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Page 1
Comparison of the efficacy between NAC and metformin in treating PCOS patients: a meta-analysis.
Song Y, Wang H, Huang H, Zhu Z. Song Y, et al. Gynecol Endocrinol. 2020 Mar;36(3):204-210. doi: 10.1080/09513590.2019.1689553. Epub 2019 Nov 21. Gynecol Endocrinol. 2020. PMID: 31749393
Our aim is to evaluate the clinical effectiveness and safety by comparing N-acetyl-cysteine (NAC) with metformin administrated by polycystic ovary syndrome (PCOS) patients. Systematic review and meta-analysis of randomized clinical trials (RCTs). ...In conclusions, …
Our aim is to evaluate the clinical effectiveness and safety by comparing N-acetyl-cysteine (NAC) with metformin administrated by pol …
N-acetylcysteine supplementation improves endocrine-metabolism profiles and ovulation induction efficacy in polycystic ovary syndrome.
Fang YQ, Ding H, Li T, Zhao XJ, Luo D, Liu Y, Li Y. Fang YQ, et al. J Ovarian Res. 2024 Oct 16;17(1):205. doi: 10.1186/s13048-024-01528-8. J Ovarian Res. 2024. PMID: 39415242 Free PMC article. Clinical Trial.
METHODS: Female C57BL/6 mice were orally administered letrozole (LE) to induce PCOS and then randomly divided into groups receiving daily oral administration of 160 mg/kg NAC (PCOS + NAC group), 200 mg/kg metformin (PCOS + Met group), or 0.5% ca …
METHODS: Female C57BL/6 mice were orally administered letrozole (LE) to induce PCOS and then randomly divided into groups receiving d …
Metformin inhibits ovarian granular cell pyroptosis through the miR-670-3p/NOX2/ROS pathway.
Zhou LH, Zou H, Hao JY, Huang Y, Zhang JN, Xu XH, Li J. Zhou LH, et al. Aging (Albany NY). 2023 May 25;15(10):4429-4443. doi: 10.18632/aging.204745. Epub 2023 May 25. Aging (Albany NY). 2023. PMID: 37244286 Free PMC article.
Recent studies have demonstrated that ovarian granular cells (OGCs) pyroptosis is present in the ovaries of polycystic ovary syndrome (PCOS) mice and that NLRP3 activation destroys follicular functions. Metformin has been shown to protect against PCOS by reducing in …
Recent studies have demonstrated that ovarian granular cells (OGCs) pyroptosis is present in the ovaries of polycystic ovary syndrome (PC …
Efficacy of N-Acetylcysteine in Polycystic Ovary Syndrome: Systematic Review and Meta-Analysis.
Viña I, Viña JR, Carranza M, Mariscal G. Viña I, et al. Nutrients. 2025 Jan 14;17(2):284. doi: 10.3390/nu17020284. Nutrients. 2025. PMID: 39861414 Free PMC article.
The effect of NAC on the reproductive outcomes of PCOS patients was examined in this meta-analysis. ...CONCLUSIONS: NAC had a major effect on progesterone, endometrial thickness, and LH levels in women with PCOS. ...
The effect of NAC on the reproductive outcomes of PCOS patients was examined in this meta-analysis. ...CONCLUSIONS: NAC …
The Role of Nutrient Supplements in Female Infertility: An Umbrella Review and Hierarchical Evidence Synthesis.
Pandey C, Maunder A, Liu J, Vaddiparthi V, Costello MF, Bahri-Khomami M, Mousa A, Ee C. Pandey C, et al. Nutrients. 2024 Dec 27;17(1):57. doi: 10.3390/nu17010057. Nutrients. 2024. PMID: 39796491 Free PMC article.
L-carnitine, coQ10, melatonin, myo-inositol, NAC and vitamin D increased clinical pregnancy rates in women with PCOS and/or undergoing MAR compared to placebo, standard or no treatment (odds ratio (OR) 11.14, 2.49, 1.66, relative risk (RR) 1.52, OR 2.15, and 1.49 re …
L-carnitine, coQ10, melatonin, myo-inositol, NAC and vitamin D increased clinical pregnancy rates in women with PCOS and/or un …
Suppression of uterine and placental ferroptosis by N-acetylcysteine in a rat model of polycystic ovary syndrome.
Hu M, Zhang Y, Ma S, Li J, Wang X, Liang M, Sferruzzi-Perri AN, Wu X, Ma H, Brännström M, Shao LR, Billig H. Hu M, et al. Mol Hum Reprod. 2021 Nov 27;27(12):gaab067. doi: 10.1093/molehr/gaab067. Mol Hum Reprod. 2021. PMID: 34850077
The mechanisms that link hyperandrogenism and insulin (INS) resistance (HAIR) to the increased miscarriage rate in women with polycystic ovary syndrome (PCOS) remain elusive. Previous studies demonstrate that increased uterine and placental ferroptosis is associated with o …
The mechanisms that link hyperandrogenism and insulin (INS) resistance (HAIR) to the increased miscarriage rate in women with polycystic ova …
A review of antioxidant N-acetylcysteine in addressing polycystic ovary syndrome.
Yifu P. Yifu P. Gynecol Endocrinol. 2024 Dec;40(1):2381498. doi: 10.1080/09513590.2024.2381498. Epub 2024 Jul 22. Gynecol Endocrinol. 2024. PMID: 39039898 Free article.
Recently, there has been increasing interest in exploring the potential benefits of NAC in addressing polycystic ovary syndrome (PCOS). However, the exact mechanisms underlying NAC's therapeutic and clinical uses remain not fully understood. ...Diverse biolog …
Recently, there has been increasing interest in exploring the potential benefits of NAC in addressing polycystic ovary syndrome (P …
Alpha lipoic acid in obstetrics and gynecology.
Di Tucci C, Di Feliciantonio M, Vena F, Capone C, Schiavi MC, Pietrangeli D, Muzii L, Benedetti Panici P. Di Tucci C, et al. Gynecol Endocrinol. 2018 Sep;34(9):729-733. doi: 10.1080/09513590.2018.1462320. Epub 2018 May 4. Gynecol Endocrinol. 2018. PMID: 29726290 Review.
ALA reduces oxidative stress and insulin resistance in women with polycystic ovary syndrome (PCOS). The association of N-acetyl cysteine (NAC), alpha-lipoic acid (ALA), and bromelain (Br) is used for prevention and treatment of endometriosis. ...
ALA reduces oxidative stress and insulin resistance in women with polycystic ovary syndrome (PCOS). The association of N-acetyl cyste …
Effects of N-acetylcysteine and metformin treatment on the stereopathological characteristics of uterus and ovary.
Rafiee B, Karbalay-Doust S, Tabei SMB, Azarpira N, Alaee S, Lohrasbi P, Bahmanpour S. Rafiee B, et al. Eur J Transl Myol. 2022 May 9;32(2):10409. doi: 10.4081/ejtm.2022.10409. Eur J Transl Myol. 2022. Retraction in: Eur J Transl Myol. 2025 Dec 19;35(4). doi: 10.4081/ejtm.2025.14616. PMID: 35535444 Free PMC article. Retracted.
In this study, the stereo-pathological effect of metformin and N-acetyl cysteine is evaluated on the uterus and ovary of polycystic ovary syndrome (PCOS) mice. 96 mature females (8-weekold, weight of 20-30 gr) BALB/c mice were classified into 6 groups including the control …
In this study, the stereo-pathological effect of metformin and N-acetyl cysteine is evaluated on the uterus and ovary of polycystic ovary sy …
N-acetylcysteine for polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled clinical trials.
Thakker D, Raval A, Patel I, Walia R. Thakker D, et al. Obstet Gynecol Int. 2015;2015:817849. doi: 10.1155/2015/817849. Epub 2015 Jan 8. Obstet Gynecol Int. 2015. PMID: 25653680 Free PMC article. Review.
To review the benefits and harms of N-acetylcysteine (NAC) in women with polycystic ovary syndrome (PCOS). Method. Literature search was conducted using the bibliographic databases, MEDLINE (Ovid), CINAHL, EMBASE, Scopus, PsyInfo, and PROQUEST (from inception to Sep …
To review the benefits and harms of N-acetylcysteine (NAC) in women with polycystic ovary syndrome (PCOS). Method. Literature …
42 results