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Page 1
Prevalence and treatment response of neuropsychiatric disorders in mast cell activation syndrome.
Weinstock LB, Afrin LB, Reiersen AM, Brook J, Blitshteyn S, Ehrlich G, Schofield JR, Kinsella L, Kaufman D, Dempsey T, Molderings GJ. Weinstock LB, et al. Brain Behav Immun Health. 2025 Jun 30;48:101048. doi: 10.1016/j.bbih.2025.101048. eCollection 2025 Oct. Brain Behav Immun Health. 2025. PMID: 40686928 Free PMC article.
BACKGROUND: Neuropsychiatric disorders have been observed in mast cell activation syndrome (MCAS). MCAS is a common, yet rarely diagnosed, inflammatory, and immunologic disease characterized by mast cell dysregulation. ...Certain mast cell …
BACKGROUND: Neuropsychiatric disorders have been observed in mast cell activation syndrome (MCAS). MCAS is a common, yet rarel …
Mast Cell Degranulation and Fibroblast Activation in the Morphine-induced Spinal Mass: Role of Mas-related G Protein-coupled Receptor Signaling.
Yaksh TL, Eddinger KA, Kokubu S, Wang Z, DiNardo A, Ramachandran R, Zhu Y, He Y, Weren F, Quang D, Malkmus SA, Lansu K, Kroeze WK, Eliceiri B, Steinauer JJ, Schiller PW, Gmeiner P, Page LM, Hildebrand KR. Yaksh TL, et al. Anesthesiology. 2019 Jul;131(1):132-147. doi: 10.1097/ALN.0000000000002730. Anesthesiology. 2019. PMID: 31225809 Free PMC article.
BACKGROUND: As the meningeally derived, fibroblast-rich, mass-produced by intrathecal morphine infusion is not produced by all opiates, but reduced by mast cell stabilizers, the authors hypothesized a role for meningeal mast cell/fibroblast activation. …
BACKGROUND: As the meningeally derived, fibroblast-rich, mass-produced by intrathecal morphine infusion is not produced by all opiates, but …
Successful treatment of postural orthostatic tachycardia and mast cell activation syndromes using naltrexone, immunoglobulin and antibiotic treatment.
Weinstock LB, Brook JB, Myers TL, Goodman B. Weinstock LB, et al. BMJ Case Rep. 2018 Jan 11;2018:bcr2017221405. doi: 10.1136/bcr-2017-221405. BMJ Case Rep. 2018. PMID: 29326369 Free PMC article.
A patient with severe postural orthostatic tachycardia syndrome (POTS) and mast cell activation syndrome (MCAS) received immunotherapy with low-dose naltrexone (LDN) and intravenous immunoglobulin (IVIg) and antibiotic therapy for small intestinal bacterial o …
A patient with severe postural orthostatic tachycardia syndrome (POTS) and mast cell activation syndrome (MCAS) received immun …
Low-dose Naltrexone Therapy for Psoriasis.
Weinstock LB, Cottel J, Aldridge L, Egeberg A. Weinstock LB, et al. Int J Pharm Compd. 2020 Mar-Apr;24(2):94-96. Int J Pharm Compd. 2020. PMID: 32196470
Two recent case reports suggested that low-dose naltrexone is effective. Cases from our practice are presented in order to further the evidence of efficacy and safety of low-dose naltrexone in the treatment of psoriasis. ...Marked improvement was seen by 53% of the …
Two recent case reports suggested that low-dose naltrexone is effective. Cases from our practice are presented in order to further th …
Psychoneuroimmunological approach to gastrointestinal related pain.
Toljan K, Vrooman B. Toljan K, et al. Scand J Pain. 2017 Oct;17:431-443. doi: 10.1016/j.sjpain.2017.10.010. Epub 2017 Nov 6. Scand J Pain. 2017. PMID: 29122501 Review.
CONCLUSIONS (BASED ON OUR FINDINGS): Rather than proceeding with established allopathic single-target central or peripheral treatments, by non-invasively modulating the brain-gut axis components such as the psychological and neuroendocrinological status, microbiota, enteric nervo …
CONCLUSIONS (BASED ON OUR FINDINGS): Rather than proceeding with established allopathic single-target central or peripheral treatments, by n …
Gastrin-releasing peptide induces itch-related responses through mast cell degranulation in mice.
Andoh T, Kuwazono T, Lee JB, Kuraishi Y. Andoh T, et al. Peptides. 2011 Oct;32(10):2098-103. doi: 10.1016/j.peptides.2011.09.003. Epub 2011 Sep 10. Peptides. 2011. PMID: 21933692
Mast cell deficiency significantly, but not completely, reduced the GRP(18-27)-induced scratching. BB(2) bombesin receptors are present in mast cells in the skin, and intradermal injection of GRP(18-27), not only induced scratching, but also led to …
Mast cell deficiency significantly, but not completely, reduced the GRP(18-27)-induced scratching. BB(2) bombesin receptors ar …
Complex Presentations, Identification and Treatment of Mast Cell Activation Syndrome and Associated Conditions: A Case Report.
Quinn AM. Quinn AM. Integr Med (Encinitas). 2023 Sep;22(4):36-41. Integr Med (Encinitas). 2023. PMID: 37752934 Free PMC article.
The patient was ultimately deemed to have other associated conditions including a mast cell-mediated disorder as well as joint hypermobility due to her response to antihistamine and mast cell stabilizing agents. Final outcomes include immense improveme …
The patient was ultimately deemed to have other associated conditions including a mast cell-mediated disorder as well as joint …
Role of meningeal mast cells in intrathecal morphine-evoked granuloma formation.
Yaksh TL, Allen JW, Veesart SL, Horais KA, Malkmus SA, Scadeng M, Steinauer JJ, Rossi SS. Yaksh TL, et al. Anesthesiology. 2013 Mar;118(3):664-78. doi: 10.1097/ALN.0b013e31828351aa. Anesthesiology. 2013. PMID: 23426209 Free PMC article.
The authors propose that these inflammatory cells exit the meningeal vasculature secondary to meningeal mast cell degranulation. METHODS: Three sets of experiments were accomplished in dogs: (1) ex vivo meningeal mast cell degranulation (histami …
The authors propose that these inflammatory cells exit the meningeal vasculature secondary to meningeal mast cell degra …
Real-World Effectiveness and Tolerability of Low Dose Naltrexone to Treat Chronic Pain: A Retrospective Cohort Study of One Pain Physician's Practice.
Aalto H, Paul S, McEwen V. Aalto H, et al. J Pain Res. 2025 Dec 10;18:6637-6649. doi: 10.2147/JPR.S561662. eCollection 2025. J Pain Res. 2025. PMID: 41399763 Free PMC article.
PURPOSE: Low-dose naltrexone (LDN) is an off-label treatment for chronic pain, with evidence supporting its use mainly consisting of small-scale studies. ...The highest response rates were seen in patients with mast cell activation syndromes and arthritis-rel …
PURPOSE: Low-dose naltrexone (LDN) is an off-label treatment for chronic pain, with evidence supporting its use mainly consisting of …
Critical role of mast cells in morphine-mediated impairment of zymosan-induced peritonitis in mice.
Kolaczkowska E, Seljelid R, Plytycz B. Kolaczkowska E, et al. Inflamm Res. 2001 Aug;50(8):415-21. doi: 10.1007/PL00000264. Inflamm Res. 2001. PMID: 11556522
The aim of the present study was to examine the putative mast cell involvement in this inhibition. SUBJECTS: Peritonitis was induced in WBB6FI mice (genetically mast cell-deficient W/Wv and their control littermaters +/+) and in Balb/c mice, with norma …
The aim of the present study was to examine the putative mast cell involvement in this inhibition. SUBJECTS: Peritonitis was i …
27 results