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Page 1
Machine Learned Cellular Phenotypes in Cardiomyopathy Predict Sudden Death.
Rogers AJ, Selvalingam A, Alhusseini MI, Krummen DE, Corrado C, Abuzaid F, Baykaner T, Meyer C, Clopton P, Giles W, Bailis P, Niederer S, Wang PJ, Rappel WJ, Zaharia M, Narayan SM. Rogers AJ, et al. Among authors: krummen de, narayan sm. Circ Res. 2021 Jan 22;128(2):172-184. doi: 10.1161/CIRCRESAHA.120.317345. Epub 2020 Nov 10. Circ Res. 2021. PMID: 33167779 Free PMC article.
RATIONALE: Susceptibility to VT/VF (ventricular tachycardia/fibrillation) is difficult to predict in patients with ischemic cardiomyopathy either by clinical tools or by attempting to translate cellular mechanisms to the bedside. ...METHODS AND RESULTS: We recorded …
RATIONALE: Susceptibility to VT/VF (ventricular tachycardia/fibrillation) is difficult to predict in patients with ischemic ca …
Spatiotemporal Progression of Early Human Ventricular Fibrillation.
Vidmar D, Krummen DE, Hayase J, Narayan SM, Ho G, Rappel WJ. Vidmar D, et al. Among authors: krummen de, narayan sm. JACC Clin Electrophysiol. 2017 Dec 11;3(12):1437-1446. doi: 10.1016/j.jacep.2017.04.009. Epub 2017 Aug 2. JACC Clin Electrophysiol. 2017. PMID: 29238755 Free PMC article.
OBJECTIVES: The objective of this study was to evaluate the spatio-temporal organization and progression of human ventricular fibrillation (VF) in the left (LV) and right (RV) ventricles. BACKGROUND: Studies suggest that localized sources contribute to VF maintenanc …
OBJECTIVES: The objective of this study was to evaluate the spatio-temporal organization and progression of human ventricular fibr …
Comparative efficacy of stellate ganglion block with bupivacaine vs pulsed radiofrequency in a patient with refractory ventricular arrhythmias.
Hayase J, Vampola S, Ahadian F, Narayan SM, Krummen DE. Hayase J, et al. Among authors: narayan sm, krummen de. J Clin Anesth. 2016 Jun;31:162-5. doi: 10.1016/j.jclinane.2016.01.026. Epub 2016 Apr 15. J Clin Anesth. 2016. PMID: 27185701
There is increasing interest in interventional therapies targeting the cardiac sympathetic nervous system to suppress ventricular arrhythmias. In this case report, we describe an 80-year-old patient with ischemic cardiomyopathy and multiple implantable cardioverter-defibri …
There is increasing interest in interventional therapies targeting the cardiac sympathetic nervous system to suppress ventricular arr …
Modifying Ventricular Fibrillation by Targeted Rotor Substrate Ablation: Proof-of-Concept from Experimental Studies to Clinical VF.
Krummen DE, Hayase J, Vampola SP, Ho G, Schricker AA, Lalani GG, Baykaner T, Coe TM, Clopton P, Rappel WJ, Omens JH, Narayan SM. Krummen DE, et al. Among authors: narayan sm. J Cardiovasc Electrophysiol. 2015 Oct;26(10):1117-26. doi: 10.1111/jce.12753. Epub 2015 Sep 6. J Cardiovasc Electrophysiol. 2015. PMID: 26179310 Free PMC article.
INTRODUCTION: Recent work has suggested a role for organized sources in sustaining ventricular fibrillation (VF). We assessed whether ablation of rotor substrate could modulate VF inducibility in canines, and used this proof-of-concept as a foundation to suppress an …
INTRODUCTION: Recent work has suggested a role for organized sources in sustaining ventricular fibrillation (VF). We assessed …
Rotor stability separates sustained ventricular fibrillation from self-terminating episodes in humans.
Krummen DE, Hayase J, Morris DJ, Ho J, Smetak MR, Clopton P, Rappel WJ, Narayan SM. Krummen DE, et al. Among authors: narayan sm. J Am Coll Cardiol. 2014 Jun 24;63(24):2712-21. doi: 10.1016/j.jacc.2014.03.037. Epub 2014 Apr 30. J Am Coll Cardiol. 2014. PMID: 24794115 Free PMC article.
OBJECTIVES: This study mapped human ventricular fibrillation (VF) to define mechanistic differences between episodes requiring defibrillation versus those that spontaneously terminate. ...METHODS: We enrolled 26 consecutive patients (age 64 10 years, n = 13 with lef …
OBJECTIVES: This study mapped human ventricular fibrillation (VF) to define mechanistic differences between episodes requiring …
Targeted ablation at stable atrial fibrillation sources improves success over conventional ablation in high-risk patients: a substudy of the CONFIRM Trial.
Baykaner T, Clopton P, Lalani GG, Schricker AA, Krummen DE, Narayan SM; CONFIRM Investigators. Baykaner T, et al. Among authors: krummen de, narayan sm. Can J Cardiol. 2013 Oct;29(10):1218-26. doi: 10.1016/j.cjca.2013.07.672. Epub 2013 Aug 30. Can J Cardiol. 2013. PMID: 23993247 Free PMC article. Clinical Trial.
We hypothesized that these comorbidities may cause higher numbers or non-PV locations of atrial fibrillation (AF) sources, where targeted source ablation (focal impulse and rotor modulation [FIRM]) should improve the single-procedure success of ablation. ...The numbers of …
We hypothesized that these comorbidities may cause higher numbers or non-PV locations of atrial fibrillation (AF) sources, where targ …
Percutaneous stellate ganglion block suppressing VT and VF in a patient refractory to VT ablation.
Hayase J, Patel J, Narayan SM, Krummen DE. Hayase J, et al. Among authors: narayan sm, krummen de. J Cardiovasc Electrophysiol. 2013 Aug;24(8):926-8. doi: 10.1111/jce.12138. Epub 2013 Apr 9. J Cardiovasc Electrophysiol. 2013. PMID: 23574305 Free PMC article.
INTRODUCTION: Electrical storm is a condition characterized by multiple episodes of ventricular tachycardia (VT) or ventricular fibrillation (VF) in a short period of time. ...DISCUSSION: This case illustrates the potential of ongoing, temporary percutaneous …
INTRODUCTION: Electrical storm is a condition characterized by multiple episodes of ventricular tachycardia (VT) or ventricular …
Diagnostic accuracy of irregularly irregular RR intervals in separating atrial fibrillation from atrial flutter.
Krummen DE, Feld GK, Narayan SM. Krummen DE, et al. Among authors: narayan sm. Am J Cardiol. 2006 Jul 15;98(2):209-14. doi: 10.1016/j.amjcard.2006.01.088. Epub 2006 May 19. Am J Cardiol. 2006. PMID: 16828594
Periodic electrocardiographic RR intervals are often used to separate atrial flutter (AFl) from atrial fibrillation (AF), but have not yet been validated. We hypothesized that irregularly irregular electrocardiographic RR intervals poorly identify AF from AFl, and that atr …
Periodic electrocardiographic RR intervals are often used to separate atrial flutter (AFl) from atrial fibrillation (AF), but have no …