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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1951 1
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1954 2
1955 1
1956 3
1957 3
1959 3
1960 3
1961 6
1962 7
1963 15
1964 13
1965 11
1966 11
1967 15
1968 21
1969 22
1970 9
1971 24
1972 34
1973 19
1974 29
1975 33
1976 32
1977 21
1978 29
1979 20
1980 38
1981 36
1982 41
1983 53
1984 58
1985 74
1986 60
1987 68
1988 74
1989 96
1990 98
1991 148
1992 125
1993 140
1994 177
1995 192
1996 169
1997 160
1998 167
1999 215
2000 188
2001 216
2002 223
2003 228
2004 245
2005 238
2006 180
2007 223
2008 210
2009 215
2010 220
2011 221
2012 241
2013 271
2014 278
2015 244
2016 230
2017 225
2018 235
2019 241
2020 236
2021 255
2022 228
2023 239
2024 238
2025 78

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7,818 results

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Page 1
NAD+ modulates p53 DNA binding specificity and function.
McLure KG, Takagi M, Kastan MB. McLure KG, et al. Mol Cell Biol. 2004 Nov;24(22):9958-67. doi: 10.1128/MCB.24.22.9958-9967.2004. Mol Cell Biol. 2004. PMID: 15509798 Free PMC article.
Cancer 2:594-604, 2002). Small-molecule manipulation of p53 DNA binding activity has been an elusive goal, but here we show that NAD(+) binds to p53 tetramers, induces a conformational change, and modulates p53 DNA binding specificity in vitro. ...These effec …
Cancer 2:594-604, 2002). Small-molecule manipulation of p53 DNA binding activity has been an elusive goal, but here we show that N …
DNA ligases in the repair and replication of DNA.
Timson DJ, Singleton MR, Wigley DB. Timson DJ, et al. Mutat Res. 2000 Aug 30;460(3-4):301-18. doi: 10.1016/s0921-8777(00)00033-1. Mutat Res. 2000. PMID: 10946235 Review.
DNA ligases are critical enzymes of DNA metabolism. The reaction they catalyse (the joining of nicked DNA) is required in DNA replication and in DNA repair pathways that require the re-synthesis of DNA. Most organisms express DNA l …
DNA ligases are critical enzymes of DNA metabolism. The reaction they catalyse (the joining of nicked DNA) is required …
Fueling genome maintenance: On the versatile roles of NAD(+) in preserving DNA integrity.
Ruszkiewicz JA, Bürkle A, Mangerich A. Ruszkiewicz JA, et al. J Biol Chem. 2022 Jun;298(6):102037. doi: 10.1016/j.jbc.2022.102037. Epub 2022 May 17. J Biol Chem. 2022. PMID: 35595095 Free PMC article. Review.
In this article, we concisely and critically review the role of NAD(+) in mechanisms promoting genome maintenance. Numerous NAD(+)-dependent reactions are involved in the preservation of genome stability, the cellular DNA damage response, and other pathways r …
In this article, we concisely and critically review the role of NAD(+) in mechanisms promoting genome maintenance. Numerous NAD …
NAD homeostasis in the bacterial response to DNA/RNA damage.
Sorci L, Ruggieri S, Raffaelli N. Sorci L, et al. DNA Repair (Amst). 2014 Nov;23:17-26. doi: 10.1016/j.dnarep.2014.07.014. Epub 2014 Aug 13. DNA Repair (Amst). 2014. PMID: 25127744 Review.
Several NAD-consuming enzymes are induced in various stress conditions and the consequent NAD decline is generally accompanied by the activation of NAD biosynthetic pathways to guarantee NAD homeostasis. ...Here we review the current knowledge on the i …
Several NAD-consuming enzymes are induced in various stress conditions and the consequent NAD decline is generally accompanied …
DNA damage and oxygen radical toxicity.
Imlay JA, Linn S. Imlay JA, et al. Science. 1988 Jun 3;240(4857):1302-9. doi: 10.1126/science.3287616. Science. 1988. PMID: 3287616 Review.
A major portion of the toxicity of hydrogen peroxide in Escherichia coli is attributed to DNA damage mediated by a Fenton reaction that generates active forms of hydroxyl radicals from hydrogen peroxide, DNA-bound iron, and a constant source of reducing equivalents. …
A major portion of the toxicity of hydrogen peroxide in Escherichia coli is attributed to DNA damage mediated by a Fenton reaction th …
DNA strand breaks, NAD metabolism, and programmed cell death.
Carson DA, Seto S, Wasson DB, Carrera CJ. Carson DA, et al. Exp Cell Res. 1986 Jun;164(2):273-81. doi: 10.1016/0014-4827(86)90028-5. Exp Cell Res. 1986. PMID: 2940104
An intimate relationship exists between DNA single-strand breaks, NAD metabolism, and cell viability in quiescent human lymphocytes. ...However, lymphocytes have a limited capacity to resynthesize NAD from nicotinamide. An increase in DNA strand break …
An intimate relationship exists between DNA single-strand breaks, NAD metabolism, and cell viability in quiescent human lympho …
NAD(+) Acts as a Protective Factor in Cellular Stress Response to DNA Alkylating Agents.
Ruszkiewicz J, Papatheodorou Y, Jäck N, Melzig J, Eble F, Pirker A, Thomann M, Haberer A, Rothmiller S, Bürkle A, Mangerich A. Ruszkiewicz J, et al. Cells. 2023 Oct 2;12(19):2396. doi: 10.3390/cells12192396. Cells. 2023. PMID: 37830610 Free PMC article.
Sulfur mustard (SM) and its derivatives are potent genotoxic agents, which have been shown to trigger the activation of poly (ADP-ribose) polymerases (PARPs) and the depletion of their substrate, nicotinamide adenine dinucleotide (NAD(+)). NAD(+) is an essential mol …
Sulfur mustard (SM) and its derivatives are potent genotoxic agents, which have been shown to trigger the activation of poly (ADP-ribose) po …
Oligomerization-mediated activation of a short prokaryotic Argonaute.
Shen Z, Yang XY, Xia S, Huang W, Taylor DJ, Nakanishi K, Fu TM. Shen Z, et al. Nature. 2023 Sep;621(7977):154-161. doi: 10.1038/s41586-023-06456-z. Epub 2023 Jul 26. Nature. 2023. PMID: 37494956 Free PMC article.
SPARTA progresses through distinct oligomeric forms, including a monomeric apo state, a monomeric RNA-DNA-bound state, two dimeric RNA-DNA-bound states and a tetrameric RNA-DNA-bound active state. ...Next, two dimers assemble into a tetramer with a central TI …
SPARTA progresses through distinct oligomeric forms, including a monomeric apo state, a monomeric RNA-DNA-bound state, two dimeric RN …
The NAD(+) Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers' Disease.
Hong Y, Zhang Z, Yangzom T, Chen A, Lundberg BC, Fang EF, Siller R, Sullivan GJ, Zeman J, Tzoulis C, Bindoff LA, Liang KX. Hong Y, et al. Int J Biol Sci. 2024 Jan 25;20(4):1194-1217. doi: 10.7150/ijbs.91624. eCollection 2024. Int J Biol Sci. 2024. PMID: 38385069 Free PMC article.
Alpers' syndrome is an early-onset neurodegenerative disorder usually caused by biallelic pathogenic variants in the gene encoding the catalytic subunit of polymerase-gamma (POLG), which is essential for mitochondrial DNA (mtDNA) replication. The disease is progressive, in …
Alpers' syndrome is an early-onset neurodegenerative disorder usually caused by biallelic pathogenic variants in the gene encoding the catal …
7,818 results