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A radioenhancing nanoparticle mediated immunoradiation improves survival and generates long-term antitumor immune memory in an anti-PD1-resistant murine lung cancer model.
Hu Y, Paris S, Barsoumian H, Abana CO, He K, Sezen D, Wasley M, Masrorpour F, Chen D, Yang L, Dunn JD, Gandhi S, Nguyen QN, Cortez MA, Welsh JW. Hu Y, et al. J Nanobiotechnology. 2021 Dec 11;19(1):416. doi: 10.1186/s12951-021-01163-1. J Nanobiotechnology. 2021. PMID: 34895262 Free PMC article.
The survivor mice at day 178 were rechallenged with 344SQR cells and tumor growth monitored thereafter. RESULTS: NBTXR3 + HDXRT + LDXRT + ICIs had significant antitumor effects against both primary and secondary tumors, improving the survival rate from 0 to 50%. Immune pro …
The survivor mice at day 178 were rechallenged with 344SQR cells and tumor growth monitored thereafter. RESULTS: NBTXR3 + HDXRT + LDX …
Radiation Therapy Enhanced by NBTXR3 Nanoparticles Overcomes Anti-PD1 Resistance and Evokes Abscopal Effects.
Hu Y, Paris S, Barsoumian H, Abana CO, He K, Wasley M, Younes AI, Masrorpour F, Chen D, Yang L, Dunn JD, Zhang J, Gandhi S, Nguyen QN, Cortez MA, Welsh J. Hu Y, et al. Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3):647-657. doi: 10.1016/j.ijrobp.2021.06.041. Epub 2021 Jul 6. Int J Radiat Oncol Biol Phys. 2021. PMID: 34242713
Here we attempted to overcome anti-PD1 resistance by combining localized radiation with a radioenhancing nanoparticle (NBTXR3) and systemic anti-PD1 treatment to achieve abscopal effects in an anti-PD1-resistant mouse model of lung cancer. ...NBTXR3 remodeled the im …
Here we attempted to overcome anti-PD1 resistance by combining localized radiation with a radioenhancing nanoparticle (NBTXR3) and sy …
NBTXR3 Radiotherapy-Activated Functionalized Hafnium Oxide Nanoparticles Show Efficient Antitumor Effects Across a Large Panel of Human Cancer Models.
Zhang P, Marill J, Darmon A, Mohamed Anesary N, Lu B, Paris S. Zhang P, et al. Int J Nanomedicine. 2021 Apr 12;16:2761-2773. doi: 10.2147/IJN.S301182. eCollection 2021. Int J Nanomedicine. 2021. PMID: 33880022 Free PMC article.
PATIENTS AND METHODS: Thanks to its physical mode of action, NBTXR3 has the potential to be used to treat any type of solid tumor. ...Beyond the effects of NBTXR3 as single agent, we show that the antitumor efficacy of cisplatin-based chemoradiotherapy treatment was …
PATIENTS AND METHODS: Thanks to its physical mode of action, NBTXR3 has the potential to be used to treat any type of solid tumor. .. …
Phase I dose-escalation study of NBTXR3 activated by intensity-modulated radiation therapy in elderly patients with locally advanced squamous cell carcinoma of the oral cavity or oropharynx.
Hoffmann C, Calugaru V, Borcoman E, Moreno V, Calvo E, Liem X, Salas S, Doger B, Jouffroy T, Mirabel X, Rodriguez J, Chilles A, Bernois K, Dimitriu M, Fakhry N, Hee Kam SW, Le Tourneau C. Hoffmann C, et al. Eur J Cancer. 2021 Mar;146:135-144. doi: 10.1016/j.ejca.2021.01.007. Epub 2021 Feb 16. Eur J Cancer. 2021. PMID: 33607477 Free article. Clinical Trial.
The MTD was not reached, and no DLTs or serious adverse event (SAEs) related to NBTXR3 were observed. Four adverse events related to NBTXR3 and/or the IT injection were reported (grade I-II). NBTXR3 remained in the injected tumour throughout RT, with no leaka …
The MTD was not reached, and no DLTs or serious adverse event (SAEs) related to NBTXR3 were observed. Four adverse events related to …
Review of clinical applications of radiation-enhancing nanoparticles.
Scher N, Bonvalot S, Le Tourneau C, Chajon E, Verry C, Thariat J, Calugaru V. Scher N, et al. Biotechnol Rep (Amst). 2020 Oct 28;28:e00548. doi: 10.1016/j.btre.2020.e00548. eCollection 2020 Dec. Biotechnol Rep (Amst). 2020. PMID: 33204660 Free PMC article. Review.
Neoadjuvant Treatment Options in Soft Tissue Sarcomas.
Spałek MJ, Kozak K, Czarnecka AM, Bartnik E, Borkowska A, Rutkowski P. Spałek MJ, et al. Cancers (Basel). 2020 Jul 26;12(8):2061. doi: 10.3390/cancers12082061. Cancers (Basel). 2020. PMID: 32722580 Free PMC article. Review.
Radiotherapy-Activated Hafnium Oxide Nanoparticles Produce Abscopal Effect in a Mouse Colorectal Cancer Model.
Zhang P, Darmon A, Marill J, Mohamed Anesary N, Paris S. Zhang P, et al. Int J Nanomedicine. 2020 May 29;15:3843-3850. doi: 10.2147/IJN.S250490. eCollection 2020. Int J Nanomedicine. 2020. PMID: 32581534 Free PMC article.
We examined the effect of radiotherapy-activated NBTXR3 on anti-tumor immune response activation and abscopal effect production using a mouse colorectal cancer model. ...CONCLUSION: These data show that radiotherapy-activated NBTXR3 could increase local and distant …
We examined the effect of radiotherapy-activated NBTXR3 on anti-tumor immune response activation and abscopal effect production using …
Endobronchial ultrasound-guided injection of NBTXR3 radio-enhancing nanoparticles into mediastinal and hilar lymph nodes: a swine model to evaluate feasibility, injection technique, safety, nanoparticle retention and dispersion.
Casal RF, Schwalk AJ, Fowlkes N, Aburto RR, Norton W, Dixon KA, Lin S, Shaitelman SF, Chintalapani G, Hill L. Casal RF, et al. J Thorac Dis. 2020 May;12(5):2317-2324. doi: 10.21037/jtd.2020.03.100. J Thorac Dis. 2020. PMID: 32642136 Free PMC article.
The goal of this study was to assess the feasibility and safety of endobronchial ultrasound (EBUS)-guided injection of NBTXR3 into mediastinal and hilar lymph nodes (LN), as well as assess nanoparticle retention in the LN post-injection. METHODS: Animals underwent bronchos …
The goal of this study was to assess the feasibility and safety of endobronchial ultrasound (EBUS)-guided injection of NBTXR3 into me …
[Use of nanoparticles as radiosensitizing agents in radiotherapy: State of play].
Verry C, Porcel E, Chargari C, Rodriguez-Lafrasse C, Balosso J. Verry C, et al. Cancer Radiother. 2019 Dec;23(8):917-921. doi: 10.1016/j.canrad.2019.07.134. Epub 2019 Sep 17. Cancer Radiother. 2019. PMID: 31540838 Review. French.
The mechanism of these radiosensitizing agents is based on the presence of atoms with a high atomic number (Z) allowing a higher dose deposition into the tumor during irradiation. The first nanoparticle used in humans is NBTXR3, composed of hafnium (Z=79), with intratumor …
The mechanism of these radiosensitizing agents is based on the presence of atoms with a high atomic number (Z) allowing a higher dose deposi …
16 results