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2021 0
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Comparison of the efficacy between NAC and metformin in treating PCOS patients: a meta-analysis.
Song Y, Wang H, Huang H, Zhu Z. Song Y, et al. Gynecol Endocrinol. 2020 Mar;36(3):204-210. doi: 10.1080/09513590.2019.1689553. Epub 2019 Nov 21. Gynecol Endocrinol. 2020. PMID: 31749393
Our aim is to evaluate the clinical effectiveness and safety by comparing N-acetyl-cysteine (NAC) with metformin administrated by polycystic ovary syndrome (PCOS) patients. ...In conclusions, NAC may be considered as an alternative supplement to metformin, bu …
Our aim is to evaluate the clinical effectiveness and safety by comparing N-acetyl-cysteine (NAC) with metformin administrated by pol …
Alpha lipoic acid in obstetrics and gynecology.
Di Tucci C, Di Feliciantonio M, Vena F, Capone C, Schiavi MC, Pietrangeli D, Muzii L, Benedetti Panici P. Di Tucci C, et al. Gynecol Endocrinol. 2018 Sep;34(9):729-733. doi: 10.1080/09513590.2018.1462320. Epub 2018 May 4. Gynecol Endocrinol. 2018. PMID: 29726290 Review.
ALA reduces oxidative stress and insulin resistance in women with polycystic ovary syndrome (PCOS). The association of N-acetyl cysteine (NAC), alpha-lipoic acid (ALA), and bromelain (Br) is used for prevention and treatment of endometriosis. ...
ALA reduces oxidative stress and insulin resistance in women with polycystic ovary syndrome (PCOS). The association of N-acetyl cyste …
Hyperandrogenism and insulin resistance-induced fetal loss: evidence for placental mitochondrial abnormalities and elevated reactive oxygen species production in pregnant rats that mimic the clinical features of polycystic ovary syndrome.
Zhang Y, Zhao W, Xu H, Hu M, Guo X, Jia W, Liu G, Li J, Cui P, Lager S, Sferruzzi-Perri AN, Li W, Wu XK, Han Y, Brännström M, Shao LR, Billig H. Zhang Y, et al. J Physiol. 2019 Aug;597(15):3927-3950. doi: 10.1113/JP277879. Epub 2019 Jul 3. J Physiol. 2019. PMID: 31206177 Free article.
KEY POINTS: Women with polycystic ovary syndrome (PCOS) commonly suffer from miscarriage, but the underlying mechanisms remain unknown. ...However, NAC administration resulted in fetal loss in normal pregnant rats, most likely due to PCOS-like endocrine abnor …
KEY POINTS: Women with polycystic ovary syndrome (PCOS) commonly suffer from miscarriage, but the underlying mechanisms remain unknow …
N-acetyl cysteine in ovulation induction of PCOS women underwent intrauterine insemination: An RCT.
Behrouzi Lak T, Hajshafiha M, Nanbakhsh F, Oshnouei S. Behrouzi Lak T, et al. Int J Reprod Biomed. 2017 Apr;15(4):203-208. Int J Reprod Biomed. 2017. PMID: 28835936 Free PMC article.
BACKGROUND: N-acetyl cysteine (NAC) was proposed as an adjuvant to clomiphene citrate for ovulation induction in patients with polycystic ovary syndrome (PCOS) without clomiphene citrate resistance. OBJECTIVE: To evaluate the effect of NAC on pregnancy rate i …
BACKGROUND: N-acetyl cysteine (NAC) was proposed as an adjuvant to clomiphene citrate for ovulation induction in patients with polycy …
Effect of clomiphene citrate on endometrial thickness, ovulation, pregnancy and live birth in anovulatory women: systematic review and meta-analysis.
Gadalla MA, Huang S, Wang R, Norman RJ, Abdullah SA, El Saman AM, Ismail AM, van Wely M, Mol BWJ. Gadalla MA, et al. Ultrasound Obstet Gynecol. 2018 Jan;51(1):64-76. doi: 10.1002/uog.18933. Epub 2017 Dec 3. Ultrasound Obstet Gynecol. 2018. PMID: 29055102 Free article. Review.
In three studies that compared CC with CC plus N-acetyl cysteine (NAC), EMT was lower in the CC group (340 women, 300 cycles; WMD, -1.51; 95% CI, -1.98 to -1.04; I(2) = 45%). In two studies that compared CC with CC + nitric oxide (NO) donor, EMT was lower in the CC group ( …
In three studies that compared CC with CC plus N-acetyl cysteine (NAC), EMT was lower in the CC group (340 women, 300 cycles; WMD, -1 …
Comparison of metformin and N-acetyl cysteine, as an adjuvant to clomiphene citrate, in clomiphene-resistant women with polycystic ovary syndrome.
Nemati M, Nemati S, Taheri AM, Heidari B. Nemati M, et al. J Gynecol Obstet Hum Reprod. 2017 Sep;46(7):579-585. doi: 10.1016/j.jogoh.2017.07.004. Epub 2017 Jul 8. J Gynecol Obstet Hum Reprod. 2017. PMID: 28698075 Clinical Trial.
MATERIALS AND METHODS: One hundred and eight CC-resistant PCOS patients participated in the study and received either metformin (1500mg/day) or NAC (1800mg/day) with 100mg/day of CC for 8 and 12 weeks. ...Treatment with metformin and NAC significantly increas …
MATERIALS AND METHODS: One hundred and eight CC-resistant PCOS patients participated in the study and received either metformin (1500 …
N-acetylcysteine for polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled clinical trials.
Thakker D, Raval A, Patel I, Walia R. Thakker D, et al. Obstet Gynecol Int. 2015;2015:817849. doi: 10.1155/2015/817849. Epub 2015 Jan 8. Obstet Gynecol Int. 2015. PMID: 25653680 Free PMC article. Review.
Objective. To review the benefits and harms of N-acetylcysteine (NAC) in women with polycystic ovary syndrome (PCOS). Method. Literature search was conducted using the bibliographic databases, MEDLINE (Ovid), CINAHL, EMBASE, Scopus, PsyInfo, and PROQUEST (from incep …
Objective. To review the benefits and harms of N-acetylcysteine (NAC) in women with polycystic ovary syndrome (PCOS). Method. …
Co-Administration of Metformin and N-Acetyl Cysteine Fails to Improve Clinical Manifestations in PCOS Individual Undergoing ICSI.
Cheraghi E, Soleimani Mehranjani M, Shariatzadeh MA, Nasr Esfahani MH, Ebrahimi Z. Cheraghi E, et al. Int J Fertil Steril. 2014 Jul;8(2):119-28. Epub 2014 Jul 8. Int J Fertil Steril. 2014. PMID: 25083175 Free PMC article.
BACKGROUND: Studies have demonstrated the efficacy of metformin (MTF ) in reducing insulin resistance and N-acetyl cysteine (NAC) in inhibiting oxidative stress which are involved in the pathogenesis of polycystic ovarian syndrome (PCOS). We aimed to compare the eff …
BACKGROUND: Studies have demonstrated the efficacy of metformin (MTF ) in reducing insulin resistance and N-acetyl cysteine (NAC) in …
The Efficacy of Inositol and N-Acetyl Cysteine Administration (Ovaric HP) in Improving the Ovarian Function in Infertile Women with PCOS with or without Insulin Resistance.
Sacchinelli A, Venturella R, Lico D, Di Cello A, Lucia A, Rania E, Cirillo R, Zullo F. Sacchinelli A, et al. Obstet Gynecol Int. 2014;2014:141020. doi: 10.1155/2014/141020. Epub 2014 Apr 30. Obstet Gynecol Int. 2014. PMID: 24876842 Free PMC article.
Objective. Substances such as inositol and N-acetylcysteine (NAC) have been recently shown to be effective in treatment of PCOS patients. ...Methods. Among the 91 PCOS patients treated with NAC + Inositol + folic, insulin resistance was present in 44 s …
Objective. Substances such as inositol and N-acetylcysteine (NAC) have been recently shown to be effective in treatment of PCOS …
A comparison between the effects of metformin and N-acetyl cysteine (NAC) on some metabolic and endocrine characteristics of women with polycystic ovary syndrome.
Javanmanesh F, Kashanian M, Rahimi M, Sheikhansari N. Javanmanesh F, et al. Gynecol Endocrinol. 2016;32(4):285-9. doi: 10.3109/09513590.2015.1115974. Epub 2015 Dec 10. Gynecol Endocrinol. 2016. PMID: 26654154 Clinical Trial.
OBJECTIVE: To compare N-acetyl cysteine (NAC) and metformin on polycystic ovary syndrome (PCOS). METHOD: Study was performed as a randomized double-blind clinical trial on women with diagnosis of PCOS without additional complications. ...High-density lipoprot …
OBJECTIVE: To compare N-acetyl cysteine (NAC) and metformin on polycystic ovary syndrome (PCOS). METHOD: Study was performed a …
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