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294 results

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Page 1
[Novel foods-What must be considered?].
Toussaint F, Wagner N. Toussaint F, et al. Dermatologie (Heidelb). 2025 May 6. doi: 10.1007/s00105-025-05504-1. Online ahead of print. Dermatologie (Heidelb). 2025. PMID: 40327064 Review. German.
Consumption of natto, a Japanese dish containing fermented soy beans, can lead to delayed anaphylaxis. Nattokinase as well as polyglutamic acid (PGA) are well-known triggering allergens. It is postulated that sensitization to PGA may be acquired from skin contact to jellyf …
Consumption of natto, a Japanese dish containing fermented soy beans, can lead to delayed anaphylaxis. Nattokinase as well as polyglu …
Precise modulation of protein refolding by rationally designed covalent organic frameworks.
Guo J, Sun X, Wang J, Hou Y, Yang M, Tan J, Zhang Z, Chen Y, Chen W. Guo J, et al. Nat Commun. 2025 May 3;16(1):4122. doi: 10.1038/s41467-025-59368-z. Nat Commun. 2025. PMID: 40316523 Free PMC article.
This strategy demonstrates high generality that can be applied to various proteins (for example, lysozyme, glucose oxidase, trypsin, nattokinase, and papain) and diverse covalent organic frameworks. An in-depth investigation of the refolding mechanism reveals that pore siz …
This strategy demonstrates high generality that can be applied to various proteins (for example, lysozyme, glucose oxidase, trypsin, natt …
Dual-purpose Bacillus subtilis fermentation: enhanced nattokinase production via oxygen-enriched fed-batch cultivation and natto starter preparation from harvested biomass.
Zheng J, Sun Y, Liao Y, Qin P, Che R, Zhao JY, Xiao Z. Zheng J, et al. Bioprocess Biosyst Eng. 2025 May 1. doi: 10.1007/s00449-025-03151-3. Online ahead of print. Bioprocess Biosyst Eng. 2025. PMID: 40310560
Nattokinase (NK) is one of the most important functional components in natto, but its content is low. ...
Nattokinase (NK) is one of the most important functional components in natto, but its content is low. ...
Abnormal Expression of Proteolytic Stress-Related Proteins and Protective Effect of Fibrinolytic Enzymes in Prion Diseases.
Kim YC, Won SY, Jeong BH. Kim YC, et al. Transbound Emerg Dis. 2025 Feb 26;2025:9527934. doi: 10.1155/tbed/9527934. eCollection 2025. Transbound Emerg Dis. 2025. PMID: 40302732 Free PMC article.
To fundamentally reduce proteolytic stress by the degradation of PrP(Sc), we performed an in vitro evaluation of the PrP(Sc) degradation abilities of fibrinolytic enzymes, including nattokinase and lumbrokinase. Furthermore, we assessed the protective effects of nattoki …
To fundamentally reduce proteolytic stress by the degradation of PrP(Sc), we performed an in vitro evaluation of the PrP(Sc) degradation abi …
Comprehensive Management of Ulcerative Colitis and its Associated Intra-Extra Intestinal Complications with a Multifunctional Inulin Hydrogel Complex.
Wu S, Hu Y, Tao Z, Yu Y, Zhu P, Li T, Jin Y, Wang Y, Qian H, Wang H, Ma Y. Wu S, et al. Small. 2025 Apr 22:e2500726. doi: 10.1002/smll.202500726. Online ahead of print. Small. 2025. PMID: 40263912
This investigation presents a multifunctional inulin complex (PB/NKase@Inulin gel) incorporating Prussian blue nanozymes (PB NZs) and the thrombolytic agent nattokinase (NKase) for the therapeutic management of dextran sulfate sodium (DSS)-induced UC and its associated int …
This investigation presents a multifunctional inulin complex (PB/NKase@Inulin gel) incorporating Prussian blue nanozymes (PB NZs) and the th …
Genomic and Transcriptomic Analysis of Mutant Bacillus subtilis with Enhanced Nattokinase Production via ARTP Mutagenesis.
Guo L, Chen Y, He Z, Wang Z, Chen Q, Chen J, Oz F, Xu Z, Zeng M. Guo L, et al. Foods. 2025 Mar 6;14(5):898. doi: 10.3390/foods14050898. Foods. 2025. PMID: 40077601 Free PMC article.
Nattokinase (NK), a serine protease with high thrombolytic activity, has significant potential for application in foods intended for special health benefits. ...
Nattokinase (NK), a serine protease with high thrombolytic activity, has significant potential for application in foods intended for …
Mechanism of influence of nattokinase terminal sequence on catalytic performance and molecular modification.
Li Y, Wang H, Yu K, Ma A, Zhu W, Li T, Ma Y, Ma Y, Li J. Li Y, et al. Int J Biol Macromol. 2025 May;307(Pt 1):141872. doi: 10.1016/j.ijbiomac.2025.141872. Epub 2025 Mar 9. Int J Biol Macromol. 2025. PMID: 40068750
Nattokinase from traditional food natto has the potential to be a thrombolytic agent. Its terminal sequence has an important effect on the catalytic performance of nattokinase, but the specific mechanism is still unclear. ...This study provides technical support for …
Nattokinase from traditional food natto has the potential to be a thrombolytic agent. Its terminal sequence has an important effect o …
Enhanced thermostability of nattokinase by rational design of disulfide bond.
Yu K, Chen L, Tang Y, Ma A, Zhu W, Wang H, Tang X, Li Y, Li J. Yu K, et al. Microb Cell Fact. 2025 Mar 4;24(1):51. doi: 10.1186/s12934-025-02681-5. Microb Cell Fact. 2025. PMID: 40033318 Free PMC article.
Nattokinase, the thrombolytically active substance in the health food natto, nevertheless, its lower thermostability restricts its use in food and pharmaceutical applications. ...Finally, the fermentation process of mutant M1 was optimized to increase the expression of …
Nattokinase, the thrombolytically active substance in the health food natto, nevertheless, its lower thermostability restricts its us …
Nattokinase as a novel food-grade enzyme for long term cell subculture.
Olenic M, Deelkens C, van Hengel J, Schauwer C, Thorrez L. Olenic M, et al. Food Res Int. 2025 Feb;203:115800. doi: 10.1016/j.foodres.2025.115800. Epub 2025 Jan 20. Food Res Int. 2025. PMID: 40022330
Cell detachment is an essential part of subculturing and to date it is achieved using either animal pancreas-derived trypsin or expensive recombinant enzymes. We found that nattokinase, a fermentation product of Bacillus subtilis subsp. Natto, can be effectively applied fo …
Cell detachment is an essential part of subculturing and to date it is achieved using either animal pancreas-derived trypsin or expensive re …
Cell membrane engineering of Bacillus licheniformis for the enhancement of heterologous protein production.
Asfandyar, Rao Y, Ishaq AR, Zhang Y, Zhang R, Cai D, He P, Chen S. Asfandyar, et al. Int J Biol Macromol. 2025 May;305(Pt 1):141178. doi: 10.1016/j.ijbiomac.2025.141178. Epub 2025 Feb 16. Int J Biol Macromol. 2025. PMID: 39965702
Ultimately, the production of nattokinase, alpha-amylase, and keratinase in DW2-RYCAS were 406.02 8.17 FU/mL, 526.80 14.77 U/mL, and 18.27 0.70 KU/mL, respectively, which increased by 493.59 %, 273.40 %, and 213.91 % compared to the control strain DW2. These results repres …
Ultimately, the production of nattokinase, alpha-amylase, and keratinase in DW2-RYCAS were 406.02 8.17 FU/mL, 526.80 14.77 U/mL, and …
294 results

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