Aug 24;2:112. doi: 10.3389/fcimb.2012.00112. eCollection 2012. Front Cell Infect Microbiol. 2012. PMID: 22937527 Free PMC article. Review.
Multiple sclerosis (MS) is an inflammatory autoimmune demyelinating disease affecting the Central Nervous System (CNS), in which Th1 and Th17 cells appear to recognize and react against certain myelin sheath components. ...Finally, cytokine effects and changes obser
Multiple sclerosis (MS) is an inflammatory autoimmune demyelinating disease affecting the Central Nervous System (CNS), in whi
Hypothesis: Multiple sclerosis is caused by three-hits, strictly in order, in genetically susceptible persons.
Kearns PKA, Casey HA, Leach JP. Kearns PKA, et al. Mult Scler Relat Disord. 2018 Aug;24:157-174. doi: 10.1016/j.msard.2018.06.014. Epub 2018 Jul 4. Mult Scler Relat Disord. 2018. PMID: 30015080
Multiple Sclerosis is a chronic, progressive and debilitating neurological disease which, despite extensive study for over 100 years, remains of enigmatic aetiology. ...Here we propose a three-tiered hypothesis: 1) a clinic-epidemiological model of multiple
Multiple Sclerosis is a chronic, progressive and debilitating neurological disease which, despite extensive study for over 100
Multiple sclerosis and environmental factors: the role of vitamin D, parasites, and Epstein-Barr virus infection.
Correale J, Gaitán MI. Correale J, et al. Acta Neurol Scand. 2015;132(199):46-55. doi: 10.1111/ane.12431. Acta Neurol Scand. 2015. PMID: 26046559 Review.
Pathogenic mechanisms underlying multiple sclerosis development have yet to be clearly identified, but considerable evidence indicates that autoimmunity plays an important role in the etiology of the disease. ...Likewise, helminth infections represent another …
Pathogenic mechanisms underlying multiple sclerosis development have yet to be clearly identified, but considerable evidence i …
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