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Magnetic resonance imaging-based biomarkers of multiple sclerosis and neuromyelitis optica spectrum disorder: a systematic review and meta-analysis.
Mirmosayyeb O, Yazdan Panah M, Moases Ghaffary E, Vaheb S, Ghoshouni H, Shaygannejad V, Pinter NK. Mirmosayyeb O, et al. J Neurol. 2024 Dec 16;272(1):77. doi: 10.1007/s00415-024-12827-x. J Neurol. 2024. PMID: 39680165 Review.
BACKGROUND/OBJECTIVE: Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are neuroinflammatory conditions with overlapping clinical and imaging features. Distinguishing between these diseases is crucial for appropriate diagnosis and ma …
BACKGROUND/OBJECTIVE: Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are neuroinflammatory conditi …
Associations Between Paramagnetic Rim Lesion Evolution and Clinical and Radiologic Disease Progression in Persons With Multiple Sclerosis.
Reeves JA, Bartnik A, Jakimovski D, Mohebbi M, Bergsland N, Salman F, Schweser F, Wilding G, Weinstock-Guttman B, Dwyer MG, Zivadinov R. Reeves JA, et al. Neurology. 2024 Nov 26;103(10):e210004. doi: 10.1212/WNL.0000000000210004. Epub 2024 Oct 24. Neurology. 2024. PMID: 39447104
BACKGROUND AND OBJECTIVES: Recent technological advances have enabled visualizing in vivo a subset of chronic active brain lesions in persons with multiple sclerosis (pwMS), referred to as "paramagnetic rim lesions" (PRLs), with iron-sensitive MRI. ...PwMS wi …
BACKGROUND AND OBJECTIVES: Recent technological advances have enabled visualizing in vivo a subset of chronic active brain lesions in person …
Real-world analysis of brain atrophy in multiple sclerosis patients with an artificial intelligence based software tool.
Reinhardt C, Angstwurm K, Freudenstein D, Lee DH, Wendl C, Linker RA. Reinhardt C, et al. Neurol Res Pract. 2024 Aug 8;6(1):40. doi: 10.1186/s42466-024-00339-y. Neurol Res Pract. 2024. PMID: 39113151 Free PMC article.
BACKGROUND: Atrophy of white and grey matter volumes occurs early in the brains of people with multiple sclerosis (pwMS) and has great clinical relevance. In clinical trials, brain atrophy can be quantified by magnetic resonance imagin …
BACKGROUND: Atrophy of white and grey matter volumes occurs early in the brains of people with multiple sclerosis (pwMS …
Predicting clinical progression and cognitive decline in patients with relapsing-remitting multiple sclerosis: a 6-year follow-up study.
Kania K, Pawlak MA, Forycka M, Wiłkość-Dębczyńska M, Michalak S, Łukaszewska A, Wyciszkiewicz A, Wypych A, Serafin Z, Marcinkowska J, Kozubski W, Kalinowska-Łyszczarz A. Kania K, et al. Neurol Neurochir Pol. 2024;58(2):176-184. doi: 10.5603/pjnns.97714. Epub 2024 Feb 7. Neurol Neurochir Pol. 2024. PMID: 38324117 Free article.
INTRODUCTION: Cognitive impairment occurs from the earliest stages of multiple sclerosis (MS) and progresses over time. The introduction of disease modifying therapies (DMTs) has changed the prognosis for MS patients, offering a potential opportunity for improvement …
INTRODUCTION: Cognitive impairment occurs from the earliest stages of multiple sclerosis (MS) and progresses over time. The in …
Enlarged choroid plexus in multiple sclerosis is associated with increased lesion load and atrophy in white matter but not gray matter atrophy.
Akaishi T, Fujimori J, Nakashima I. Akaishi T, et al. Mult Scler Relat Disord. 2024 Feb;82:105424. doi: 10.1016/j.msard.2024.105424. Epub 2024 Jan 2. Mult Scler Relat Disord. 2024. PMID: 38181695
BACKGROUND: Enlargement of the choroid plexus (CP) is reported to associate with inflammatory activity and contribute to brain atrophy in patients with multiple sclerosis (pwMS). However, a recent study in healthy volunteers (HVTs) has suggested that CP enlar …
BACKGROUND: Enlargement of the choroid plexus (CP) is reported to associate with inflammatory activity and contribute to brain atrophy …
Brain Atrophy and Physical and Cognitive Disability in Multiple Sclerosis.
Peño LIC, De Silanes De Miguel CL, de Torres L, Ortiz ME, Moreno MJG, Rodeño BO, Carpio RT, Muñoz JS, Montoya BPD, Sepúlveda MÁS, De Antonio Sanz E, Ayuso SA, Salaices MG. Peño LIC, et al. Basic Clin Neurosci. 2023 Mar-Apr;14(2):311-316. doi: 10.32598/bcn.2021.1893.1. Epub 2023 Mar 1. Basic Clin Neurosci. 2023. PMID: 38107523 Free PMC article.
INTRODUCTION: Brain atrophy is associated with physical disability in multiple sclerosis (MS), but there is a great variability between different studies and methodologies, and its use is still limited to research projects. ...PLAIN LANGUAGE SUMMARY: Conventi …
INTRODUCTION: Brain atrophy is associated with physical disability in multiple sclerosis (MS), but there is a great var …
Early Neuroaxonal Damage in Neurologic Disorders Associated With GAD65 Antibodies.
Eisenhut K, Faber J, Engels D, Gerhards R, Lewerenz J, Doppler K, Sommer C, Markewitz R, Falk KK, Rössling R, Pruess H, Finke C, Wickel J, Geis C, Ratuszny D, Pfeffer LK, Bittner S, Piepgras J, Kraft A, Klausewitz J, Nuscher B, Kümpfel T, Thaler FS; German Network for Research on Autoimmune Encephalitis (GENERATE). Eisenhut K, et al. Neurol Neuroimmunol Neuroinflamm. 2023 Nov 1;11(1):e200176. doi: 10.1212/NXI.0000000000200176. Print 2024 Jan. Neurol Neuroimmunol Neuroinflamm. 2023. PMID: 37914416 Free PMC article.
METHODS: In a multicentric cohort of 50 patients, we measured serum neurofilament light chain (sNfL) in relation to disease duration and disease phenotypes, applied automated MRI volumetry, and analyzed clinical characteristics. RESULTS: In patients with neurologic …
METHODS: In a multicentric cohort of 50 patients, we measured serum neurofilament light chain (sNfL) in relation to disease duration and dis …
Reliability of brain atrophy measurements in multiple sclerosis using MRI: an assessment of six freely available software packages for cross-sectional analyses.
van Nederpelt DR, Amiri H, Brouwer I, Noteboom S, Mokkink LB, Barkhof F, Vrenken H, Kuijer JPA. van Nederpelt DR, et al. Neuroradiology. 2023 Oct;65(10):1459-1472. doi: 10.1007/s00234-023-03189-8. Epub 2023 Aug 1. Neuroradiology. 2023. PMID: 37526657 Free PMC article.
PURPOSE: Volume measurement using MRI is important to assess brain atrophy in multiple sclerosis (MS). However, differences between scanners, acquisition protocols, and analysis software introduce unwanted variability of volumes. ...Smallest detectable …
PURPOSE: Volume measurement using MRI is important to assess brain atrophy in multiple sclerosis (MS). However, …
Patterns of brain atrophy in recently-diagnosed relapsing-remitting multiple sclerosis.
Meijboom R, York EN, Kampaite A, Harris MA, White N, Valdés Hernández MDC, Thrippleton MJ, MacDougall NJJ, Connick P, Hunt DPJ, Chandran S, Waldman AD; FutureMS Consortium. Meijboom R, et al. PLoS One. 2023 Jul 28;18(7):e0288967. doi: 10.1371/journal.pone.0288967. eCollection 2023. PLoS One. 2023. PMID: 37506096 Free PMC article.
Recurrent neuroinflammation in relapsing-remitting MS (RRMS) is thought to lead to neurodegeneration, resulting in progressive disability. Repeated magnetic resonance imaging (MRI) of the brain provides non-invasive measures of atrophy over time …
Recurrent neuroinflammation in relapsing-remitting MS (RRMS) is thought to lead to neurodegeneration, resulting in progressive disability. R …
Functional Disability and Brain MRI Volumetry Results among Multiple Sclerosis Patients during 5-Year Follow-Up.
Strautmane S, Balodis A, Teivane A, Grabovska D, Naudins E, Urbanovics D, Fisermans E, Mednieks J, Flintere-Flinte A, Priede Z, Millers A, Zolovs M. Strautmane S, et al. Medicina (Kaunas). 2023 Jun 4;59(6):1082. doi: 10.3390/medicina59061082. Medicina (Kaunas). 2023. PMID: 37374286 Free PMC article.
Background and Objectives: We aimed to determine the link between brain volumetry results and functional disability calculated using the Expanded Disability Status Scale (EDSS) among multiple sclerosis (MS) patients in relation to the provided treatment (dise …
Background and Objectives: We aimed to determine the link between brain volumetry results and functional disability calculated using …
83 results