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The effect of clinically relevant changes in extracellular electrolyte concentrations on human atrial arrhythmias.
Corrado C, Roney CH, Narayan SM, Giles WR, Niederer SA. Corrado C, et al. Among authors: narayan sm. Commun Med (Lond). 2025 Dec 2;6(1):7. doi: 10.1038/s43856-025-01260-4. Commun Med (Lond). 2025. PMID: 41331342 Free PMC article.
However, the mechanistic effects of these electrolyte alterations on atrial electrophysiology remain incompletely understood. This study aims to investigate how clinically relevant variations in extracellular electrolyte concentrations influence human atrial electri …
However, the mechanistic effects of these electrolyte alterations on atrial electrophysiology remain incompletely understood. This st …
Comparison of Detailed and Simplified Models of Human Atrial Myocytes to Recapitulate Patient Specific Properties.
Lombardo DM, Fenton FH, Narayan SM, Rappel WJ. Lombardo DM, et al. Among authors: narayan sm. PLoS Comput Biol. 2016 Aug 5;12(8):e1005060. doi: 10.1371/journal.pcbi.1005060. eCollection 2016 Aug. PLoS Comput Biol. 2016. PMID: 27494252 Free PMC article.
In this study we develop physiologically accurate computational human atrial models by fitting parameters of a detailed and of a simplified model to clinical data for five patients undergoing ablation therapy. Parameters were simultaneously fitted to action potential (AP) …
In this study we develop physiologically accurate computational human atrial models by fitting parameters of a detailed and of a simp …
The precise timing of tachycardia entrainment is determined by the postpacing interval, the tachycardia cycle length, and the pacing rate: Theoretical insights and practical applications.
Kaiser DW, Hsia HH, Dubin AM, Liem LB, Viswanathan MN, Zei PC, Wang PJ, Narayan SM, Turakhia MP. Kaiser DW, et al. Among authors: narayan sm. Heart Rhythm. 2016 Mar;13(3):695-703. doi: 10.1016/j.hrthm.2015.11.032. Epub 2015 Dec 2. Heart Rhythm. 2016. PMID: 26611239 Free PMC article.
For accuracy, we corrected for rate-related changes in conduction velocity. RESULTS: We derived the equations NNE = |(PPI - TCL)/(TCL - PCL)| + 1 and Tachycardia advancement = (NNE - 1) (TCL - PCL) - (PPI - TCL), which state that the NNE and the amount of tachycardi …
For accuracy, we corrected for rate-related changes in conduction velocity. RESULTS: We derived the equations NNE = |(PPI - TC …
Mechanisms Underlying AF: Triggers, Rotors, Other?
Krummen DE, Hebsur S, Salcedo J, Narayan SM, Lalani GG, Schricker AA. Krummen DE, et al. Among authors: narayan sm. Curr Treat Options Cardiovasc Med. 2015 Apr;17(4):371. doi: 10.1007/s11936-015-0371-4. Curr Treat Options Cardiovasc Med. 2015. PMID: 25778423 Free PMC article.
Rapid activation from such triggers interacts with transitional mechanisms including conduction velocity slowing, action potential duration (APD) alternans, and steep APD restitution to cause conduction block and initiate functional reentry. ...Ablation of ro …
Rapid activation from such triggers interacts with transitional mechanisms including conduction velocity slowing, action poten …
Intermittent atrial tachycardia promotes repolarization alternans and conduction slowing during rapid rates, and increases susceptibility to atrial fibrillation in a free-behaving sheep model.
Monigatti-Tenkorang J, Jousset F, Pascale P, Vesin JM, Ruchat P, Fromer M, Narayan SM, Pruvot E. Monigatti-Tenkorang J, et al. Among authors: narayan sm. J Cardiovasc Electrophysiol. 2014 Apr;25(4):418-427. doi: 10.1111/jce.12353. Epub 2014 Jan 30. J Cardiovasc Electrophysiol. 2014. PMID: 24383960
Right atrial kinetics of activation recovery interval (ARI) as a surrogate for action potential duration, of conduction time and velocity, and of repolarization alternans were analyzed at incremental pacing rates during the remodeling process induced by weeks …
Right atrial kinetics of activation recovery interval (ARI) as a surrogate for action potential duration, of conduction time a …
Atrial conduction slows immediately before the onset of human atrial fibrillation: a bi-atrial contact mapping study of transitions to atrial fibrillation.
Lalani GG, Schricker A, Gibson M, Rostamian A, Krummen DE, Narayan SM. Lalani GG, et al. Among authors: narayan sm. J Am Coll Cardiol. 2012 Feb 7;59(6):595-606. doi: 10.1016/j.jacc.2011.10.879. J Am Coll Cardiol. 2012. PMID: 22300695 Free PMC article.
METHODS: In 28 patients with AF (left atrial size 43 5 mm; n = 13 persistent) and 3 control subjects (no AF) at electrophysiological study, we measured bi-atrial conduction time (CT) electrogram fractionation at 64 or 128 electrodes with baskets in left (n = …
METHODS: In 28 patients with AF (left atrial size 43 5 mm; n = 13 persistent) and 3 control subjects (no AF) at electrophysiological …