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2020 2
2021 2
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Comparison of the efficacy between NAC and metformin in treating PCOS patients: a meta-analysis.
Song Y, Wang H, Huang H, Zhu Z. Song Y, et al. Gynecol Endocrinol. 2020 Mar;36(3):204-210. doi: 10.1080/09513590.2019.1689553. Epub 2019 Nov 21. Gynecol Endocrinol. 2020. PMID: 31749393
Our aim is to evaluate the clinical effectiveness and safety by comparing N-acetyl-cysteine (NAC) with metformin administrated by polycystic ovary syndrome (PCOS) patients. ...In conclusions, NAC may be considered as an alternative supplement to metformin, bu …
Our aim is to evaluate the clinical effectiveness and safety by comparing N-acetyl-cysteine (NAC) with metformin administrated by pol …
Suppression of uterine and placental ferroptosis by N-acetylcysteine in a rat model of polycystic ovary syndrome.
Hu M, Zhang Y, Ma S, Li J, Wang X, Liang M, Sferruzzi-Perri AN, Wu X, Ma H, Brännström M, Shao LR, Billig H. Hu M, et al. Mol Hum Reprod. 2021 Nov 27;27(12):gaab067. doi: 10.1093/molehr/gaab067. Mol Hum Reprod. 2021. PMID: 34850077
The mechanisms that link hyperandrogenism and insulin (INS) resistance (HAIR) to the increased miscarriage rate in women with polycystic ovary syndrome (PCOS) remain elusive. Previous studies demonstrate that increased uterine and placental ferroptosis is associated with o …
The mechanisms that link hyperandrogenism and insulin (INS) resistance (HAIR) to the increased miscarriage rate in women with polycystic ova …
Alpha lipoic acid in obstetrics and gynecology.
Di Tucci C, Di Feliciantonio M, Vena F, Capone C, Schiavi MC, Pietrangeli D, Muzii L, Benedetti Panici P. Di Tucci C, et al. Gynecol Endocrinol. 2018 Sep;34(9):729-733. doi: 10.1080/09513590.2018.1462320. Epub 2018 May 4. Gynecol Endocrinol. 2018. PMID: 29726290 Review.
ALA reduces oxidative stress and insulin resistance in women with polycystic ovary syndrome (PCOS). The association of N-acetyl cysteine (NAC), alpha-lipoic acid (ALA), and bromelain (Br) is used for prevention and treatment of endometriosis. ...
ALA reduces oxidative stress and insulin resistance in women with polycystic ovary syndrome (PCOS). The association of N-acetyl cyste …
Hyperandrogenism and insulin resistance-induced fetal loss: evidence for placental mitochondrial abnormalities and elevated reactive oxygen species production in pregnant rats that mimic the clinical features of polycystic ovary syndrome.
Zhang Y, Zhao W, Xu H, Hu M, Guo X, Jia W, Liu G, Li J, Cui P, Lager S, Sferruzzi-Perri AN, Li W, Wu XK, Han Y, Brännström M, Shao LR, Billig H. Zhang Y, et al. J Physiol. 2019 Aug;597(15):3927-3950. doi: 10.1113/JP277879. Epub 2019 Jul 3. J Physiol. 2019. PMID: 31206177 Free article.
KEY POINTS: Women with polycystic ovary syndrome (PCOS) commonly suffer from miscarriage, but the underlying mechanisms remain unknown. ...However, NAC administration resulted in fetal loss in normal pregnant rats, most likely due to PCOS-like endocrine abnor …
KEY POINTS: Women with polycystic ovary syndrome (PCOS) commonly suffer from miscarriage, but the underlying mechanisms remain unknow …
[Polycystic ovary syndrome: physiopathology review].
Fux Otta C, Fiol de Cuneo M, Szafryk de Mereshian P. Fux Otta C, et al. Rev Fac Cien Med Univ Nac Cordoba. 2013;70(1):27-30. Rev Fac Cien Med Univ Nac Cordoba. 2013. PMID: 23920100 Review. Spanish.
Although the cause of PCOS is still unknown, there are several hypotheses attempting to explain the primary defect; the most commonly accepted is insulin resistance. ...From the study of the intrauterine environment in recent years it has been suggested that PCOS ma …
Although the cause of PCOS is still unknown, there are several hypotheses attempting to explain the primary defect; the most commonly …
N-acetyl-cysteine as adjuvant therapy in female infertility: a systematic review and meta-analysis.
Devi N, Boya C, Chhabra M, Bansal D. Devi N, et al. J Basic Clin Physiol Pharmacol. 2020 Nov 19;32(5):899-910. doi: 10.1515/jbcpp-2020-0107. J Basic Clin Physiol Pharmacol. 2020. PMID: 34592079 Review.
NAC was found less efficacious and safe than metformin in all outcomes. Overall, NAC showed statistically insignificant (OR=0.98-2.47). OUTLOOK: NAC can be an effective adjuvant in PCOS related and unexplained female infertility. ...
NAC was found less efficacious and safe than metformin in all outcomes. Overall, NAC showed statistically insignificant (OR=0.
Oxidative Stress in Polycystic Ovarian Syndrome and the Effect of Antioxidant N-Acetylcysteine on Ovulation and Pregnancy Rate.
Sandhu JK, Waqar A, Jain A, Joseph C, Srivastava K, Ochuba O, Alkayyali T, Ruo SW, Poudel S. Sandhu JK, et al. Cureus. 2021 Sep 11;13(9):e17887. doi: 10.7759/cureus.17887. eCollection 2021 Sep. Cureus. 2021. PMID: 34660086 Free PMC article. Review.
N-acetylcysteine (NAC), a novel antioxidant, is being used as an adjuvant to treat infertility in females suffering from PCOS. This review aims to evaluate oxidative stress in females suffering from PCOS and assess whether the anti-oxidizing properties of …
N-acetylcysteine (NAC), a novel antioxidant, is being used as an adjuvant to treat infertility in females suffering from PCOS. …
N-acetyl cysteine in ovulation induction of PCOS women underwent intrauterine insemination: An RCT.
Behrouzi Lak T, Hajshafiha M, Nanbakhsh F, Oshnouei S. Behrouzi Lak T, et al. Int J Reprod Biomed. 2017 Apr;15(4):203-208. Int J Reprod Biomed. 2017. PMID: 28835936 Free PMC article.
BACKGROUND: N-acetyl cysteine (NAC) was proposed as an adjuvant to clomiphene citrate for ovulation induction in patients with polycystic ovary syndrome (PCOS) without clomiphene citrate resistance. OBJECTIVE: To evaluate the effect of NAC on pregnancy rate i …
BACKGROUND: N-acetyl cysteine (NAC) was proposed as an adjuvant to clomiphene citrate for ovulation induction in patients with polycy …
N-acetylcysteine for polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled clinical trials.
Thakker D, Raval A, Patel I, Walia R. Thakker D, et al. Obstet Gynecol Int. 2015;2015:817849. doi: 10.1155/2015/817849. Epub 2015 Jan 8. Obstet Gynecol Int. 2015. PMID: 25653680 Free PMC article. Review.
Objective. To review the benefits and harms of N-acetylcysteine (NAC) in women with polycystic ovary syndrome (PCOS). Method. Literature search was conducted using the bibliographic databases, MEDLINE (Ovid), CINAHL, EMBASE, Scopus, PsyInfo, and PROQUEST (from incep …
Objective. To review the benefits and harms of N-acetylcysteine (NAC) in women with polycystic ovary syndrome (PCOS). Method. …
Effects of N-acetylcysteine and metformin treatment on the stereopathological characteristics of uterus and ovary.
Rafiee B, Karbalay-Doust S, Tabei SMB, Azarpira N, Alaee S, Lohrasbi P, Bahmanpour S. Rafiee B, et al. Eur J Transl Myol. 2022 May 9;32(2):10409. doi: 10.4081/ejtm.2022.10409. Eur J Transl Myol. 2022. PMID: 35535444 Free PMC article.
In this study, the stereo-pathological effect of metformin and N-acetyl cysteine is evaluated on the uterus and ovary of polycystic ovary syndrome (PCOS) mice. 96 mature females (8-weekold, weight of 20-30 gr) BALB/c mice were classified into 6 groups including the control …
In this study, the stereo-pathological effect of metformin and N-acetyl cysteine is evaluated on the uterus and ovary of polycystic ovary sy …
32 results