Abstract
Picamilon, a sodium salt of N-nicotinoyl-gamma-aminobutyric acid, was shown to induce a significant increase of cerebral blood flow in conscious cats. Picamilon was found to inhibit neurogenic spasms of cerebral vessels that was followed by suppression of tonic activity and reflectory discharges in sympathetic nerves. Picamilon led to restoration of the initial condition of cerebral hemodynamics disturbed by a previous administration of serotonin.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Animals
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Cats
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Cerebrovascular Circulation / drug effects*
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Cerebrovascular Disorders / chemically induced
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Cerebrovascular Disorders / drug therapy
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Cerebrovascular Disorders / physiopathology
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Drug Evaluation, Preclinical
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Electrocardiography
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Hemodynamics / drug effects
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Ischemic Attack, Transient / drug therapy
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Ischemic Attack, Transient / etiology
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Ischemic Attack, Transient / physiopathology
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Serotonin / pharmacology
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Wakefulness / drug effects
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Wakefulness / physiology
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Xenon Radioisotopes
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gamma-Aminobutyric Acid / analogs & derivatives*
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gamma-Aminobutyric Acid / pharmacology
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gamma-Aminobutyric Acid / therapeutic use
Substances
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Xenon Radioisotopes
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Serotonin
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gamma-Aminobutyric Acid