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2011 1
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52 results

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Page 1
IRE1alpha silences dsRNA to prevent taxane-induced pyroptosis in triple-negative breast cancer.
Xu L, Peng F, Luo Q, Ding Y, Yuan F, Zheng L, He W, Zhang SS, Fu X, Liu J, Mutlu AS, Wang S, Nehring RB, Li X, Tang Q, Li C, Lv X, Dobrolecki LE, Zhang W, Han D, Zhao N, Jaehnig E, Wang J, Wu W, Graham DA, Li Y, Chen R, Peng W, Chen Y, Catic A, Zhang Z, Zhang B, Mustoe AM, Koong AC, Miles G, Lewis MT, Wang MC, Rosenberg SM, O'Malley BW, Westbrook TF, Xu H, Zhang XH, Osborne CK, Li JB, Ellis MJ, Rimawi MF, Rosen JM, Chen X. Xu L, et al. Among authors: zhao n. Cell. 2024 Dec 12;187(25):7248-7266.e34. doi: 10.1016/j.cell.2024.09.032. Epub 2024 Oct 16. Cell. 2024. PMID: 39419025 Free PMC article.
Here, we identify the ER stress sensor IRE1alpha as a critical checkpoint that restricts the immunostimulatory effects of taxane chemotherapy and prevents the innate immune recognition of immunologically cold triple-negative breast cancer (TNBC). IRE1alpha RNase sil …
Here, we identify the ER stress sensor IRE1alpha as a critical checkpoint that restricts the immunostimulatory effects of taxane chemotherap …
Targeting eIF4A triggers an interferon response to synergize with chemotherapy and suppress triple-negative breast cancer.
Zhao N, Kabotyanski EB, Saltzman AB, Malovannaya A, Yuan X, Reineke LC, Lieu N, Gao Y, Pedroza DA, Calderon SJ, Smith AJ, Hamor C, Safari K, Savage S, Zhang B, Zhou J, Solis LM, Hilsenbeck SG, Fan C, Perou CM, Rosen JM. Zhao N, et al. J Clin Invest. 2023 Dec 15;133(24):e172503. doi: 10.1172/JCI172503. J Clin Invest. 2023. PMID: 37874652 Free PMC article.
Protein synthesis is frequently dysregulated in cancer and selective inhibition of mRNA translation represents an attractive cancer therapy. ...A similar induction of IFN-stimulated genes was observed in breast cancer patient biopsies following zotatif …
Protein synthesis is frequently dysregulated in cancer and selective inhibition of mRNA translation represents an attractive cance …
Breast cancer heterogeneity through the lens of single-cell analysis and spatial pathologies.
Zhao N, Rosen JM. Zhao N, et al. Semin Cancer Biol. 2022 Jul;82:3-10. doi: 10.1016/j.semcancer.2021.07.010. Epub 2021 Jul 16. Semin Cancer Biol. 2022. PMID: 34274486 Free PMC article. Review.
Breast cancer ecosystems are composed of complex cell types, including tumor, stromal and immune cells, each of which can assume diverse phenotypes. ...In this review, we discuss the insights gained through single-cell analysis and spatial pathologies on breast …
Breast cancer ecosystems are composed of complex cell types, including tumor, stromal and immune cells, each of which can assu …
CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer.
Yuan X, Hao X, Chan HL, Zhao N, Pedroza DA, Liu F, Le K, Smith AJ, Calderon SJ, Lieu N, Soth MJ, Jones P, Zhang XH, Rosen JM. Yuan X, et al. Among authors: zhao n. JCI Insight. 2024 Sep 17;9(20):e182621. doi: 10.1172/jci.insight.182621. JCI Insight. 2024. PMID: 39287984 Free PMC article.
Tumor-associated neutrophils (TANs) have been shown to promote immunosuppression and tumor progression, and a high TAN frequency predicts poor prognosis in triple-negative breast cancer (TNBC). Dysregulation of CREB-binding protein (CBP)/P300 function has been obser …
Tumor-associated neutrophils (TANs) have been shown to promote immunosuppression and tumor progression, and a high TAN frequency predicts po …
Chemotherapy Coupled to Macrophage Inhibition Induces T-cell and B-cell Infiltration and Durable Regression in Triple-Negative Breast Cancer.
Singh S, Lee N, Pedroza DA, Bado IL, Hamor C, Zhang L, Aguirre S, Hu J, Shen Y, Xu Y, Gao Y, Zhao N, Chen SH, Wan YW, Liu Z, Chang JT, Hollern D, Perou CM, Zhang XHF, Rosen JM. Singh S, et al. Among authors: zhao n. Cancer Res. 2022 Jun 15;82(12):2281-2297. doi: 10.1158/0008-5472.CAN-21-3714. Cancer Res. 2022. PMID: 35442423 Free PMC article.
A murine TAM signature derived from the T12 model was highly conserved in human claudin-low breast cancers, and high expression of the TAM signature correlated with reduced overall survival in patients with breast cancer. This TAM signature may help identify …
A murine TAM signature derived from the T12 model was highly conserved in human claudin-low breast cancers, and high expression of th …
Patient-Derived Xenografts of Triple-Negative Breast Cancer Enable Deconvolution and Prediction of Chemotherapy Responses.
Lei JT, Dobrolecki LE, Huang C, Srinivasan RR, Vasaikar SV, Lewis AN, Sallas C, Zhao N, Cao J, Landua JD, Moon CI, Liao Y, Hilsenbeck SG, Osborne CK, Rimawi MF, Ellis MJ, Petrosyan V, Wen B, Li K, Saltzman AB, Jain A, Malovannaya A, Wulf GM, Marangoni E, Li S, Kraushaar DC, Wang T, Damodaran S, Zheng X, Meric-Bernstam F, Echeverria GV, Anurag M, Chen X, Welm BE, Welm AL, Zhang B, Lewis MT. Lei JT, et al. Among authors: zhao n. bioRxiv [Preprint]. 2025 Jan 8:2024.12.09.627518. doi: 10.1101/2024.12.09.627518. bioRxiv. 2025. PMID: 39713418 Free PMC article. Preprint.
Combination chemotherapy remains essential for clinical management of triple-negative breast cancer (TNBC). Consequently, responses to multiple single agents cannot be delineated at the single patient level, even though some patients might not require all drugs in t …
Combination chemotherapy remains essential for clinical management of triple-negative breast cancer (TNBC). Consequently, resp …
Circular RNA circ_ABCB10 in cancer.
Liu B, Zhao N, Zhou Y, Lu Y, Chen W, Huang Z, Wang D, Xu Y, Wai Ping Yam J, Cui Y. Liu B, et al. Among authors: zhao n. Clin Chim Acta. 2021 Jul;518:93-100. doi: 10.1016/j.cca.2021.03.010. Epub 2021 Mar 18. Clin Chim Acta. 2021. PMID: 33746018 Review.
It exists widely and possesses a stable structure, is highly conserved and has cell-specific expression. circRNA is associated with disease occurence in general and cancer specifically due to its role in cell differentiation, proliferation, invasion and metastasis. Recentl …
It exists widely and possesses a stable structure, is highly conserved and has cell-specific expression. circRNA is associated with disease …
Sohlh2 inhibits breast cancer cell proliferation by suppressing Wnt/beta-catenin signaling pathway.
Zhang X, Liu R, Zhao N, Ji S, Hao C, Cui W, Zhang R, Hao J. Zhang X, et al. Among authors: zhao n. Mol Carcinog. 2019 Jun;58(6):1008-1018. doi: 10.1002/mc.22989. Epub 2019 Mar 5. Mol Carcinog. 2019. PMID: 30720232
We previously identified that sohlh2 functioned as a tumor suppressor in ovarian cancer. Here, we examined the expression levels of sohlh2 in human breast cancer and its potential role in disease pathogenesis. ...Conversely, silencing of sohlh2 enhanced br …
We previously identified that sohlh2 functioned as a tumor suppressor in ovarian cancer. Here, we examined the expression levels of s …
Dual inhibition of AKT and autophagy sensitizes triple negative breast cancer cells to carboplatin.
Zhou JZ, Wen JY, Xu XW, Zhao N, Tang JJ, Xiao YR, Xiang LY, Jiang Y, Jiang JW, Hong H, Zhang Q. Zhou JZ, et al. Among authors: zhao n. Transl Oncol. 2025 Aug;58:102434. doi: 10.1016/j.tranon.2025.102434. Epub 2025 Jun 1. Transl Oncol. 2025. PMID: 40450899 Free PMC article.
Triple-negative breast cancer (TNBC) exhibits the highest recurrence and mortality rates among breast cancer subtypes. ...Analysis of the TCGA database revealed that AKT1 and autophagy are activated in breast cancer, playing crucial roles …
Triple-negative breast cancer (TNBC) exhibits the highest recurrence and mortality rates among breast cancer sub …
GSK3beta regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer.
Vijay GV, Zhao N, Den Hollander P, Toneff MJ, Joseph R, Pietila M, Taube JH, Sarkar TR, Ramirez-Pena E, Werden SJ, Shariati M, Gao R, Sobieski M, Stephan CC, Sphyris N, Miura N, Davies P, Chang JT, Soundararajan R, Rosen JM, Mani SA. Vijay GV, et al. Among authors: zhao n. Breast Cancer Res. 2019 Mar 7;21(1):37. doi: 10.1186/s13058-019-1125-0. Breast Cancer Res. 2019. PMID: 30845991 Free PMC article.
Consequently, patients diagnosed with TNBCs have reduced overall and disease-free survival rates compared to patients with other subtypes of breast cancer. TNBCs are characterized by the presence of cancer cells with mesenchymal properties, indicating that th …
Consequently, patients diagnosed with TNBCs have reduced overall and disease-free survival rates compared to patients with other subtypes of …
52 results