Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2006 3
2007 6
2008 2
2009 4
2010 2
2011 4
2012 5
2013 8
2014 7
2015 5
2016 5
2017 5
2018 3
2019 3
2022 2
2023 5
2025 0

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

63 results

Results by year

Filters applied: . Clear all
Page 1
Structural basis for flagellin-induced NAIP5 activation.
Paidimuddala B, Cao J, Zhang L. Paidimuddala B, et al. Sci Adv. 2023 Dec 8;9(49):eadi8539. doi: 10.1126/sciadv.adi8539. Epub 2023 Dec 6. Sci Adv. 2023. PMID: 38055825 Free PMC article.
Here, we investigated the dynamics of the ligand-binding region of inactive NAIP5 and solved the cryo-EM structure of NAIP5 in complex with its specific ligand, FliC from flagellin, at 2.9-A resolution. The structure revealed a "trap and lock" mechanism in Fl …
Here, we investigated the dynamics of the ligand-binding region of inactive NAIP5 and solved the cryo-EM structure of NAIP5 in …
The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.
Zhao Y, Yang J, Shi J, Gong YN, Lu Q, Xu H, Liu L, Shao F. Zhao Y, et al. Nature. 2011 Sep 14;477(7366):596-600. doi: 10.1038/nature10510. Nature. 2011. PMID: 21918512
NAIP5 directly and specifically interacted with flagellin, which determined the inflammasome-stimulation activities of different bacterial flagellins. NAIP5 engagement by flagellin promoted a physical NAIP5-NLRC4 association, rendering fu …
NAIP5 directly and specifically interacted with flagellin, which determined the inflammasome-stimulation activities of differe …
Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity.
Ren T, Zamboni DS, Roy CR, Dietrich WF, Vance RE. Ren T, et al. PLoS Pathog. 2006 Mar;2(3):e18. doi: 10.1371/journal.ppat.0020018. Epub 2006 Mar 17. PLoS Pathog. 2006. PMID: 16552444 Free PMC article.
All mutants were deficient in expression of flagellin, the primary flagellar subunit, and failed to induce caspase-1-mediated macrophage death. Interestingly, a previously isolated flagellar mutant (fliI) that expresses, but does not assemble, flagellin did not repl …
All mutants were deficient in expression of flagellin, the primary flagellar subunit, and failed to induce caspase-1-mediated macroph …
Formation and structure of a NAIP5-NLRC4 inflammasome induced by direct interactions with conserved N- and C-terminal regions of flagellin.
Halff EF, Diebolder CA, Versteeg M, Schouten A, Brondijk TH, Huizinga EG. Halff EF, et al. J Biol Chem. 2012 Nov 9;287(46):38460-72. doi: 10.1074/jbc.M112.393512. Epub 2012 Sep 25. J Biol Chem. 2012. PMID: 23012363 Free PMC article.
The NOD-like receptors NAIP5 and NLRC4 play an essential role in the innate immune response to the bacterial tail protein flagellin. Upon flagellin detection, NAIP5 and NLRC4 form a hetero-oligomeric inflammasome that induces caspase-1-dependent cell d …
The NOD-like receptors NAIP5 and NLRC4 play an essential role in the innate immune response to the bacterial tail protein flagelli …
Structural basis for flagellin induced NAIP5 activation.
Paidimuddala B, Cao J, Zhang L. Paidimuddala B, et al. bioRxiv [Preprint]. 2023 Jun 13:2023.06.13.544801. doi: 10.1101/2023.06.13.544801. bioRxiv. 2023. Update in: Sci Adv. 2023 Dec 8;9(49):eadi8539. doi: 10.1126/sciadv.adi8539. PMID: 37398004 Free PMC article. Updated. Preprint.
To understand this process, we investigated the dynamics of the ligand binding region of inactive NAIP5 and solved the cryo-EM structure of NAIP5 in complex with its specific ligand, FliC from flagellin, at 2.93 A resolution. The structure revealed a "trap an …
To understand this process, we investigated the dynamics of the ligand binding region of inactive NAIP5 and solved the cryo-EM struct …
Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5.
Matusiak M, Van Opdenbosch N, Vande Walle L, Sirard JC, Kanneganti TD, Lamkanfi M. Matusiak M, et al. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1541-6. doi: 10.1073/pnas.1417945112. Epub 2015 Jan 20. Proc Natl Acad Sci U S A. 2015. PMID: 25605939 Free PMC article.
Both Naip5 and phosphorylation of Nlrc4 at Ser533 are required for flagellin-induced inflammasome activation, but how these events converge upon inflammasome activation is not known. Here, we showed that Nlrc4 phosphorylation occurs independently of Naip5 det …
Both Naip5 and phosphorylation of Nlrc4 at Ser533 are required for flagellin-induced inflammasome activation, but how these ev …
Flagellin induces antibody responses through a TLR5- and inflammasome-independent pathway.
López-Yglesias AH, Zhao X, Quarles EK, Lai MA, VandenBos T, Strong RK, Smith KD. López-Yglesias AH, et al. J Immunol. 2014 Feb 15;192(4):1587-96. doi: 10.4049/jimmunol.1301893. Epub 2014 Jan 17. J Immunol. 2014. PMID: 24442437 Free PMC article.
Flagellin is a potent immunogen that activates the innate immune system via TLR5 and Naip5/6, and generates strong T and B cell responses. The adaptor protein MyD88 is critical for signaling by TLR5, as well as IL-1Rs and IL-18Rs, major downstream mediators of the …
Flagellin is a potent immunogen that activates the innate immune system via TLR5 and Naip5/6, and generates strong T and B cel …
Carboxyl-terminal fusion of E7 into Flagellin shifts TLR5 activation to NLRC4/NAIP5 activation and induces TLR5-independent anti-tumor immunity.
Lin KH, Chang LS, Tian CY, Yeh YC, Chen YJ, Chuang TH, Liu SJ, Leng CH. Lin KH, et al. Sci Rep. 2016 Apr 11;6:24199. doi: 10.1038/srep24199. Sci Rep. 2016. PMID: 27063435 Free PMC article.
Flagellin has the capacity to activate both Toll-like receptor 5 (TLR5) and Nod-like receptor C4 (NLRC4)/neuronal apoptosis inhibitory protein 5 (NAIP5) inflammasome signaling. We fused E7m (the inactivated E7 of human papillomavirus) to either end of the flagell …
Flagellin has the capacity to activate both Toll-like receptor 5 (TLR5) and Nod-like receptor C4 (NLRC4)/neuronal apoptosis inhibitor …
Deimmunization of flagellin adjuvant for clinical application.
Rhee JH, Khim K, Puth S, Choi Y, Lee SE. Rhee JH, et al. Curr Opin Virol. 2023 Jun;60:101330. doi: 10.1016/j.coviro.2023.101330. Epub 2023 Apr 19. Curr Opin Virol. 2023. PMID: 37084463 Free article. Review.
Flagellin is the cognate ligand for host pattern recognition receptors, toll-like receptor 5 (TLR5) in the cell surface, and NAIP5/NLRC4 inflammasome in the cytosol. ...The highly conserved C-terminal 35 amino acids of flagellin were proved to be responsible …
Flagellin is the cognate ligand for host pattern recognition receptors, toll-like receptor 5 (TLR5) in the cell surface, and NAIP5 …
Structural basis for specific flagellin recognition by the NLR protein NAIP5.
Yang X, Yang F, Wang W, Lin G, Hu Z, Han Z, Qi Y, Zhang L, Wang J, Sui SF, Chai J. Yang X, et al. Cell Res. 2018 Jan;28(1):35-47. doi: 10.1038/cr.2017.148. Epub 2017 Nov 28. Cell Res. 2018. PMID: 29182158 Free PMC article.
Binding to NAIP5 results in a nearly complete burial of the flagellin derivative, thus stabilizing the active conformation of NAIP5. The extreme C-terminal side of the flagellin is anchored to a sterically constrained binding pocket of NAIP5, wh …
Binding to NAIP5 results in a nearly complete burial of the flagellin derivative, thus stabilizing the active conformation of …
63 results