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Low Dose Naltrexone in the Treatment of Fibromyalgia.
Metyas S, Chen CL, Yeter K, Solyman J, Arkfeld DG. Metyas S, et al. Curr Rheumatol Rev. 2018;14(2):177-180. doi: 10.2174/1573397113666170321120329. Curr Rheumatol Rev. 2018. PMID: 28325149 Clinical Trial.
Thus, there is still a need for adjunctive therapies. METHOD: Naltrexone is an opioid receptor antagonist used to treat alcohol and opioid dependence. It is hypothesized that low dose naltrexone causes transient blockade of opioid receptors centrally resulting in a …
Thus, there is still a need for adjunctive therapies. METHOD: Naltrexone is an opioid receptor antagonist used to treat alcohol and o …
Low-dose Naltrexone for the treatment of sarcoidosis.
Weinstock LB, Myers TL, Shetty A. Weinstock LB, et al. Sarcoidosis Vasc Diffuse Lung Dis. 2017;34(2):184-187. doi: 10.36141/svdld.v34i2.5303. Epub 2017 Apr 28. Sarcoidosis Vasc Diffuse Lung Dis. 2017. PMID: 32476841 Free PMC article.
Neuropeptides (e.g., enkephalins and endorphins) are present in the gastrointestinal tract and endocrine cells and modulate immune responses (9). Up-regulation of met-enkephelin and opioid receptors can be induced by a rebound effect by short-acting LDN (10). Higher …
Neuropeptides (e.g., enkephalins and endorphins) are present in the gastrointestinal tract and endocrine cells and modulate immune re …
Endogenous opioids in cerebrospinal fluid of opioid-dependent humans.
O'Brien CP, Terenius LY, Nyberg F, McLellan AT, Eriksson I. O'Brien CP, et al. Biol Psychiatry. 1988 Oct;24(6):649-62. doi: 10.1016/0006-3223(88)90139-4. Biol Psychiatry. 1988. PMID: 2844315 Free article.
During detoxification, both RRA fraction I and beta-endorphin showed a generally similar pattern of changes. Both were lowest when measured 40-50 hr after the last opioid dose, and both showed an apparent rebound to higher than methadone maintenance values at 60-70 …
During detoxification, both RRA fraction I and beta-endorphin showed a generally similar pattern of changes. Both were lowest when me …
Effects of endogenous and exogenous opioids on splenic natural killer cell activity.
Kraut RP, Greenberg AH. Kraut RP, et al. Nat Immun Cell Growth Regul. 1986;5(1):28-40. Nat Immun Cell Growth Regul. 1986. PMID: 3010087
In a further test of the hypothesis that opioids alter NK activity mice were given a single intraperitoneal injection of morphine or [D-Ala2-Met5]-beta-endorphin, a relatively stable analogue of beta-endorphin, an endogenous opioid. Contrary to expectations these op …
In a further test of the hypothesis that opioids alter NK activity mice were given a single intraperitoneal injection of morphine or [D-Ala2 …