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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1977 1
1978 1
1980 1
1981 3
1983 1
1985 2
1986 2
1987 1
1988 4
1989 6
1990 7
1991 4
1992 10
1993 12
1994 16
1995 19
1996 16
1997 22
1998 11
1999 27
2000 21
2001 25
2002 19
2003 27
2004 25
2005 32
2006 46
2007 47
2008 55
2009 49
2010 48
2011 49
2012 60
2013 73
2014 75
2015 66
2016 59
2017 63
2018 58
2019 54
2020 55
2021 62
2022 47
2023 48
2024 47
2025 25

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1,222 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Naltrexone/bupropion for binge-eating disorder: A randomized, double-blind, placebo-controlled trial.
Grilo CM, Lydecker JA, Jastreboff AM, Pittman B, McKee SA. Grilo CM, et al. Obesity (Silver Spring). 2023 Nov;31(11):2762-2773. doi: 10.1002/oby.23898. Epub 2023 Sep 26. Obesity (Silver Spring). 2023. PMID: 37751990 Free PMC article. Clinical Trial.
Few evidence-based treatments exist for BED, particularly pharmacological options. This study tested the efficacy of naltrexone/bupropion for BED. METHODS: A randomized, double-blind, placebo-controlled, 12-week trial tested naltrexone/bupropion for BED with and wit …
Few evidence-based treatments exist for BED, particularly pharmacological options. This study tested the efficacy of naltrexone/bupro …
Bupropion and Naltrexone in Methamphetamine Use Disorder.
Trivedi MH, Walker R, Ling W, Dela Cruz A, Sharma G, Carmody T, Ghitza UE, Wahle A, Kim M, Shores-Wilson K, Sparenborg S, Coffin P, Schmitz J, Wiest K, Bart G, Sonne SC, Wakhlu S, Rush AJ, Nunes EV, Shoptaw S. Trivedi MH, et al. N Engl J Med. 2021 Jan 14;384(2):140-153. doi: 10.1056/NEJMoa2020214. N Engl J Med. 2021. PMID: 33497547 Free PMC article. Clinical Trial.
BACKGROUND: The use of naltrexone plus bupropion to treat methamphetamine use disorder has not been well studied. ...In the first stage, 18 of 109 participants (16.5%) in the naltrexone-bupropion group and 10 of 294 (3.4%) in the placebo group had a response. In the …
BACKGROUND: The use of naltrexone plus bupropion to treat methamphetamine use disorder has not been well studied. ...In the first sta …
Naltrexone-bupropion (Mysimba) in management of obesity: A systematic review and meta-analysis of unpublished clinical study reports.
Onakpoya IJ, Lee JJ, Mahtani KR, Aronson JK, Heneghan CJ. Onakpoya IJ, et al. Br J Clin Pharmacol. 2020 Apr;86(4):646-667. doi: 10.1111/bcp.14210. Epub 2020 Feb 4. Br J Clin Pharmacol. 2020. PMID: 31918448 Free PMC article.
Naltrexone-bupropion had significantly beneficial effects on other cardiovascular risk factors; however, the true effect sizes for these are uncertain because of incomplete outcome data. ...CONCLUSIONS: Naltrexone-bupropion significantly reduces body weight by a sma …
Naltrexone-bupropion had significantly beneficial effects on other cardiovascular risk factors; however, the true effect sizes for th …
Is low-dose naltrexone effective in chronic pain management?
Radi R, Huang H, Rivera J, Lyon C, DeSanto K. Radi R, et al. J Fam Pract. 2023 Sep;72(7):320-321. doi: 10.12788/jfp.0654. J Fam Pract. 2023. PMID: 37729143 Clinical Trial.
YES. Low-dose naltrexone is as effective as amitriptyline in the treatment of painful diabetic neuropathy and has a superior safety profile (strength of recommendation [SOR], B; single randomized controlled trial [RCT]). Low-dose naltrexone significantly reduced pai …
YES. Low-dose naltrexone is as effective as amitriptyline in the treatment of painful diabetic neuropathy and has a superior safety p …
Naltrexone 6 mg once daily versus placebo in women with fibromyalgia: a randomised, double-blind, placebo-controlled trial.
Due Bruun K, Christensen R, Amris K, Vaegter HB, Blichfeldt-Eckhardt MR, Bye-Møller L, Holsgaard-Larsen A, Toft P. Due Bruun K, et al. Lancet Rheumatol. 2024 Jan;6(1):e31-e39. doi: 10.1016/S2665-9913(23)00278-3. Epub 2023 Dec 5. Lancet Rheumatol. 2024. PMID: 38258677 Clinical Trial.
BACKGROUND: Low-dose naltrexone is used to treat fibromyalgia despite minimal evidence for its efficacy. This trial aimed to investigate whether 12-week treatment with 6 mg low-dose naltrexone was superior to placebo for reducing pain in women with fibromyalgia. ... …
BACKGROUND: Low-dose naltrexone is used to treat fibromyalgia despite minimal evidence for its efficacy. This trial aimed to investig …
Pharmacotherapy for Alcohol Use Disorder: A Systematic Review and Meta-Analysis.
McPheeters M, O'Connor EA, Riley S, Kennedy SM, Voisin C, Kuznacic K, Coffey CP, Edlund MD, Bobashev G, Jonas DE. McPheeters M, et al. JAMA. 2023 Nov 7;330(17):1653-1665. doi: 10.1001/jama.2023.19761. JAMA. 2023. PMID: 37934220 Free PMC article.
The numbers needed to treat to prevent 1 person from returning to any drinking were 11 (95% CI, 1-32) for acamprosate and 18 (95% CI, 4-32) for oral naltrexone at a dose of 50 mg/d. Compared with placebo, oral naltrexone (50 mg/d) was associated with lower rates of …
The numbers needed to treat to prevent 1 person from returning to any drinking were 11 (95% CI, 1-32) for acamprosate and 18 (95% CI, 4-32) …
Low-dose naltrexone for the treatment of fibromyalgia: findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels.
Younger J, Noor N, McCue R, Mackey S. Younger J, et al. Arthritis Rheum. 2013 Feb;65(2):529-38. doi: 10.1002/art.37734. Arthritis Rheum. 2013. PMID: 23359310 Clinical Trial.
OBJECTIVE: To determine whether low dosages (4.5 mg/day) of naltrexone reduce fibromyalgia severity as compared with the nonspecific effects of placebo. ...Low-dose naltrexone was rated equally tolerable as placebo, and no serious side effects were reported. ...
OBJECTIVE: To determine whether low dosages (4.5 mg/day) of naltrexone reduce fibromyalgia severity as compared with the nonspecific …
Utility of Naltrexone Treatment for Chronic Inflammatory Dermatologic Conditions: A Systematic Review.
Ekelem C, Juhasz M, Khera P, Mesinkovska NA. Ekelem C, et al. JAMA Dermatol. 2019 Feb 1;155(2):229-236. doi: 10.1001/jamadermatol.2018.4093. JAMA Dermatol. 2019. PMID: 30484835
This phenomenon has piqued the interest of researchers and practitioners in regard to low-dose naltrexone's potential in the treatment of several autoimmune conditions. OBJECTIVE: To review the existing literature on naltrexone treatment for dermatologic cond …
This phenomenon has piqued the interest of researchers and practitioners in regard to low-dose naltrexone's potential in the t …
Sustained-release naltrexone for opioid dependence.
Kornør H, Lobmaier PPK, Kunøe N. Kornør H, et al. Cochrane Database Syst Rev. 2025 May 9;5(5):CD006140. doi: 10.1002/14651858.CD006140.pub3. Cochrane Database Syst Rev. 2025. PMID: 40342086 Review.
Three studies compared sustained-release naltrexone with opioid agonist treatment, five with oral naltrexone, six with placebo, nine with treatment as usual and one with psychosocial intervention. ...Sustained-release naltrexone compared with oral naltrexo …
Three studies compared sustained-release naltrexone with opioid agonist treatment, five with oral naltrexone, six with placebo …
Naltrexone effects on subjective responses to alcohol in the human laboratory: A systematic review and meta-analysis.
Ray LA, Green R, Roche DJO, Magill M, Bujarski S. Ray LA, et al. Addict Biol. 2019 Nov;24(6):1138-1152. doi: 10.1111/adb.12747. Epub 2019 May 30. Addict Biol. 2019. PMID: 31148304 Free PMC article.
Naltrexone (NTX) has been widely studied for the treatment of alcohol use disorder with overall support for its efficacy. ...In order to provide a quantitative estimate of the effects of naltrexone on subjective response to alcohol, the aims of this meta-analytic re …
Naltrexone (NTX) has been widely studied for the treatment of alcohol use disorder with overall support for its efficacy. ...In order …
1,222 results