najafov a - Search Results

Year	Number of Results
2004	1
2007	1
2010	2
2011	1
2012	3
2013	1
2015	3
2016	4
2017	4
2018	6
2019	4
2020	3
2021	4
2022	2
2025	1
2026	1

1

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.

Ito Y, Ofengeim D, Najafov A, Das S, Saberi S, Li Y, Hitomi J, Zhu H, Chen H, Mayo L, Geng J, Amin P, DeWitt JP, Mookhtiar AK, Florez M, Ouchida AT, Fan JB, Pasparakis M, Kelliher MA, Ravits J, Yuan J. Ito Y, et al. Among authors: najafov a. Science. 2016 Aug 5;353(6299):603-8. doi: 10.1126/science.aaf6803. Science. 2016. PMID: 27493188 Free PMC article.

2

Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model.

Xu X, Sun Y, Cen X, Shan B, Zhao Q, Xie T, Wang Z, Hou T, Xue Y, Zhang M, Peng D, Sun Q, Yi C, Najafov A, Xia H. Xu X, et al. Among authors: najafov a. Protein Cell. 2021 Oct;12(10):769-787. doi: 10.1007/s13238-021-00858-3. Epub 2021 Jul 21. Protein Cell. 2021. PMID: 34291435 Free PMC article.

3

Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer's disease mouse model.

Cen X, Chen Y, Xu X, Wu R, He F, Zhao Q, Sun Q, Yi C, Wu J, Najafov A, Xia H. Cen X, et al. Among authors: najafov a. Nat Commun. 2020 Nov 12;11(1):5731. doi: 10.1038/s41467-020-19547-6. Nat Commun. 2020. PMID: 33184293 Free PMC article.

4

Necroptosis and Cancer.

Najafov A, Chen H, Yuan J. Najafov A, et al. Trends Cancer. 2017 Apr;3(4):294-301. doi: 10.1016/j.trecan.2017.03.002. Trends Cancer. 2017. PMID: 28451648 Free PMC article.

5

SIGLEC12 mediates plasma membrane rupture during necroptotic cell death.

Noh H, Hashem Z, Boms E, Najafov A. Noh H, et al. Among authors: najafov a. Nature. 2026 Jan;649(8096):460-466. doi: 10.1038/s41586-025-09741-1. Epub 2025 Nov 12. Nature. 2026. PMID: 41225007 Free PMC article.

6

Necroptosis in development and diseases.

Shan B, Pan H, Najafov A, Yuan J. Shan B, et al. Among authors: najafov a. Genes Dev. 2018 Mar 1;32(5-6):327-340. doi: 10.1101/gad.312561.118. Genes Dev. 2018. PMID: 29593066 Free PMC article. Review.

7

Modulating TRADD to restore cellular homeostasis and inhibit apoptosis.

Xu D, Zhao H, Jin M, Zhu H, Shan B, Geng J, Dziedzic SA, Amin P, Mifflin L, Naito MG, Najafov A, Xing J, Yan L, Liu J, Qin Y, Hu X, Wang H, Zhang M, Manuel VJ, Tan L, He Z, Sun ZJ, Lee VMY, Wagner G, Yuan J. Xu D, et al. Among authors: najafov a. Nature. 2020 Nov;587(7832):133-138. doi: 10.1038/s41586-020-2757-z. Epub 2020 Sep 23. Nature. 2020. PMID: 32968279

8

NEK1-mediated retromer trafficking promotes blood-brain barrier integrity by regulating glucose metabolism and RIPK1 activation.

Wang H, Qi W, Zou C, Xie Z, Zhang M, Naito MG, Mifflin L, Liu Z, Najafov A, Pan H, Shan B, Li Y, Zhu ZJ, Yuan J. Wang H, et al. Among authors: najafov a. Nat Commun. 2021 Aug 10;12(1):4826. doi: 10.1038/s41467-021-25157-7. Nat Commun. 2021. PMID: 34376696 Free PMC article.

9

Synergistic effect of a novel autophagy inhibitor and Quizartinib enhances cancer cell death.

Ouchida AT, Li Y, Geng J, Najafov A, Ofengeim D, Sun X, Yu Q, Yuan J. Ouchida AT, et al. Among authors: najafov a. Cell Death Dis. 2018 Jan 26;9(2):138. doi: 10.1038/s41419-017-0170-9. Cell Death Dis. 2018. PMID: 29374185 Free PMC article.

10

Roles of Caspases in Necrotic Cell Death.

Yuan J, Najafov A, Py BF. Yuan J, et al. Among authors: najafov a. Cell. 2016 Dec 15;167(7):1693-1704. doi: 10.1016/j.cell.2016.11.047. Cell. 2016. PMID: 27984721 Free PMC article. Review.

11

MENA is a transcriptional target of the Wnt/beta-catenin pathway.

Najafov A, Seker T, Even I, Hoxhaj G, Selvi O, Ozel DE, Koman A, Birgül-İyison N. Najafov A, et al. PLoS One. 2012;7(5):e37013. doi: 10.1371/journal.pone.0037013. Epub 2012 May 17. PLoS One. 2012. PMID: 22615875 Free PMC article.

12

Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis.

Amin P, Florez M, Najafov A, Pan H, Geng J, Ofengeim D, Dziedzic SA, Wang H, Barrett VJ, Ito Y, LaVoie MJ, Yuan J. Amin P, et al. Among authors: najafov a. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5944-E5953. doi: 10.1073/pnas.1806973115. Epub 2018 Jun 11. Proc Natl Acad Sci U S A. 2018. PMID: 29891719 Free PMC article.

13

Activation of necroptosis in multiple sclerosis.

Ofengeim D, Ito Y, Najafov A, Zhang Y, Shan B, DeWitt JP, Ye J, Zhang X, Chang A, Vakifahmetoglu-Norberg H, Geng J, Py B, Zhou W, Amin P, Berlink Lima J, Qi C, Yu Q, Trapp B, Yuan J. Ofengeim D, et al. Among authors: najafov a. Cell Rep. 2015 Mar 24;10(11):1836-49. doi: 10.1016/j.celrep.2015.02.051. Cell Rep. 2015. PMID: 25801023 Free PMC article.

14

RIPK1 Promotes Energy Sensing by the mTORC1 Pathway.

Najafov A, Luu HS, Mookhtiar AK, Mifflin L, Xia HG, Amin PP, Ordureau A, Wang H, Yuan J. Najafov A, et al. Mol Cell. 2021 Jan 21;81(2):370-385.e7. doi: 10.1016/j.molcel.2020.11.008. Epub 2020 Dec 2. Mol Cell. 2021. PMID: 33271062 Free article.

15

Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1.

Najafov A, Sommer EM, Axten JM, Deyoung MP, Alessi DR. Najafov A, et al. Biochem J. 2011 Jan 15;433(2):357-69. doi: 10.1042/BJ20101732. Biochem J. 2011. PMID: 21087210

16

Casein kinase-1γ1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3.

Lee SY, Kim H, Li CM, Kang J, Najafov A, Jung M, Kang S, Wang S, Yuan J, Jung YK. Lee SY, et al. Among authors: najafov a. Cell Death Dis. 2019 Dec 4;10(12):923. doi: 10.1038/s41419-019-2146-4. Cell Death Dis. 2019. PMID: 31801942 Free PMC article.

17

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids.

Hoxhaj G, Caddye E, Najafov A, Houde VP, Johnson C, Dissanayake K, Toth R, Campbell DG, Prescott AR, MacKintosh C. Hoxhaj G, et al. Among authors: najafov a. Elife. 2016 Apr 22;5:e12278. doi: 10.7554/eLife.12278. Elife. 2016. PMID: 27244671 Free PMC article.

18

TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL.

Najafov A, Mookhtiar AK, Luu HS, Ordureau A, Pan H, Amin PP, Li Y, Lu Q, Yuan J. Najafov A, et al. Mol Cell. 2019 Aug 8;75(3):457-468.e4. doi: 10.1016/j.molcel.2019.05.022. Epub 2019 Jun 20. Mol Cell. 2019. PMID: 31230815 Free article.

19

GECO: gene expression correlation analysis after genetic algorithm-driven deconvolution.

Najafov J, Najafov A. Najafov J, et al. Among authors: najafov a. Bioinformatics. 2019 Jan 1;35(1):156-159. doi: 10.1093/bioinformatics/bty623. Bioinformatics. 2019. PMID: 30010797

20

ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation.

Wu Y, Zhang C, Liu X, He Z, Shan B, Zeng Q, Zhao Q, Zhu H, Liao H, Cen X, Xu X, Zhang M, Hou T, Wang Z, Yan H, Yang S, Sun Y, Chen Y, Wu R, Xie T, Chen W, Najafov A, Ying S, Xia H. Wu Y, et al. Among authors: najafov a. Nat Commun. 2021 Apr 20;12(1):2346. doi: 10.1038/s41467-021-22467-8. Nat Commun. 2021. PMID: 33879767 Free PMC article.

21

Uncoupling the Warburg effect from cancer.

Najafov A, Alessi DR. Najafov A, et al. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19135-6. doi: 10.1073/pnas.1014047107. Epub 2010 Nov 1. Proc Natl Acad Sci U S A. 2010. PMID: 21041650 Free PMC article. No abstract available.

22

BRAF and AXL oncogenes drive RIPK3 expression loss in cancer.

Najafov A, Zervantonakis IK, Mookhtiar AK, Greninger P, March RJ, Egan RK, Luu HS, Stover DG, Matulonis UA, Benes CH, Yuan J. Najafov A, et al. PLoS Biol. 2018 Aug 29;16(8):e2005756. doi: 10.1371/journal.pbio.2005756. eCollection 2018 Aug. PLoS Biol. 2018. PMID: 30157175 Free PMC article.

23

G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L.

Zhang T, Dong K, Liang W, Xu D, Xia H, Geng J, Najafov A, Liu M, Li Y, Han X, Xiao J, Jin Z, Peng T, Gao Y, Cai Y, Qi C, Zhang Q, Sun A, Lipinski M, Zhu H, Xiong Y, Pandolfi PP, Li H, Yu Q, Yuan J. Zhang T, et al. Among authors: najafov a. Elife. 2015 Mar 30;4:e06734. doi: 10.7554/eLife.06734. Elife. 2015. PMID: 25821988 Free PMC article.

24

Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis.

Geng J, Ito Y, Shi L, Amin P, Chu J, Ouchida AT, Mookhtiar AK, Zhao H, Xu D, Shan B, Najafov A, Gao G, Akira S, Yuan J. Geng J, et al. Among authors: najafov a. Nat Commun. 2017 Aug 25;8(1):359. doi: 10.1038/s41467-017-00406-w. Nat Commun. 2017. PMID: 28842570 Free PMC article.

25

PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development.

Venigalla RK, McGuire VA, Clarke R, Patterson-Kane JC, Najafov A, Toth R, McCarthy PC, Simeons F, Stojanovski L, Arthur JS. Venigalla RK, et al. Among authors: najafov a. EMBO J. 2013 Apr 3;32(7):1008-22. doi: 10.1038/emboj.2013.40. Epub 2013 Mar 5. EMBO J. 2013. PMID: 23463102 Free PMC article.

26

Correction to: Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model.

Xu X, Sun Y, Cen X, Shan B, Zhao Q, Xie T, Wang Z, Hou T, Xue Y, Zhang M, Peng D, Sun Q, Yi C, Najafov A, Xia H. Xu X, et al. Among authors: najafov a. Protein Cell. 2022 Mar;13(3):227-229. doi: 10.1007/s13238-021-00873-4. Protein Cell. 2022. PMID: 34725788 Free PMC article. No abstract available.

27

ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC.

Dziedzic SA, Su Z, Jean Barrett V, Najafov A, Mookhtiar AK, Amin P, Pan H, Sun L, Zhu H, Ma A, Abbott DW, Yuan J. Dziedzic SA, et al. Among authors: najafov a. Nat Cell Biol. 2018 Jan;20(1):58-68. doi: 10.1038/s41556-017-0003-1. Epub 2017 Dec 4. Nat Cell Biol. 2018. PMID: 29203883 Free PMC article.

28

Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death.

Xia HG, Najafov A, Geng J, Galan-Acosta L, Han X, Guo Y, Shan B, Zhang Y, Norberg E, Zhang T, Pan L, Liu J, Coloff JL, Ofengeim D, Zhu H, Wu K, Cai Y, Yates JR, Zhu Z, Yuan J, Vakifahmetoglu-Norberg H. Xia HG, et al. Among authors: najafov a. J Cell Biol. 2015 Aug 31;210(5):705-16. doi: 10.1083/jcb.201503044. J Cell Biol. 2015. PMID: 26323688 Free PMC article.

29

Publisher's Note: ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase.

Hoxhaj G, Najafov A, Toth R, Campbell DG, Prescott AR, MacKintosh C. Hoxhaj G, et al. Among authors: najafov a. J Cell Sci. 2022 Mar 15;135(6):jcs259936. doi: 10.1242/jcs.259936. Epub 2022 Mar 10. J Cell Sci. 2022. PMID: 35267011 Free PMC article. No abstract available.

30

Clinicopathological and genetic study of early-onset demyelinating neuropathy.

Parman Y, Battaloglu E, Baris I, Bilir B, Poyraz M, Bissar-Tadmouri N, Williams A, Ammar N, Nelis E, Timmerman V, De Jonghe P, Najafov A, Deymeer F, Serdaroglu P, Brophy PJ, Said G. Parman Y, et al. Among authors: najafov a. Brain. 2004 Nov;127(Pt 11):2540-50. doi: 10.1093/brain/awh275. Epub 2004 Oct 6. Brain. 2004. PMID: 15469949

31

ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner.

Su Z, Dziedzic SA, Hu D, Barrett VJ, Broekema N, Li W, Qian L, Jia N, Ofengeim D, Najafov A, Zhu H, Knipe DM, Yuan J. Su Z, et al. Among authors: najafov a. Cell Death Differ. 2019 Jun;26(6):1077-1088. doi: 10.1038/s41418-018-0215-3. Epub 2018 Oct 19. Cell Death Differ. 2019. PMID: 30341420 Free PMC article.

32

The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegans.

Landsverk ML, Li S, Hutagalung AH, Najafov A, Hoppe T, Barral JM, Epstein HF. Landsverk ML, et al. Among authors: najafov a. J Cell Biol. 2007 Apr 23;177(2):205-10. doi: 10.1083/jcb.200607084. Epub 2007 Apr 16. J Cell Biol. 2007. PMID: 17438072 Free PMC article.

33

Correction: Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death.

Xia HG, Najafov A, Geng J, Galan-Acosta L, Han X, Guo Y, Shan B, Zhang Y, Norberg E, Zhang T, Pan L, Liu J, Coloff JL, Ofengeim D, Zhu H, Wu K, Cai Y, Yates JR, Zhu Z, Yuan J, Vakifahmetoglu-Norberg H. Xia HG, et al. Among authors: najafov a. J Cell Biol. 2016 Mar 28;212(7):881-2. doi: 10.1083/jcb.20150304403082016c. Epub 2016 Mar 21. J Cell Biol. 2016. PMID: 27002169 Free PMC article. No abstract available.

34

ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase.

Hoxhaj G, Najafov A, Toth R, Campbell DG, Prescott AR, MacKintosh C. Hoxhaj G, et al. Among authors: najafov a. J Cell Sci. 2012 Oct 1;125(Pt 19):4662-75. doi: 10.1242/jcs.110296. Epub 2012 Jul 13. J Cell Sci. 2012. PMID: 22797923 Free PMC article.

35

Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors.

Najafov A, Shpiro N, Alessi DR. Najafov A, et al. Biochem J. 2012 Dec 1;448(2):285-95. doi: 10.1042/BJ20121287. Biochem J. 2012. PMID: 23030823

36

CrossCheck: an open-source web tool for high-throughput screen data analysis.

Najafov J, Najafov A. Najafov J, et al. Among authors: najafov a. Sci Rep. 2017 Jul 19;7(1):5855. doi: 10.1038/s41598-017-05960-3. Sci Rep. 2017. PMID: 28724888 Free PMC article.

37

Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets.

Kavak E, Najafov A, Ozturk N, Seker T, Cavusoglu K, Aslan T, Duru AD, Saygili T, Hoxhaj G, Hiz MC, Unal DO, Birgül-Iyison N, Ozturk M, Koman A. Kavak E, et al. Among authors: najafov a. Cell Signal. 2010 Oct;22(10):1523-35. doi: 10.1016/j.cellsig.2010.05.021. Epub 2010 Jun 9. Cell Signal. 2010. PMID: 20538055

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